-
1
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill L.A., Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 2007, 7:353-364.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
2
-
-
70350356853
-
Activating immunity: lessons from the TLRs and NLRs
-
Monie T.P., et al. Activating immunity: lessons from the TLRs and NLRs. Trends Biochem. Sci. 2009, 34:553-561.
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 553-561
-
-
Monie, T.P.1
-
3
-
-
77950542752
-
Targeting Toll-like receptors: emerging therapeutics? Nat
-
Hennessy E.J., et al. Targeting Toll-like receptors: emerging therapeutics? Nat. Rev. Drug. Discov. 2010, 9:293-307.
-
(2010)
Rev. Drug. Discov.
, vol.9
, pp. 293-307
-
-
Hennessy, E.J.1
-
4
-
-
35649022764
-
Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
-
Butler M.P., et al. Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. J. Biol. Chem. 2007, 282:29729-29737.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 29729-29737
-
-
Butler, M.P.1
-
5
-
-
77953302679
-
IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)
-
Dunne A., et al. IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). J. Biol. Chem. 2010, 285:18276-18282.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 18276-18282
-
-
Dunne, A.1
-
6
-
-
36348932904
-
IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination
-
Keating S.E., et al. IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination. J. Biol. Chem. 2007, 282:33435-33443.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 33435-33443
-
-
Keating, S.E.1
-
7
-
-
33744543517
-
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
-
Gray P., et al. MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J. Biol. Chem. 2006, 281:10489-10495.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 10489-10495
-
-
Gray, P.1
-
8
-
-
31344467156
-
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
-
Mansell A., et al. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat. Immunol. 2006, 7:148-155.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 148-155
-
-
Mansell, A.1
-
9
-
-
33745124663
-
Trif-related adapter molecule is phosphorylated by PKC{varepsilon} during Toll-like receptor 4 signaling
-
McGettrick A.F., et al. Trif-related adapter molecule is phosphorylated by PKC{varepsilon} during Toll-like receptor 4 signaling. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:9196-9201.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 9196-9201
-
-
McGettrick, A.F.1
-
10
-
-
33748871187
-
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
-
Carty M., et al. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat. Immunol. 2006, 7:1074-1081.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1074-1081
-
-
Carty, M.1
-
11
-
-
34047098731
-
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
-
Khor C.C., et al. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat. Genet. 2007, 39:523-528.
-
(2007)
Nat. Genet.
, vol.39
, pp. 523-528
-
-
Khor, C.C.1
-
12
-
-
77957846970
-
Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive Haemophilus influenzae serotype b infection in immunized children
-
Ladhani S.N., et al. Association between single-nucleotide polymorphisms in Mal/TIRAP and interleukin-10 genes and susceptibility to invasive Haemophilus influenzae serotype b infection in immunized children. Clin. Infect. Dis. 2010, 51:761-767.
-
(2010)
Clin. Infect. Dis.
, vol.51
, pp. 761-767
-
-
Ladhani, S.N.1
-
13
-
-
67649880546
-
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock
-
Ferwerda B., et al. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:10272-10277.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 10272-10277
-
-
Ferwerda, B.1
-
14
-
-
48749109290
-
Pyogenic bacterial infections in humans with MyD88 deficiency
-
von Bernuth H., et al. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 2008, 321:691-696.
-
(2008)
Science
, vol.321
, pp. 691-696
-
-
von Bernuth, H.1
-
15
-
-
48749127416
-
Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa
-
Walsh C., et al. Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa. J. Immunol. 2008, 181:1245-1254.
-
(2008)
J. Immunol.
, vol.181
, pp. 1245-1254
-
-
Walsh, C.1
-
16
-
-
69949161905
-
An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4
-
Motshwene P.G., et al. An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4. J. Biol. Chem. 2009, 284:25404-25411.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 25404-25411
-
-
Motshwene, P.G.1
-
17
-
-
77953714711
-
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling
-
Lin S.C., et al. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 2010, 465:885-890.
-
(2010)
Nature
, vol.465
, pp. 885-890
-
-
Lin, S.C.1
-
18
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park B.S., et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 2009, 458:1191-1195.
-
(2009)
Nature
, vol.458
, pp. 1191-1195
-
-
Park, B.S.1
-
19
-
-
34548608447
-
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
-
Jin M.S., et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 2007, 130:1071-1082.
-
(2007)
Cell
, vol.130
, pp. 1071-1082
-
-
Jin, M.S.1
-
20
-
-
42349090335
-
Structural basis of toll-like receptor 3 signaling with double-stranded RNA
-
Liu L., et al. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 2008, 320:379-381.
-
(2008)
Science
, vol.320
, pp. 379-381
-
-
Liu, L.1
-
21
-
-
33748090945
-
Toll-like receptors as molecular switches
-
Gay N.J., et al. Toll-like receptors as molecular switches. Nat. Rev. Immunol. 2006, 6:693-698.
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 693-698
-
-
Gay, N.J.1
-
22
-
-
40749097627
-
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
-
Nunez Miguel R., et al. A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS One 2007, 2:e788.
-
(2007)
PLoS One
, vol.2
-
-
Nunez Miguel, R.1
-
23
-
-
40949134086
-
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
-
Kagan J.C., et al. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat. Immunol. 2008, 9:361-368.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 361-368
-
-
Kagan, J.C.1
-
24
-
-
33646908228
-
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
-
Kagan J.C., Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 2006, 125:943-955.
-
(2006)
Cell
, vol.125
, pp. 943-955
-
-
Kagan, J.C.1
Medzhitov, R.2
-
25
-
-
33646567507
-
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
-
Rowe D.C., et al. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:6299-6304.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 6299-6304
-
-
Rowe, D.C.1
-
26
-
-
34548459868
-
Structure and function of Toll receptors and their ligands
-
Gay N.J., Gangloff M. Structure and function of Toll receptors and their ligands. Annu. Rev. Biochem. 2007, 76:141-165.
-
(2007)
Annu. Rev. Biochem.
, vol.76
, pp. 141-165
-
-
Gay, N.J.1
Gangloff, M.2
-
27
-
-
0035425256
-
The death domain superfamily: a tale of two interfaces?
-
Weber C.H., Vincenz C. The death domain superfamily: a tale of two interfaces?. Trends Biochem. Sci. 2001, 26:475-481.
-
(2001)
Trends Biochem. Sci.
, vol.26
, pp. 475-481
-
-
Weber, C.H.1
Vincenz, C.2
-
28
-
-
34247842740
-
The death domain superfamily in intracellular signaling of apoptosis and inflammation
-
Park H.H., et al. The death domain superfamily in intracellular signaling of apoptosis and inflammation. Annu. Rev. Immunol. 2007, 25:561-586.
-
(2007)
Annu. Rev. Immunol.
, vol.25
, pp. 561-586
-
-
Park, H.H.1
-
29
-
-
33846702221
-
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex
-
Park H.H., et al. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 2007, 128:533-546.
-
(2007)
Cell
, vol.128
, pp. 533-546
-
-
Park, H.H.1
-
30
-
-
78651399661
-
Two human MYD88 variants, S34Y and R98C, interfere with MYD88-IRAK4-myddosome assembly
-
George J., et al. Two human MYD88 variants, S34Y and R98C, interfere with MYD88-IRAK4-myddosome assembly. J. Biol. Chem. 2011, 286:1341-1353.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 1341-1353
-
-
George, J.1
-
31
-
-
57749089751
-
Assembly of oligomeric death domain complexes during Toll receptor signaling
-
Moncrieffe M.C., et al. Assembly of oligomeric death domain complexes during Toll receptor signaling. J. Biol. Chem. 2008, 283:33447-33454.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 33447-33454
-
-
Moncrieffe, M.C.1
-
32
-
-
33748363077
-
Dynamically driven protein allostery
-
Popovych N., et al. Dynamically driven protein allostery. Nat. Struct. Mol. Biol. 2006, 13:831-838.
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 831-838
-
-
Popovych, N.1
-
33
-
-
60549106191
-
The Fas-FADD death domain complex structure unravels signalling by receptor clustering
-
Scott F.L., et al. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature 2009, 457:1019-1022.
-
(2009)
Nature
, vol.457
, pp. 1019-1022
-
-
Scott, F.L.1
-
34
-
-
78549236456
-
The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations
-
Wang L., et al. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat. Struct. Mol. Biol. 2010, 17:1324-1329.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 1324-1329
-
-
Wang, L.1
-
35
-
-
70349308508
-
Cell regulation: determined to signal discrete cooperation
-
Gibson T.J. Cell regulation: determined to signal discrete cooperation. Trends Biochem. Sci. 2009, 34:471-482.
-
(2009)
Trends Biochem. Sci.
, vol.34
, pp. 471-482
-
-
Gibson, T.J.1
|