NAD(P)H:Quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I

Toxicology and Applied Pharmacology

Volumn 265, Issue 3, 2012, Pages 360-367

  Levova, Katerina ^a   Moserova, Michaela ^a   Nebert, Daniel W ^b   Phillips, David H ^c   Frei, Eva ^d   Schmeiser, Heinz H ^d   Arlt, Volker M ^c   Stiborova, Marie ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Aristolochic acid nephropathy Balkan endemic nephropathy NAD(P):quinone oxidoreductase Protein expression Metabolic activation DNA adducts Mouse models; Aristolochic acid nephropathy; Balkan endemic nephropathy; DNA adducts; Metabolic activation; Mouse models; NAD(P):quinone oxidoreductase; Protein expression

Indexed keywords

ARISTOLOCHIC ACID; CARCINOGEN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; OXIDOREDUCTASE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CYTOSOLIC FRACTION; ENZYME ACTIVITY; ENZYME METABOLISM; FEMALE; IN VIVO STUDY; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SINGLE DRUG DOSE;

ANIMALS; ARISTOLOCHIC ACIDS; BALKAN NEPHROPATHY; BLOTTING, WESTERN; CELL LINE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOSOL; DNA ADDUCTS; FEMALE; HUMANS; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NAD(P)H DEHYDROGENASE (QUINONE);

MUS; MUS MUSCULUS;

EID: 84870302951     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.09.004     Document Type: Article

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