메뉴 건너뛰기




Volumn 51, Issue 1, 1999, Pages 35-40

The role of an α-amino group on H+-dependent transepithelial transport of cephalosporins in Caco-2 cells

Author keywords

[No Author keywords available]

Indexed keywords

CEFACLOR; CEFADROXIL; CEFALEXIN; CEFALOGLYCIN; CEFALORIDINE; CEFALOTIN; CEFAMANDOLE; CEFAZOLIN; CEFOPERAZONE; CEFOTAXIME; CEFOXITIN; CEFRADINE; CEFSULODIN; CEFTAZIDIME; CEFUROXIME; CEPHALOSPORIN DERIVATIVE;

EID: 0033051810     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991772060     Document Type: Article
Times cited : (35)

References (27)
  • 2
    • 0025878066 scopus 로고
    • Structural requirements for the intestinal mucosal-cell peptide transporter: The need for N-terminal α-amino group
    • Bai, P.-F., Subramanian, P., Mosberg, H. I., Amidon, G. L. (1991) Structural requirements for the intestinal mucosal-cell peptide transporter: the need for N-terminal α-amino group. Pharm. Res. 8: 593-599
    • (1991) Pharm. Res. , vol.8 , pp. 593-599
    • Bai, P.-F.1    Subramanian, P.2    Mosberg, H.I.3    Amidon, G.L.4
  • 3
    • 0021668927 scopus 로고
    • Pharmacokinetics of beta-lactam antibiotics
    • Began, T. (1984) Pharmacokinetics of beta-lactam antibiotics. Scand. J. Infect. Dis. (Suppl.) 42: 83-98
    • (1984) Scand. J. Infect. Dis. (Suppl.) , vol.42 , pp. 83-98
    • Began, T.1
  • 4
    • 0026535563 scopus 로고
    • The relationship between peptide structure and transport across epithelial cell monolayers
    • Burton, P. S., Conradi, R. A., Hilgers, A. R., Ho, N. F. H., Maggiora, L. L. (1992) The relationship between peptide structure and transport across epithelial cell monolayers. J. Contr. Rel. 19: 87-98
    • (1992) J. Contr. Rel. , vol.19 , pp. 87-98
    • Burton, P.S.1    Conradi, R.A.2    Hilgers, A.R.3    Ho, N.F.H.4    Maggiora, L.L.5
  • 6
    • 0025046860 scopus 로고
    • Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2
    • Dantzig, A. H., Bergin, L. (1990) Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2. Biochim. Biophys. Acta 1027: 211-217
    • (1990) Biochim. Biophys. Acta , vol.1027 , pp. 211-217
    • Dantzig, A.H.1    Bergin, L.2
  • 7
    • 0026496355 scopus 로고
    • Cefaclor uptake by the proton-dependent dipeptide transport carrier of human intestinal Caco-2 cells and comparison to cephalexin uptake
    • Dantzig, A. H., Tabas, B. L., Bergin, L. (1992) Cefaclor uptake by the proton-dependent dipeptide transport carrier of human intestinal Caco-2 cells and comparison to cephalexin uptake. Biochim. Biophys. Acta 1112: 167-173
    • (1992) Biochim. Biophys. Acta , vol.1112 , pp. 167-173
    • Dantzig, A.H.1    Tabas, B.L.2    Bergin, L.3
  • 8
    • 0028345208 scopus 로고
    • Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells
    • Dantzig, A. H., Duckworth, D. C., Tabas, L. B. (1994) Transport mechanisms responsible for the absorption of loracarbef, cefixime, and cefuroxime axetil into human intestinal Caco-2 cells. Biochim. Biophys. Acta 1191: 7-13
    • (1994) Biochim. Biophys. Acta , vol.1191 , pp. 7-13
    • Dantzig, A.H.1    Duckworth, D.C.2    Tabas, L.B.3
  • 9
    • 0024891564 scopus 로고
    • Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: Enalapril and fosinopril
    • Friedman, D. I., Amidon, G. L. (1989) Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril. Pharm. Res. 6: 1043-1047
    • (1989) Pharm. Res. , vol.6 , pp. 1043-1047
    • Friedman, D.I.1    Amidon, G.L.2
  • 10
    • 0028826927 scopus 로고
    • Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2
    • Ganapathy, M. E., Brandsch, M., Prasad, P. D., Ganapathy, V., Leibach, F. H. (1995) Differential recognition of β-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. J. Biol. Chem. 43: 25672-25677
    • (1995) J. Biol. Chem. , vol.43 , pp. 25672-25677
    • Ganapathy, M.E.1    Brandsch, M.2    Prasad, P.D.3    Ganapathy, V.4    Leibach, F.H.5
  • 11
    • 0028324534 scopus 로고
    • Uptake and transepithelial transport of the orally absorbed cephalosporin cephalexin, in the human intestinal cell line, Caco-2
    • Gochoco, C. H., Ryan, F. M., Miller, J., Smith, P., Hidalgo, I. J. (1994) Uptake and transepithelial transport of the orally absorbed cephalosporin cephalexin, in the human intestinal cell line, Caco-2. Int. J. Pharm. 104: 187-202
    • (1994) Int. J. Pharm. , vol.104 , pp. 187-202
    • Gochoco, C.H.1    Ryan, F.M.2    Miller, J.3    Smith, P.4    Hidalgo, I.J.5
  • 12
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • Hidalgo, I. J., Raub, T. J., Borchardt, R. T. (1989) Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 96: 736-749
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 13
    • 0343202207 scopus 로고
    • Cephalothin: Activity in vitro, absorption and excretion in normal subjects and clinical observations on 40 patients
    • Klein, J. O., Eickhoff, T. C., Tilles, J. G., Finland, M. (1964) Cephalothin: activity in vitro, absorption and excretion in normal subjects and clinical observations on 40 patients. Am. J. Med. Sci. 248: 640-656
    • (1964) Am. J. Med. Sci. , vol.248 , pp. 640-656
    • Klein, J.O.1    Eickhoff, T.C.2    Tilles, J.G.3    Finland, M.4
  • 14
    • 0025106137 scopus 로고
    • Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics
    • Kramer, W., Girbig, F., Gutjaher, U., Kleemann, H., Leipe, I., Urbach, H., Wagner, A. (1990) Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics. Biochim. Biophys. Acta 1027: 25-30
    • (1990) Biochim. Biophys. Acta , vol.1027 , pp. 25-30
    • Kramer, W.1    Girbig, F.2    Gutjaher, U.3    Kleemann, H.4    Leipe, I.5    Urbach, H.6    Wagner, A.7
  • 15
    • 0030054574 scopus 로고    scopus 로고
    • Molecular modeling study of structural requirements for oligopeptide transporter
    • Li, J., Hidalgo, I. J. (1996) Molecular modeling study of structural requirements for oligopeptide transporter. Drug Targeting 4: 9-17
    • (1996) Drug Targeting , vol.4 , pp. 9-17
    • Li, J.1    Hidalgo, I.J.2
  • 17
    • 0025021981 scopus 로고
    • Uptake of cephalosporins by human intestinal brush-border membrane vesicles
    • Lowther, J., Hammond, S. M., Russel, K. (1990) Uptake of cephalosporins by human intestinal brush-border membrane vesicles. J. Antimicrob. Chemother. 25: 183-185
    • (1990) J. Antimicrob. Chemother. , vol.25 , pp. 183-185
    • Lowther, J.1    Hammond, S.M.2    Russel, K.3
  • 18
    • 0027963234 scopus 로고
    • Transcellular transport of oral cephalosporins in human intestinal epithelial cells, Caco-2: Interaction with dipeptide transport systems in apical and basolateral membranes
    • Matsumoto, S., Hideyuki, S., Inui, K. (1994) Transcellular transport of oral cephalosporins in human intestinal epithelial cells, Caco-2: interaction with dipeptide transport systems in apical and basolateral membranes. J. Pharmacol. Exp. Ther. 270: 498-504
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 498-504
    • Matsumoto, S.1    Hideyuki, S.2    Inui, K.3
  • 19
    • 0028020042 scopus 로고
    • Characteristics of ceftibuten uptake into Caco-2 cells
    • Muranushi, N., Horie, K., Masuda, K., Hirano, K. (1994) Characteristics of ceftibuten uptake into Caco-2 cells. Pharm. Res. 11: 1761-1771
    • (1994) Pharm. Res. , vol.11 , pp. 1761-1771
    • Muranushi, N.1    Horie, K.2    Masuda, K.3    Hirano, K.4
  • 20
    • 0022512635 scopus 로고
    • +-gradient-dependent transport of aminocephalosporins in rat intestinal brush-border membrane vesicles
    • +-gradient-dependent transport of aminocephalosporins in rat intestinal brush-border membrane vesicles. Biochem. Pharmacol. 35: 1781-1786
    • (1986) Biochem. Pharmacol. , vol.35 , pp. 1781-1786
    • Okano, T.1    Inui, K.2    Takano, M.3    Hori, R.4
  • 21
    • 0002790490 scopus 로고
    • Effects of altering fluid transport on the absorption of benzylpenicillin and mannitol across rat intestinal mucosal in vitro
    • Ryan, F. M., Smith, P. L. (1989) Effects of altering fluid transport on the absorption of benzylpenicillin and mannitol across rat intestinal mucosal in vitro. Pharm. Res. 6: S88
    • (1989) Pharm. Res. , vol.6
    • Ryan, F.M.1    Smith, P.L.2
  • 22
    • 0027319297 scopus 로고
    • Dipeptide transporters in the apical and basolateral membranes of the human intestinal cell line, Caco-2
    • Saito, H., Inui, K. (1993) Dipeptide transporters in the apical and basolateral membranes of the human intestinal cell line, Caco-2. Am. J. Physiol. 265: G289-G294
    • (1993) Am. J. Physiol. , vol.265
    • Saito, H.1    Inui, K.2
  • 24
    • 0025143832 scopus 로고
    • Contribution of passive transport mechanisms to the intestinal absorption of β-lactam antibiotics
    • Sugawara, M., Saitoh, H., Iseki, K., Miyazaki, K., Arita, T. (1990) Contribution of passive transport mechanisms to the intestinal absorption of β-lactam antibiotics. J. Pharm. Pharmacol. 42: 314-318
    • (1990) J. Pharm. Pharmacol. , vol.42 , pp. 314-318
    • Sugawara, M.1    Saitoh, H.2    Iseki, K.3    Miyazaki, K.4    Arita, T.5
  • 25
    • 0025783111 scopus 로고
    • + coupled transport of orally active cephalosporins lacking an α-amino group across brush-border membrane vesicles from rat small intestine
    • + coupled transport of orally active cephalosporins lacking an α-amino group across brush-border membrane vesicles from rat small intestine. J. Pharm. Pharmacol. 43: 433-435
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 433-435
    • Sugawara, M.1    Iseki, K.2    Miyazaki, K.3
  • 26
    • 0023145208 scopus 로고
    • Saturable uptake of cefixime, a new oral cephalosporin without an α-amino group, by the rat intestine
    • Tsuji, A., Hirooka, H., Terasaki, T., Tamai, I., Nakashima, E. (1987) Saturable uptake of cefixime, a new oral cephalosporin without an α-amino group, by the rat intestine. J. Pharm. Pharmacol. 39: 272-277
    • (1987) J. Pharm. Pharmacol. , vol.39 , pp. 272-277
    • Tsuji, A.1    Hirooka, H.2    Terasaki, T.3    Tamai, I.4    Nakashima, E.5
  • 27
    • 0028840804 scopus 로고
    • Stereoselective uptake of β-lactam antibiotics by the intestinal peptide transporter
    • Wenzel, U., Thwaites, D. T., Daniel, H. (1995) Stereoselective uptake of β-lactam antibiotics by the intestinal peptide transporter. Br. J. Pharmacol. 116: 3021-3027
    • (1995) Br. J. Pharmacol. , vol.116 , pp. 3021-3027
    • Wenzel, U.1    Thwaites, D.T.2    Daniel, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.