RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events

Journal of Immunology

Volumn 192, Issue 12, 2014, Pages 5963-5973

  Colak, Elif ^a   Leslie, Alasdair ^b   Zausmer, Kieran ^b   Khatamzas, Elham ^b   Kubarenko, Andriy V ^a,i   Pichulik, Tica ^c   Klimosch, Sascha N ^c   Mayer, Alice ^b   Siggs, Owen ^d   Hector, Andreas ^c   Fischer, Roman ^b   Klesser, Benedikt ^b   Rautanen, Anna ^e   Frank, Martin ^a,j   Hill, Adrian V S ^e   Manoury, Bélnéldicte ^f,g   Beutler, Bruce ^h   Hartl, Dominik ^c   Simmons, Alison ^b,k   Weber, Alexander N R ^a,c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f INSERM   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

^h UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

ⁱ UNIVERSITY HOSPITAL BONN   (Germany)

^j BIOGNOS AB   (Sweden)

^k AFRICA HEALTH RESEARCH INSTITUTE   (South Africa)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; OLIGORIBONUCLEOTIDE; RESIQUIMOD; RNA; RNA 40; STAT3 PROTEIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE CONTROL; GENETIC TRANSCRIPTION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ACTIVITY RELATION; UPREGULATION;

ANIMALS; HEK293 CELLS; HUMANS; MICE; OLIGORIBONUCLEOTIDES; PROTEIN STRUCTURE, TERTIARY; QUINOLINIUM COMPOUNDS; RNA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 84902123849     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303058     Document Type: Article

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