Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches

International Journal of Molecular Sciences

Volumn 15, Issue 6, 2014, Pages 10271-10295

  Stiborová, Marie ^a   Frei, Eva ^b   Schmeiser, Heinz H ^b   Arlt, Volker M ^c   Martínek, Václav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

3 nitrobenzanthrone; Aristolochic acid I; Cytochrome P450; DNA adducts; Molecular modeling; NAD(P)H:quinone oxidoreductase; Nitro aromatics

Indexed keywords

3 NITROBENZANTHRONE; ARISTOLOCHIC ACID; CYTOCHROME P450; NITRO DERIVATIVE; NITROAROMATICS; NORADRENALIN TRANSPORTER; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFOTRANSFERASE 1A1; SULFOTRANSFERASE 1A2; UNCLASSIFIED DRUG; 3-NITROBENZANTHRONE; ACYLTRANSFERASE; ARISTOLOCHIC ACID I; BENZ[A]ANTHRACENE DERIVATIVE; DNA ADDUCT; ENZYME; SULFOTRANSFERASE; UNSPECIFIC MONOOXYGENASE;

BINDING AFFINITY; DETOXIFICATION; DNA ADDUCT; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; GENE EXPRESSION; HUMAN; LANGEVIN DIPOLES MODEL; MOLECULAR MODEL; NONHUMAN; POLARIZABLE CONDUCTOR CALCULATION MODEL; PROTEIN CLEAVAGE; REDUCTION; REVIEW; ANIMAL; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM;

ACETYLTRANSFERASES; ANIMALS; ARISTOLOCHIC ACIDS; ARYL HYDROCARBON HYDROXYLASES; BENZ(A)ANTHRACENES; BIOCATALYSIS; DNA ADDUCTS; ENZYMES; HUMANS; MODELS, MOLECULAR; NAD(P)H DEHYDROGENASE (QUINONE); SULFOTRANSFERASES;

EID: 84902268459     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms150610271     Document Type: Review

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