메뉴 건너뛰기




Volumn 15, Issue 6, 2014, Pages 9924-9944

Steatosis and steatohepatitis: Complex disorders

Author keywords

ASH; NASH; Steatohepatitis; Steatosis

Indexed keywords

2, 4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ALPHA 2 MACROGLOBULIN; ALPHA TOCOPHEROL; APOLIPOPROTEIN A1; BINDING PROTEIN; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; ESTROGEN; FAS ANTIGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; I KAPPA B KINASE BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIVER TRIACYLGLYCEROL LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MANGANESE SUPEROXIDE DISMUTASE; MICRORNA; MICRORNA 122; MICRORNA 34A; OMEGA 3 FATTY ACID; PENTOXIFYLLINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REACTIVE OXYGEN METABOLITE; SALICYLIC ACID DERIVATIVE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84901921708     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15069924     Document Type: Review
Times cited : (33)

References (156)
  • 1
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig, J.; Viggiano, T.R.; McGill, D.B.; Oh, B.J. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc. 1980, 55, 434-438.
    • (1980) Mayo Clin. Proc , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Oh, B.J.4
  • 2
    • 34547732002 scopus 로고    scopus 로고
    • GI epidemiology: Non-alcoholic fatty liver disease
    • Angulo, P. GI epidemiology: Non-alcoholic fatty liver disease. Aliment. Pharmacol. Ther. 2007, 25, 883-889.
    • (2007) Aliment. Pharmacol. Ther , vol.25 , pp. 883-889
    • Angulo, P.1
  • 3
    • 78049452485 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Law, K.; Brunt, E.M. Nonalcoholic fatty liver disease. Clin. Liver Dis. 2010, 14, 591-604.
    • (2010) Clin. Liver Dis , vol.14 , pp. 591-604
    • Law, K.1    Brunt, E.M.2
  • 4
    • 48449103834 scopus 로고    scopus 로고
    • Review article: Diagnosis and treatment of non-alcoholic fatty liver disease
    • Oh, M.K.; Winn, J.; Poordad, F. Review article: Diagnosis and treatment of non-alcoholic fatty liver disease. Aliment. Pharmacol. Ther. 2008, 28, 503-522.
    • (2008) Aliment. Pharmacol. Ther , vol.28 , pp. 503-522
    • Oh, M.K.1    Winn, J.2    Poordad, F.3
  • 6
    • 77950858243 scopus 로고    scopus 로고
    • Pathology of nonalcoholic fatty liver disease
    • Brunt, E.M. Pathology of nonalcoholic fatty liver disease. Nat. Rev. Gastroenterol. Hepatol. 2010, 7, 195-203.
    • (2010) Nat. Rev. Gastroenterol. Hepatol , vol.7 , pp. 195-203
    • Brunt, E.M.1
  • 7
    • 79959284653 scopus 로고    scopus 로고
    • Update on fatty liver disease and steatohepatitis
    • Aly, F.Z.; Kleiner, D.E. Update on fatty liver disease and steatohepatitis. Adv. Anat. Pathol. 2011, 18, 294-300.
    • (2011) Adv. Anat. Pathol , vol.18 , pp. 294-300
    • Aly, F.Z.1    Kleiner, D.E.2
  • 10
    • 33750620948 scopus 로고    scopus 로고
    • Assessing the outcome of nonalcoholic steatohepatitis? It's time to get serious
    • Ratziu, V.; Poynard, T. Assessing the outcome of nonalcoholic steatohepatitis? It's time to get serious. Hepatology 2006, 44, 802-805.
    • (2006) Hepatology , vol.44 , pp. 802-805
    • Ratziu, V.1    Poynard, T.2
  • 12
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell, E.E.; Cooksley, W.G.; Hanson, R.; Searle, J.; Halliday, J.W.; Powell, L.W. The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years. Hepatology 1990, 11, 74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 13
    • 0242361733 scopus 로고    scopus 로고
    • Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease
    • Schwimmer, J.B.; Deutsch, R.; Rauch, J.B.; Behling, C.; Newbury, R.; Lavine, J.E. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J. Pediatr. 2003, 143, 500-505.
    • (2003) J. Pediatr , vol.143 , pp. 500-505
    • Schwimmer, J.B.1    Deutsch, R.2    Rauch, J.B.3    Behling, C.4    Newbury, R.5    Lavine, J.E.6
  • 14
    • 77954151050 scopus 로고    scopus 로고
    • Association of the components of the metabolic syndrome with non-alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents
    • Kelishadi, R.; Cook, S.R.; Adibi, A.; Faghihimani, Z.; Ghatrehsamani, S.; Beihaghi, A.; Salehi, H.; Khavarian, N.; Poursafa, P. Association of the components of the metabolic syndrome with non-alcoholic fatty liver disease among normal-weight, overweight and obese children and adolescents. Diabetol. Metab. Syndr. 2009, 1, 29.
    • (2009) Diabetol. Metab. Syndr , vol.1 , pp. 29
    • Kelishadi, R.1    Cook, S.R.2    Adibi, A.3    Faghihimani, Z.4    Ghatrehsamani, S.5    Beihaghi, A.6    Salehi, H.7    Khavarian, N.8    Poursafa, P.9
  • 15
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day, C.P.; James, O.F. Steatohepatitis: A tale of two "hits"? Gastroenterology 1998, 114, 842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 16
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
    • Tilg, H.; Moschen, A.R. Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis. Hepatology 2010, 52, 1836-1846.
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 20
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study
    • Bedogni, G.; Miglioli, L.; Masutti, F.; Tiribelli, C.; Marchesini, G.; Bellentani, S. Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study. Hepatology 2005, 42, 44-52.
    • (2005) Hepatology , vol.42 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3    Tiribelli, C.4    Marchesini, G.5    Bellentani, S.6
  • 21
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy
    • Williams, C.D.; Stengel, J.; Asike, M.I.; Torres, D.M.; Shaw, J.; Contreras, M.; Landt, C.L.; Harrison, S.A. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterology 2011, 140, 124-131.
    • (2011) A Prospective Study. Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3    Torres, D.M.4    Shaw, J.5    Contreras, M.6    Landt, C.L.7    Harrison, S.A.8
  • 22
    • 0344393668 scopus 로고    scopus 로고
    • Increase in the prevalence of fatty liver in Japan over the past 12 years: Analysis of clinical background
    • Kojima, S.-I.; Watanabe, N.; Numata, M.; Ogawa, T.; Matsuzaki, S. Increase in the prevalence of fatty liver in Japan over the past 12 years: Analysis of clinical background. J. Gastroenterol. 2003, 38, 954-961.
    • (2003) J. Gastroenterol , vol.38 , pp. 954-961
    • Kojima, S.-I.1    Watanabe, N.2    Numata, M.3    Ogawa, T.4    Matsuzaki, S.5
  • 24
    • 56949097660 scopus 로고    scopus 로고
    • Epidemiology of non-alcoholic fatty liver disease in China
    • Fan, J.-G.; Farrell, G.C. Epidemiology of non-alcoholic fatty liver disease in China. J. Hepatol. 2009, 50, 204-210.
    • (2009) J. Hepatol , vol.50 , pp. 204-210
    • Fan, J.-G.1    Farrell, G.C.2
  • 25
    • 34347389654 scopus 로고    scopus 로고
    • Prevalence and risk factors of non-alcoholic fatty liver disease in potential living liver donors in Korea: A review of 589 consecutive liver biopsies in a single center
    • Lee, J.Y.; Kim, K.M.; Lee, S.G.; Yu, E.; Lim, Y.-S.; Lee, H.C.; Chung, Y.-H.; Lee, Y.S.; Suh, D.-J. Prevalence and risk factors of non-alcoholic fatty liver disease in potential living liver donors in Korea: A review of 589 consecutive liver biopsies in a single center. J. Hepatol. 2007, 47, 239-244.
    • (2007) J. Hepatol , vol.47 , pp. 239-244
    • Lee, J.Y.1    Kim, K.M.2    Lee, S.G.3    Yu, E.4    Lim, Y.-S.5    Lee, H.C.6    Chung, Y.-H.7    Lee, Y.S.8    Suh, D.-J.9
  • 26
  • 29
    • 66249083485 scopus 로고    scopus 로고
    • Chronic liver disease among two American Indian patient populations in the southwestern United States, 2000-2003
    • Bialek, S.R.; Redd, J.T.; Lynch, A.; Vogt, T.; Lewis, S.; Wilson, C.; Bell, B.P. Chronic liver disease among two American Indian patient populations in the southwestern United States, 2000-2003. J. Clin. Gastroenterol. 2008, 42, 949-954.
    • (2008) J. Clin. Gastroenterol , vol.42 , pp. 949-954
    • Bialek, S.R.1    Redd, J.T.2    Lynch, A.3    Vogt, T.4    Lewis, S.5    Wilson, C.6    Bell, B.P.7
  • 30
    • 84872343935 scopus 로고    scopus 로고
    • Overview of screening methods for fatty liver disease in children
    • Devadason, C.A.; Scheimann, A.O. Overview of screening methods for fatty liver disease in children. World J. Hepatol. 2012, 4, 1-4.
    • (2012) World J. Hepatol , vol.4 , pp. 1-4
    • Devadason, C.A.1    Scheimann, A.O.2
  • 31
    • 84868314304 scopus 로고    scopus 로고
    • Ethnicity and elevated liver transaminases among newly diagnosed children with type 2 diabetes
    • Hudson, O.D.; Nunez, M.; Shaibi, G.Q. Ethnicity and elevated liver transaminases among newly diagnosed children with type 2 diabetes. BMC Pediatr. 2012, 12, 174.
    • (2012) BMC Pediatr , vol.12 , pp. 174
    • Hudson, O.D.1    Nunez, M.2    Shaibi, G.Q.3
  • 32
    • 16444367799 scopus 로고    scopus 로고
    • Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents
    • Schwimmer, J.B.; McGreal, N.; Deutsch, R.; Finegold, M.J.; Lavine, J.E. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 2005, 115, e561-e565.
    • (2005) Pediatrics , vol.115
    • Schwimmer, J.B.1    McGreal, N.2    Deutsch, R.3    Finegold, M.J.4    Lavine, J.E.5
  • 33
    • 48749130930 scopus 로고    scopus 로고
    • Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease
    • Chen, Z.; Chen, L.; Dai, H.; Chen, J.; Fang, L. Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease. J. Zhejiang Univ. Sci. B 2008, 9, 616-622.
    • (2008) J. Zhejiang Univ. Sci. B , vol.9 , pp. 616-622
    • Chen, Z.1    Chen, L.2    Dai, H.3    Chen, J.4    Fang, L.5
  • 36
    • 0036117990 scopus 로고    scopus 로고
    • Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women
    • Carr, M.C.; Ayyobi, A.F.; Murdoch, S.J.; Deeb, S.S.; Brunzell, J.D. Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women. Arterioscler. Thromb. Vasc. Biol. 2002, 22, 667-673.
    • (2002) Arterioscler. Thromb. Vasc. Biol , vol.22 , pp. 667-673
    • Carr, M.C.1    Ayyobi, A.F.2    Murdoch, S.J.3    Deeb, S.S.4    Brunzell, J.D.5
  • 37
    • 48349114960 scopus 로고    scopus 로고
    • Risk factors and mechanisms of non-alcoholic steatohepatitis
    • Rivera, C.A. Risk factors and mechanisms of non-alcoholic steatohepatitis. Pathophysiol. Off. J. Int. Soc. Pathophysiol. 2008, 15, 109-114.
    • (2008) Pathophysiol. Off. J. Int. Soc. Pathophysiol , vol.15 , pp. 109-114
    • Rivera, C.A.1
  • 38
    • 0032986811 scopus 로고    scopus 로고
    • Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals
    • Elbers, J.M.; Asscheman, H.; Seidell, J.C.; Gooren, L.J. Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals. Am. J. Physiol. 1999, 276, E317-E325.
    • (1999) Am. J. Physiol , vol.276
    • Elbers, J.M.1    Asscheman, H.2    Seidell, J.C.3    Gooren, L.J.4
  • 39
    • 0026347185 scopus 로고
    • Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause
    • Haarbo, J.; Marslew, U.; Gotfredsen, A.; Christiansen, C. Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism. 1991, 40, 1323-1326.
    • (1991) Metabolism , vol.40 , pp. 1323-1326
    • Haarbo, J.1    Marslew, U.2    Gotfredsen, A.3    Christiansen, C.4
  • 41
    • 33748110788 scopus 로고    scopus 로고
    • Hepatic histology in obese patients undergoing bariatric surgery
    • Machado, M.; Marques-Vidal, P.; Cortez-Pinto, H. Hepatic histology in obese patients undergoing bariatric surgery. J. Hepatol. 2006, 45, 600-606.
    • (2006) J. Hepatol , vol.45 , pp. 600-606
    • Machado, M.1    Marques-Vidal, P.2    Cortez-Pinto, H.3
  • 43
    • 0242443339 scopus 로고    scopus 로고
    • Prevalence and predictors of asymptomatic liver disease in patients undergoing gastric bypass surgery
    • Beymer, C.; Kowdley, K.V.; Larson, A.; Edmonson, P.; Dellinger, E.P.; Flum, D.R. Prevalence and predictors of asymptomatic liver disease in patients undergoing gastric bypass surgery. Arch. Surg. Chic. Ill 1960 2003, 138, 1240-1244.
    • (2003) Arch. Surg. Chic. Ill 1960 , vol.138 , pp. 1240-1244
    • Beymer, C.1    Kowdley, K.V.2    Larson, A.3    Edmonson, P.4    Dellinger, E.P.5    Flum, D.R.6
  • 45
    • 4043132498 scopus 로고    scopus 로고
    • Portal fibrosis and hepatic steatosis in morbidly obese subjects: A spectrum of nonalcoholic fatty liver disease
    • Abrams, G.A.; Kunde, S.S.; Lazenby, A.J.; Clements, R.H. Portal fibrosis and hepatic steatosis in morbidly obese subjects: A spectrum of nonalcoholic fatty liver disease. Hepatology 2004, 40, 475-483.
    • (2004) Hepatology , vol.40 , pp. 475-483
    • Abrams, G.A.1    Kunde, S.S.2    Lazenby, A.J.3    Clements, R.H.4
  • 48
    • 84859942552 scopus 로고    scopus 로고
    • Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease
    • Lomonaco, R.; Ortiz-Lopez, C.; Orsak, B.; Webb, A.; Hardies, J.; Darland, C.; Finch, J.; Gastaldelli, A.; Harrison, S.; Tio, F. et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology 2012, 55, 1389-1397.
    • (2012) Hepatology , vol.55 , pp. 1389-1397
    • Lomonaco, R.1    Ortiz-Lopez, C.2    Orsak, B.3    Webb, A.4    Hardies, J.5    Darland, C.6    Finch, J.7    Gastaldelli, A.8    Harrison, S.9    Tio, F.10
  • 49
    • 84865553250 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism
    • Musso, G.; Cassader, M.; de Michieli, F.; Rosina, F.; Orlandi, F.; Gambino, R. Nonalcoholic steatohepatitis versus steatosis: Adipose tissue insulin resistance and dysfunctional response to fat ingestion predict liver injury and altered glucose and lipoprotein metabolism. Hepatology 2012, 56, 933-942.
    • (2012) Hepatology , vol.56 , pp. 933-942
    • Musso, G.1    Cassader, M.2    de Michieli, F.3    Rosina, F.4    Orlandi, F.5    Gambino, R.6
  • 50
    • 77957746634 scopus 로고    scopus 로고
    • Roles of liver innate immune cells in nonalcoholic fatty liver disease
    • Zhan, Y.-T.; An, W. Roles of liver innate immune cells in nonalcoholic fatty liver disease. World J. Gastroenterol. 2010, 16, 4652-4660.
    • (2010) World J. Gastroenterol , vol.16 , pp. 4652-4660
    • Zhan, Y.-T.1    An, W.2
  • 51
    • 33846322877 scopus 로고    scopus 로고
    • The role of cytokines in non-alcoholic steatohepatitis. A review
    • Copaci, I.; Micu, L.; Voiculescu, M. The role of cytokines in non-alcoholic steatohepatitis. A review. J. Gastrointest. Liver Dis. 2006, 15, 363-373.
    • (2006) J. Gastrointest. Liver Dis , vol.15 , pp. 363-373
    • Copaci, I.1    Micu, L.2    Voiculescu, M.3
  • 53
    • 84864112587 scopus 로고    scopus 로고
    • Mechanisms of disease progression in NASH: New paradigms
    • Bohinc, B.N.; Diehl, A.M. Mechanisms of disease progression in NASH: New paradigms. Clin. Liver Dis. 2012, 16, 549-565.
    • (2012) Clin. Liver Dis , vol.16 , pp. 549-565
    • Bohinc, B.N.1    Diehl, A.M.2
  • 54
    • 84861573996 scopus 로고    scopus 로고
    • NASH CRN Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
    • Guy, C.D.; Suzuki, A.; Zdanowicz, M.; Abdelmalek, M.F.; Burchette, J.; Unalp, A.; Diehl, A.M. NASH CRN Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. Hepatology 2012, 55, 1711-1721.
    • (2012) Hepatology , vol.55 , pp. 1711-1721
    • Guy, C.D.1    Suzuki, A.2    Zdanowicz, M.3    Abdelmalek, M.F.4    Burchette, J.5    Unalp, A.6    Diehl, A.M.7
  • 55
    • 77953526530 scopus 로고    scopus 로고
    • Role of microRNAs in non-alcoholic steatohepatitis
    • Cheung, O.; Sanyal, A.J. Role of microRNAs in non-alcoholic steatohepatitis. Curr. Pharm. Des. 2010, 16, 1952-1957.
    • (2010) Curr. Pharm. Des , vol.16 , pp. 1952-1957
    • Cheung, O.1    Sanyal, A.J.2
  • 59
    • 79955065145 scopus 로고    scopus 로고
    • The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats
    • Li, W.-Q.; Chen, C.; Xu, M.-D.; Guo, J.; Li, Y.-M.; Xia, Q.-M.; Liu, H.-M.; He, J.; Yu, H.-Y.; Zhu, L. The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats. FEBS J. 2011, 278, 1522-1532.
    • (2011) FEBS J , vol.278 , pp. 1522-1532
    • Li, W.-Q.1    Chen, C.2    Xu, M.-D.3    Guo, J.4    Li, Y.-M.5    Xia, Q.-M.6    Liu, H.-M.7    He, J.8    Yu, H.-Y.9    Zhu, L.10
  • 60
    • 84871221881 scopus 로고    scopus 로고
    • miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    • Castro, R.E.; Ferreira, D.M.S.; Afonso, M.B.; Borralho, P.M.; Machado, M.V.; Cortez-Pinto, H.; Rodrigues, C.M.P. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J. Hepatol. 2013, 58, 119-125.
    • (2013) J. Hepatol , vol.58 , pp. 119-125
    • Castro, R.E.1    Ferreira, D.M.S.2    Afonso, M.B.3    Borralho, P.M.4    Machado, M.V.5    Cortez-Pinto, H.6    Rodrigues, C.M.P.7
  • 61
    • 84862267335 scopus 로고    scopus 로고
    • Japan Study Group of Nonalcoholic Fatty Liver Disease. Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese
    • Kawaguchi, T.; Sumida, Y.; Umemura, A.; Matsuo, K.; Takahashi, M.; Takamura, T.; Yasui, K.; Saibara, T.; Hashimoto, E.; Kawanaka, M. et al. Japan Study Group of Nonalcoholic Fatty Liver Disease. Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese. PLoS One 2012, 7, e38322.
    • (2012) PLoS One , vol.7
    • Kawaguchi, T.1    Sumida, Y.2    Umemura, A.3    Matsuo, K.4    Takahashi, M.5    Takamura, T.6    Yasui, K.7    Saibara, T.8    Hashimoto, E.9    Kawanaka, M.10
  • 62
    • 77956636268 scopus 로고    scopus 로고
    • NASH CRN The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease
    • Rotman, Y.; Koh, C.; Zmuda, J.M.; Kleiner, D.E.; Liang, T.J. NASH CRN The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. Hepatology 2010, 52, 894-903.
    • (2010) Hepatology , vol.52 , pp. 894-903
    • Rotman, Y.1    Koh, C.2    Zmuda, J.M.3    Kleiner, D.E.4    Liang, T.J.5
  • 69
    • 0018390236 scopus 로고
    • Ultrasound in the detection of chronic liver disease (the "bright liver")
    • Joseph, A.E.; Dewbury, K.C.; McGuire, P.G. Ultrasound in the detection of chronic liver disease (the "bright liver"). Br. J. Radiol. 1979, 52, 184-188.
    • (1979) Br. J. Radiol , vol.52 , pp. 184-188
    • Joseph, A.E.1    Dewbury, K.C.2    McGuire, P.G.3
  • 72
    • 38949142374 scopus 로고    scopus 로고
    • CT and MRI for determining hepatic fat content
    • author reply W168
    • Reeder, S.B.; Ranallo, F.; Taylor, A.J. CT and MRI for determining hepatic fat content. Am. J. Roentgenol. 2008, 190, W167; author reply W168.
    • (2008) Am. J. Roentgenol , vol.190
    • Reeder, S.B.1    Ranallo, F.2    Taylor, A.J.3
  • 73
    • 84872322497 scopus 로고    scopus 로고
    • Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver disease
    • Fitzpatrick, E.; Quaglia, A.; Vimalesvaran, S.; Basso, M.S.; Dhawan, A. Transient elastography is a useful noninvasive tool for the evaluation of fibrosis in paediatric chronic liver disease. J. Pediatr. Gastroenterol. Nutr. 2013, 56, 72-76.
    • (2013) J. Pediatr. Gastroenterol. Nutr , vol.56 , pp. 72-76
    • Fitzpatrick, E.1    Quaglia, A.2    Vimalesvaran, S.3    Basso, M.S.4    Dhawan, A.5
  • 75
    • 33644607568 scopus 로고    scopus 로고
    • Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease
    • LIDO Study Group and CYTOL Study Group
    • Ratziu, V.; Massard, J.; Charlotte, F.; Messous, D.; Imbert-Bismut, F.; Bonyhay, L.; Tahiri, M.; Munteanu, M.; Thabut, D.; Cadranel, J.F. et al. LIDO Study Group and CYTOL Study Group. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol. 2006, 6, 6.
    • (2006) BMC Gastroenterol , vol.6 , pp. 6
    • Ratziu, V.1    Massard, J.2    Charlotte, F.3    Messous, D.4    Imbert-Bismut, F.5    Bonyhay, L.6    Tahiri, M.7    Munteanu, M.8    Thabut, D.9    Cadranel, J.F.10
  • 76
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning, J.D.; Horton, J.D. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Investig. 2004, 114, 147-152.
    • (2004) J. Clin. Investig , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 77
    • 77958175188 scopus 로고    scopus 로고
    • The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis
    • Sozio, M.; Liangpunsakul, S.; Crabb, D. The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis. Semin. Liver Dis. 2010, 30, 378-390.
    • (2010) Semin. Liver Dis , vol.30 , pp. 378-390
    • Sozio, M.1    Liangpunsakul, S.2    Crabb, D.3
  • 78
    • 77649337140 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Pathology and pathogenesis
    • Tiniakos, D.G.; Vos, M.B.; Brunt, E.M. Nonalcoholic fatty liver disease: Pathology and pathogenesis. Annu. Rev. Pathol. 2010, 5, 145-171.
    • (2010) Annu. Rev. Pathol , vol.5 , pp. 145-171
    • Tiniakos, D.G.1    Vos, M.B.2    Brunt, E.M.3
  • 80
    • 13844314223 scopus 로고    scopus 로고
    • Fat cells: Afferent and efferent messages define new approaches to treat obesity
    • Lafontan, M. Fat cells: Afferent and efferent messages define new approaches to treat obesity. Annu. Rev. Pharmacol. Toxicol. 2005, 45, 119-146.
    • (2005) Annu. Rev. Pharmacol. Toxicol , vol.45 , pp. 119-146
    • Lafontan, M.1
  • 81
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • Fontana, L.; Eagon, J.C.; Trujillo, M.E.; Scherer, P.E.; Klein, S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 2007, 56, 1010-1013.
    • (2007) Diabetes , vol.56 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4    Klein, S.5
  • 82
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day, C.P. From fat to inflammation. Gastroenterology 2006, 130, 207-210.
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 83
    • 12344332455 scopus 로고    scopus 로고
    • Cytokines and the pathogenesis of non-alcoholic steatohepatitis
    • Diehl, A.M.; Li, Z.P.; Lin, H.Z.; Yang, S.Q. Cytokines and the pathogenesis of non-alcoholic steatohepatitis. Gut 2005, 54, 303-306.
    • (2005) Gut , vol.54 , pp. 303-306
    • Diehl, A.M.1    Li, Z.P.2    Lin, H.Z.3    Yang, S.Q.4
  • 86
    • 0036787345 scopus 로고    scopus 로고
    • Removal of visceral fat prevents insulin resistance and glucose intolerance of aging an adipokine-mediated process?
    • Gabriely, I.; Ma, X.H.; Yang, X.M.; Atzmon, G.; Rajala, M.W.; Berg, A.H.; Scherer, P.; Rossetti, L.; Barzilai, N. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging an adipokine-mediated process? Diabetes 2002, 51, 2951-2958.
    • (2002) Diabetes , vol.51 , pp. 2951-2958
    • Gabriely, I.1    Ma, X.H.2    Yang, X.M.3    Atzmon, G.4    Rajala, M.W.5    Berg, A.H.6    Scherer, P.7    Rossetti, L.8    Barzilai, N.9
  • 87
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki, T.; Yamauchi, T.; Kubota, N.; Hara, K.; Ueki, K.; Tobe, K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J. Clin. Investig. 2006, 116, 1784-1792.
    • (2006) J. Clin. Investig , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 88
    • 2942687834 scopus 로고    scopus 로고
    • Adiponectin: A novel adipokine linking adipocytes and vascular function
    • Goldstein, B.J.; Scalia, R. Adiponectin: A novel adipokine linking adipocytes and vascular function. J. Clin. Endocrinol. Metab. 2004, 89, 2563-2568.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 2563-2568
    • Goldstein, B.J.1    Scalia, R.2
  • 90
    • 28844440050 scopus 로고    scopus 로고
    • Decreased serum adiponectin: An early event in pediatric nonalcoholic fatty liver disease
    • Louthan, M.V.; Barve, S.; McClain, C.J.; Joshi-Barve, S. Decreased serum adiponectin: An early event in pediatric nonalcoholic fatty liver disease. J. Pediatr. 2005, 147, 835-838.
    • (2005) J. Pediatr , vol.147 , pp. 835-838
    • Louthan, M.V.1    Barve, S.2    McClain, C.J.3    Joshi-Barve, S.4
  • 93
    • 4344666158 scopus 로고    scopus 로고
    • Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease
    • Diehl, A.M. Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease. Clin. Liver Dis. 2004, 8, 619-638.
    • (2004) Clin. Liver Dis , vol.8 , pp. 619-638
    • Diehl, A.M.1
  • 94
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden, M.S.; Ghosh, S. Signaling to NF-κB. Genes Dev. 2004, 18, 2195-2224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 95
    • 0025186310 scopus 로고
    • Effect of weight reduction on hepatic abnormalities in overweight patients
    • Palmer, M.; Schaffner, F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology 1990, 99, 1408-1413.
    • (1990) Gastroenterology , vol.99 , pp. 1408-1413
    • Palmer, M.1    Schaffner, F.2
  • 96
    • 0029433619 scopus 로고
    • Effect of weight control on hepatic abnormalities in obese patients with fatty liver
    • Park, H.S.; Kim, M.W.; Shin, E.S. Effect of weight control on hepatic abnormalities in obese patients with fatty liver. J. Korean Med. Sci. 1995, 10, 414-421.
    • (1995) J. Korean Med. Sci , vol.10 , pp. 414-421
    • Park, H.S.1    Kim, M.W.2    Shin, E.S.3
  • 98
    • 58949102847 scopus 로고    scopus 로고
    • Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial
    • Harrison, S.A.; Fecht, W.; Brunt, E.M.; Neuschwander-Tetri, B.A. Orlistat for overweight subjects with nonalcoholic steatohepatitis: A randomized, prospective trial. Hepatology 2009, 49, 80-86.
    • (2009) Hepatology , vol.49 , pp. 80-86
    • Harrison, S.A.1    Fecht, W.2    Brunt, E.M.3    Neuschwander-Tetri, B.A.4
  • 99
    • 0025959287 scopus 로고
    • Hepatic effects of dietary weight loss in morbidly obese subjects
    • Andersen, T.; Gluud, C.; Franzmann, M.B.; Christoffersen, P. Hepatic effects of dietary weight loss in morbidly obese subjects. J. Hepatol. 1991, 12, 224-229.
    • (1991) J. Hepatol , vol.12 , pp. 224-229
    • Andersen, T.1    Gluud, C.2    Franzmann, M.B.3    Christoffersen, P.4
  • 100
    • 84655169624 scopus 로고    scopus 로고
    • Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
    • Rolo, A.P.; Teodoro, J.S.; Palmeira, C.M. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic. Biol. Med. 2012, 52, 59-69.
    • (2012) Free Radic. Biol. Med , vol.52 , pp. 59-69
    • Rolo, A.P.1    Teodoro, J.S.2    Palmeira, C.M.3
  • 101
    • 77953714513 scopus 로고    scopus 로고
    • Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes
    • Narasimhan, S.; Gokulakrishnan, K.; Sampathkumar, R.; Farooq, S.; Ravikumar, R.; Mohan, V.; Balasubramanyam, M. Oxidative stress is independently associated with non-alcoholic fatty liver disease (NAFLD) in subjects with and without type 2 diabetes. Clin. Biochem. 2010, 43, 815-821.
    • (2010) Clin. Biochem , vol.43 , pp. 815-821
    • Narasimhan, S.1    Gokulakrishnan, K.2    Sampathkumar, R.3    Farooq, S.4    Ravikumar, R.5    Mohan, V.6    Balasubramanyam, M.7
  • 102
    • 84857462541 scopus 로고    scopus 로고
    • Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress
    • Rezazadeh, A.; Yazdanparast, R.; Molaei, M. Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress. J. Biomed. Sci. 2012, 19, 26.
    • (2012) J. Biomed. Sci , vol.19 , pp. 26
    • Rezazadeh, A.1    Yazdanparast, R.2    Molaei, M.3
  • 103
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study
    • Lavine, J.E. Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study. J. Pediatr. 2000, 136, 734-738.
    • (2000) J. Pediatr , vol.136 , pp. 734-738
    • Lavine, J.E.1
  • 105
    • 3242745192 scopus 로고    scopus 로고
    • Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
    • Tiikkainen, M.; Häkkinen, A.-M.; Korsheninnikova, E.; Nyman, T.; Mäkimattila, S.; Yki-Järvinen, H. Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 2004, 53, 2169-2176.
    • (2004) Diabetes , vol.53 , pp. 2169-2176
    • Tiikkainen, M.1    Häkkinen, A.-M.2    Korsheninnikova, E.3    Nyman, T.4    Mäkimattila, S.5    Yki-Järvinen, H.6
  • 107
    • 77953368192 scopus 로고    scopus 로고
    • The effect of Metformin and standard therapy versus standard therapy alone in nondiabetic patients with insulin resistance and nonalcoholic steatohepatitis (NASH): A pilot trial
    • Shields, W.W.; Thompson, K.E.; Grice, G.A.; Harrison, S.A.; Coyle, W.J. The effect of Metformin and standard therapy versus standard therapy alone in nondiabetic patients with insulin resistance and nonalcoholic steatohepatitis (NASH): A pilot trial. Ther. Adv. Gastroenterol. 2009, 2, 157-163.
    • (2009) Ther. Adv. Gastroenterol , vol.2 , pp. 157-163
    • Shields, W.W.1    Thompson, K.E.2    Grice, G.A.3    Harrison, S.A.4    Coyle, W.J.5
  • 109
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
    • Neuschwander-Tetri, B.A.; Brunt, E.M.; Wehmeier, K.R.; Oliver, D.; Bacon, B.R. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone. Hepatology 2003, 38, 1008-1017.
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 111
    • 77649216380 scopus 로고    scopus 로고
    • Review article: Omega-3 fatty acids-A promising novel therapy for non-alcoholic fatty liver disease
    • Masterton, G.S.; Plevris, J.N.; Hayes, P.C. Review article: Omega-3 fatty acids-A promising novel therapy for non-alcoholic fatty liver disease. Aliment. Pharmacol. Ther. 2010, 31, 679-692.
    • (2010) Aliment. Pharmacol. Ther , vol.31 , pp. 679-692
    • Masterton, G.S.1    Plevris, J.N.2    Hayes, P.C.3
  • 112
    • 79953763871 scopus 로고    scopus 로고
    • Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease
    • Li, W.; Zheng, L.; Sheng, C.; Cheng, X.; Qing, L.; Qu, S. Systematic review on the treatment of pentoxifylline in patients with non-alcoholic fatty liver disease. Lipids Health Dis. 2011, 10, 49.
    • (2011) Lipids Health Dis , vol.10 , pp. 49
    • Li, W.1    Zheng, L.2    Sheng, C.3    Cheng, X.4    Qing, L.5    Qu, S.6
  • 113
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKKβ/IκB/NF-κB axis in obesity-and diet-induced insulin resistance
    • Shoelson, S.E.; Lee, J.; Yuan, M. Inflammation and the IKKβ/IκB/NF-κB axis in obesity-and diet-induced insulin resistance. Int. J. Obes. 2003, 27, S49-S52.
    • (2003) Int. J. Obes , vol.27
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 115
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    • Cai, D.; Yuan, M.; Frantz, D.F.; Melendez, P.A.; Hansen, L.; Lee, J.; Shoelson, S.E. Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat. Med. 2005, 11, 183-190.
    • (2005) Nat. Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 117
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: Update
    • Seki, E.; Brenner, D.A. Toll-like receptors and adaptor molecules in liver disease: Update. Hepatology 2008, 48, 322-335.
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 120
    • 34548272744 scopus 로고    scopus 로고
    • Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis
    • Rivera, C.A.; Adegboyega, P.; van Rooijen, N.; Tagalicud, A.; Allman, M.; Wallace, M. Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. J. Hepatol. 2007, 47, 571-579.
    • (2007) J. Hepatol , vol.47 , pp. 571-579
    • Rivera, C.A.1    Adegboyega, P.2    van Rooijen, N.3    Tagalicud, A.4    Allman, M.5    Wallace, M.6
  • 122
    • 67649990082 scopus 로고    scopus 로고
    • Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis
    • Syn, W.-K.; Teaberry, V.; Choi, S.S.; Diehl, A.M. Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. Semin. Liver Dis. 2009, 29, 200-210.
    • (2009) Semin. Liver Dis , vol.29 , pp. 200-210
    • Syn, W.-K.1    Teaberry, V.2    Choi, S.S.3    Diehl, A.M.4
  • 123
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • Chen, G.; Liang, G.; Ou, J.; Goldstein, J.L.; Brown, M.S. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc. Natl. Acad. Sci. USA 2004, 101, 11245-11250.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 124
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J.D.; Goldstein, J.L.; Brown, M.S. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Investig. 2002, 109, 1125-1131.
    • (2002) J. Clin. Investig , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 125
  • 129
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • Shimomura, I.; Bashmakov, Y.; Horton, J.D. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J. Biol. Chem. 1999, 274, 30028-30032.
    • (1999) J. Biol. Chem , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.D.3
  • 130
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • Shimomura, I.; Matsuda, M.; Hammer, R.E.; Bashmakov, Y.; Brown, M.S.; Goldstein, J.L. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 2000, 6, 77-86.
    • (2000) Mol. Cell , vol.6 , pp. 77-86
    • Shimomura, I.1    Matsuda, M.2    Hammer, R.E.3    Bashmakov, Y.4    Brown, M.S.5    Goldstein, J.L.6
  • 131
    • 0030753971 scopus 로고    scopus 로고
    • Regulation of the expression of lipogenic enzyme genes by carbohydrate
    • Towle, H.C.; Kaytor, E.N.; Shih, H.-M. Regulation of the expression of lipogenic enzyme genes by carbohydrate. Annu. Rev. Nutr. 1997, 17, 405-433.
    • (1997) Annu. Rev. Nutr , vol.17 , pp. 405-433
    • Towle, H.C.1    Kaytor, E.N.2    Shih, H.-M.3
  • 132
    • 51449106076 scopus 로고    scopus 로고
    • ChREBP: A glucose-activated transcription factor involved in the development of metabolic syndrome
    • Iizuka, K.; Horikawa, Y. ChREBP: A glucose-activated transcription factor involved in the development of metabolic syndrome. Endocr. J. 2008, 55, 617-624.
    • (2008) Endocr. J , vol.55 , pp. 617-624
    • Iizuka, K.1    Horikawa, Y.2
  • 133
    • 2442435802 scopus 로고    scopus 로고
    • Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    • Iizuka, K.; Bruick, R.K.; Liang, G.; Horton, J.D.; Uyeda, K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc. Natl. Acad. Sci. USA 2004, 101, 7281-7286.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 7281-7286
    • Iizuka, K.1    Bruick, R.K.2    Liang, G.3    Horton, J.D.4    Uyeda, K.5
  • 134
    • 33745896223 scopus 로고    scopus 로고
    • Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice
    • Iizuka, K.; Miller, B.; Uyeda, K. Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. Am. J. Physiol. Endocrinol. Metab. 2006, 291, E358-E364.
    • (2006) Am. J. Physiol. Endocrinol. Metab , vol.291
    • Iizuka, K.1    Miller, B.2    Uyeda, K.3
  • 135
    • 77952574852 scopus 로고    scopus 로고
    • Pathogenesis of alcoholic liver disease: The role of nuclear receptors
    • Gyamfi, M.A.; Wan, Y.-J.Y. Pathogenesis of alcoholic liver disease: The role of nuclear receptors. Exp. Biol. Med. 2010, 235, 547-560.
    • (2010) Exp. Biol. Med , vol.235 , pp. 547-560
    • Gyamfi, M.A.1    Wan, Y.-J.Y.2
  • 137
    • 0142060202 scopus 로고    scopus 로고
    • SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCα transcription in hepatocytes
    • Zhang, Y.; Yin, L.; Hillgartner, F.B. SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCα transcription in hepatocytes. J. Lipid Res. 2003, 44, 356-368.
    • (2003) J. Lipid Res , vol.44 , pp. 356-368
    • Zhang, Y.1    Yin, L.2    Hillgartner, F.B.3
  • 138
    • 33847006599 scopus 로고    scopus 로고
    • The Liver X Receptor (LXR) and hepatic lipogenesis. The Carbohydrate-response element-binding protein is a target gene of LXR
    • Cha, J.-Y.; Repa, J.J. The Liver X Receptor (LXR) and hepatic lipogenesis. The Carbohydrate-response element-binding protein is a target gene of LXR. J. Biol. Chem. 2007, 282, 743-751.
    • (2007) J. Biol. Chem , vol.282 , pp. 743-751
    • Cha, J.-Y.1    Repa, J.J.2
  • 141
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signaling pathway mediated by the nuclear receptor LXRα
    • Janowski, B.A.; Willy, P.J.; Devi, T.R.; Falck, J.R.; Mangelsdorf, D.J. An oxysterol signaling pathway mediated by the nuclear receptor LXRα. Nature 1996, 383, 728-731.
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1    Willy, P.J.2    Devi, T.R.3    Falck, J.R.4    Mangelsdorf, D.J.5
  • 143
    • 9644290860 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the action of ethanol in the liver
    • You, M.; Matsumoto, M.; Pacold, C.M.; Cho, W.K.; Crabb, D.W. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 2004, 127, 1798-1808.
    • (2004) Gastroenterology , vol.127 , pp. 1798-1808
    • You, M.1    Matsumoto, M.2    Pacold, C.M.3    Cho, W.K.4    Crabb, D.W.5
  • 144
    • 38949104356 scopus 로고    scopus 로고
    • Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver
    • García-Villafranca, J.; Guillén, A.; Castro, J. Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver. Biochimie 2008, 90, 460-466.
    • (2008) Biochimie , vol.90 , pp. 460-466
    • García-Villafranca, J.1    Guillén, A.2    Castro, J.3
  • 145
    • 35349024283 scopus 로고    scopus 로고
    • Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
    • Song, Z.; Deaciuc, I.; Zhou, Z.; Song, M.; Chen, T.; Hill, D.; McClain, C.J. Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. Am. J. Physiol. Gastrointest. Liver Physiol. 2007, 293, G894-G902.
    • (2007) Am. J. Physiol. Gastrointest. Liver Physiol , vol.293
    • Song, Z.1    Deaciuc, I.2    Zhou, Z.3    Song, M.4    Chen, T.5    Hill, D.6    McClain, C.J.7
  • 146
    • 42249098410 scopus 로고    scopus 로고
    • Chronic activation of AMP-activated protein kinase-α1 in liver leads to decreased adiposity in mice
    • Yang, J.; Maika, S.; Craddock, L.; King, J.A.; Liu, Z.-M. Chronic activation of AMP-activated protein kinase-α1 in liver leads to decreased adiposity in mice. Biochem. Biophys. Res. Commun. 2008, 370, 248-253.
    • (2008) Biochem. Biophys. Res. Commun , vol.370 , pp. 248-253
    • Yang, J.1    Maika, S.2    Craddock, L.3    King, J.A.4    Liu, Z.-M.5
  • 147
    • 44849131936 scopus 로고    scopus 로고
    • Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
    • Shang, J.; Chen, L.; Xiao, F.; Sun, H.; Ding, H.; Xiao, H. Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase. Acta Pharmacol. Sin. 2008, 29, 698-706.
    • (2008) Acta Pharmacol. Sin , vol.29 , pp. 698-706
    • Shang, J.1    Chen, L.2    Xiao, F.3    Sun, H.4    Ding, H.5    Xiao, H.6
  • 148
    • 48449089518 scopus 로고    scopus 로고
    • Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice
    • Wada, S.; Yamazaki, T.; Kawano, Y.; Miura, S.; Ezaki, O. Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice. J. Hepatol. 2008, 49, 441-450.
    • (2008) J. Hepatol , vol.49 , pp. 441-450
    • Wada, S.1    Yamazaki, T.2    Kawano, Y.3    Miura, S.4    Ezaki, O.5
  • 149
    • 39849099238 scopus 로고    scopus 로고
    • Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
    • Kallwitz, E.R.; McLachlan, A.; Cotler, S.J. Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. World J. Gastroenterol. 2008, 14, 22-28.
    • (2008) World J. Gastroenterol , vol.14 , pp. 22-28
    • Kallwitz, E.R.1    McLachlan, A.2    Cotler, S.J.3
  • 150
    • 0030007427 scopus 로고    scopus 로고
    • ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
    • Kim, J.B.; Spiegelman, B.M. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 1996, 10, 1096-1107.
    • (1996) Genes Dev , vol.10 , pp. 1096-1107
    • Kim, J.B.1    Spiegelman, B.M.2
  • 151
  • 152
    • 0344375097 scopus 로고    scopus 로고
    • Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ
    • Savage, D.B.; Tan, G.D.; Acerini, C.L.; Jebb, S.A.; Agostini, M.; Gurnell, M.; Williams, R.L.; Umpleby, A.M.; Thomas, E.L.; Bell, J.D. et al. Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ. Diabetes 2003, 52, 910-917.
    • (2003) Diabetes , vol.52 , pp. 910-917
    • Savage, D.B.1    Tan, G.D.2    Acerini, C.L.3    Jebb, S.A.4    Agostini, M.5    Gurnell, M.6    Williams, R.L.7    Umpleby, A.M.8    Thomas, E.L.9    Bell, J.D.10
  • 153
    • 79954488395 scopus 로고    scopus 로고
    • The cytoskeleton in nonalcoholic steatohepatitis: 100 years old but still youthful
    • Molnar, A.; Haybaeck, J.; Lackner, C.; Strnad, P. The cytoskeleton in nonalcoholic steatohepatitis: 100 years old but still youthful. Expert Rev. Gastroenterol. Hepatol. 2011, 5, 167-177.
    • (2011) Expert Rev. Gastroenterol. Hepatol , vol.5 , pp. 167-177
    • Molnar, A.1    Haybaeck, J.2    Lackner, C.3    Strnad, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.