The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol

Biochemistry

Volumn 45, Issue 20, 2006, Pages 6372-6378

  Asher, Gad ^a   Dym, Orly ^a   Tsvetkov, Peter ^a   Adler, Julia ^a   Shaul, Yosef ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; ENZYME INHIBITION; LARGE SCALE SYSTEMS; PROTEINS; TUMORS;

DICOUMAROL; NAD(P)H QUINONE OXIDOREDUCTASE 1 (NQO1); ORNITHINE DECARBOXYLASE (ODC);

ENZYME KINETICS;

DICOUMAROL; DUROQUINONE; FLAVINE ADENINE NUCLEOTIDE; FLAVOPROTEIN; HYDROQUINONE; NADPH QUINONE OXIDOREDUCTASE 1; PROTEIN P53; PROTEIN P73; QUINONE DERIVATIVE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME STRUCTURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; STRUCTURE ANALYSIS;

ANIMALS; APOPROTEINS; BENZOQUINONES; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DICUMAROL; ENZYME INHIBITORS; HUMANS; INDOLEQUINONES; MODELS, MOLECULAR; NAD(P)H DEHYDROGENASE (QUINONE); PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; TRIAZINES; TYROSINE;

EID: 33646857902     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0600087     Document Type: Article

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