Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2

Gene

Volumn 258, Issue 1-2, 2000, Pages 15-29

  Sinha, Sumita ^a   Abraham, Susamma ^a   Gronostajski, Richard M ^b   Campbell, Christine E ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Development; Gene duplication; Holt Oram; Ulnar mammary

Indexed keywords

DNA BINDING PROTEIN; GLYCINE CLEAVAGE SYSTEM; PALINDROMIC DNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; DNA TRANSFECTION; GENE DUPLICATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RABBIT; TRANSCRIPTION REGULATION; XENOPUS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; DNA; GENE EXPRESSION REGULATION; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; T-BOX DOMAIN PROTEINS; TRANSCRIPTION, GENETIC; TRANSFECTION; XENOPUS; XENOPUS PROTEINS;

EID: 0034722673     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(00)00417-0     Document Type: Article

References (37)

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2. Evolution of mouse T-box genes by tandem duplication and cluster dispersion
3. Three novel T-box genes in Caenorhabditis elegans
4. Cloning, mapping, and expression analysis of TBX15, a new member of the T-box gene family
5. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
6. Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome
7. Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations
8. An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus
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10. Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene
11. Genomic organization of T-box genes indicates conservation between distantly related family members
12. Brachyury-related transcription factor tbx2 and repression of the melanocyte-specific TRP-1 promoter
13. The T-box transcription factor Brachyury regulates expression of eFGF through binding to a non-palindromic response element
14. Tbx6, a mouse T-box gene implicated in paraxial mesoderm formation at gastrulation
15. Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development
16. Isolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 gene
17. Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity
18. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling
19. Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin
20. Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome
21. Action of the Brachyury gene in mouse embryogenesis
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24. Homologs of the mouse Brachyury gene are involved in the specification of posterior terminal structures in Drosophila, Tribolium, and Locusta
25. The T protein encoded by Brachyury is a tissue-specific transcription factor
26. Two novel chick T-box genes related to mouse Brachyury are expressed in different, non-overlapping mesodermal domains during gastrulation
27. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
28. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
29. Construction of plasmids that express E. coli beta-galactosidase in mammalian cells
30. Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
31. The T transcription factor functions as a dimer and exhibits a common human polymorphism Gly-177-Asp in the conserved DNA-binding domain
32. A screen for targets of the Xenopus T-box gene xbra
33. Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway
34. Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
35. A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family
36. Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18 and TBX19
37. Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning