Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients

Fitoterapia

Volumn 97, Issue , 2014, Pages 1-14

  Ajazuddin, ^a   Alexander, Amit ^a   Qureshi, Azra ^a   Kumari, Leena ^a   Vaishnav, Pramudita ^a   Sharma, Mukesh ^a   Saraf, Swarnlata ^b   Saraf, Shailendra ^b  

^a RUNGTA COLLEGE OF PHARMACEUTICAL SCIENCES AND RESEARCH   (India)

^b PT RAVISHANKAR SHUKLA UNIVERSITY   (India)

Author keywords

Active Pharmaceutical Ingredient; Bioavailability; Bioefficacy; Bioenhancer; Pharmacokinetic parameters

Indexed keywords

ACONITINE; AMPICILLIN; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; AURANTIIN; CURCUMIN; DILTIAZEM; DOCETAXEL; EPIGALLOCATECHIN GALLATE; FLUOROURACIL; GENISTEIN; GINGER EXTRACT; GLYCYRRHIZIC ACID; HERBACEOUS AGENT; HERBAL BIOENHANCER; METHOTREXATE; NORFLOXACIN; PACLITAXEL; PAEONIFLORIN; PENETRATION ENHANCING AGENT; PIOGLITAZONE; PIPERINE; PLANT GLYCOSIDE; QUERCETIN; SINOMENINE; TAMOXIFEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; ALKALOID; AMIDE; ERGOLINE DERIVATIVE; FLAVANONE DERIVATIVE; LYSERGOL; MORPHINAN DERIVATIVE; PHARMACEUTICAL VEHICLES AND ADDITIVES; PIPERIDINE DERIVATIVE; PLANT EXTRACT;

ANALGESIC ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIDEPRESSANT ACTIVITY; ANTIDIARRHEAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIPYRETIC ACTIVITY; AREA UNDER THE CURVE; CARAWAY; CUMIN; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG TARGETING; HUMAN; INTESTINE ABSORPTION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TIME TO MAXIMUM PLASMA CONCENTRATION; BIOAVAILABILITY; CARUM; CUMINUM; GINGER;

ADJUVANTS, PHARMACEUTIC; ALKALOIDS; BENZODIOXOLES; BIOLOGICAL AVAILABILITY; CARUM; CUMINUM; CURCUMIN; ERGOLINES; FLAVANONES; GENISTEIN; GINGER; GLYCYRRHIZIC ACID; HUMANS; MORPHINANS; PIPERIDINES; PLANT EXTRACTS; POLYUNSATURATED ALKAMIDES; QUERCETIN;

EID: 84902003293     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.05.005     Document Type: Review

References (123)

1. Ajazuddin, and S. Saraf Applications of novel drug delivery system for herbal formulations Fitoterapia 81 2010 680 689
2. J. Khan, A. Alexander, Ajazuddin, S. Saraf, and S. Saraf Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives J Control Release 168 2013 50 60
3. A. Alexander, S. Dwivedi, Ajazuddin, T.K. Giri, S. Saraf, and D.K. Tripathi Approaches for breaking the barriers of drug permeation through transdermal drug delivery J Control Release 164 2012 26 40
4. +-dependent transepithelial transport of cephalosporins in Caco-2 cells J Pharm Pharmacol 51 1999 35 40 (Pubitemid 29097266)
5. Y. Adachi, H. Suzuki, and Y. Sugiyama Quantitative evaluation of the function of small intestinal P-glycoprotein: comparative studies between in situ and in vitro Pharm Res 20 2003 1163 1169 (Pubitemid 36951840)
6. M. Rawat, S. Saraf, and S. Saraf Influence of selected formulation variables on the preparation of enzyme-entrapped Eudragit S100 microspheres AAPS PharmSciTech 8 2007 E116
7. S. Saraf, V.K. Dixit, S.C. Tripathi, and G.K. Patnaik Antihepatotoxic activity of Cassia occidentalis Pharm Biol 32 1994 178 183 (Pubitemid 24220641)
8. S. Bajad, K.L. Bedi, A.K. Singla, and R.K. Johri Antidiarrhoeal activity of piperine in mice Planta Med 67 2001 284 287 (Pubitemid 32304205)
9. A. Khajuria, N. Thusu, and U. Zutshi Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: influence on brush border membrane fluidity, ultrastructure and enzyme kinetics Phytomedicine 9 2002 224 231 (Pubitemid 34475555)
10. W. Reanmongkol, W. Janthasoot, W. Wattanatorn, P. Dhumma-Upakorn, and P. Chudapongse Effects of piperine on bioenergetic functions of isolated rat liver mitochondria Biochem Pharmacol 37 1988 753 757 (Pubitemid 18053757)
11. C.K. Atal, U. Zutshi, and P.G. Rao Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs J Ethnopharmacol 4 1981 229 232 (Pubitemid 11014202)
12. R.K. Johri, N. Thusu, A. Khajuria, and U. Zutshi Piperine-mediated changes in the permeability of rat intestinal epithelial cells: the status of γ-glutamyl transpeptidase activity, uptake of amino acids and lipid peroxidation Biochem Pharmacol 43 1992 1401 1407
13. C.B. Thakur, V.K. Dixit, and S. Saraf Hepatoprotective activity of Astercantha longifolia Indian Drugs 28 1991 400
14. V. Badmaev, M. Majeed, and E.P. Norkus Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation Nutr Res 19 1999 381 388 (Pubitemid 29164841)
15. A.M. Mujumdar, J.N. Dhuley, V.K. Deshmukh, P.H. Raman, and S.R. Naik Anti-inflammatory activity of piperine Jpn J Med Sci Biol 43 1990 95 100 (Pubitemid 20346986)
16. S. Kumar, V. Singhal, R. Roshan, A. Sharma, G.W. Rembhotkar, and B. Ghosh Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation Eur J Pharmacol 575 2007 177 186 (Pubitemid 47576069)
17. V.S. Parmar, S.C. Jain, K.S. Bisht, R. Jain, P. Taneja, and A. Jha et al. Phytochemistry of the genus Piper Phytochemistry 46 1997 597 673 (Pubitemid 27483827)
18. H.M.D. Navickiene, A.C. Alécio, M.J. Kato, V.d.S. Bolzani, M.C.M. Young, and A.J. Cavalheiro et al. Antifungal amides from Piper hispidum and Piper tuberculatum Phytochemistry 55 2000 621 626
19. R. Mittal, and R.L. Gupta In vitro antioxidant activity of piperine Methods Find Exp Clin Pharmacol 22 2000 271 274 (Pubitemid 30664411)
20. K.A. Naidu, and N.B. Thippeswamy Inhibition of human low density lipoprotein oxidation by active principles from spices Mol Cell Biochem 229 2002 19 23 (Pubitemid 34187671)
21. R.S. Vijayakumar, D. Surya, and N. Nalini Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress Redox Rep 9 2004 105 110 (Pubitemid 39010935)
22. I. Gulcin The antioxidant and radical scavenging activities of black pepper (Piper nigrum) seeds Int J Food Sci Nutr 56 2005 491 499
23. K. Selvendiran, S.M. Banu, and D. Sakthisekaran Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in Benzo(a)pyrene induced experimental lung carcinogenesis Mol Cell Biochem 268 2005 141 147 (Pubitemid 40287836)
24. R.S. Vijayakumar, and N. Nalini Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats J Basic Clin Physiol Pharmacol 17 2006 71 86 (Pubitemid 44048040)
25. R. El Hamss, M. Idaomar, A. Alonso-Moraga, and A. Munoz Serrano Antimutagenic properties of bell and black peppers Food Chem Toxicol 41 2003 41 47 (Pubitemid 35346772)
26. K. Srinivasan Black pepper and its pungent principle-piperine: a review of diverse physiological effects Crit Rev Food Sci Nutr 47 2007 735 748 (Pubitemid 350072517)
27. S. Wongpa, L. Himakoun, S. Soontornchai, and P. Temcharoen Antimutagenic effects of piperine on cyclophosphamide-induced chromosome aberrations in rat bone marrow cells Asian Pac J Cancer Prev 8 2007 623 627
28. E.S. Sunila, and G. Kuttan Immunomodulatory and antitumor activity of Piper longum Linn. and piperine J Ethnopharmacol 90 2004 339 346 (Pubitemid 38180485)
29. S. Manoharan, S. Balakrishnan, V.P. Menon, L.M. Alias, and A.R. Reena Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a] anthracene-induced hamster buccal pouch carcinogenesis Singapore Med J 50 2009 139 146
30. S.A. Lee, S.S. Hong, X.H. Han, J.S. Hwang, G.J. Oh, and K.S. Lee et al. Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity Chem Pharm Bull 53 2005 832 835 (Pubitemid 41327633)
31. S. Li, C. Wang, M. Wang, W. Li, K. Matsumoto, and Y. Tang Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms Life Sci 80 2007 1373 1381 (Pubitemid 46367065)
32. J. Wattanathorn, P. Chonpathompikunlert, S. Muchimapura, A. Priprem, and O. Tankamnerdthai Piperine, the potential functional food for mood and cognitive disorders Food Chem Toxicol 46 2008 3106 3110
33. H. Matsuda, K. Ninomiya, T. Morikawa, D. Yasuda, I. Yamaguchi, and M. Yoshikawa Protective effects of amide constituents from the fruit of Piper chaba on D-galactosamine/TNF-alpha-induced cell death in mouse hepatocytes Bioorg Med Chem Lett 18 2008 2038 2042 (Pubitemid 351380870)
34. S.I. Taqvi, A.J. Shah, and A.H. Gilani Blood pressure lowering and vasomodulator effects of piperine J Cardiovasc Pharmacol 52 2008 452 458
35. A. Sehgal, M. Kumar, M. Jain, and D.K. Dhawan Combined effects of curcumin and piperine in ameliorating benzo(a)pyrene induced DNA damage Food Chem Toxicol 49 2011 3002 3006
36. S.C. Shin, J.S. Choi, and X. Li Enhanced bioavailability of tamoxifen after oral administration of tamoxifen with quercetin in rats Int J Pharm 313 2006 144 149
37. S.N. Umathe, P.V. Dixit, V. Kumar, K.U. Bansod, and M.M. Wanjari Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibition Biochem Pharmacol 75 2008 1670 1676
38. K. Janakiraman, and R. Manavalan Compatibility and stability studies of ampicillin trihydrate and piperine mixture Int J Pharm Sci Res 2 2011 1176 1181
39. V. Sama, M. Nadipelli, P. Yenumula, M.R. Bommineni, and R. Mullangi Effect of piperine on antihyperglycemic activity and pharmacokinetic profile of nateglinide Arzneimittelforschung 62 2012 384 388
40. S. Venkatesh, K.D. Durga, Y. Padmavathi, B.M. Reddy, and R. Mullangi Influence of piperine on ibuprofen induced antinociception and its pharmacokinetics Arzneimittelforschung 61 2011 506 509
41. J.J. Johnson, M. Nihal, I.A. Siddiqui, C.O. Scarlett, H.H. Bailey, and H. Mukhtar et al. Enhancing the bioavailability of resveratrol by combining it with piperine Mol Nutr Food Res 55 2011 1169 1176
42. M.J. Jin, and H.K. Han Effect of piperine, a major component of black pepper, on the intestinal absorption of fexofenadine and its implication on food-drug interaction J Food Sci 75 2010 H93 H96
43. S. Pattanaik, D. Hota, S. Prabhakar, P. Kharbanda, and P. Pandhi Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients Phytother Res 23 2009 1281 1286
44. R. Kasibhatta, and M.U. Naidu Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study Drugs R&D 8 2007 383 391 (Pubitemid 350014790)
45. S. Pattanaik, D. Hota, S. Prabhakar, P. Kharbanda, and P. Pandhi Effect of piperine on the steady-state pharmacokinetics of phenytoin in patients with epilepsy Phytother Res 20 2006 683 686
46. V. Sharma, B. Nehru, A. Munshi, and A. Jyothy Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats Methods Find Exp Clin Pharmacol 32 2010 227 232
47. J.D. Lambert, J. Hong, D.H. Kim, V.M. Mishin, and C.S. Yang Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3- gallate in mice J Nutr 134 2004 1948 1952 (Pubitemid 39031322)
48. S.K. Gupta, P. Bansal, R.K. Bhardwaj, and T. Velpandian Comparative anti-nociceptive, anti-inflammatory and toxicity profile of nimesulide vs nimesulide and piperine combination Pharmacol Res 41 2000 657 662
49. R.J. Nijveldt, E. van Nood, D.E. van Hoorn, P.G. Boelens, K. van Norren, and P.A. van Leeuwen Flavonoids: a review of probable mechanisms of action and potential applications Am J Clin Nutr 74 2001 418 425 (Pubitemid 32880250)
50. S.L. Hsiu, Y.C. Hou, Y.H. Wang, C.W. Tsao, S.F. Su, and P.D. Chao Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats Life Sci 72 2002 227 235
51. J.S. Choi, and H.K. Han Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats Int J Pharm 305 2005 122 128
52. J.S. Choi, and X. Li Enhanced diltiazem bioavailability after oral administration of diltiazem with quercetin to rabbits Int J Pharm 297 2005 1 8 (Pubitemid 40720260)
53. J.S. Choi, Y.J. Piao, and K.W. Kang Effects of quercetin on the bioavailability of doxorubicin in rats: role of CYP3A4 and P-gp inhibition by quercetin Arch Pharm Res 34 2011 607 613
54. J.S. Choi, and S.C. Shin Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to rats Int J Pharm 292 2005 149 156
55. X. Li, and J.S. Choi Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats Int J Pharm 337 2007 188 193 (Pubitemid 46756050)
56. P. Wang, D. Heber, and S.M. Henning Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo Food Funct 3 2012 635 642
57. P.R. Babu, K.N. Babu, P.L. Peter, K. Rajesh, and P.J. Babu Influence of quercetin on the pharmacokinetics of ranolazine in rats and in vitro models, drug development and industrial pharmacy 2012
58. V.R. Challa, P. Ravindra Babu, S.R. Challa, B. Johnson, and C. Maheswari Pharmacokinetic interaction study between quercetin and valsartan in rats and in vitro models Drug Dev Ind Pharm 39 6 2012 865 872
59. J.H. Lee, Y.J. Shin, J.H. Oh, and Y.J. Lee Pharmacokinetic interactions of clopidogrel with quercetin, telmisartan, and cyclosporine A in rats and dogs Arch Pharm Res 35 2012 1831 1837
60. X. Li, and J.S. Choi Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats Anticancer Res 29 2009 1411 1415
61. T. Bansal, A. Awasthi, M. Jaggi, R.K. Khar, and S. Talegaonkar Pre-clinical evidence for altered absorption and biliary excretion of irinotecan (CPT-11) in combination with quercetin: possible contribution of P-glycoprotein Life Sci 83 2008 250 259
62. Y.H. Wang, P.D. Chao, S.L. Hsiu, K.C. Wen, and Y.C. Hou Lethal quercetin-digoxin interaction in pigs Life Sci 74 2004 1191 1197
63. R.A. Dixon, and C.L. Steele Flavonoids and isoflavonoids - a gold mine for metabolic engineering Trends Plant Sci 4 1999 394 400
64. S.C. Lim, and J.S. Choi Effects of naringin on the pharmacokinetics of intravenous paclitaxel in rats Biopharm Drug Dispos 27 2006 443 447
65. H. Zhang, C.W. Wong, P.F. Coville, and S. Wanwimolruk Effect of the grapefruit flavonoid naringin on pharmacokinetics of quinine in rats Drug Metabol Drug Interact 17 2000 351 363 (Pubitemid 32047541)
66. M.A. Lassoued, S. Sfar, A. Bouraoui, and F. Khemiss Absorption enhancement studies of clopidogrel hydrogen sulphate in rat everted gut sacs J Pharm Pharmacol 64 2012 541 552
67. J.S. Choi, and K.W. Kang Enhanced tamoxifen bioavailability after oral administration of tamoxifen in rats pretreated with naringin Arch Pharm Res 31 2008 1631 1636
68. C.H. Yeum, and J.S. Choi Effect of naringin pretreatment on bioavailability of verapamil in rabbits Arch Pharm Res 29 2006 102 107
69. U. Fuhr, A. Maier-Bruggemann, H. Blume, W. Muck, S. Unger, and J. Kuhlmann et al. Grapefruit juice increases oral nimodipine bioavailability Int J Clin Pharmacol Ther 36 1998 126 132 (Pubitemid 28135032)
70. A. Weber, R. Jager, A. Borner, G. Klinger, R. Vollanth, and K. Matthey et al. Can grapefruit juice influence ethinylestradiol bioavailability? Contraception 53 1996 41 47 (Pubitemid 26043592)
71. D.G. Bailey, J.M. Arnold, C. Munoz, and J.D. Spence Grapefruit juice-felodipine interaction: mechanism, predictability, and effect of naringin Clin Pharmacol Ther 53 1993 637 642 (Pubitemid 23188114)
72. M.S. Kurzer, and X. Xu Dietary phytoestrogens Annu Rev Nutr 17 1997 353 381 (Pubitemid 27328805)
73. A. Sparreboom, J. van Asperen, U. Mayer, A.H. Schinkel, J.W. Smit, and D.K. Meijer et al. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine Proc Natl Acad Sci U S A 94 1997 2031 2035 (Pubitemid 27113956)
74. M.T. Huisman, A.A. Chhatta, O. van Tellingen, J.H. Beijnen, and A.H. Schinkel MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid Int J Cancer 116 2005 824 829 (Pubitemid 41099717)
75. L. Doyle, and D.D. Ross Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2) Oncogene 22 2003 7340 7358 (Pubitemid 37487163)
76. J.D. Lambert, S.J. Kwon, J. Ju, M. Bose, M.J. Lee, and J. Hong et al. Effect of genistein on the bioavailability and intestinal cancer chemopreventive activity of (-)-epigallocatechin-3-gallate Carcinogenesis 29 2008 2019 2024
77. K. Chan, Z.Q. Liu, Z.H. Jiang, H. Zhou, Y.F. Wong, and H.X. Xu et al. The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model J Ethnopharmacol 103 2006 425 432 (Pubitemid 43143379)
78. Z.Q. Liu, H. Zhou, L. Liu, Z.H. Jiang, Y.F. Wong, and Y. Xie et al. Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats J Ethnopharmacol 99 2005 61 67 (Pubitemid 40575688)
79. Y.D. Yan, D.H. Kim, J.H. Sung, C.S. Yong, and H.G. Choi Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin Int J Pharm 399 2010 116 120
80. M.S. Ahshawat, S. Saraf, and S. Saraf Preparation and characterization of herbal creams for improvement of skin viscoelastic properties Int J Cosmet Sci 30 2008 183 193 (Pubitemid 351623842)
81. W. Zhang, and L.Y. Lim Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro Int J Cancer 36 2008 1283 1290 (Pubitemid 351929312)
82. W. Zhang, T.M. Tan, and L.Y. Lim Impact of curcumin-induced changes in P-glycoprotein and CYP3A expression on the pharmacokinetics of peroral celiprolol and midazolam in rats Int J Cancer 35 2007 110 115 (Pubitemid 46036483)
83. B.H. Pavithra, N. Prakash, and K. Jayakumar Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits J Vet Sci 10 2009 293 297
84. L. Chen, J. Yang, A.K. Davey, Y.X. Chen, J.P. Wang, and X.Q. Liu Effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism Xenobiotica 39 2009 955 963
85. T. Imai, M. Sakai, H. Ohtake, H. Azuma, and M. Otagiri Absorption-enhancing effect of glycyrrhizin induced in the presence of capric acid Int J Pharm 294 2005 11 21 (Pubitemid 40462319)
86. P.S. Khanuja Suman, S. Arya Jai, K. Srivastava Santosh, K. Shasany Ajit, R. Santha Kumar Tiruppadiripuliyur, and P. Darokar Mahendra et al. Antibiotic pharmaceutical composition with lysergol as bio-enhancer and method of treatment 2007
87. J. Yamahara, M. Mochizuki, H.Q. Rong, H. Matsuda, and H. Fujimura The anti-ulcer effect in rats of ginger constituents J Ethnopharmacol 23 1988 299 304
88. H. Wu, D. Ye, Y. Bai, and Y. Zhao Effect of dry ginger and roasted ginger on experimental gastric ulcers in rats Zhongguo Zhong Yao Za Zhi 15 1990 278 280 [317-8]
89. M. Thomson, K.K. Al-Qattan, S.M. Al-Sawan, M.A. Alnaqeeb, I. Khan, and M. Ali The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent Prostaglandins Leukot Essent Fatty Acids 67 2002 475 478 (Pubitemid 35398910)
90. G.C. Jagetia, M.S. Baliga, P. Venkatesh, and J.N. Ulloor Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation Radiat Res 160 2003 584 592 (Pubitemid 38055207)
91. C. Ficker, M.L. Smith, K. Akpagana, M. Gbeassor, J. Zhang, and T. Durst et al. Bioassay-guided isolation and identification of antifungal compounds from ginger Phytother Res 17 2003 897 902 (Pubitemid 37152754)
92. R. Grzanna, L. Lindmark, and C.G. Frondoza Ginger - an herbal medicinal product with broad anti-inflammatory actions J Med Food 8 2005 125 132 (Pubitemid 41008974)
93. J.A. Ojewole Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats Phytother Res 20 2006 764 772 (Pubitemid 44408657)
94. J.K. Kim, Y. Kim, K.M. Na, Y.J. Surh, and T.Y. Kim [6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo Free Radic Res 41 2007 603 614 (Pubitemid 46511125)
95. Y. Shukla, and M. Singh Cancer preventive properties of ginger: a brief review Food Chem Toxicol 45 2007 683 690 (Pubitemid 46452881)
96. Qazi GN, Bedi KL, Johri RK, Tikoo MK, Tikoo AK, Sharma SC, et al. Bioavailability enchancing activity of Zingiber officinale Linn and its extracts/fractions thereof, Google Patents, 2002.
97. N.S. Iacobellis, P. Lo Cantore, F. Capasso, and F. Senatore Antibacterial activity of Cuminum cyminum L. and Carum carvi L. essential oils J Agric Food Chem 53 2005 57 61 (Pubitemid 40066470)
98. T. Malini, and G. Vanithakumari Estrogenic activity of Cuminum cyminum in rats Indian J Exp Biol 25 1987 442 444 (Pubitemid 17134649)
99. S. Dhandapani, V.R. Subramanian, S. Rajagopal, and N. Namasivayam Hypolipidemic effect of Cuminum cyminum L. on alloxan-induced diabetic rats Pharmacol Res 46 2002 251 255 (Pubitemid 35300764)
100. Gagandeep, S. Dhanalakshmi, E. Mendiz, A.R. Rao, and R.K. Kale Chemopreventive effects of Cuminum cyminum in chemically induced forestomach and uterine cervix tumors in murine model systems Nutr Cancer 47 2003 171 180 (Pubitemid 38590890)
101. L. Gachkar, D. Yadegari, M.B. Rezaei, M. Taghizadeh, S.A. Astaneh, and I. Rasooli Chemical and biological characteristics of Cuminum cyminum and Rosmarinus officinalis essential oils Food Chem 102 2007 898 904 (Pubitemid 46127608)
102. A.H. El-Ghorab, M. Nauman, F.M. Anjum, S. Hussain, and M. Nadeem A comparative study on chemical composition and antioxidant activity of ginger (Zingiber officinale) and cumin (Cuminum cyminum) J Agric Food Chem 58 2010 8231 8237
103. M.B. Pai, G.M. Prashant, K.S. Murlikrishna, K.M. Shivakumar, and G.N. Chandu Antifungal efficacy of Punica granatum, Acacia nilotica, Cuminum cyminum and Foeniculum vulgare on Candida albicans: an in vitro study Indian J Dent Res 21 2010 334 336
104. A. Boumendjel, A. Di Pietro, C. Dumontet, and D. Barron Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance Med Res Rev 22 2002 512 529
105. Qazi GN, Bedi KL, Johri RK, Tikoo MK, Tikoo AK, Sharma SC, et al. Bioavailability enhancing activity of Carum carvi extracts and fractions thereof, Google Patents 2003.
106. G.N. Qazi, K.L. Bedi, R.K. Johri, S.C. Sharma, M.K. Tikoo, and A.K. Tikoo et al. Bioavailability/bioefficacy enhancing activity of Cuminum cyminum and extracts and fractions thereof EP Pat 1 2007 526,860
107. M.T. Khayyal, M.A. El-Ghazaly, S.A. Kenawy, M. Seif-el-Nasr, L.G. Mahran, and Y.A. Kafafi et al. Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination Arzneimittelforschung 51 2001 545 553 (Pubitemid 32664392)
108. M. Eddouks, A. Lemhadri, and J.B. Michel Caraway and caper: potential anti-hyperglycaemic plants in diabetic rats J Ethnopharmacol 94 2004 143 148 (Pubitemid 38942846)
109. L. De Martino, V. De Feo, F. Fratianni, and F. Nazzaro Chemistry, antioxidant, antibacterial and antifungal activities of volatile oils and their components Nat Prod Commun 4 2009 1741 1750
110. S. Lahlou, A. Tahraoui, Z. Israili, and B. Lyoussi Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats J Ethnopharmacol 110 2007 458 463 (Pubitemid 46386355)
111. A. Najda, J. Dyduch, and N. Brzozowski Flavonoid content and antioxidant activity of caraway roots (Carum Carvi L.) Veg Crop Res Bull 2008 127
112. S. Shukla, R. Mathur, and A.O. Prakash Antifertility profile of the aqueous extract of Moringa oleifera roots J Ethnopharmacol 22 1988 51 62 (Pubitemid 18047907)
113. A. Caceres, O. Cabrera, O. Morales, P. Mollinedo, and P. Mendia Pharmacological properties of Moringa oleifera. 1: preliminary screening for antimicrobial activity J Ethnopharmacol 33 1991 213 216
114. A. Caceres, A. Saravia, S. Rizzo, L. Zabala, E. De Leon, and F. Nave Pharmacologic properties of Moringa oleifera. 2: screening for antispasmodic, antiinflammatory and diuretic activity J Ethnopharmacol 36 1992 233 237
115. K. Aruna, and V. Sivaramakrishnan Anticarcinogenic effects of some Indian plant products Food Chem Toxicol 30 1992 953 956 (Pubitemid 23014794)
116. A. Guevara, C. Vargas, and M. Uy Anti-inflammatory and antitumor activities of seed extracts of malunggay, Moringa oleifera L. (Moringaceae) Philipp J Sci 125 1996
117. A.H. Gilani, K. Aftab, A. Suria, S. Siddiqui, R. Salem, and B.S. Siddiqui et al. Pharmacological studies on hypotensive and spasmolytic activities of pure compounds from Moringa oleifera Phytother Res 8 1994 87 91 (Pubitemid 24125123)
118. M.O. Nwosu, and J.I. Okafor Preliminary studies of the antifungal activities of some medicinal plants against Basidiobolus and some other pathogenic fungi Mycoses 38 1995 191 195
119. S.K. Pal, P.K. Mukherjee, and B.P. Saha Studies on the antiulcer activity of Moringa oleifera leaf extract on gastric ulcer models in rats Phytother Res 9 1995 463 465
120. P. Siddhuraju, and K. Becker Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves J Agric Food Chem 51 2003 2144 2155
121. N. Oinam, A. Urooj, P. Phillips, and N. Niranjan Effect of dietary lipids and drumstick leaves (Moringa oleifera) on lipid profile & antioxidant parameters in rats Food Nutr Sci 3 2012 141 145
122. L. Pari, and N.A. Kumar Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats J Med Food 5 2002 171 177 (Pubitemid 35283422)
123. Khanuja SPS, Arya JS, Tiruppadiripuliyur RSK, Saikia D, Kaur H, Singh M, et al. Nitrile glycoside useful as a bioenhancer of drugs and nutrients, process of its isolation from Moringa oleifera, Google Patents 2005.