Cytokine transcriptional events during helper T cell subset differentiation

Journal of Experimental Medicine

Volumn 184, Issue 2, 1996, Pages 397-406

  Lederer, James A ^a   Perez, Victor L ^a   DesRoches, Lori ^a   Kim, So Mee ^a   Abbas, Abul K ^a   Lichtman, Andrew H ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; GENE EXPRESSION; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 0029788387     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.2.397     Document Type: Article

References (31)

1. Romagnani, S. 1994. Lymphocyte production by human T cells in disease states. Annu. Rev. Immunol. 12:227-257.
2. Seder, R.A., and W.E. Paul. 1994. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12:635-673.
3. + T cells producing IL-2 or IL-4. J. Immunol. 148:1031-1036.
4. Kamogawa, Y., L.A. Minasi, S.R. Carding, K. Bottomly, and R.A. Flavell. 1993. The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 75:985-995.
5. Perez, V.L., J.A. Lederer, A.H. Lichtman, and A.K. Abbas. 1995. Stability of Th1 and Th2 populations. Int. Immunol. 7:1179-1186.
6. Lederer, J.A., J.S. Liou, M.D. Todd, L.H. Glimcher, and A.H. Lichtman. 1994. Regulation of cytokine gene expression in T helper cell subsets. J. Immunol. 152:77-86.
7. Szabo, S.J., J.S. Gold, T.L. Murphy, and K.M. Murphy. 1993. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc. Mol. Cell. Biol. 13:4793-4805.
8. Todd, M.D., M.J. Grusby, J.A. Lederer, E. Lacy, A.H. Lichtman, and L.H. Glimcher. 1993. Transcription of the interleukin 4 gene is regulated by multiple promoter elements. J. Exp. Med. 177:1663-1674.
9. Crabtree, G.R. 1989. Contingent genetic regulatory events in T lymphocyte activation. Science (Wash. DC). 243:355-361.
10. Young, H.A., J.Y. Ghosh, J.A. Lederer, A.H. Lichtman, J.R. Gerard, L. Penix, C.B. Wilson, A.J. Melvin, M.E. McGirn, D.B. Lewis, and D.D. Taub. 1994. Differentiation of T helper phenotypes by analysis of the methylation state of the IFN-γ gene. J. Immunol. 153:3603-3610.
11. Penix, L., W.M. Weaver, Y. Pang, H.A. Young, and C.B. Wilson. 1993. Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells. J. Exp. Med 178:1483-1496.
12. Hsieh, C.-S., A.B. Heimburger, J.S. Gold, A. O'Garra, and K.M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T cell receptor transgenic system. Proc. Natl. Acad. Sci. USA. 89: 6065-6069.
13. + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA. 90:10188-10192.
14. + T lymphokines from T cell receptor transgenic mice. J. Immunol. 153:5220-5225.
15. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature (Lond.). 341:746-748.
16. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2,3,4 or 5 using modified cDNA expression vectors. Eur. J. Immunol. 18:97-104.
17. Ausubel, F.M. 1992. Short Protocols in Molecular Biology. 2nd ed. Greene Publishing Associates and John Wiley & Sons, New York.
18. Platzer, C., G. Richter, K. Uberla, W. Muller, H. Blocker, T. Diamantstein, and T. Blankenstein. 1992. Analysis of cytokine mRNA levels in interleukin-4 transgenic mice by quantitative polymerase chain reaction. Eur. J. Immunol. 22: 1179-1184.
19. Luckow, B., and G. Schutz. 1987. CAT constructions with multiple unique restriction sites for the functional anlaysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15:5490-5493.
20. Glimcher, L.H., T. Hamano, R. Asofsky, D.H. Sachs, M. Pierres, L.E. Samelson, S.O. Sharrow, and W.E. Paul. 1983. IA mutant functional antigen-presenting cell lines. J. Immunol. 130:2287-2294.
21. Chuvpilo, S., G. Schomberg, R. Gerwig, A. Heinfling, R. Reeves, F. Grummt, and E. Serfling. 1993. Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 21:5694-5704.
22. Schindler, C., H. Kashleva, A. Pernis, R. Pine, and P. Rothman. 1994. STF-IL-4: a novel IL-4-induced signal transducing factor. EMBO (Eur. Mol. Biol. Organ. J. 13:1350-1356.
23. Hou, J., U. Schinder, W.J. Henzel, T.C. Ho, M. Brasseur, and S.L. McKnight. 1994. An interleukin-4-induced transcription factor: IL-4 Stat. Science (Wash. DC). 265:1701-1707.
24. Kotanides, H., and N.C. Reich. 1993. Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science (Wash. DC). 262:1265-1267.
25. Mocci, S., and R.L. Coffman. 1995. Induction of a Th2 population from a polarized leishmania-specific Th1 population by in vitro culture with IL-4. J. Immunol. 154:3779-3787.
26. Szabo, S.J., N.G. Jacobson, A.S. Dighe, U. Gubler, and K.M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2:665-675.
27. Seder, R.A., R.N. Germain, P.S. Linsley, and W.E. Paul. 1994. CD28-mediated costimulation of interleukin-2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon γ production. J. Exp. Med. 179:299-304.
28. Shimoda, K., J. Deursen, M.Y. Sangster, S. Sarawar, R.T. Carson, R.A. Tripp, C. Chu, F.W. Quelle, T. Nosaka, D.A.A. Vignali, P.C. Doherty, G. Grosveld, W.E. Paul, and J.N. Ihle. 1996. Nature (Lond.). Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. 380:630-633.
29. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S.-I. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature (Lond.). 380:627-630.
30. Kaplan, M.H., U. Schnidler, S.T. Smiley, and M.J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity. 4:313-319.
31. Bucy, R.P., A. Panoskaltsis-Mortari, G.-Q. Huang, J. Li, L. Karr, M. Ross, J.H. Russel, K.M. Murphy, and C.T. Weaver. 1994. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J. Exp. Med. 180:1251-1262.