-
1
-
-
42049096372
-
Chemical origins of isoform selectivity in histone deacetylase inhibitors
-
Butler, K. V.; Kozikowski, A. P. Chemical origins of isoform selectivity in histone deacetylase inhibitors. Curr. Pharmaceutl Des., 2008, 14 (6), 505-528.
-
(2008)
Curr. Pharmaceutl Des.
, vol.14
, Issue.6
, pp. 505-528
-
-
Butler, K.V.1
Kozikowski, A.P.2
-
2
-
-
58149378600
-
The structure and function of histone deacetylases: The target for anti-cancer therapy
-
Zhang, Y.; Fang, H.; Jiao, J.; Xu, W. The structure and function of histone deacetylases: the target for anti-cancer therapy. Curr. Medicinal Chemistry, 2008, 15 (27), 2840-2849.
-
(2008)
Curr. Medicinal Chemistry
, vol.15
, Issue.27
, pp. 2840-2849
-
-
Zhang, Y.1
Fang, H.2
Jiao, J.3
Xu, W.4
-
3
-
-
33947239221
-
Molecular insights into azumamide e histone deacetylases inhibitory activity
-
Maulucci, N.; Chini, M. G.; Micco, S. D.; Izzo, I.; Cafaro, E.; Russo, A.; Gallinari, P.; Paolini, C.; Nardi, M. C.; Casapullo, A.; Riccio, R.; Bifulco, G.; Riccardis, F. D. Molecular insights into azumamide e histone deacetylases inhibitory activity. J. Am. Chem. Soc., 2007, 129 (10), 3007-3012.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, Issue.10
, pp. 3007-3012
-
-
Maulucci, N.1
Chini, M.G.2
Micco, S.D.3
Izzo, I.4
Cafaro, E.5
Russo, A.6
Gallinari, P.7
Paolini, C.8
Nardi, M.C.9
Casapullo, A.10
Riccio, R.11
Bifulco, G.12
Riccardis, F.D.13
-
4
-
-
0242522928
-
Histone deacetylase inhibitors
-
Miller, T. A.; Witter, D. J.; Belvedere, S. Histone deacetylase inhibitors. J. Med. Chem., 2003, 46 (24), 5097-116.
-
(2003)
J. Med. Chem.
, vol.46
, Issue.24
, pp. 5097-5116
-
-
Miller, T.A.1
Witter, D.J.2
Belvedere, S.3
-
5
-
-
36148950575
-
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity
-
Moradei, O. M.; Mallais, T. C.; Frechette, S.; Paquin, I.; Tessier, P. E.; Leit, S. M.; Fournel, M.; Bonfils, C.; Trachy-Bourget, M. C.; Liu, J.; Yan, T. P.; Lu, A. H.; Rahil, J.; Wang, J.; Lefebvre, S.; Li, Z.; Vaisburg, A. F.; Besterman, J. M. Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J. Med. Chem., 2007, 50 (23), 5543-5546.
-
(2007)
J. Med. Chem.
, vol.50
, Issue.23
, pp. 5543-5546
-
-
Moradei, O.M.1
Mallais, T.C.2
Frechette, S.3
Paquin, I.4
Tessier, P.E.5
Leit, S.M.6
Fournel, M.7
Bonfils, C.8
Trachy-Bourget, M.C.9
Liu, J.10
Yan, T.P.11
Lu, A.H.12
Rahil, J.13
Wang, J.14
Lefebvre, S.15
Li, Z.16
Vaisburg, A.F.17
Besterman, J.M.18
-
6
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
Duvic, M.; Talpur, R.; Ni, X.; Zhang, C.; Hazarika, P.; Kelly, C.; Chiao, J. H.; Reilly, J. F.; Ricker, J. L.; Richon, V. M.; Frankel, S. R. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood, 2007, 109 (1), 31-39.
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
Zhang, C.4
Hazarika, P.5
Kelly, C.6
Chiao, J.H.7
Reilly, J.F.8
Ricker, J.L.9
Richon, V.M.10
Frankel, S.R.11
-
7
-
-
28144438533
-
Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors
-
Mai, A.; Massa, S.; Lavu, S.; Pezzi, R.; Simeoni, S.; Ragno, R.; Mariotti, F. R.; Chiani, F.; Camilloni, G.; Sinclair, D. A. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J. Med. Chem., 2005, 48 (24), 7789-7795.
-
(2005)
J. Med. Chem.
, vol.48
, Issue.24
, pp. 7789-7795
-
-
Mai, A.1
Massa, S.2
Lavu, S.3
Pezzi, R.4
Simeoni, S.5
Ragno, R.6
Mariotti, F.R.7
Chiani, F.8
Camilloni, G.9
Sinclair, D.A.10
-
8
-
-
55549137996
-
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2)
-
Methot, J. L.; Hamblett, C. L.; Mampreian, D. M.; Jung, J.; Harsch, A.; Szewczak, A. A.; Dahlberg, W. K.; Middleton, R. E.; Hughes, B.; Fleming, J. C.; Wang, H.; Kral, A. M.; Ozerova, N.; Cruz, J. C.; Haines, B.; Chenard, M.; Kenific, C. M.; Secrist, J. P.; Miller, T. A. SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg. Med. Chem. Lett., 2008, 18 (23), 6104-6109.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, Issue.23
, pp. 6104-6109
-
-
Methot, J.L.1
Hamblett, C.L.2
Mampreian, D.M.3
Jung, J.4
Harsch, A.5
Szewczak, A.A.6
Dahlberg, W.K.7
Middleton, R.E.8
Hughes, B.9
Fleming, J.C.10
Wang, H.11
Kral, A.M.12
Ozerova, N.13
Cruz, J.C.14
Haines, B.15
Chenard, M.16
Kenific, C.M.17
Secrist, J.P.18
Miller, T.A.19
-
9
-
-
77958572898
-
A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer
-
Tang, Y. A.; Wen, W. L.; Chang, J. W.; Wei, T. T.; Tan, Y. H.; Salunke, S.; Chen, C. T.; Chen, C. S.; Wang, Y. C. A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer. PloS one, 2010, 5 (9), e12417.
-
(2010)
PloS One
, vol.5
, Issue.9
-
-
Tang, Y.A.1
Wen, W.L.2
Chang, J.W.3
Wei, T.T.4
Tan, Y.H.5
Salunke, S.6
Chen, C.T.7
Chen, C.S.8
Wang, Y.C.9
-
10
-
-
42049103914
-
From natural products to small molecule ketone histone deacetylase inhibitors: Development of new class specific agents
-
Jones, P.; Steinkuhler, C. From natural products to small molecule ketone histone deacetylase inhibitors: development of new class specific agents. Curr. Pharmaceut. Des., 2008, 14 (6), 545-561.
-
(2008)
Curr. Pharmaceut. Des.
, vol.14
, Issue.6
, pp. 545-561
-
-
Jones, P.1
Steinkuhler, C.2
-
11
-
-
0037444803
-
Histone deacetylases (HDACs): Characterization of the classical HDAC family
-
De Ruijter, A. J.; van Gennip, A. H.; Caron, H. N.; Kemp, S.; van Kuilenburg, A. B. Histone deacetylases (HDACs): characterization of the classical HDAC family. The Biochem. J., 2003, 370 (Pt 3), 737-749.
-
(2003)
The Biochem. J.
, vol.370
, Issue.PART 3
, pp. 737-749
-
-
de Ruijter, A.J.1
van Gennip, A.H.2
Caron, H.N.3
Kemp, S.4
van Kuilenburg, A.B.5
-
12
-
-
41149089267
-
Histone deacetylase inhibitors: From bench to clinic
-
Paris, M.; Porcelloni, M.; Binaschi, M.; Fattori, D. Histone deacetylase inhibitors: from bench to clinic. J. Med. Chem., 2008, 51 (6), 1505-1529.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.6
, pp. 1505-1529
-
-
Paris, M.1
Porcelloni, M.2
Binaschi, M.3
Fattori, D.4
-
13
-
-
78649706802
-
HDAC1, a novel marker for benign teratomas
-
Simboeck, E.; Di Croce, L., HDAC1, a novel marker for benign teratomas. EMBO J,2010, 29 (23), 3893-3895.
-
(2010)
EMBO J
, vol.29
, Issue.23
, pp. 3893-3895
-
-
Simboeck, E.1
Di Croce, L.2
-
14
-
-
77950814683
-
HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells
-
Schuler, S.; Fritsche, P.; Diersch, S.; Arlt, A.; Schmid, R. M.; Saur, D.; Schneider, G. HDAC2 attenuates TRAIL-induced apoptosis of pancreatic cancer cells. Mol. Cancer, 2010, 9, 80.
-
(2010)
Mol. Cancer
, vol.9
, pp. 80
-
-
Schuler, S.1
Fritsche, P.2
Diersch, S.3
Arlt, A.4
Schmid, R.M.5
Saur, D.6
Schneider, G.7
-
15
-
-
77955463320
-
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease
-
Bradner, J. E.; Mak, R.; Tanguturi, S. K.; Mazitschek, R.; Haggarty, S. J.; Ross, K.; Chang, C. Y.; Bosco, J.; West, N.; Morse, E.; Lin, K.; Shen, J. P.; Kwiatkowski, N. P.; Gheldof, N.; Dekker, J.; DeAngelo, D. J.; Carr, S. A.; Schreiber, S. L.; Golub, T. R.; Ebert, B. L. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc. National Academy of Sciences USA, 2010, 107 (28), 12617-12622.
-
(2010)
Proc. National Academy of Sciences USA
, vol.107
, Issue.28
, pp. 12617-12622
-
-
Bradner, J.E.1
Mak, R.2
Tanguturi, S.K.3
Mazitschek, R.4
Haggarty, S.J.5
Ross, K.6
Chang, C.Y.7
Bosco, J.8
West, N.9
Morse, E.10
Lin, K.11
Shen, J.P.12
Kwiatkowski, N.P.13
Gheldof, N.14
Dekker, J.15
Deangelo, D.J.16
Carr, S.A.17
Schreiber, S.L.18
Golub, T.R.19
Ebert, B.L.20
more..
-
16
-
-
78449288141
-
Targeting the correct HDAC(s) to treat cognitive disorders
-
Fischer, A.; Sananbenesi, F.; Mungenast, A.; Tsai, L. H. Targeting the correct HDAC(s) to treat cognitive disorders. Trends Pharmacol. Sci., 2010, 31 (12), 605-617.
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, Issue.12
, pp. 605-617
-
-
Fischer, A.1
Sananbenesi, F.2
Mungenast, A.3
Tsai, L.H.4
-
17
-
-
0242362600
-
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A
-
Mai, A.; Massa, S.; Pezzi, R.; Rotili, D.; Loidl, P.; Brosch, G. Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A. J. Med. Chem., 2003, 46 (23), 4826-4829.
-
(2003)
J. Med. Chem.
, vol.46
, Issue.23
, pp. 4826-4829
-
-
Mai, A.1
Massa, S.2
Pezzi, R.3
Rotili, D.4
Loidl, P.5
Brosch, G.6
-
18
-
-
58549085379
-
Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors
-
Smil, D. V.; Manku, S.; Chantigny, Y. A.; Leit, S.; Wahhab, A.; Yan, T. P.; Fournel, M.; Maroun, C.; Li, Z.; Lemieux, A. M.; Nicolescu, A.; Rahil, J.; Lefebvre, S.; Panetta, A.; Besterman, J. M.; Deziel, R. Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors. Bioorg. Med. Chem. Lett., 2009, 19 (3), 688-692.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, Issue.3
, pp. 688-692
-
-
Smil, D.V.1
Manku, S.2
Chantigny, Y.A.3
Leit, S.4
Wahhab, A.5
Yan, T.P.6
Fournel, M.7
Maroun, C.8
Li, Z.9
Lemieux, A.M.10
Nicolescu, A.11
Rahil, J.12
Lefebvre, S.13
Panetta, A.14
Besterman, J.M.15
Deziel, R.16
-
19
-
-
20944435415
-
(IIa)- selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides
-
Mai, A.; Massa, S.; Pezzi, R.; Simeoni, S.; Rotili, D.; Nebbioso, A.; Scognamiglio, A.; Altucci, L.; Loidl, P.; Brosch, G. Class II (IIa)- selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. J. Med. Chem., 2005, 48 (9), 3344-3353.
-
(2005)
J. Med. Chem.
, vol.48
, Issue.9
, pp. 3344-3353
-
-
Mai, A.1
Massa, S.2
Pezzi, R.3
Simeoni, S.4
Rotili, D.5
Nebbioso, A.6
Scognamiglio, A.7
Altucci, L.8
Loidl, P.9
Brosch, G.10
Class, I.I.11
-
20
-
-
35848945959
-
Design, synthesis, structure-- selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors
-
Itoh, Y.; Suzuki, T.; Kouketsu, A.; Suzuki, N.; Maeda, S.; Yoshida, M.; Nakagawa, H.; Miyata, N. Design, synthesis, structure-- selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J. Med. Chem., 2007, 50 (22), 5425-5438.
-
(2007)
J. Med. Chem.
, vol.50
, Issue.22
, pp. 5425-5438
-
-
Itoh, Y.1
Suzuki, T.2
Kouketsu, A.3
Suzuki, N.4
Maeda, S.5
Yoshida, M.6
Nakagawa, H.7
Miyata, N.8
-
21
-
-
78650575875
-
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents
-
Namdar, M.; Perez, G.; Ngo, L.; Marks, P. A. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc. National Academy Sci. USA, 2010, 107 (46), 20003-20008.
-
(2010)
Proc. National Academy Sci. USA
, vol.107
, Issue.46
, pp. 20003-20008
-
-
Namdar, M.1
Perez, G.2
Ngo, L.3
Marks, P.A.4
-
22
-
-
33746894565
-
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate
-
Suzuki, T.; Kouketsu, A.; Itoh, Y.; Hisakawa, S.; Maeda, S.; Yoshida, M.; Nakagawa, H.; Miyata, N. Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. J. Med. Chem., 2006, 49 (16), 4809-4812.
-
(2006)
J. Med. Chem.
, vol.49
, Issue.16
, pp. 4809-4812
-
-
Suzuki, T.1
Kouketsu, A.2
Itoh, Y.3
Hisakawa, S.4
Maeda, S.5
Yoshida, M.6
Nakagawa, H.7
Miyata, N.8
-
23
-
-
78149280636
-
Inhibitors selective for HDAC6 in enzymes and cells
-
Gupta, P. K.; Reid, R. C.; Liu, L.; Lucke, A. J.; Broomfield, S. A.; Andrews, M. R.; Sweet, M. J.; Fairlie, D. P. Inhibitors selective for HDAC6 in enzymes and cells. Bioorg. Med. Chem. Lett.,2010, 20 (23), 7067-7070.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, Issue.23
, pp. 7067-7070
-
-
Gupta, P.K.1
Reid, R.C.2
Liu, L.3
Lucke, A.J.4
Broomfield, S.A.5
Andrews, M.R.6
Sweet, M.J.7
Fairlie, D.P.8
-
24
-
-
77955914870
-
Identification of typespecific anticancer histone deacetylase inhibitors: Road to success
-
Noureen, N.; Rashid, H.; Kalsoom, S. Identification of typespecific anticancer histone deacetylase inhibitors: road to success. Cancer Chemother. Pharmacol., 2010, 66 (4), 625-633.
-
(2010)
Cancer Chemother. Pharmacol.
, vol.66
, Issue.4
, pp. 625-633
-
-
Noureen, N.1
Rashid, H.2
Kalsoom, S.3
-
25
-
-
34247376560
-
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors
-
Krennhrubec, K.; Marshall, B. L.; Hedglin, M.; Verdin, E.; Ulrich, S. M. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg. Med. Chem. Lett., 2007, 17 (10), 2874-2878.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, Issue.10
, pp. 2874-2878
-
-
Krennhrubec, K.1
Marshall, B.L.2
Hedglin, M.3
Verdin, E.4
Ulrich, S.M.5
-
26
-
-
77953139148
-
On the inhibition of histone deacetylase 8
-
Estiu, G.; West, N.; Mazitschek, R.; Greenberg, E.; Bradner, J. E.; Wiest, O. On the inhibition of histone deacetylase 8. Bioorg. Med. Chem., 2010, 18 (11), 4103-4110.
-
(2010)
Bioorg. Med. Chem.
, vol.18
, Issue.11
, pp. 4103-4110
-
-
Estiu, G.1
West, N.2
Mazitschek, R.3
Greenberg, E.4
Bradner, J.E.5
Wiest, O.6
-
27
-
-
41649103241
-
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode
-
Neugebauer, R. C.; Uchiechowska, U.; Meier, R.; Hruby, H.; Valkov, V.; Verdin, E.; Sippl, W.; Jung, M. Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J. Med. Chem., 2008, 51 (5), 1203-1213.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.5
, pp. 1203-1213
-
-
Neugebauer, R.C.1
Uchiechowska, U.2
Meier, R.3
Hruby, H.4
Valkov, V.5
Verdin, E.6
Sippl, W.7
Jung, M.8
-
28
-
-
20144372893
-
SIRT1 regulates HIV transcription via Tat deacetylation
-
Pagans, S.; Pedal, A.; North, B. J.; Kaehlcke, K.; Marshall, B. L.; Dorr, A.; Hetzer-Egger, C.; Henklein, P.; Frye, R.; McBurney, M. W.; Hruby, H.; Jung, M.; Verdin, E.; Ott, M. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol., 2005, 3 (2), e41.
-
(2005)
PLoS Biol
, vol.3
, Issue.2
-
-
Pagans, S.1
Pedal, A.2
North, B.J.3
Kaehlcke, K.4
Marshall, B.L.5
Dorr, A.6
Hetzer-Egger, C.7
Henklein, P.8
Frye, R.9
McBurney, M.W.10
Hruby, H.11
Jung, M.12
Verdin, E.13
Ott, M.14
-
29
-
-
9744284968
-
An in silico approach to discovering novel inhibitors of human sirtuin type 2
-
Tervo, A. J.; Kyrylenko, S.; Niskanen, P.; Salminen, A.; Leppanen, J.; Nyronen, T. H.; Jarvinen, T.; Poso, A. An in silico approach to discovering novel inhibitors of human sirtuin type 2. J. Med. Chem., 2004, 47 (25), 6292-6298.
-
(2004)
J. Med. Chem.
, vol.47
, Issue.25
, pp. 6292-6298
-
-
Tervo, A.J.1
Kyrylenko, S.2
Niskanen, P.3
Salminen, A.4
Leppanen, J.5
Nyronen, T.H.6
Jarvinen, T.7
Poso, A.8
-
30
-
-
33845476236
-
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition
-
Trapp, J.; Jochum, A.; Meier, R.; Saunders, L.; Marshall, B.; Kunick, C.; Verdin, E.; Goekjian, P.; Sippl, W.; Jung, M. Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J. Medicinal Chem., 2006, 49 (25), 7307-7316.
-
(2006)
J. Medicinal Chem.
, vol.49
, Issue.25
, pp. 7307-7316
-
-
Trapp, J.1
Jochum, A.2
Meier, R.3
Saunders, L.4
Marshall, B.5
Kunick, C.6
Verdin, E.7
Goekjian, P.8
Sippl, W.9
Jung, M.10
-
31
-
-
77955480670
-
Strategies in developing promising histone deacetylase inhibitors
-
Zhang, L.; Fang, H.; Xu, W. Strategies in developing promising histone deacetylase inhibitors. Med. Res. Rev., 2010, 30 (4), 585-602.
-
(2010)
Med. Res. Rev.
, vol.30
, Issue.4
, pp. 585-602
-
-
Zhang, L.1
Fang, H.2
Xu, W.3
-
32
-
-
77950860448
-
Inside HDAC with HDAC inhibitors
-
Bertrand, P. Inside HDAC with HDAC inhibitors. Eur. J. Med. Chem., 2010, 45 (6), 2095-2116.
-
(2010)
Eur. J. Med. Chem.
, vol.45
, Issue.6
, pp. 2095-2116
-
-
Bertrand, P.1
-
33
-
-
36148975704
-
The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor
-
Yurek-George, A.; Cecil, A. R.; Mo, A. H.; Wen, S.; Rogers, H.; Habens, F.; Maeda, S.; Yoshida, M.; Packham, G.; Ganesan, A. The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor. J. Med. Chem., 2007, 50 (23), 5720-5726.
-
(2007)
J. Med. Chem.
, vol.50
, Issue.23
, pp. 5720-5726
-
-
Yurek-George, A.1
Cecil, A.R.2
Mo, A.H.3
Wen, S.4
Rogers, H.5
Habens, F.6
Maeda, S.7
Yoshida, M.8
Packham, G.9
Ganesan, A.10
-
34
-
-
34249081115
-
Bispyridinium dienes: Histone deacetylase inhibitors with selective activities
-
Perez-Balado, C.; Nebbioso, A.; Rodriguez-Grana, P.; Minichiello, A.; Miceli, M.; Altucci, L.; de Lera, A. R. Bispyridinium dienes: histone deacetylase inhibitors with selective activities. J. Med. Chem., 2007, 50 (10), 2497-2505.
-
(2007)
J. Med. Chem.
, vol.50
, Issue.10
, pp. 2497-2505
-
-
Perez-Balado, C.1
Nebbioso, A.2
Rodriguez-Grana, P.3
Minichiello, A.4
Miceli, M.5
Altucci, L.6
de Lera, A.R.7
-
35
-
-
60549102514
-
Non-peptide macrocyclic histone deacetylase inhibitors
-
Oyelere, A. K.; Chen, P. C.; Guerrant, W.; Mwakwari, S. C.; Hood, R.; Zhang, Y.; Fan, Y. Non-peptide macrocyclic histone deacetylase inhibitors. J. Med. Chem., 2009, 52 (2), 456-468.
-
(2009)
J. Med. Chem.
, vol.52
, Issue.2
, pp. 456-468
-
-
Oyelere, A.K.1
Chen, P.C.2
Guerrant, W.3
Mwakwari, S.C.4
Hood, R.5
Zhang, Y.6
Fan, Y.7
-
36
-
-
47749102080
-
Discovery of N-(2-aminophenyl)- 4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor
-
Zhou, N.; Moradei, O.; Raeppel, S.; Leit, S.; Frechette, S.; Gaudette, F.; Paquin, I.; Bernstein, N.; Bouchain, G.; Vaisburg, A.; Jin, Z.; Gillespie, J.; Wang, J.; Fournel, M.; Yan, P. T.; Trachy-Bourget, M. C.; Kalita, A.; Lu, A.; Rahil, J.; MacLeod, A. R.; Li, Z.; Besterman, J. M.; Delorme, D. Discovery of N-(2-aminophenyl)- 4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor. J. Med. Chem., 2008, 51 (14), 4072-4075.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.14
, pp. 4072-4075
-
-
Zhou, N.1
Moradei, O.2
Raeppel, S.3
Leit, S.4
Frechette, S.5
Gaudette, F.6
Paquin, I.7
Bernstein, N.8
Bouchain, G.9
Vaisburg, A.10
Jin, Z.11
Gillespie, J.12
Wang, J.13
Fournel, M.14
Yan, P.T.15
Trachy-Bourget, M.C.16
Kalita, A.17
Lu, A.18
Rahil, J.19
Macleod, A.R.20
Li, Z.21
Besterman, J.M.22
Delorme, D.23
more..
-
37
-
-
43949130430
-
Structural origin of selectivity in class II-selective histone deacetylase inhibitors
-
Estiu, G.; Greenberg, E.; Harrison, C. B.; Kwiatkowski, N. P.; Mazitschek, R.; Bradner, J. E.; Wiest, O. Structural origin of selectivity in class II-selective histone deacetylase inhibitors. J. Med. Chem., 2008, 51 (10), 2898-2906.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.10
, pp. 2898-2906
-
-
Estiu, G.1
Greenberg, E.2
Harrison, C.B.3
Kwiatkowski, N.P.4
Mazitschek, R.5
Bradner, J.E.6
Wiest, O.7
-
38
-
-
42049103773
-
A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo
-
Jones, P.; Altamura, S.; De Francesco, R.; Paz, O. G.; Kinzel, O.; Mesiti, G.; Monteagudo, E.; Pescatore, G.; Rowley, M.; Verdirame, M.; Steinkuhler, C. A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo. J. Med. Chem., 2008, 51 (8), 2350-2353.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.8
, pp. 2350-2353
-
-
Jones, P.1
Altamura, S.2
de Francesco, R.3
Paz, O.G.4
Kinzel, O.5
Mesiti, G.6
Monteagudo, E.7
Pescatore, G.8
Rowley, M.9
Verdirame, M.10
Steinkuhler, C.11
-
39
-
-
55549093722
-
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors
-
Muraglia, E.; Altamura, S.; Branca, D.; Cecchetti, O.; Ferrigno, F.; Orsale, M. V.; Palumbi, M. C.; Rowley, M.; Scarpelli, R.; Steinkuhler, C.; Jones, P. 2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors. Bioorg. Med. Chem. Lett., 2008, 18 (23), 6083-6087.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, Issue.23
, pp. 6083-6087
-
-
Muraglia, E.1
Altamura, S.2
Branca, D.3
Cecchetti, O.4
Ferrigno, F.5
Orsale, M.V.6
Palumbi, M.C.7
Rowley, M.8
Scarpelli, R.9
Steinkuhler, C.10
Jones, P.11
-
40
-
-
45749103747
-
A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum
-
Chen, Y.; Lopez-Sanchez, M.; Savoy, D. N.; Billadeau, D. D.; Dow, G. S.; Kozikowski, A. P. A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum. J. Med. Chem., 2008, 51 (12), 3437-3448.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.12
, pp. 3437-3448
-
-
Chen, Y.1
Lopez-Sanchez, M.2
Savoy, D.N.3
Billadeau, D.D.4
Dow, G.S.5
Kozikowski, A.P.6
-
41
-
-
57749208364
-
Sulfamides as novel histone deacetylase inhibitors
-
Wahhab, A.; Smil, D.; Ajamian, A.; Allan, M.; Chantigny, Y.; Therrien, E.; Nguyen, N.; Manku, S.; Leit, S.; Rahil, J.; Petschner, A. J.; Lu, A. H.; Nicolescu, A.; Lefebvre, S.; Montcalm, S.; Fournel, M.; Yan, T. P.; Li, Z.; Besterman, J. M.; Deziel, R. Sulfamides as novel histone deacetylase inhibitors. Bioorg. Med. Chem. Lett., 2009, 19 (2), 336-340.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, Issue.2
, pp. 336-340
-
-
Wahhab, A.1
Smil, D.2
Ajamian, A.3
Allan, M.4
Chantigny, Y.5
Therrien, E.6
Nguyen, N.7
Manku, S.8
Leit, S.9
Rahil, J.10
Petschner, A.J.11
Lu, A.H.12
Nicolescu, A.13
Lefebvre, S.14
Montcalm, S.15
Fournel, M.16
Yan, T.P.17
Li, Z.18
Besterman, J.M.19
Deziel, R.20
more..
-
42
-
-
43049129992
-
Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors
-
Varghese, S.; Senanayake, T.; Murray-Stewart, T.; Doering, K.; Fraser, A.; Casero, R. A., Jr.; Woster, P. M. Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors. J. Med. Chem., 2008, 51 (8), 2447-2456.
-
(2008)
J. Med. Chem.
, vol.51
, Issue.8
, pp. 2447-2456
-
-
Varghese, S.1
Senanayake, T.2
Murray-Stewart, T.3
Doering, K.4
Fraser, A.5
Casero Jr., R.A.6
Woster, P.M.7
|