The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes p450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase

Drug Metabolism and Disposition

Volumn 34, Issue 8, 2006, Pages 1398-1405

  Stiborová, Marie ^a   Dračínská, Helena ^a   Hájková, Jana ^a   Kadeřábková, Pavla ^a   Frei, Eva ^b   Schmeiser, Heinz H ^b   Souček, Pavel ^c   Phillips, David H ^d   Arlt, Volker M ^d  

^a CHARLES UNIVERSITY   (Czech Republic)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOBENZANTHRONE; 3 NITROBENZANTHRONE; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DRUG METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; CYTOSOLIC FRACTION; DNA ADDUCT; ENZYME ACTIVITY; ENZYME INDUCTION; EXHAUST GAS; INCUBATION TIME; LIVER; LIVER MICROSOME; MALE; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BENZ(A)ANTHRACENES; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; HUMANS; LIVER; MALE; MICROSOMES, LIVER; NAD(P)H DEHYDROGENASE (QUINONE); RABBITS; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 33746075616     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.009373     Document Type: Article

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