DNA adduct and tumor formations in rats after intratracheal administration of the urban air pollutant 3-nitrobenzanthrone

Carcinogenesis

Volumn 26, Issue 10, 2005, Pages 1821-1828

  Nagy, Eszter ^a   Zeisig, Magnus ^a   Kawamura, Ken ^b   Hisamatsu, Yoshiharu ^c   Sugeta, Akiko ^d   Adachi, Shuichi ^d   Möller, Lennart ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAGAWA NUTRITION UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^d SAGAMI WOMEN'S UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROBENZANTHRONE; DNA; NUCLEOTIDE; PHOSPHORUS 32;

ADENOCARCINOMA; AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA ADDUCT; FEMALE; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INHALATION; KIDNEY; LIFESPAN; LIVER; LUNG; LUNG TUMOR; NONHUMAN; PRIORITY JOURNAL; RAT; SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL METAPLASIA; TISSUE TYPES; TRACHEA; URBAN AREA;

AIR POLLUTANTS; ANIMALS; BENZ(A)ANTHRACENES; DNA ADDUCTS; FEMALE; KIDNEY; LIVER; LUNG; RATS; RATS, INBRED F344;

EID: 27144447686     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi141     Document Type: Article

References (39)

1. Enya, T., Suzuki, H., Watanabe, T., Hirayama, T. and Hisamatsu, Y. (1997) 3-Nitrobenzanthrone, a powerful bacterial mutagen and suspected human carcinogen found in diesel exhaust and airborne particulates. Environ. Sci. Technol., 30, 2772-2776.
2. Enya, T., Kawanishi, M., Suzuki, H., Matsui, S. and Hisamatsu, Y. (1998) An unusual DNA adduct derived from the powerfully mutagenic environmental contaminant 3-nitroberizanthrone. Chem. Res. Toxicol, 11, 1460-1467.
3. Arlt, V.M., Glatt, H., Muckel, E., Pabel, U., Sorg, B.L., Seidel, A., Frank, H., Schmeiser, H.H. and Phillips, D.H. (2003) Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells. Int. J. Cancer, 105, 583-592.
4. Arlt, V.M., Bieler, C.A., Mier, W., Wiessler, M. and Schmeiser, H.H. (2001) DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined by (32)P-postlabeling. Int. J. Cancer, 93, 450-454.
5. Arlt, V.M., Hewer, A., Sorg, B.L., Schmeiser, H.H., Phillips, D.H. and Stiborova, M. (2004) 3-Aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: Evidence for activation by cytochrome P450 1A1 and P450 1A2. Chem. Res. Toxicol., 17, 1092-1101.
6. Bieler, C.A., Wiessler, M., Erdinger, L., Suzuki, H., Enya, T. and Schmeiser, H.H. (1999) DNA adduct formation from the mutagenic air pollutant 3-nitrobenzanthrone. Mutat. Res., 439, 307-311.
7. Bieler, C.A., Arlt, V.M., Wiessler, M. and Schmeiser, H.H. (2003) DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone in V79 cells expressing human cytochrome P450 enzymes. Cancer Lett., 200, 9-18.
8. Arlt, V.M., Zhan, L., Schmeiser, H.H., Honma, M., Hayashi, M., Phillips, D.H. and Suzuki, T. (2004) DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse. Environ. Mol. Mutagen. 43, 186-195.
9. Turesky, R.J. (2004) The role of genetic polymorphisms in metabolism of carcinogenic heterocyclic aromatic amines. Curr. Drug Metab., 5, 169-180.
10. Arlt, V.M., Glatt, H., Muckel, E., Pabel, U., Sorg, B.L., Schmeiser, H.H. and Phillips, D.H. (2002) Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase. Carcinogenesis, 23, 1937-1945.
11. Arlt, V.M., Stiborova, M., Hewer, A., Schmeiser, H.H. and Phillips, D.H. (2003) Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: Evidence for reductive activation by human NADPH:CYtochrome P450 reductase. Cancer Res., 63, 2752-2761.
12. Carlberg, C.E., Möller, L., Paakki, P., Kantola, M., Stockmann, H., Purkunen, R., Wagner, P., Lauper, U., Kaha, M., Elovaara, E., Kirkinen, P. and Pasanen, M. (2000) DNA adducts in human placenta as biomarkers for environmental pollution, analysed by the 32P-HPLC method. Biomarkers, 5, 182-191.
13. Garner, R.C. (1998) The role of DNA adducts in chemical carcinogenesis. Mutat. Res., 402, 67-75.
14. Zeisig, M. and Moller, L. (1995) 32P-HPLC suitable for characterization of DNA adducts formed in vitro by polycyclic aromatic hydrocarbons and derivatives. Carcinogenesis, 16, 1-9.
15. Borlak, J., Hansen, T., Yuan, Z., Sikka, H.C., Kumar, S., Schimdbauer, S., Frank, H., Jakob, J. and Seidel, A. (2000) Metabolism and DNA-binding of 3-nitrobenzanthrone in primary rat alveolar type II cells, in human fetal bronchial, rat epithelial and mesenchymal cell lines. Polycyclic Aromat, Compds, 21, 73-86.
16. Arlt, V.M., Stiborova, M., Henderson, C.J., Osborne, M.R., Bieler, C.A., Frei, E., Martinek, V., Sopko, B., Wolt, C.R., Schmeiser, H.H. and Phillips, D.H. (2005) Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H: quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols. Cancer Res., 65, 2644-2652.
17. Arlt, V.M., Henderson, C.L., Wolf, C.R., Schmeiser, H.H., Phillips, D.H. and Stiborova, M. (2005) Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: Evidence for DNA adduct formation mediated by cytochrome P450 enzyme and peroxidases. Cancer Lett., 7, (Epub ahead of print).
18. Bieler, C.A., Cornelius, M.G., Klein, R., Arli, V.M., Wiessler, M., Phillips, D.H. and Schmeiser, H.H. (2005) DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in rats. Int. J. Cancer, 26, (Epub ahead or print).
19. Iwanari, M., Nakajima, M., Kizu, R., Hayakawa, K, and Yokoi, T. (2002) Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemicalcytochrome P450 isoform-, and cell-specific differences. Arch, Toxicol., 76, 287-298.
20. Shimada, T., Hayes, C.L., Yamazaki, H., Amin, S., Hecht, S.S., Guengerich, F.P. and Sutter, T.R. (1996) Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res., 56, 2979-2984.
21. Li, W., Harper, P.A., Tang, B.K. and Okey, A.B. (1998) Regulation of cytochrome P450 enzymes by ary1 hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxon or 3-methylcholanthrene. Biochem. Phamacol., 56, 599-612.
22. Arlt, V.M., Sorg, B.L., Osborne, M., Hewer, A., Seidel, A., Schmeiser, H.H. and Phillips, D.H. (2003) DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats. Bioche. Biophys. Res. Commun., 300, 107 114.
23. Guengerich, F.P. (2000) Metabolism of chemical carcinogens. Carcinogenesis, 21, 345-351.
24. Spivack, S.D., Hurteau, G.J., Fasco, M.J. and Kaminsky, L.S. (2003) Phase I and II carcinogen metabolism gene expression in human lung tissue and tumors. Clin. Cancer Res., 9, 6002-6011.
25. Hein, D.W. (2(H)2) Molecular genetics and function of NAT1 and NAT2: role in aromatic airline metabolism and carcinogenesis. Mutat. Res., 506-507, 65-77.
26. IARC (1975) Some aziridines, N-, S-, O-mustards and selenium. International Agency for Research on Cancer, vol. 9, pp. 181-192.
27. Taylor, H.W. and Lijinsky, W. (1985) Squainous-cell carcinoma of the lung. NHMI-induced squamous-cell carcinoma in the lungs of rats. Am. J. Pathol., 119, 169-170.
28. Beland, F.A., Fullerton, N.F., Smith, B.A. and Heflich, R.H. (1994) Formation of DNA adducts and induction of mutations in rats treated with tumorigenic doses of 1.6-dinitropyrene. Environ. Health Perspect., 102 (Suppl 6), 185-189.
29. Smith, B.A., Fullerton, N.F., Heflich, R.H. and Beland, F.A. (1995) DNA adduct formation and T-lymphocyte mutation induction in F344 rats implanted with tumorigenic doses of 1,6-dinitropyrene. Cancer Res., 55, 2316-2324.
30. Takayama, S., Ishikawa, J., Nakajima, H. and Sato, S. (1985) Lung carcinoma induction in Syrian golden hamsters by intratracheal instillation of 1,6-dinitropyrene. Jpn. J. Cancer Res., 76, 457-461.
31. Horikawa, K., Sera, N., Otofuji, T., Murakami, K., Tokiwa, H., Iwagawa, M., Izumi, K. and Otsuka, H. (1991) Pulmonary carcinogenicity of 3,9- and 3,7-dinitrofluoranthene, 3-nitrofluoranthene and benzo[a]pyrene in F344 rats. Carcinogenesis, 12, 1003-1007.
32. Iwagawa, M., Maeda, T., Izumi, K., Otsuka, H., Nishifuji, K., Ohnishi, Y. and Aoki, S. (1989) Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats. Carcinogenesis, 10, 1285-1290.
33. Maeda, T., Izumi, K., Otsuka, H., Manabe, Y., Kinouchi, T. and Ohnishi, Y. (1986) Induction of squamous cell carcinoma in the rat lung by 1,6-dinitropyrene. J. Natl Cancer Inst., 76, 693-701.
34. Lamy, E., Kassie, F., Gminski, R., Schmeiser, H.H. and Mersch-Sundermann, V. (2004) 3-Nitrobenzanthrone (3-NBA) induced micronucleus formation and DNA damage in human hepatoma (HepG2) cells. Toxicol. Lett., 146, 103-109.
35. Seidel, A., Dahmann, D., Krekeler, H. and Jacob, J. (2002) Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel exhaust. Int. J. Hyg. Environ. Health, 204, 333-338.
36. Cui, X.S., Torndal, U.B., Eriksson, L.C. and Moller, L. (1995) Early formation of DNA adducts compared with tumor formation in a long-term tumor study in rats after administration of 2-nitrofluorene. Carcinogenesis, 16, 2135 -2141.
37. Kawanishi, M., Enya, T., Suzuki, H., Takebe, H., Matsui, S. and Yalgi, T. (1998) Mutagenic specificity of a derivative of 3-nitrobenzanthrone in the supF shuttle vector plasmids. Chem. Res. Toxicol., 11, 1468-1473.
38. Shelton, M.L. and DeMarini, D.M. (1995) Mutagenicity and mutation spectra of 2-acetylaminofluorene at frameshift and base-substitution alleles in four DNA repair backgrounds of Salmonella. Mutat. Res., 327. 75-80.
39. Shibutani, S. and Grollman, A.P. (1997) Molecular mechanisms of mutagenesis by aromatic amines and amides. Mutat. Res., 376, 71-78.