Effects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the potential mechanism

Xenobiotica

Volumn 39, Issue 12, 2009, Pages 955-963

  Chen, L ^a   Yang, J ^a   Davey, A K ^b   Chen, Y X ^a   Wang, J P ^b   Liu, X Q ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Aconitine; Diammonium glycyrrhizinate; P glycoprotein; Pharmacokinetics

Indexed keywords

ACONITINE; DIAMMONIUM GLYCYRRHIZINATE; GLYCOPROTEIN P; GLYCYRRHIZIC ACID DERIVATIVE; ISOCORYDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INHIBITION; DRUG MECHANISM; DRUG TRANSPORT; IN VITRO STUDY; INTESTINE; LIVER HILUS; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PORTAL VEIN; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; VEIN;

ACONITINE; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL TRANSPORT; CYCLOSPORINE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GLYCYRRHIZIC ACID; INTESTINAL ABSORPTION; MALE; MEMBRANE TRANSPORT PROTEINS; NITROPHENOLS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; VERAPAMIL;

RATTUS;

EID: 70849091552     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498250903271997     Document Type: Article

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