The T-box family

Genome Biology

Volumn 3, Issue 6, 2002, Pages

  Wilson, Val ^a   Conlon, Frank L ^b  

^a Centre for Genome Research   (United Kingdom)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T BOX TRANSCRIPTION FACTOR;

CANCER; CELL FATE; CONGENITAL MALFORMATION; CONTROLLED STUDY; DIGEORGE SYNDROME; GENE AMPLIFICATION; GENE MUTATION; GENETIC VARIABILITY; HOLT ORAM SYNDROME; HUMAN; MORPHOGENESIS; MOUSE; MULTIGENE FAMILY; NEMATODE; NONHUMAN; ORGANOGENESIS; PHENOTYPE; REVIEW; TISSUE DIFFERENTIATION; VERTEBRATE; ZEBRA FISH;

ANIMALS; COMPUTATIONAL BIOLOGY; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; GENES, REGULATOR; HUMANS; MULTIGENE FAMILY; ORGAN SPECIFICITY; PROTEIN STRUCTURE, TERTIARY; T-BOX DOMAIN PROTEINS;

ANIMALIA; ARABIDOPSIS; ARABIDOPSIS THALIANA; CTENOPHORA (COELENTERATES); DANIO RERIO; MAMMALIA; NEMATODA; VERTEBRATA;

EID: 0036076091     PISSN: 14656906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (61)

1. Cloning of the T gene required in mesoderm formation in the mouse
2. A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding
3. T-box genes in development: From hydra to humans
4. T-box genes: What they do and how they do it
5. The T-box gene family
6. Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target leads to a short-tail phenotype
7. The T genes in embryogenesis
8. Conservation of the T-box gene family from Mus musculus to Caenorhabditis elegans
9. Newly identified paralogous groups on mouse chromosomes 5 and 11 reveal the age of a T-box cluster duplication
10. Evolution of mouse T-box genes by tandem duplication and cluster dispersion
11. A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members of the T-box family
12. Differential expression of VegT and Antipodean protein isoforms in Xenopus
13. The Brachyury gene encodes a novel DNA binding protein
14. The chick Brachyury gene: Developmental expression pattern and response to axial induction by localized activin
15. Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm
16. Determinants of T box protein specificity
17. Crystallographic structure of the T domain-DNA complex of the Brachyury transcription factor
18. Three novel T-box genes in Caenorhabditis elegans
19. Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif
20. Molecular characterization of a new human T-box gene (TBX22) located in Xq21.1. encoding a protein containing a truncated T-domain
21. The T protein encoded by Brachyury is a tissue-specific transcription factor
22. Development of the short-tailed mutant in the house mouse
23. The development of two tailless mutants in the house mouse
24. The development of normal and homozygous brachy (T/T) mouse embryos in the extraembryonic coelem of the chick
25. Expression pattern of the mouse T gene and its role in mesoderm formation
26. A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras
27. Chimeric analysis of T Brachyury gene function
28. T-box genes and the formation of vertebrate fore-limb-and hindlimb specific pattern
29. Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development
30. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
31. Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome
32. The T-box genes Tbx4 and Tbx5 regulate limb outgrowth and identity
33. Tbx genes and limb identity in chick embryo development
34. Mutations in human cause limb and cardiac malformation in Holt-Oram syndrome
35. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
36. Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations
37. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome
38. DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1
39. Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice
40. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers
41. Upstream and downstream from Brachyury, a gene required for vertebrate mesoderm formation
42. T-targets: Clues to understanding the functions of T-box proteins
43. Expression of the T-box gene Eomesodermin during early mouse development
44. Eomesodermin is required for mouse trophoblast development and mesoderm formation
45. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
46. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
47. Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2
48. Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19
49. Tbx19, a tissue-selective regulator of POMC gene expression
50. T-Brain expression in the apical organ of hemichordate tornaria larvae suggests its evolutionary link to the vertebrate forebrain
51. A novel transcription factor, T-bet, directs Th1 lineage commitment
52. TBX10, a member of the Tbx1-subfamily of conserved developmental genes, is located at human chromosome 11q13 and proximal mouse chromosome 19
53. Cloning, mapping, and expression analysis of TBX15, a new member of the T-box gene family
54. tbx20, a new vertebrate T-box gene expressed in the cranial motor neurons and developing cardiovascular structures in zebrafish
55. Characterization of the human TBX20 gene, a new member of the T-Box gene family closely related to the Drosophila H15 gene
56. The T-box transcription factor gene TBX22 is mutated in X-linked cleft palate and ankyloglossia
57. Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene
58. Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity
59. Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6
60. Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome