The molecular hug between the ER and the mitochondria

Current Opinion in Cell Biology

Volumn 25, Issue 4, 2013, Pages 443-448

  Kornmann, Benoît ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM ION; HYBRID PROTEIN; LIPID; MITOCHONDRIAL ENZYME; MITOCHONDRIAL PROTEIN; MITOFUSIN 2; SYNAPTOBREVIN; VOLTAGE DEPENDENT ANION CHANNEL;

APOPTOSIS; CALCIUM TRANSPORT; CELL FUNCTION; CELL ORGANELLE; CELL ULTRASTRUCTURE; ENDOPLASMIC RETICULUM; GENE INTERACTION; ION EXCHANGE; LIPID TRANSPORT; LIPOGENESIS; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REVIEW; SEDIMENTATION RATE; STARVATION;

ANIMALS; CALCIUM; ENDOPLASMIC RETICULUM; LIPID METABOLISM; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PROTEIN TRANSPORT; YEASTS;

EID: 84883451708     PISSN: 09550674     EISSN: 18790410     Source Type: Journal    
DOI: 10.1016/j.ceb.2013.02.010     Document Type: Review

References (40)

1. Urbani L., Simoni R.D. Cholesterol and vesicular stomatitis virus G protein take separate routes from the endoplasmic reticulum to the plasma membrane. J Biol Chem 1990, 265:1919-1923.
2. Kok J.W., Babia T., Klappe K., Egea G., Hoekstra D. Ceramide transport from endoplasmic reticulum to Golgi apparatus is not vesicle-mediated. Biochem J 1998, 333(Pt 3):779-786.
3. Vance J.E., Aasman E.J., Szarka R. Brefeldin A does not inhibit the movement of phosphatidylethanolamine from its sites for synthesis to the cell surface. J Biol Chem 1991, 266:8241-8247.
4. Robertson J.D. The molecular structure and contact relationships of cell membranes. Prog Biophys Mol Biol 1960, 10:343-418.
5. Vance J. Phospholipid synthesis in a membrane fraction associated with mitochondria. J Biol Chem 1990, 265:7248.
6. 3-sensitive channels that are sensed by neighboring mitochondria. Science 1993, 262:744-747.
7. Kornmann B., Currie E., Collins S.R., Schuldiner M., Nunnari J., Weissman J.S., Walter P. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 2009, 325:477-481.
8. Csordás G., Renken C., Várnai P., Walter L., Weaver D., Buttle K.F., Balla T., Mannella C.A., Hajnóczky G. Structural and functional features and significance of the physical linkage between ER and mitochondria. J Cell Biol 2006, 174:915-921.
9. 2+ channels. J Cell Biol 2006, 175:901-911.
10. De Brito O.M., Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008, 456:605-610.
11. Iwasawa R., Mahul-Mellier A-L., Datler C., Pazarentzos E., Grimm S. Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J 2011, 30:556-568.
12. De Vos K.J., Mórotz G.M., Stoica R., Tudor E.L., Lau K-F., Ackerley S., Warley A., Shaw C.E., Miller C.C.J. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. Hum Mol Genet 2012, 21:1299-1311.
13. Rusiñol A.E., Cui Z., Chen M.H., Vance J.E. A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins. J Biol Chem 1994, 269:27494-27502.
14. Achleitner G., Gaigg B., Krasser A., Kainersdorfer E., Kohlwein S.D., Perktold A., Zellnig G., Daum G. Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact. Eur J Biochem 1999, 264:545-553.
15. Voelker D. Lipid synthesis and transport in mitochondrial biogenesis. Top Curr Genet 2004, 8:267-291.
16. Lev S. Non-vesicular lipid transport by lipid-transfer proteins and beyond. Nat Rev Mol Cell Biol 2010, 11:739-750.
17. Toulmay A., Prinz W.A. Lipid transfer and signaling at organelle contact sites: the tip of the iceberg. Curr Opin Cell Biol 2011, 23:458-463.
18. De Saint-Jean M., Delfosse V., Douguet D., Chicanne G., Payrastre B., Bourguet W., Antonny B., Drin G. Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. J Cell Biol 2011, 195:965-978.
19. Kopec K.O., Alva V., Lupas A.N. Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria. Bioinformatics 2010, 26:1927-1931.
20. Voss C., Lahiri S., Young B.P., Loewen C.J., Prinz W.A. ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae. J Cell Sci 2012, 125:4791-4799.
21. Nguyen T.T., Lewandowska A., Choi J-Y., Markgraf D.F., Junker M., Bilgin M., Ejsing C.S., Voelker D.R., Rapoport T.A., Shaw J.M. Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic 2012, 13:880-890.
22. Papadopoulos V., Miller W.L. Role of mitochondria in steroidogenesis. Best Pract Res Clin Endocrinol Metab 2012, 26:771-790.
23. Denton R.M. Regulation of mitochondrial dehydrogenases by calcium ions. Biochim Biophys Acta 2009, 1787:1309-1316.
24. 2+ waves in rat cortical astrocytes. J Cell Biol 1999, 145:795-808.
25. Carafoli E., Lehninger A.L. A survey of the interaction of calcium ions with mitochondria from different tissues and species. Biochem J 1971, 122:681-690.
26. Clapham D.E. Calcium signaling. Cell 2007, 131:1047-1058.
27. Carafoli E. The interplay of mitochondria with calcium: an historical appraisal. Cell Calcium 2012, 52:1-8.
28. Baughman J.M., Perocchi F., Girgis H.S., Plovanich M., Belcher-Timme C.A., Sancak Y., Bao X.R., Strittmatter L., Goldberger O., Bogorad R.L., et al. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 2011, 476:341-345.
29. De Stefani D., Raffaello A., Teardo E., Szabò I., Rizzuto R. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 2011, 476:336-340.
30. Perocchi F., Gohil V.M., Girgis H.S., Bao X.R., McCombs J.E., Palmer A.E., Mootha V.K. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature 2010, 467:291-296.
31. 2+ uptake that regulates cellular metabolism. Nat Cell Biol 2012, 14:1336-1343.
32. 2+ transfer to mitochondria. Cell 2010, 142:270-283.
33. Friedman J.R., Lackner L.L., West M., DiBenedetto J.R., Nunnari J., Voeltz G.K. ER tubules mark sites of mitochondrial division. Science 2011, 334:358-362.
34. Guo X., Macleod G.T., Wellington A., Hu F., Panchumarthi S., Schoenfield M., Marin L., Charlton M.P., Atwood H.L., Zinsmaier K.E. The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. Neuron 2005, 47:379-393.
35. 2+-dependent regulation of kinesin-mediated mitochondrial motility. Cell 2009, 136:163-174.
36. Frederick R.L., McCaffery J.M., Cunningham K.W., Okamoto K., Shaw J.M. Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol 2004, 167:87-98.
37. Stroud D.A., Oeljeklaus S., Wiese S., Bohnert M., Lewandrowski U., Sickmann A., Guiard B., Van der Laan M., Warscheid B., Wiedemann N. Composition and topology of the endoplasmic reticulum-mitochondria encounter structure. J Mol Biol 2011, 413:743-750.
38. Kornmann B., Osman C., Walter P. The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A 2011, 108:14151-14156.
39. Swayne T.C., Zhou C., Boldogh I.R., Charalel J.K., McFaline-Figueroa J.R., Thoms S., Yang C., Leung G., McInnes J., Erdmann R., et al. Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast. Curr Biol 2011, 21:1994-1999.
40. 2+ signaling. Physiology (Bethesda) 2008, 23:84-94.