Carcinogenic and nephrotoxic alkaloids aristolochic acids upon activation by NADPH: Cytochrome P450 reductase form adducts found in DNA of patients with Chinese herbs nephropathy

General Physiology and Biophysics

Volumn 20, Issue 4, 2001, Pages 375-392

  Stiborova M ^a   Hajek M ^a   Frei, E ^a   Schmeiser, H H ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

32P postlabelling; Aristolochic acid; Chinese herbs nephropathy; DNA adducts; NADPH:cytochrome P450 reductase; Reductive activation

Indexed keywords

ALKALOID DERIVATIVE; ARISTOLOCHIC ACID; ARISTOLOLACTAM; AROMATIC NITRO COMPOUND; CARCINOGEN; CYTOCHROME P450 REDUCTASE; DEOXYADENOSINE DERIVATIVE; DNA; ENZYME INHIBITOR; MICROSOME ENZYME; NITROREDUCTASE; NUCLEASE; PHOSPHORUS 32; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; CHEMICAL CARCINOGENESIS; CHINESE HERB; CONTROLLED STUDY; DNA ADDUCT; ENZYME PURIFICATION; ISOTOPE LABELING; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY MICROSOME; KIDNEY PARENCHYMA; LIVER MICROSOME; MALE; METABOLIC ACTIVATION; METABOLITE; NEPHROTOXICITY; NONHUMAN; RAT; REDUCTION; URINARY TRACT CANCER;

ANIMALS; ARISTOLOCHIC ACIDS; CARCINOGENS; CATTLE; DNA; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; KIDNEY; LIVER; MALE; MICROSOMES, LIVER; MODELS, CHEMICAL; NADPH-FERRIHEMOPROTEIN REDUCTASE; PHENANTHRENES; RATS; RATS, WISTAR; TIME FACTORS;

ANIMALIA;

EID: 0035721136     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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