Influence of Ginger Rhizome (Zingiber officinale Rosc) on Survival, Glutathione and Lipid Peroxidation in Mice after Whole-Body Exposure to Gamma Radiation

Radiation Research

Volumn 160, Issue 5, 2003, Pages 584-592

  Jagetia, Ganesh Chandra ^a   Baliga, Manjeshwar Shrinath ^a   Venkatesh, Ponemone ^a   Ulloor, Jagadish N ^b  

^a KASTURBA MEDICAL COLLEGE   (India)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GINGER EXTRACT; GLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; BONE MARROW DISEASE; BONE MARROW SYNDROME; CANDIDA ALBICANS; CELL SURVIVAL; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG ISOLATION; DRUG SCREENING; ESCHERICHIA COLI; GAMMA RADIATION; GASTROINTESTINAL DISEASE; LD 50; LIPID PEROXIDATION; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION; RADIATION SICKNESS; SALMONELLA TYPHIMURIUM; WHOLE BODY RADIATION;

ADMINISTRATION, ORAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; GINGER; GLUTATHIONE; INJECTIONS, INTRAPERITONEAL; LIPID PEROXIDATION; LIVER; MALE; MICE; PLANT EXTRACTS; RADIATION INJURIES, EXPERIMENTAL; RADIATION TOLERANCE; RADIATION-PROTECTIVE AGENTS; RHIZOME; SURVIVAL RATE; WHOLE-BODY IRRADIATION;

ANIMALIA; CANDIDA; CANDIDA ALBICANS; ESCHERICHIA COLI; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; ZINGIBER; ZINGIBER OFFICINALE;

EID: 0348226530     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3057     Document Type: Article

References (58)

1. H. M. Patt, E. B. Tyree, R. L. Straube and D. E. Smith, Cysteine protection against X-irradiation. Science 110, 213-214 (1949).
2. T. R. Sweeney, A Survey of Compounds from the Antiradiation Drug Development Program of the U.S. Army Medical Research and Development Command. Publication 308-318, U.S. Government Printing Office, Washington, DC, 1979.
3. A. K. Nadkarni, Indian Materia Medica, 3rd ed., pp. 1308-1315. Popular Press Ltd., Mumbai, India, 1976.
4. CHEMEXCIL, Selected Medicinal Plants of India, pp. 205-207. Basic Chemicals, Pharmaceutical and Cosmetic Export Promotion Council, Bombay, India, 1992.
5. P. K. Warrier, V. P. K. Nambiar and C. Ramankutty, Indian Medicinal Plants, Vol. 5, pp. 225-228. Orient Longman Ltd, Hyderabad, India, 1996.
6. R. M. Rastogi and B. N. Mehrotra, Compendium of Indian Medicinal Plants, Vol. 1, pp. 388-389. Central Drug Research Institute, Lucknow, India, 1990.
7. R. Aeschbach, J. Loliger, B. C. Scott, A. Murcia, J. Butler, B. Halliwell and A. Oi, Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem. Toxicol. 32, 31-36 (1994).
8. T. Tanaka, Cancer chemoprevention by natural products. Oncol. Rep. 1, 1139-1155 (1994).
9. T. Kong Ah-Ng, R. Yu, C. Chen, S. Mandlekar and T. Primiano, Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch. Pharm. Res. 23, 1-16 (2000).
10. R. S. Ahmed, V. Seth and B. D. Banerjee, Influence of dietary ginger (Zingiber officinales Rosc) on antioxidant defense system in rat: Comparison with ascorbic acid. Indian J. Exp. Biol. 38, 604-606 (2000).
11. H. Nagata, T. Sugahara and T. Tanaka, Radiation protection by 2-mercaptopropionylglycine in mice. J. Radiat. Res. 13, 163-166 (1972).
12. Geeta, D. M. Vasudevan, R. Kedlaya, S. Deepa and M. Ballal, Activity of Ocimum sanctum (the traditional Indian medicinal plant) against the enteric pathogens. Indian J. Med. Sci. 55, 434-438 (2001).
13. P. Uma Devi, Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum sanctum (Tulasi). Indian J. Exp. Biol. 39, 185-190 (2001).
14. P. Uma Devi and A. Ganasoundari, Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum. Indian J. Exp. Biol. 33, 205-209 (1995).
15. M. Suffness and Douros, Drugs of plant origin. Methods Cancer Res. 16, 73-94 (1979).
16. G. C. Jagetia and M. S. Baliga, Influence of the leaf extract of Mentha arvensis Linn. (mint) on the survival of mice exposed to different doses of gamma radiation. Strahlenther. Onkol. 178, 91-98 (2002).
17. D. J. Prieur, D. M. Young, R. D. Davis, D. A. Cooney, E. R. Homan, R. L. Dixon and A. M. Guarino, Procedures for preclinical toxicologic evaluation of cancer chemotherapeutic agents: Protocols of the laboratory of toxicology. Cancer Chemother. Rep. 4, 1-28 (1973).
18. M. N. Ghosh, Toxicity studies. In Fundamentals of Experimental Pharmacology (M. N. Ghosh, Ed.), pp. 153-158. Scientific Book Agency, Calcutta, India, 1984.
19. 50 and its error by means of logarithmic-probit graph paper. Proc. Soc. Exp. Biol. Med. 57, 261 (1944).
20. O. H. Lowry, N. J. Rosebrough and A. L. Farr, Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275 (1951).
21. M. S. Moron, J. W. Depierre and B. Mannervik, Levels of glutathione, glutathione reductase and glutathione-s-transferase activities in rat lung and liver. Biochim. Biophys. Acta 582, 67-78 (1979).
22. J. A. Beuege and S. D. Aust, Microsomal lipid peroxidation. Methods Enzymol. 30, 302-310 (1978).
23. R. Cruickshank, J. P. Duguid, B. P. Manoin and R. H. A. Swain, The Practice of Medical Microbiology, Vol. II, pp. 196. Churchill Livingstone, London, 1975.
24. G. C. Jagetia, N. G. Ganapathi and M. K. Unnikrishnan, Copperglycinate protects mice exposed to various doses of gamma radiation. Strahlenther. Onkol. 5, 323-328 (1993).
25. V. P. Bond, T. M. Fliedner and J. O. Archambeau, Mammalian Radiation Lethality. Academic Press, New York, 1965.
26. F. Thomson, Radiation Protection in Mammals. Reinhold Publishing, New York, 1962.
27. A. V. Rao, P. Uma Devi and R. Kamath, In vivo radioprotective effect of Moringa oleifera leaves. Indian J. Exp. Biol. 39, 858-863 (2001).
28. K. Meyer, J. Schwartz, D. Crater and B. Keyes, Zingiber officinale (ginger) used to prevent 8-Mop associated nausea. Dermatol. Nurs. 7, 242-244 (1995).
29. Q. M. Gong, S. L. Wang and C. Gan, A clinical study on the treatment of acute upper digestive tract hemorrhage with wen-she decoction. Zhong Xi Yi Jie He Za Zhi 9, 272-273 (1989). [in Chinese]
30. J. Yamahara, M. Mochizuki, H. Q. Rong, H. Matsuda and H. Fujimura, The anti-ulcer effect in rats of ginger constituents. J. Ethnopharmacol. 23, 299-304 (1988).
31. J. Yamahara, S. Hatakeyama, K. Taniguchi, M. Kawamura and M. Yoshikawa, Stomachic principles in ginger. II. Pungent and anti-ulcer effects of low polar constituents isolated from ginger, the dried rhizoma of Zingiber officinale Rosc cultivated in Taiwan. The absolute stereostructure of a new diarylheptanoid. Yakugaku Zasshi. 12, 645-655 (1992).
32. M. A. Al-Yahya, S. Rafatullah, J. S. Mossa, A. M. Ageel, N. S. Parmar and M. Tariq, Gastroprotective activity of ginger Zingiber officinale rosc, in albino rats. Am. J. Chin. Med. 17, 51-56 (1989).
33. H. Wu, D. Ye, Y. Bai and Y. Zhao, Effect of dry ginger and roasted ginger on experimental gastric ulcers in rats. Hongguo Zhong Yao Za Zhi. 15, 278-280 (1990).
34. M. Yoshikawa, S. Hatakeyama, K. Taniguchi, H. Matuda and J. Yamahara, 6-Gingesulfonic acid, a new anti-ulcer principle, and gingerglycolipids A, B, and C, three new monoacyldigalactosyl glycerols, from Zingiberis rhizoma originating in Taiwan. Chem. Pharm. Bull. 40, 2239-2241 (1992).
35. J. S. Zhang, C. P. Sigdestad, M. A. Gemmell and D. J. Grdina, Modification of radiation response in mice by fractionated extracts of Panax ginseng. Radiat. Res. 112, 156-163 (1987).
36. G. C. Jagetia, M. S. Baliga, K. J. Malagi and M. S, Kamath, The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation. Phytomedicine 9, 99-108 (2002).
37. G. C. Jagetia and M. S. Baliga, Cystone, an ayurvedic herbal drug imparts protection to the mice against the lethal effects of gamma-radiation: A preliminary study. Nahrung 46, 332-336 (2002).
38. G. C. Jagetia, M. S. Baliga, R. Aruna, G. K. Rajanikant and V. Jain, Effect of abana (a herbal preparation) on the radiation-induced mortality in mice. J. Ethnopharmacol. 86, 159-165 (2003).
39. H. C. Gugnani and E. C. Ezenwanze, Antibacterial activity of extracts of ginger and African oil bean seed. J. Commun. Dis. Sep. 17, 233-236 (1985).
40. J. P. Chaumont and D. Leger, Campaign against allergic moulds in dwellings. Inhibitor properties of essential oil geranium "Bourbon", citronellol, geraniol and citral. Ann. Pharm. Fr. 50, 156-166 (1992).
41. S. Pattnaik, V. R. Subramanyan, M. Bapaji and C. R. Kole, Antibacterial and antifungal activity of aromatic constituents of essential oils. Microbios 89, 39-46 (1997).
42. C. Holden, Antibiotic basis for spice use. Science 277, 321 (1997).
43. T. P. Krishnakantha and B. R. Lokesh, Scavenging of superoxide anions by spice principles. Indian J. Biochem. Biophys. 30, 133-134 (1993).
44. Z. F. Cao, Z, G. Chen, P. Guo, S. M. Zhang, L. X. Lian, L. Luo and W. M. Hu, Scavenging effects of ginger on superoxide anion and hydroxyl radical. Chung Kuo Chung Yao Tsa Chih. 18, 750-751 (1993).
45. A. Jitoe, T. Masuda, I. G. P. Tengah, D. N. Supragupta, I. W. Gara and N. Nakatani, Antioxidant activity of tropical ginger extracts and analysis of the contained curcuminoids. Med. Hypotheses 29, 25-28 (1989).
46. 2. Jpn. J. Pharmacol. 75, 363-370 (1997).
47. J. H. Guh, F. N. Ko, T. T. Jong and C. M. Ting, Antiplatelet effect of gingerol isolated from Zingiber officinale. J. Pharm. Pharmacol. 47, 329-332 (1995).
48. K. K. Park, K. S. Chun, J. M. Lee, S. S. Lee and Y. J. Surh, Inhibitory effects of (6)-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice. Cancer Lett. 129, 139-144 (1998).
49. W. S. Chang, Y. H. Chang, F. J. Lu and H. C. Chiang, Inhibitory effects of phenolics on xanthine oxidase. Anticancer Res. 14, 501-506 (1994).
50. Y. Hori, T. Miura, Y. Hirai, M. Fukumura, Y. Nemoto, K. Toriizuka and Y. Ida, Pharmacognostic studies on ginger and related drugs-part 1: Five sulfonated compounds from Zingiberis rhizome (Shokyo). Phytochemistry 62, 613-617 (2003).
51. J. A. Raleigh, W. Kremers and B. Gaboury, Dose-rate and oxygen effects in models of lipid membranes: Linoleic acid. Int. J. Radiat. Biol. 31, 203-213 (1977).
52. W. Leyko and G. Bartosz, Membrane effects of ionizing radiation and hyperthermia. Int. J. Radiat. Biol. 49, 743-770 (1986).
53. Y. Noda, P. L. McGeer, E. G. McGeer and M. Comporti, Lipid peroxidation. Biopathological significance. Mol. Aspects Med. 14, 199-207 (1993).
54. A. C. Reddy and B. R. Lokesh, Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol. Cell. Biochem. 111, 117-124 (1992).
55. R. S. Ahmed, V. Seth, S. T. Pasha and B. D. Banerjee, Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats. Food Chem. Toxicol. 38, 443-450 (2000).
56. W. Y. Chung, C. M. Yow and I. F. Benzie, Assessment of membrane protection by traditional Chinese medicines using a flow cytometric technique: Preliminary findings. Redox. Rep. 8, 31-33 (2003).
57. S. Banerjee, R. Sharma, R. K. Kale and A. R. Rao, Influence of certain essential oils on carcinogen metabolizing enzymes and acid-soluble sulphydryls in mouse liver. Nutr. Cancer 21, 263-269 (1994).
58. D. Kilic, H. Sayan, B. Gonul and I. Egehan, The effect of granulocyte macrophage-colony stimulating factor on glutathione and lipid peroxidation in a rat model. Eur. J. Surg. Oncol. 26, 701-704 (2000).