The role of protein modifications of T-bet in cytokine production and differentiation of T helper cells

Journal of Immunology Research

Volumn 2014, Issue , 2014, Pages

  Oh, Sera ^a   Hwang, Eun Sook ^a  

^a Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLYCOGEN SYNTHASE KINASE 3; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LYSINE; PROTEIN BCL 6; SERINE; THREONINE; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR RUNX3; TRANSCRIPTION FACTOR T BET; TYROSINE; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ADAPTIVE IMMUNITY; ALPHA HELIX; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL MATURATION; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HELPER CELL; HUMAN; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOID CELL; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; UBIQUITINATION; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; MICE; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; TH2 CELLS; UBIQUITINATION;

EID: 84901799828     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2014/589672     Document Type: Review

References (64)

1. Szabo S. J., Kim S. T., Costa G. L., Zhang X., Fathman C. G., Glimcher L. H., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000 100 6 655 669 2-s2.0-0034677646
2. Lighvani A. A., Frucht D. M., Jankovic D., Yamane H., Aliberti J., Hissong B. D., Nguyen B. V., Gadina M., Sher A., Paul W. E., O'Shea J. J., T-bet is rapidly induced by interferon- γ in lymphoid and myeloid cells. Proceedings of the National Academy of Sciences of the United States of America 2001 98 26 15137 15142 2-s2.0-0035910037 10.1073/pnas.261570598 (Pubitemid 34013982)
3. Lugo-Villarino G., Maldonado-López R., Possemato R., Peñaranda C., Glimcher L. H., T-bet is required for optimal production of IFN- γ and antigen-specific T cell activation by dendritic cells. Proceedings of the National Academy of Sciences of the United States of America 2003 100 13 7749 7754 2-s2.0-0037934497 10.1073/pnas.1332767100 (Pubitemid 36760041)
4. Townsend M. J., Weinmann A. S., Matsuda J. L., Salomon R., Farnham P. J., Biron C. A., Gapin L., Glimcher L. H., T-bet regulates the terminal maturation and homeostasis of NK and V α 14i NKT cells. Immunity 2004 20 4 477 494 2-s2.0-1842785209 10.1016/S1074-7613(04)00076-7 (Pubitemid 38482125)
5. Hwang E. S., Szabo S. J., Schwartzberg P. L., Glimcher L. H., T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 2005 307 5708 430 433 2-s2.0-12344269852 10.1126/science.1103336 (Pubitemid 40139989)
6. Wang J., Fathman J. W., Lugo-Villarino G., Scimone L., von Andrian U., Dorfman D. M., Glimcher L. H., Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. Journal of Clinical Investigation 2006 116 2 414 421 2-s2.0-32444448971 10.1172/JCI26631 (Pubitemid 43228358)
7. Garrett W. S., Lord G. M., Punit S., Lugo-Villarino G., Mazmanian S., Ito S., Glickman J. N., Glimcher L. H., Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007 131 1 33 45 2-s2.0-34848889673 10.1016/j.cell.2007.08.017 (Pubitemid 47505255)
8. Powell N., Walker A. W., Stolarczyk E., The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells. Immunity 2012 37 4 674 684
9. Klose C. S., Kiss E. A., Schwierzeck V., A T-bet gradient controls the fate and function of CCR6-RORgammat+ innate lymphoid cells. Nature 2013 494 7436 261 265
10. Lazarevic V., Glimcher L. H., T-bet in disease. Nature Immunology 2011 12 7 597 606 2-s2.0-79959473134 10.1038/ni.2059
11. Lazarevic V., Glimcher L. H., Lord G. M., T-bet: a bridge between innate and adaptive immunity. Nature Reviews Immunology 2013 13 11 777 789
12. Wang Y., Godec J., Ben-Aissa K., The transcription factors T-bet and Runx are Reruired for the ontogeny of pathogenic interferon-gamma-producing T Helper 17 cells. Immunity 2014 40 3 355 366
13. Wilson V., Conlon F. L., The T-box family. Genome Biology 2002 3 6, article 3008 2-s2.0-0036076091
14. Papaioannou V. E., Silver L. M., The T-box gene family. Bioessays 1998 20 1 9 19 (Pubitemid 28111327)
15. Conlon F. L., Fairclough L., Price B. M. J., Casey E. S., Smith J. C., Determinants of T box protein specificity. Development 2001 128 19 3749 3758 2-s2.0-0034778407 (Pubitemid 32998924)
16. Muller C. W., Herrmann B. G., Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor. Nature 1997 389 6653 884 888 (Pubitemid 27462986)
17. Sinha S., Abraham S., Gronostajski R. M., Campbell C. E., Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. Gene 2000 258 1-2 15 29 2-s2.0-0034722673 10.1016/S0378-1119(00)00417-0
18. Szabo S. J., Sullivan B. M., Sternmann C., Satoskar A. R., Sleckman B. P., Glimcher L. H., Distinct effects of T-bet in Th1 lineage commitment and IFN- γ production in CD4 and CD8 T cells. Science 2002 295 5553 338 342 2-s2.0-0037059462 10.1126/science.1065543 (Pubitemid 34074366)
19. Hwang E. S., Hong J.-H., Glimcher L. H., IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. Journal of Experimental Medicine 2005 202 9 1289 1300 2-s2.0-27744461314 10.1084/jem.20051044 (Pubitemid 41586959)
20. Mathur A. N., Chang H.-C., Zisoulis D. G., Kapur R., Belladonna M. L., Kansas G. S., Kaplan M. H., T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood 2006 108 5 1595 1601 2-s2.0-33748174156 10.1182/blood-2006-04-015016 (Pubitemid 44316127)
21. Lazarevic V., Chen X., Shim J.-H., Hwang E.-S., Jang E., Bolm A. N., Oukka M., Kuchroo V. K., Glimcher L. H., T-bet represses TH 17 differentiation by preventing Runx1-mediated activation of the gene encoding ROR γ t. Nature Immunology 2011 12 1 96 104 2-s2.0-78650306567 10.1038/ni.1969
22. Koch M. A., Tucker-Heard G., Perdue N. R., Killebrew J. R., Urdahl K. B., Campbell D. J., The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nature Immunology 2009 10 6 595 602 2-s2.0-65749103365 10.1038/ni.1731
23. Nakayamada S., Kanno Y., Takahashi H., Jankovic D., Lu K. T., Johnson T. A., Sun H.-W., Vahedi G., Hakim O., Handon R., Schwartzberg P. L., Hager G. L., O'Shea J. J., Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity 2011 35 6 919 931 2-s2.0-84255178198 10.1016/j.immuni.2011. 11.012
24. Oestreich K. J., Huang A. C., Weinmann A. S., The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. Journal of Experimental Medicine 2011 208 5 1001 1013 2-s2.0-79956201473 10.1084/jem.20102144
25. Oestreich K. J., Mohn S. E., Weinmann A. S., Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nature Immunology 2012 13 4 405 411 2-s2.0-84858706847 10.1038/ni.2242
26. Riddle E. L., Schwartzman R. A., Bond M., Insel P. A., Multi-tasking RGS proteins in the heart: the next therapeutic target? Circulation Research 2005 96 4 401 411 2-s2.0-14844343100 10.1161/01.RES.0000158287.49872.4e (Pubitemid 40354533)
27. Moriwaki K., Chan F. K., RIP3: a molecular switch for necrosis and inflammation. Genes and Development 2013 27 15 1640 1649
28. Chen A., Lee S.-M., Gao B., Shannon S., Zhu Z., Fang D., c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation. Molecular and Cellular Biology 2011 31 16 3445 3456 2-s2.0-79961146064 10.1128/MCB.05383-11
29. Jang E. J., Park H. R., Hong J. H., Hwang E. S., Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet. Journal of Immunology 2013 190 11 5764 5770
30. Mosmann T. R., Cherwinski H., Bond M. W., Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. Journal of Immunology 1986 136 7 2348 2357 2-s2.0-0022640843 (Pubitemid 16136806)
31. Bettelli E., Korn T., Kuchroo V. K., Th17: the third member of the effector T cell trilogy. Current Opinion in Immunology 2007 19 6 652 657 2-s2.0-35348960243 10.1016/j.coi.2007.07.020 (Pubitemid 350236805)
32. Wang Y.-H., Liu Y.-J., The IL-17 cytokine family and their role in allergic inflammation. Current Opinion in Immunology 2008 20 6 697 702 2-s2.0-56349118794 10.1016/j.coi.2008.09.004
33. Yang X. O., Nurieva R., Martinez G. J., Kang H. S., Chung Y., Pappu B. P., Shah B., Chang S. H., Schluns K. S., Watowich S. S., Feng X.-H., Jetten A. M., Dong C., Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008 29 1 44 56 2-s2.0-46749138596 10.1016/j.immuni.2008.05.007
34. Zhu J., Yamane H., Paul W. E., Differentiation of effector CD4+ T cell populations. Annual Review of Immunology 2010 28 445 489 2-s2.0-77952313777 10.1146/annurev-immunol-030409-101212
35. Ben-Sasson S. Z., Le Gros G., Conrad D. H., Finkelman F. D., Paul W. E., IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production. Journal of Immunology 1990 145 4 1127 1136 2-s2.0-0025004188 (Pubitemid 20258714)
36. Le Gros G., Ben-Sasson S. Z., Seder R., Finkelman F. D., Paul W. E., Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. Journal of Experimental Medicine 1990 172 3 921 929 2-s2.0-0025082313 10.1084/jem.172.3.921 (Pubitemid 20301238)
37. Iwamoto I., Tomoe S., Tomioka H., Takatsu K., Yoshida S., Role of CD4+ T lymphocytes and interleukin-5 in antigen-induced eosinophil recruitment into the site of cutaneous late-phase reaction in mice. Journal of Leukocyte Biology 1992 52 5 572 578 2-s2.0-0026564202
38. Gavett S. H., O'Hearn D. J., Li X., Huang S.-K., Finkelman F. D., Wills-Karp M., Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. Journal of Experimental Medicine 1995 182 5 1527 1536 2-s2.0-0028821825 10.1084/jem.182.5.1527
39. Kontgen F., Grumont R. J., Strasser A., Metcalf D., Li R., Tarlinton D., Gerondakis S., Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes and Development 1995 9 16 1965 1977 2-s2.0-0029150389
40. Abbas A. K., Murphy K. M., Sher A., Functional diversity of helper T lymphocytes. Nature 1996 383 6603 787 793 (Pubitemid 26372655)
41. Bliss J., van Cleave V., Murray K., IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response. Journal of Immunology 1996 156 3 887 894 (Pubitemid 26048079)
42. Ho I. C., Hodge M. R., Rooney J. W., Glimcher L. H., The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 1996 85 7 973 983 (Pubitemid 26231165)
43. Kaplan M. H., Sun Y. L., Hoey T., Grusby M. J., Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996 382 6587 174 177 (Pubitemid 26242885)
44. Lederer J. A., Perez V. L., DesRoches L., Cytokine transcriptional events during helper T cell subset differentiation. Journal of Experimental Medicine 1996 184 2 397 406 (Pubitemid 26324093)
45. Mori A., Suko M., Kaminuma O., IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506. Journal of Immunology 1997 158 8 3659 3665 (Pubitemid 127488719)
46. Nakamura T., Kamogawa Y., Bottomly K., Flavell R. A., Polarization of IL-4- and IFN-gamma-producing CD4+ T cells following activation of naive CD4+ T cells. Journal of Immunology 1997 158 3 1085 1094 (Pubitemid 127469928)
47. Szabo S. J., Dighe A. S., Gubler U., Murphy K. M., Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. Journal of Experimental Medicine 1997 185 5 817 824 (Pubitemid 27119865)
48. Zheng W., Flavell R. A., The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997 89 4 587 596 (Pubitemid 27511769)
49. He Y.-W., Deftos M. L., Ojala E. W., Bevan M. J., ROR γ t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 1998 9 6 797 806 2-s2.0-0032217092 10.1016/S1074-7613(00)80645-7 (Pubitemid 29024459)
50. Ho I.-C., Lo D., Glimcher L. H., c-maf Promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. Journal of Experimental Medicine 1998 188 10 1859 1866 2-s2.0-0032538985 10.1084/jem.188.10.1859 (Pubitemid 28536773)
51. Rogge L., D'Ambrosio D., Biffi M., Penna G., Minetti L. J., Presky D. H., Adorini L., Sinigaglia F., The role of Stat4 in species-specific regulation of Th cell development by type I IFNs. Journal of Immunology 1998 161 12 6567 6574 2-s2.0-0032534672 (Pubitemid 28562196)
52. Zamorano J., Wang H. Y., Wang R., Shi Y., Longmore G. D., Keegan A. D., Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression. Journal of Immunology 1998 160 7 3502 3512 2-s2.0-0032055611 (Pubitemid 28164745)
53. Glimcher L. H., Murphy K. M., Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes and Development 2000 14 14 1693 1711 2-s2.0-0034661356 (Pubitemid 30602989)
54. Ouyang W., Löhning M., Gao Z., Assenmacher M., Ranganath S., Radbruch A., Murphy K. M., Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 2000 12 1 27 37 2-s2.0-0033973582 (Pubitemid 30069212)
55. Finotto S., Hausding M., Doganci A., Maxeiner J. H., Lehr H. A., Luft C., Galle P. R., Glimcher L. H., Asthmatic changes in mice lacking T-bet are mediated by IL-13. International Immunology 2005 17 8 993 1007 2-s2.0-23844473010 10.1093/intimm/dxh281 (Pubitemid 41158383)
56. Neurath M. F., Weigmann B., Finotto S., Glickman J., Nieuwenhuis E., Iijima H., Mizoguchi A., Mizoguchi E., Mudter J., Galle P. R., Bhan A., Autschbach F., Sullivan B. M., Szabo S. J., Glimcher L. H., Blumberg R. S., The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. Journal of Experimental Medicine 2002 195 9 1129 1143 2-s2.0-0037029649 10.1084/jem.20011956 (Pubitemid 34517139)
57. Finotto S., Neurath M. F., Glickman J. N., Qin S., Lehr H. A., Green F. H. Y., Ackerman K., Haley K., Galle P. R., Szabo S. J., Drazen J. M., de Sanctis G. T., Glimcher L. H., Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 2002 295 5553 336 338 2-s2.0-0037059509 10.1126/science.1065544 (Pubitemid 34074365)
58. Kiwamoto T., Ishii Y., Morishima Y., Yoh K., Maeda A., Ishizaki K., Iizuka T., Hegab A. E., Matsuno Y., Homma S., Nomura A., Sakamoto T., Takahashi S., Sekizawa K., Transcription factors T-bet and GATA-3 regulate development of airway remodeling. The American Journal of Respiratory and Critical Care Medicine 2006 174 2 142 151 2-s2.0-33745748325 10.1164/rccm.200601-079OC (Pubitemid 44015387)
59. Park J. W., Min H. J., Sohn J. H., Kim J. Y., Hong J. H., Sigrist K. S., Glimcher L. H., Hwang E. S., Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma. Journal of Allergy and Clinical Immunology 2009 123 2 479 e6 2-s2.0-59449090710 10.1016/j.jaci.2008.10. 035
60. Sullivan B. M., Jobe O., Lazarevic V., Vasquez K., Bronson R., Glimcher L. H., Kramnik I., Increased susceptibility of mice lacking T-bet to infection with Mycobacterium tuberculosis correlates with increased IL-10 and decreased IFN- γ production. Journal of Immunology 2005 175 7 4593 4602 2-s2.0-25444482624 (Pubitemid 41361998)
61. Ravindran R., Foley J., Stoldasek T., Glimcher L. H., McSorley S. J., Expression of T-bet by CD4 T cells is essential for resistance to Salmonella infection. Journal of Immunology 2005 175 7 4603 4610 2-s2.0-25444439804 (Pubitemid 41361999)
62. Way S. S., Wilson C. B., Cutting edge: immunity and IFN- γ production during Listeria monocytes infection in the absence of T-bet. Journal of Immunology 2004 173 10 5918 5922 2-s2.0-8444242090 (Pubitemid 39487744)
63. Esensten J. H., Lee M. R., Glimcher L. H., Bluestone J. A., T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function. Journal of Immunology 2009 183 1 75 82 2-s2.0-68949102074 10.4049/jimmunol.0804154
64. Bettelli E., Sullivan B., Szabo S. J., Sobel R. A., Glimcher L. H., Kuchroo V. K., Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. Journal of Experimental Medicine 2004 200 1 79 87 2-s2.0-3142724732 10.1084/jem.20031819 (Pubitemid 38924730)