Conserved features in the extracellular domain of human toll-like receptor 8 are essential for pH-dependent signaling

Journal of Biological Chemistry

Volumn 281, Issue 37, 2006, Pages 27503-27511

  Gibbard, Rebecca J ^a   Morley, Peter J ^b   Gay, Nicholas J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MUTAGENESIS; NUCLEIC ACIDS; PROTEINS; RNA; SIGNALING; SOLENOIDS;

ANTIVIRAL COMPOUND; ASPARTIC ACID; ECTODOMAIN STRUCTURE; TOLL-LIKE RECEPTOR (TLR);

IMMUNOLOGY;

ASPARTIC ACID; CPG OLIGODEOXYNUCLEOTIDE; CYSTEINE; LEUCINE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; RESIQUIMOD; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

ACIDITY; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CELL COMPARTMENTALIZATION; CELL PH; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; ENDOPLASMIC RETICULUM; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PH MEASUREMENT; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTON TRANSPORT; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STIMULUS RESPONSE; STRUCTURAL PROTEOMICS;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; CPG ISLANDS; ENDOPLASMIC RETICULUM; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 8; TOLL-LIKE RECEPTOR 9;

EID: 33748065439     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605003200     Document Type: Article

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