Neural tissue engineering options for peripheral nerve regeneration

Biomaterials

Volumn 35, Issue 24, 2014, Pages 6143-6156

  Gu, Xiaosong ^a   Ding, Fei ^a   Williams, David F ^b  

^a NANTONG UNIVERSITY   (China)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Neural templates; Neural tissue engineering; Peripheral nerve regeneration; Physicochemical and biological cues; Tissue engineered nerve graft (TENG)

Indexed keywords

BIOCOMPATIBILITY; MATERIALS HANDLING; REPAIR; SCAFFOLDS (BIOLOGY); TISSUE;

NEURAL TEMPLATES; NEURAL TISSUE ENGINEERING; PERIPHERAL NERVE REGENERATION; PHYSICOCHEMICAL AND BIOLOGICAL CUES; TISSUE ENGINEERED NERVE GRAFTS;

TISSUE REGENERATION;

BIOMATERIAL;

ANIMAL; CHEMISTRY; DRUG EFFECTS; HUMAN; NERVE REGENERATION; PERIPHERAL NERVE; PHYSIOLOGY; PROCEDURES; RNA INTERFERENCE; TISSUE ENGINEERING; TISSUE SCAFFOLD;

ANIMALS; BIOCOMPATIBLE MATERIALS; HUMANS; NERVE REGENERATION; PERIPHERAL NERVES; RNA INTERFERENCE; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84901460324     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.04.064     Document Type: Article

References (279)

1. Noble J., Munro C.A., Prasad V.S., Midha R. Analysis of upper and lower extremity peripheral nerve injuries in a population of patients with multiple injuries. JTrauma 1998, 45:116-122.
2. Robinson L.R. Traumatic injury to peripheral nerves. Muscle Nerve 2000, 23:863-873.
3. Taylor C.A., Braza D., Rice J.B., Dillingham T. The incidence of peripheral nerve injury in extremity trauma. Am J Phys Med Rehabil 2008, 87:381-385.
4. Asplund M., Nilsson M., Jacobsson A., von Holst H. Incidence of traumatic peripheral nerve injuries and amputations in Sweden between 1998 and 2006. Neuroepidemiology 2009, 32:217-228.
5. Artico M., Cervoni L., Nucci F., Giuffr R. Birthday of peripheral nervous system surgery: the contribution of Gabriele Ferrara (1543-1627). Neurosurgery 1996, 39:380.
6. Battiston B., Papalia I., Tos P., Geuna S. peripheral nerve repair and regeneration research a historical note. Int Rev Neurobiol 2009, 87:1-7.
7. Lundborg G. Nerve injury and repair 1988, Longman Group UK, New York.
8. Ortiguela M.E., Wood M.B., Cahill D.R. Anatomy of the sural nerve complex. JHand Surg 1987, 12:1119.
9. Mackinnon S.E., Hudson A.R. Clinical application of peripheral nerve transplantation. Plast Reconstr Surg 1992, 90:695.
10. Schmidt C.E., Leach J.B. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 2003, 5:293-347.
11. Chalfoun C.T., Wirth G.A., Evans G.R. Tissue engineered nerve constructs: where do we stand?. JCell Mol Med 2006, 10:309-317.
12. Johnson E.O., Charchanti A., Soucacos P.N. Nerve repair: experimental and clinical evaluation of neurotrophic factors in peripheral nerve regeneration. Injury 2008, 39(Suppl.3):S37-S42.
13. Johnson E.O., Soucacos P.N. Nerve repair: experimental and clinical evaluation of biodegradable artificial nerve guides. Injury 2008, 39(Suppl.3):S30-S36.
14. Seidlits S.K., Lee J.Y., Schmidt C.E. Nanostructured scaffolds for neural applications. Nanomedicine (Lond) 2008, 3:183-199.
15. Deumens R., Bozkurt A., Meek M.F., Marcus M.A., Joosten E.A., Weis J., et al. Repairing injured peripheral nerves: bridging the gap. Prog Neurobiol 2010, 92:245-276.
16. Jiang X., Lim S.H., Mao H.-Q., Chew S.Y. Current applications and future perspectives of artificial nerve conduits. Exp Neurol 2010, 223:86-101.
17. Gu X., Ding F., Yang Y., Liu J. Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Prog Neurobiol 2011, 93:204-230.
18. Daly W., Yao L., Zeugolis D., Windebank A., Pandit A. Abiomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery. JR Soc Interface 2012, 9:202-221.
19. Rajaram A., Chen X.-B., Schreyer D.J. Strategic design and recent fabrication techniques for bioengineered tissue scaffolds to improve peripheral nerve regeneration. Tissue Eng Part B 2012, 18:454-467.
20. Zochodne D.W. The challenges and beauty of peripheral nerve regrowth. JPeripher Nerv Syst 2012, 17:1-18.
21. Williams D.F. The biomaterials conundrum in tissue engineering. Tissue Eng Part A 2014, 20:1129-1131.
22. Williams D.F. To engineer is to create: the link between engineering and regeneration. Trends Biotechnol 2006, 24:4-8.
23. Williams D.F. On the mechanisms of biocompatibility. Biomaterials 2008, 29:2941-2953.
24. Williams D.F. Essential biomaterials science 2014, Cambridge University Press, Cambridge, UK, In Press.
25. Seckel B.R. Enhancement of peripheral nerve regeneration. Muscle Nerve 1990, 13:785-800.
26. Hudson T.W., Evans G.R., Schmidt C.E. Engineering strategies for peripheral nerve repair. Orthop Clin North Am 2000, 31:485-498.
27. Evans G.R. Peripheral nerve injury: a review and approach to tissue engineered constructs. Anat Rec 2001, 263:396-404.
28. Meek M.F., Coert J.H. US Food and Drug Administration/Conformit Europe - approved absorbable nerve conduits for clinical repair of peripheral and cranial nerves. Ann Plast Surg 2008, 60:466-472.
29. Kehoe S., Zhang X.F., Boyd D. FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. Injury 2012, 43:553-572.
30. Khaing Z.Z., Schmidt C.E. Advances in natural biomaterials for nerve tissue repair. Neurosci Lett 2012, 519:103-114.
31. Hvistendahl M. China's push in tissue engineering. Science 2012, 338:900-902.
32. Ashley W.W., Weatherly T., Park T.S. Collagen nerve guides for surgical repair of brachial plexus birth injury. JNeurosurg 2006, 105:452-456.
33. Battiston B., Geuna S., Ferrero M., Tos P. Nerve repair by means of tubulization: literature review and personal clinical experience comparing biological and synthetic conduits for sensory nerve repair. Microsurgery 2005, 25:258-267.
34. Bushnell B.D., McWilliams A.D., Whitener G.B., Messer T.M. Early clinical experience with collagen nerve tubes in digital nerve repair. JHand Surg Am 2008, 33:1081-1087.
35. Crawley W.A., Dellon A.L. Inferior alveolar nerve reconstruction with a polyglycolic acid bioabsorbable nerve conduit. Plast Reconstr Surg 1992, 90:300-302.
36. Dellon A.L., Maloney C.T. Salvage of sensation in a hallux-to-thumb transfer by nerve tube reconstruction. JHand Surg Am 2006, 31:1495-1498.
37. den Dunnen W.F., Meek M.F. Sensory nerve function and auto-mutilation after reconstruction of various gap lengths with nerve guides and autologous nerve grafts. Biomaterials 2001, 22:1171-1176.
38. Den Dunnen W.F., Meek M.F., Robinson P.H., Schakernraad J.M. Peripheral nerve regeneration through P(DLLA-epsilon-CL) nerve guides. JMater Sci Mater Med 1998, 9:811-814.
39. den Dunnen W.F., Stokroos I., Blaauw E.H., Holwerda A., Pennings A.J., Robinson P.H., et al. Light-microscopic and electron-microscopic evaluation of short-term nerve regeneration using a biodegradable poly(dl-lactide-epsilon-caprolacton) nerve guide. JBiomed Mater Res 1996, 31:105-115.
40. Donoghoe N., Rosson G.D., Dellon A.L. Reconstruction of the human median nerve in the forearm with the neurotube. Microsurgery 2007, 27:595-600.
41. Jansen K., Meek M.F., van der Werff J.F., van Wachem P.B., van Luyn M.J. Long-term regeneration of the rat sciatic nerve through a biodegradable poly(dl-lactide-epsilon-caprolactone) nerve guide: tissue reactions with focus on collagen III/IV reformation. JBiomed Mater Res A 2004, 69:334-341.
42. Karabekmez F.E., Duymaz A., Moran S.L. Early clinical outcomes with the use of decellularized nerve allograft for repair of sensory defects within the hand. Hand (N Y) 2009, 4:245-249.
43. Kim J., Dellon A.L. Reconstruction of a painful post-traumatic medial plantar neuroma with a bioabsorbable nerve conduit: a case report. JFoot Ankle Surg 2001, 40:318-323.
44. Lohmeyer J.A., Siemers F., Machens H.G., Mailander P. The clinical use of artificial nerve conduits for digital nerve repair: a prospective cohort study and literature review. JReconstr Microsurg 2009, 25:55-61.
45. Mackinnon S.E., Dellon A.L. Clinical nerve reconstruction with a bioabsorbable polyglycolic acid tube. Plast Reconstr Surg 1990, 85:419-424.
46. Meek M.F. More than just sunshine with implantation of resorbable (p(DLLA-epsilon-CL)) biomaterials. Bio-Med Mat Eng 2007, 17:329-334.
47. Meek M.F., Den Dunnen W.F., Schakenraad J.M., Robinson P.H. Evaluation of functional nerve recovery after reconstruction with a poly (DL-lactide-epsilon-caprolactone) nerve guide, filled with modified denatured muscle tissue. Microsurgery 1996, 17:555-561.
48. Meek M.F., Den Dunnen W.F., Schakenraad J.M., Robinson P.H. Long-term evaluation of functional nerve recovery after reconstruction with a thin-walled biodegradable poly (dl-lactide-epsilon-caprolactone) nerve guide, using walking track analysis and electrostimulation tests. Microsurgery 1999, 19:247-253.
49. Meek M.F., Van Der Werff J.F., Nicolai J.P., Gramsbergen A. Biodegradable p(DLLA-epsilon-CL) nerve guides versus autologous nerve grafts: electromyographic and video analysis. Muscle Nerve 2001, 24:753-759.
50. Moore A.M., Nicoson M.C., Chenard K., Santosa K., Kasukurthi R., Hunter D.A., et al. 211B: processed allograft versus cold-preservation on nerve regeneration: a comparison study. Plast Reconstr Surg 2010, 125:138.
51. Navissano M., Malan F., Carnino R., Battiston B. Neurotube for facial nerve repair. Microsurgery 2005, 25:268-271.
52. Rosson G.D., Williams E.H., Dellon A.L. Motor nerve regeneration across a conduit. Microsurgery 2009, 29:107-114.
53. Smith R.M., Wiedl C., Chubb P., Greene C.H. Role of small intestine submucosa (SIS) as a nerve conduit: preliminary report. JInvest Surg 2004, 17:339-344.
54. Taras J.S., Nanavati V., Steelman P. Nerve conduits. JHand Ther 2005, 18:191-197.
55. Tyner T.R., Parks N., Faria S., Simons M., Stapp B., Curtis B., et al. Effects of collagen nerve guide on neuroma formation and neuropathic pain in a rat model. Am J Surg 2007, 193:e1-e6.
56. Weber R.A., Breidenbach W.C., Brown R.E., Jabaley M.E., Mass D.P. Arandomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans. Plast Reconstr Surg 2000, 106:1036-1045.
57. Whitlock E.L., Tuffaha S.H., Luciano J.P., Yan Y., Hunter D.A., Magill C.K., et al. Processed allografts and type I collagen conduits for repair of peripheral nerve gaps. Muscle Nerve 2009, 39:787-799.
58. Jeans L.A., Gilchrist T., Healy D. Peripheral nerve repair by means of a flexible biodegradable glass fibre wrap: a comparison with microsurgical epineurial repair. JPlast Reconstr Aesthet Surg 2007, 60:1302-1308.
59. Starritt N.E., Kettle S.A.J., Glasby M.A. Sutureless repair of the facial nerve using biodegradable glass fabric. Laryngoscope 2011, 121:1614-1619.
60. Seil J.T., Webster T.J. Electrically active nanomaterials as improved neural tissue regeneration scaffolds. Wiley Interdiscip Rev Nanomed Nanobiotech 2010, 2:635-647.
61. Jin G.-Z., Kim M., Shin U.S., Kim H.-W. Neurite outgrowth of dorsal root ganglia neurons is enhanced on aligned nanofibrous biopolymer scaffold with carbon nanotube coating. Neurosci Lett 2011, 501:10-14.
62. Tavangarian F., Li Y. Carbon nanostructures as nerve scaffolds for repairing large gaps in severed nerves. Ceram Int 2012, 38:6075-6090.
63. Veith M., Aktas O.C., Lee J., Miro M.M., Akkan C.K., Schafer K.H., et al. Biphasic nano-materials and applications in life sciences: Id Al/Al2o3 nanostructures for improved neuron cell culturing. Nanostructured materials and systems: ceramic transactions 2010, 117-121. Wiley, New Jersey. S. Mathur, H. Shen (Eds.).
64. Guan R., Cipriano A., Zhao Z., Lock J., Tie D., Zhao T., et al. Development and evaluation of a magnesium-zinc-strontium alloy for biomedical applications-alloy processing, microstructure, mechanical properties, and biodegradation. Mater Sci Eng C 2013, 33:3661-3669.
65. Iskandar M.E., Aslani A., Liu H. The effects of nanostructured hydroxyapatite coating on the biodegradation and cytocompatibility of magnesium implants. JBiomed Mater Res A 2013, 101:2340-2354.
66. Hu W.-J., Eaton J.W., Ugarova T.P., Tang L. Molecular basis of biomaterial-mediated foreign body reactions. Blood 2001, 98:1231-1238.
67. Malik A.F., Hoque R., Ouyang X., Ghani A., Hong E., Khan K., et al. Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc Natl Acad Sci U S A 2011, 108:20095-20100.
68. Benowitz L.I., Popovich P.G. Inflammation and axon regeneration. Curr Opin Neurol 2011, 24:577-583.
69. Meinel L., Hofmann S., Karageorgiou V., Kirker-Head C., McCool J., Gronowicz G., et al. The inflammatory responses to silk films invitro and invivo. Biomaterials 2005, 26:147-155.
70. Hu N., Wu H., Xue C., Gong Y., Wu J., Xiao Z., et al. Long-term outcome of the repair of 50 mm long median nerve defects in rhesus monkeys with marrow mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts. Biomaterials 2013, 34:100-111.
71. de Ruiter G.C., Spinner R.J., Malessy M.J.A., Moore M.J., Sorenson E.J., Currier B.L., et al. Accuracy of motor axon regeneration across autograft, single-lumen, and multichannel poly(lactic-co-glycolic acid) nerve tubes. Neurosurgery 2008, 63:144-153.
72. Hu X., Huang J., Ye Z., Xia L., Li M., Lv B., et al. Anovel scaffold with longitudinally oriented microchannels promotes peripheral nerve regeneration. Tissue Eng Part A 2009, 15:3297-3308.
73. Yao L., Billiar K.L., Windebank A.J., Pandit A. Multichanneled collagen conduits for peripheral nerve regeneration: design, fabrication, and characterization. Tissue Eng Part C 2010, 16:1585-1596.
74. de Ruiter G.C., Onyeneho I.A., Liang E.T., Moore M.J., Knight A.M., Malessy M.J., et al. Methods for invitro characterization of multichannel nerve tubes. JBiomed Mater Res A 2008, 84:643-651.
75. Dubey N., Letourneau P.C., Tranquillo R.T. Guided neurite elongation and Schwann cell invasion into magnetically aligned collagen in simulated peripheral nerve regeneration. Exp Neurol 1999, 158:338-350.
76. Matsumoto K., Ohnishi K., Kiyotani T., Sekine T., Ueda H., Nakamura T., et al. Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)-collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nerves. Brain Res 2000, 868:315-328.
77. Cai J., Peng X., Nelson K.D., Eberhart R., Smith G.M. Permeable guidance channels containing microfilament scaffolds enhance axon growth and maturation. JBiomed Mater Res A 2005, 75:374-386.
78. Chew S.Y., Mi R., Hoke A., Leong K.W. Aligned protein-polymer composite fibers enhance nerve regeneration: a potential tissue-engineering platform. Adv Funct Mater 2007, 17:1288-1296.
79. Wang X., Hu W., Cao Y., Yao J., Wu J., Gu X. Dog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial nerve graft. Brain 2005, 128:1897-1910.
80. Yang Y., Ding F., Wu J., Hu W., Liu W., Liu J., et al. Development and evaluation of silk fibroin-based nerve grafts used for peripheral nerve regeneration. Biomaterials 2007, 28:5526-5535.
81. Ichihara S., Inada Y., Nakada A., Endo K., Azuma T., Nakai R., et al. Development of new nerve guide tube for repair of long nerve defects. Tissue Eng Part C 2009, 15:387-402.
82. Hoppen H.J., Leenslag J.W., Pennings A.J., van der Lei B., Robinson P.H. Two-ply biodegradable nerve guide: basic aspects of design, construction and biological performance. Biomaterials 1990, 11:286-290.
83. Dunnen W.F.A., Schakenraad J.M., Zondervan G.J., Pennings A.J., Lei B., Robinson P.H. Anew PLLA/PCL copolymer for nerve regeneration. JMater Sci Mater Med 1993, 4:521-525.
84. Widmer M.S., Gupta P.K., Lu L., Meszlenyi R.K., Evans G.R.D., Brandt K., et al. Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. Biomaterials 1998, 19:1945-1955.
85. Schlosshauer B., Muller E., Schroder B., Planck H., Muller H.W. Rat Schwann cells in bioresorbable nerve guides to promote and accelerate axonal regeneration. Brain Res 2003, 963:321-326.
86. Hadlock T., Sundback C., Hunter D., Cheney M., Vacanti J.P. Apolymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration. Tissue Eng 2000, 6:119-127.
87. Sundback C., Hadlock T., Cheney M., Vacanti J. Manufacture of porous polymer nerve conduits by a novel low-pressure injection molding process. Biomaterials 2003, 24:819-830.
88. Mooney D.J., Mazzoni C.L., Breuer C., McNamara K., Hern D., Vacanti J.P., et al. Stabilized polyglycolic acid fibre-based tubes for tissue engineering. Biomaterials 1996, 17:115-124.
89. Bini T.B., Gao S., Xu X., Wang S., Ramakrishna S., Leong K.W. Peripheral nerve regeneration by microbraided poly(L-lactide-co-glycolide) biodegradable polymer fibers. JBiomed Mater Res A 2004, 68:286-295.
90. Dalton P.D., Flynn L., Shoichet M.S. Manufacture of poly (2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels. Biomaterials 2002, 23:3843-3851.
91. Piquilloud G., Christen T., Pfister L.A., Gander B., Papaloïzos M.Y. Variations in glial cell line-derived neurotrophic factor release from biodegradable nerve conduits modify the rate of functional motor recovery after rat primary nerve repairs. Eur J Neurosci 2007, 26:1109-1117.
92. Dellon A.L., Mackinnon S.E. An alternative to the classical nerve graft for the management of the short nerve gap. Plast Reconstr Surg 1988, 82:849.
93. Madduri S., Papaloizos M., Gander B. Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration. Biomaterials 2011, 31:2323-2334.
94. Uebersax L., Mattotti M., Papaloïzos M., Merkle H.P., Gander B., Meinel L. Silk fibroin matrices for the controlled release of nerve growth factor (NGF). Biomaterials 2007, 28:4449-4460.
95. Yao L., de Ruiter G.C.W., Wang H., Knight A.M., Spinner R.J., Yaszemski M.J., et al. Controlling dispersion of axonal regeneration using a multichannel collagen nerve conduit. Biomaterials 2010, 31:5789-5797.
96. Kim Y., Haftel V.K., Kumar S., Bellamkonda R.V. The role of aligned polymer fiber-based constructs in the bridging of long peripheral nerve gaps. Biomaterials 2008, 29:3117-3127.
97. Madduri S., Gander B. Growth factor delivery systems and repair strategies for damaged peripheral nerves. JControl Release 2011, 161:274-282.
98. Zhang N., Huang Y., Wen X. Formation of highly aligned grooves on inner surface of semipermeable hollow fiber membrane for directional axonal outgrowth. JManuf Sci Eng 2008, 130. 021011-1.
99. Ribeiro-Resende V.T., Koenig B., Nichterwitz S., Oberhoffner S., Schlosshauer B. Strategies for inducing the formation of bands of Büngner in peripheral nerve regeneration. Biomaterials 2009, 30:5251-5259.
100. Hill P.S., Apel P.J., Barnwell J., Smith T., Koman L.A., Atala A., et al. Repair of peripheral nerve defects in rabbits using keratin hydrogel scaffolds. Tissue Eng Part A 2011, 17:1499-1505.
101. Pancrazio J.J., Wang F., Kelley C.A. Enabling tools for tissue engineering. Biosens Bioelectron 2007, 22:2803-2811.
102. Cao H., Liu T., Chew S.Y. The application of nanofibrous scaffolds in neural tissue engineering. Adv Drug Deliv Rev 2009, 61:1055-1064.
103. Spivey E.C., Khaing Z.Z., Shear J.B., Schmidt C.E. The fundamental role of subcellular topography in peripheral nerve repair therapies. Biomaterials 2012, 33:4264-4276.
104. Lee J.Y., Bashur C.A., Goldstein A.S., Schmidt C.E. Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applications. Biomaterials 2009, 30:4325-4335.
105. Prabhakaran M.P., Venugopal J.R., Ramakrishna S. Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering. Biomaterials 2009, 30:4996-5003.
106. Stokols S., Tuszynski M.H. The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury. Biomaterials 2004, 25:5839-5846.
107. Li J., Rickett T.A., Shi R. Biomimetic nerve scaffolds with aligned intraluminal microchannels: a "sweet" approach to tissue engineering. Langmuir 2009, 25:1813-1817.
108. Tysseling-Mattiace V.M., Sahni V., Niece K.L., Birch D., Czeisler C., Fehlings M.G., et al. Self-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury. JNeurosci 2008, 28:3814-3823.
109. Gelain F., Unsworth L.D., Zhang S. Slow and sustained release of active cytokines from self-assembling peptide scaffolds. JControl Release 2010, 145:231-239.
110. Yang F., Murugan R., Ramakrishna S., Wang X., Ma Y.X., Wang S. Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials 2004, 25:1891-1900.
111. Yang F., Murugan R., Wang S., Ramakrishna S. Electrospinning of nano/micro scale poly(l-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 2005, 26:2603-2610.
112. Panseri S., Cunha C., Lowery J., Del Carro U., Taraballi F., Amadio S., et al. Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnol 2008, 8:39.
113. Tohill M., Terenghi G. Stem-cell plasticity and therapy for injuries of the peripheral nervous system. Biotechnol Appl Biochem 2004, 40:17-24.
114. Fairless R., Barnett S.C. Olfactory ensheathing cells: their role in central nervous system repair. Inter J Biochem Cell Biol 2005, 37:693-699.
115. Verdu E., Navarro X., Gudino-Cabrera G., Rodriguez F.J., Ceballos D., Valero A., et al. Olfactory bulb ensheathing cells enhance peripheral nerve regeneration. Neuroreport 1999, 10:1097-1101.
116. Andrews M.R., Stelzner D.J. Modification of the regenerative response of dorsal column axons by olfactory ensheathing cells or peripheral axotomy in adult rat. Exp Neurol 2004, 190:311-327.
117. Dombrowski M.A., Sasaki M., Lankford K.L., Kocsis J.D., Radtke C. Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells. Brain Res 2006, 1125:1-8.
118. Radtke C., Aizer A.A., Agulian S.K., Lankford K.L., Vogt P.M., Kocsis J.D. Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair. Brain Res 2009, 1254:10-17.
119. Guerout N., Duclos C., Drouot L., Abramovici O., Bon-Mardion N., Lacoume Y., et al. Transplantation of olfactory ensheathing cells promotes axonal regeneration and functional recovery of peripheral nerve lesion in rats. Muscle Nerve 2011, 43:543-551.
120. Johnson A., Dorshkind K. Stromal cells in myeloid and lymphoid long-term bone marrow cultures can support multiple hemopoietic lineages and modulate their production of hemopoietic growth factors. Blood 1986, 68:1348.
121. Deryugina E.I., Mulller-Sieburg C.E. Stromal cells in long-term cultures: keys to the elucidation of hematopoietic development?. Crit Rev Immunol 1993, 13:115.
122. Bianco P., Riminucci M., Gronthos S., Robey P.G. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 2001, 19:180.
123. Abdallah B.M., Kassem M. Human mesenchymal stem cells: from basic biology to clinical applications. Gene Ther 2007, 15:109-116.
124. Phinney D.G., Prockop D.J. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair current views. Stem Cells 2007, 25:2896.
125. Franchi S., Valsecchi A.E., Borsani E., Procacci P., Ferrari D., Zaffa C., et al. Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration in experimental neuropathy. Pain 2012, 153:850-861.
126. Horwitz E.M., Gordon P.L., Koo W.K., Marx J.C., Neel M.D., McNall R.Y., et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A 2002, 99:8932-8937.
127. Fickert S., Fiedler J., Brenner R.E. Identification, quantification and isolation of mesenchymal progenitor cells from osteoarthritic synovium by fluorescence automated cell sorting. Osteoarthr Cartil 2003, 11:790-800.
128. Ortiz L.A., Gambelli F., McBride C., Gaupp D., Baddoo M., Kaminski N., et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci U S A 2003, 100:8407-8411.
129. Kunter U., Rong S., Djuric Z., Boor P., Muller-Newen G., Yu D., et al. Transplanted mesenchymal stem cells accelerate glomerular healing in experimental glomerulonephritis. JAm Soc Nephrol 2006, 17:2202-2212.
130. Lee R.H., Seo M.J., Reger R.L., Spees J.L., Pulin A.A., Olson S.D., et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci U S A 2006, 103:17438-17443.
131. Minguell J.J., Erices A. Mesenchymal stem cells and the treatment of cardiac disease. Exp Biol Med (Maywood) 2006, 231:39-49.
132. Ringden O., Uzunel M., Rasmusson I., Remberger M., Sundberg B., Lonnies H., et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006, 81:1390-1397.
133. Ding F., Wu J., Yang Y., Hu W., Zhu Q., Tang X., et al. Use of tissue-engineered nerve grafts consisting of a chitosan/poly (lactic-co-glycolic acid)-based scaffold included with bone marrow mesenchymal cells for bridging 50-mm dog sciatic nerve gaps. Tissue Eng Part A 2010, 16:3779-3790.
134. Yang Y., Yuan X., Ding F., Yao D., Gu Y., Liu J., et al. Repair of rat sciatic nerve gap by a silk fibroin-based scaffold added with bone marrow mesenchymal stem cells. Tissue Eng Part A 2011, 17:2231-2244.
135. Xue C., Hu N., Gu Y., Yang Y., Liu Y., Liu J., et al. Joint use of a chitosan/PLGA scaffold and MSCs to bridge an extra large gap in dog sciatic nerve. Neurorehab Neural Re 2012, 26:96-106.
136. Uemura T., Takamatsu K., Ikeda M., Okada M., Kazuki K., Ikada Y., et al. Transplantation of induced pluripotent stem cell-derived neurospheres for peripheral nerve repair. Biochem Biophys Res Commun 2012, 419:130-135.
137. Fernandes K.J.L., McKenzie I.A., Mill P., Smith K.M., Akhavan M., Barnabé-Heider F., et al. Adermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol 2004, 6:1082-1093.
138. McKenzie I.A., Biernaskie J., Toma J.G., Midha R., Miller F.D. Skin-derived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system. JNeurosci 2006, 26:6651-6660.
139. Chen Z., Pradhan S., Liu C., Le L.Q. Skin-derived precursors as a source of progenitors for cutaneous nerve regeneration. Stem Cells 2012, 30:2261-2270.
140. Marchesi C., Pluderi M., Colleoni F., Belicchi M., Meregalli M., Farini A., et al. Skin-derived stem cells transplanted into resorbable guides provide functional nerve regeneration after sciatic nerve resection. Glia 2007, 55:425-438.
141. Park B.W., Kang D.H., Kang E.J., Byun J.H., Lee J.S., Maeng G.H., et al. Peripheral nerve regeneration using autologous porcine skin-derived mesenchymal stem cells. JTissue Eng Regen Med 2012, 6:113-124.
142. Walsh S., Biernaskie J., Kemp S.W., Midha R. Supplementation of acellular nerve grafts with skin derived precursor cells promotes peripheral nerve regeneration. Neuroscience 2009, 164:1097-1107.
143. Kingham P.J., Kalbermatten D.F., Mahay D., Armstrong S.J., Wiberg M., Terenghi G. Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth invitro. Exp Neurol 2007, 207:267-274.
144. Xu Y., Liu L., Li Y., Zhou C., Xiong F., Liu Z., et al. Myelin-forming ability of Schwann cell-like cells induced from rat adipose-derived stem cells invitro. Brain Res 2008, 1239:49-55.
145. Rider D.A., Dombrowski C., Sawyer A.A., Ng G.H.B., Leong D., Hutmacher D.W., et al. Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells. Stem Cells 2008, 26:1598-1608.
146. Erba P., Mantovani C., Kalbermatten D.F., Pierer G., Terenghi G., Kingham P.J. Regeneration potential and survival of transplanted undifferentiated adipose tissue-derived stem cells in peripheral nerve conduits. JPlast Reconstr Aesthet Surg 2010, 63:e811-e817.
147. Zhang Y., Luo H., Zhang Z., Lu Y., Huang X., Yang L., et al. Anerve graft constructed with xenogeneic acellular nerve matrix and autologous adipose-derived mesenchymal stem cells. Biomaterials 2010, 31:5312-5324.
148. di Summa P.G., Kalbermatten D.F., Pralong E., Raffoul W., Kingham P.J., Terenghi G. Long-term invivo regeneration of peripheral nerves through bioengineered nerve grafts. Neuroscience 2011, 181:278-291.
149. Liu G.B., Cheng Y.X., Feng Y.K., Pang C.J., Li Q., Wang Y., et al. Adipose-derived stem cells promote peripheral nerve repair. Arch Med Sci 2011, 7:592-596.
150. Scholz T., Sumarto A., Krichevsky A., Evans G.R. Neuronal differentiation of human adipose tissue-derived stem cells for peripheral nerve regeneration invivo. Arch Surg 2011, 146:666-674.
151. Sun F., Zhou K., Mi W.J., Qiu J.H. Combined use of decellularized allogeneic artery conduits with autologous transdifferentiated adipose-derived stem cells for facial nerve regeneration in rats. Biomaterials 2011, 32:8118-8128.
152. Wei Y., Gong K., Zheng Z., Wang A., Ao Q., Gong Y., et al. Chitosan/silk fibroin-based tissue-engineered graft seeded with adipose-derived stem cells enhances nerve regeneration in a rat model. JMater Sci Mater Med 2011, 22:1947-1964.
153. Gu J.H., Ji Y.H., Dhong E.S., Kim D.H., Yoon E.S. Transplantation of adipose derived stem cells for peripheral nerve regeneration in sciatic nerve defects of the rat. Curr Stem Cell Res Ther 2012, 7:347-355.
154. Orbay H., Uysal A.C., Hyakusoku H., Mizuno H. Differentiated and undifferentiated adipose-derived stem cells improve function in rats with peripheral nerve gaps. JPlast Reconstr Aesthet Surg 2012, 65:657-664.
155. Shen C.C., Yang Y.C., Liu B.S. Peripheral nerve repair of transplanted undifferentiated adipose tissue-derived stem cells in a biodegradable reinforced nerve conduit. JBiomed Mater Res A 2012, 100:48-63.
156. Tomita K., Madura T., Mantovani C., Terenghi G. Differentiated adipose-derived stem cells promote myelination and enhance functional recovery in a rat model of chronic denervation. JNeurosci Res 2012, 90:1392-1402.
157. Carriel V., Garrido-Gomez J., Hernandez-Cortes P., Garzon I., Garcia-Garcia S., Saez-Moreno J.A., et al. Combination of fibrin-agarose hydrogels and adipose-derived mesenchymal stem cells for peripheral nerve regeneration. JNeural Eng 2013, 10:026022.
158. Mohammadi R., Azizi S., Amini K. Effects of undifferentiated cultured omental adipose-derived stem cells on peripheral nerve regeneration. JSurg Res 2013, 180:e91-e97.
159. Suganuma S., Tada K., Hayashi K., Takeuchi A., Sugimoto N., Ikeda K., et al. Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration. JOrthop Sci 2013, 18:145-151.
160. Tomita K., Madura T., Sakai Y., Yano K., Terenghi G., Hosokawa K. Glial differentiation of human adipose-derived stem cells: implications for cell-based transplantation therapy. Neuroscience 2013, 236:55-65.
161. Rooney G.E., Moran C., McMahon S.S., Ritter T., Maenz M., Flugel A., et al. Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate. Tissue Eng Part A 2008, 14:681-690.
162. Cheng F.-C., Tai M.-H., Sheu M.-L., Chen C.-J., Yang D.-Y., Su H.-L., et al. Enhancement of regeneration with glia cell line-derived neurotrophic factor-transduced human amniotic fluid mesenchymal stem cells after sciatic nerve crush injury: laboratory investigation. JNeurosurg 2010, 112:868-879.
163. Fu K.Y., Dai L.G., Chiu I.M., Chen J.R., Hsu S.H. Sciatic nerve regeneration by microporous nerve conduits seeded with glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor gene transfected neural stem cells. Artif Organs 2011, 35:363-372.
164. Nectow A.R., Marra K.G., Kaplan D.L. Biomaterials for the development of peripheral nerve guidance conduits. Tissue Eng Part B 2012, 18:40-50.
165. Wood M.D., Gordon T., Kemp S.W., Liu E.H., Kim H., Shoichet M.S., et al. Functional motor recovery is improved due to local placement of GDNF microspheres after delayed nerve repair. Biotechnol Bioeng 2013, 110:1272-1281.
166. Kokai L.E., Ghaznavi A.M., Marra K.G. Incorporation of double-walled microspheres into polymer nerve guides for the sustained delivery of glial cell line-derived neurotrophic factor. Biomaterials 2010, 31:2313-2322.
167. Kokai L.E., Bourbeau D., Weber D., McAtee J., Marra K.G. Sustained growth factor delivery promotes axonal regeneration in long gap peripheral nerve repair. Tissue Eng Part A 2011, 17:1263-1275.
168. de Boer R., Borntraeger A., Knight A.M., Hebert-Blouin M.N., Spinner R.J., Malessy M.J., et al. Short- and long-term peripheral nerve regeneration using a poly-lactic-co-glycolic-acid scaffold containing nerve growth factor and glial cell line-derived neurotrophic factor releasing microspheres. JBiomed Mater Res Part A 2012, 100:2139-2146.
169. Timmer M., Robben S., Muller-Ostermeyer F., Nikkhah G., Grothe C. Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2. Cell Transpl 2003, 12:265-277.
170. Haastert K., Fischer M., Timmer M., Grothe C. Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms. Neurobiol Dis 2006, 21:138-153.
171. Haastert K., Ying Z., Grothe C., Gómez-Pinilla F. The effects of FGF-2 gene therapy combined with voluntary exercise on axonal regeneration across peripheral nerve gaps. Neurosci Lett 2008, 443:179-183.
172. May F., Matiasek K., Vroemen M., Caspers C., Mrva T., Arndt C., et al. GDNF-transduced Schwann cell grafts enhance regeneration of erectile nerves. Eur Urol 2008, 54:1179-1187.
173. May F., Buchner A., Schlenker B., Gratzke C., Arndt C., Stief C., et al. Schwann cell-mediated delivery of glial cell line-derived neurotrophic factor restores erectile function after cavernous nerve injury. Int J Urol 2013, 20:344-348.
174. Ikeda M., Uemura T., Takamatsu K., Okada M., Kazuki K., Tabata Y., et al. Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblastgrowth factor drug delivery system. JBiomed Mater Res A 2014, 102:1370-1378.
175. Sakiyama-Elbert S.E., Panitch A., Hubbell J.A. Development of growth factor fusion proteins for cell-triggered drug delivery. FASEB J 2001, 15:1300-1302.
176. Sun W., Lin H., Chen B., Zhao W., Zhao Y., Dai J. Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen-targeting human nerve growth factor-beta. JBiomed Mater Res A 2007, 83:1054-1061.
177. Yang Y., Zhao W., He J., Zhao Y., Ding F., Gu X. Nerve conduits based on immobilization of nerve growth factor onto modified chitosan by using genipin as a crosslinking agent. Eur J Pharm Biopharm 2011, 79:519-525.
178. Wang H., Zhao Q., Zhao W., Liu Q., Gu X., Yang Y. Repairing rat sciatic nerve injury by a nerve-growth-factor-roaded, chitosan-based nerve conduit. Biotech Appl Biochem 2012, 59:388-394.
179. Chang C. The effect of pulse-released nerve growth factor from genipin-crosslinked gelatin in schwann cell-seeded polycaprolactone conduits on large-gap peripheral nerve regeneration. Tissue Eng Part A 2009, 15:547-557.
180. Hsieh S.C., Tang C.M., Huang W.T., Hsieh L.L., Lu C.M., Chang C.J., et al. Comparison between two different methods of immobilizing NGF in poly(dl-lactic acid-co-glycolic acid) conduit for peripheral nerve regeneration by EDC/NHS/MES and genipin. JBiomed Mater Res Part A 2011, 99:576-585.
181. Chung T.W., Yang M.C., Tseng C.C., Sheu S.H., Wang S.S., Huang Y.Y., et al. Promoting regeneration of peripheral nerves in-vivo using new PCL-NGF/tirofiban nerve conduits. Biomaterials 2011, 32:734-743.
182. Chung T.W., Liu D.Z., Wang S.Y., Wang S.S. Enhancement of the growth of human endothelial cells by surface roughness at nanometer scale. Biomaterials 2003, 24:4655-4661.
183. Wang C.Y., Liu J.J., Fan C.Y., Mo X.M., Ruan H.J., Li F.F. The effect of aligned core-shell nanofibres delivering NGF on the promotion of sciatic nerve regeneration. JBiomater Sci Polym Ed 2012, 23:167-184.
184. Liu J.J., Wang C.Y., Wang J.G., Ruan H.J., Fan C.Y. Peripheral nerve regeneration using composite poly (lactic acid-caprolactone)/nerve growth factor conduits prepared by coaxial electrospinning. JBiomed Mater Res A 2011, 96:13-20.
185. Tang S., Zhu J., Xu Y., Xiang A.P., Jiang M.H., Quan D. The effects of gradients of nerve growth factor immobilized PCLA scaffolds on neurite outgrowth invitro and peripheral nerve regeneration in rats. Biomaterials 2013, 34:7086-7096.
186. Bosher J.F.L.M., Labouesse M. RNA interference: genetic wand and genetic watchdog. Nat Cell Biol 2000, 2:E31-E36.
187. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
188. Mello C.C., Conte D. Revealing the world of RNA interference. Nature 2004, 431:338-342.
189. Lee S.-K., Kumar P. Conditional RNAi: towards a silent gene therapy. Adv Drug Deliv Rev 2009, 61:650-664.
190. Hengst U., Cox L.J., Macosko E.Z., Jaffrey S.R. Functional and selective RNA interference in developing axons and growth cones. JNeurosci 2006, 26:5727-5732.
191. Murashov A.K., Chintalgattu V., Islamov R.R., Lever T.E., Pak E.S., Sierpinski P.L., et al. RNAi pathway is functional in peripheral nerve axons. FASEB J 2007, 21:656-670.
192. Toth C., Shim S.Y., Wang J., Jiang Y., Neumayer G., Belzil C., et al. Ndel1 promotes axon regeneration via intermediate filaments. PloS One 2008, 3:e2014.
193. Christie K.J., Webber C.A., Martinez J.A., Singh B., Zochodne D.W. PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons. JNeurosci 2010, 30:9306-9315.
194. Hausott B., Vallant N., Auer M., Yang L., Dai F., Brand-Saberi B., et al. Sprouty2 down-regulation promotes axon growth by adult sensory neurons. Mol Cell Neurosci 2009, 42:328-340.
195. Wang Y., Zheng Z., Hu D. Inhibition of EphA4 expression promotes Schwann cell migration and peripheral nerve regeneration. Neurosci Lett 2013, 548:201-205.
196. Maurel P., Einheber S., Galinska J., Thaker P., Lam I., Rubin M.B., et al. Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination. JCell Biol 2007, 178:861-874.
197. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
198. Friedman R.C., Farh K.K., Burge C.B., Bartel D.P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009, 19:92-105.
199. Eacker S.M., Dawson T.M., Dawson V.L. Understanding microRNAs in neurodegeneration. Nat Rev Neurosci 2009, 10:837-841.
200. Fineberg S.K., Kosik K.S., Davidson B.L. MicroRNAs potentiate neural development. Neuron 2009, 64:303-309.
201. Zhou S., Yu B., Qian T., Yao D., Wang Y., Ding F., et al. Early changes of microRNAs expression in the dorsal root ganglia following rat sciatic nerve transection. Neurosci Lett 2011, 494:89-93.
202. Wu D., Murashov A.K. Molecular mechanisms of peripheral nerve regeneration: emerging roles of microRNAs. Front Physiol 2013, 4:55.
203. Wu D., Raafat M., Pak E., Hammond S., Murashov A.K. MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern. Neuroscience 2011, 190:386-397.
204. Strickland I.T., Richards L., Holmes F.E., Wynick D., Uney J.B., Wong L.F. Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons. PloS One 2011, 6:e23423.
205. Zhang H.Y., Zheng S.J., Zhao J.H., Zhao W., Zheng L.F., Zhao D., et al. MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection. Brain Res 2011, 1383:62-70.
206. Zhou S., Shen D., Wang Y., Gong L., Tang X., Yu B., et al. microRNA-222 targeting PTEN promotes neurite outgrowth from adult dorsal root ganglion neurons following sciatic nerve transection. PloS One 2012, 7:e44768.
207. Li S., Yu B., Wang S., Gu Y., Yao D., Wang Y., et al. Identification and functional analysis of novel micro-RNAs in rat dorsal root ganglia after sciatic nerve resection. JNeurosci Res 2012, 90:791-801.
208. Bremer J., O'Connor T., Tiberi C., Rehrauer H., Weis J., Aguzzi A. Ablation of dicer from murine Schwann cells increases their proliferation while blocking myelination. PloS One 2010, 5:e12450.
209. Dugas J.C., Cuellar T.L., Scholze A., Ason B., Ibrahim A., Emery B., et al. Dicer1 and miR-219 are required for normal oligodendrocyte differentiation and myelination. Neuron 2010, 65:597-611.
210. Pereira J.A., Baumann R., Norrmen C., Somandin C., Miehe M., Jacob C., et al. Dicer in Schwann cells is required for myelination and axonal integrity. JNeurosci 2010, 30:6763-6775.
211. Yun B., Anderegg A., Menichella D., Wrabetz L., Feltri M.L., Awatramani R. MicroRNA-deficient Schwann cells display congenital hypomyelination. JNeurosci 2010, 30:7722-7728.
212. Viader A., Chang L.W., Fahrner T., Nagarajan R., Milbrandt J. MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes. JNeurosci 2011, 31:17358-17369.
213. Yu B., Qian T., Wang Y., Zhou S., Ding G., Ding F., et al. miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury. Nucleic Acids Res 2012, 40:10356-10365.
214. Yu B., Zhou S., Wang Y., Qian T., Ding G., Ding F., et al. miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury. JCell Sci 2012, 125:2675-2683.
215. Costa F.F. Non-coding RNAs: meet thy masters. Bioessays 2010, 32:599-608.
216. Ravasi T., Suzuki H., Pang K.C., Katayama S., Furuno M., Okunishi R., et al. Experimental validation of the regulated expression of large numbers of non-coding RNAs from the mouse genome. Genome Res 2006, 16:11-19.
217. Ponjavic J., Oliver P.L., Lunter G., Ponting C.P. Genomic and transcriptional co-localization of protein-coding and long non-coding RNA pairs in the developing brain. PLoS Genet 2009, 5:e1000617.
218. Wilusz J.E., Sunwoo H., Spector D.L. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev 2009, 23:1494-1504.
219. Wapinski O., Chang H.Y. Long noncoding RNAs and human disease. Trends Cell Biol 2011, 21:354-361.
220. Yu B., Zhou S., Hu W., Qian T., Gao R., Ding G., et al. Altered long noncoding RNA expressions in dorsal root ganglion after rat sciatic nerve injury. Neurosci Lett 2013, 534:117-122.
221. Guzman-Villanueva D., El-Sherbiny I.M., Herrera-Ruiz D., Vlassov A.V., Smyth H.D. Formulation approaches to short interfering RNA and MicroRNA: challenges and implications. JPharm Sci 2012, 101:4046-4066.
222. Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 8:129-138.
223. Kesharwani P., Gajbhiye V., Jain N.K. Areview of nanocarriers for the delivery of small interfering RNA. Biomaterials 2012, 33:7138-7150.
224. Low W.C., Rujitanaroj P.O., Lee D.K., Messersmith P.B., Stanton L.W., Goh E., et al. Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells. Biomaterials 2013, 34:3581-3590.
225. Mittnacht U., Hartmann H., Hein S., Oliveira H., Dong M., Pego A.P., et al. Chitosan/siRNA nanoparticles biofunctionalize nerve implants and enable neurite outgrowth. Nano Lett 2010, 10:3933-3939.
226. Hoffmann N., Mittnacht U., Hartmann H., Baumer Y., Kjems J., Oberhoffner S., et al. Neuronal and glial responses to siRNA-coated nerve guide implants invitro. Neurosci Lett 2011, 494:14-18.
227. Zhou S., Gao R., Hu W., Qian T., Wang N., Ding G., et al. miR-9 inhibits Schwann cell migration by targeting Cthrc1 following sciatic nerve injury. JCell Sci 2014, 127:967-976.
228. Oh S.H., Kim J.H., Song K.S., Jeon B.H., Yoon J.H., Seo T.B., et al. Peripheral nerve regeneration within an asymmetrically porous PLGA/Pluronic F127 nerve guide conduit. Biomaterials 2008, 29:1601-1609.
229. Park S.C., Oh S.H., Seo T.B., Namgung U., Kim J.M., Lee J.H. Ultrasound-stimulated peripheral nerve regeneration within asymmetrically porous PLGA/Pluronic F127 nerve guide conduit. JBiomed Mater Res B Appl Biomater 2010, 94:359-366.
230. Novosel E.C., Kleinhans C., Kluger P.J. Vascularization is the key challenge in tissue engineering. Adv Drug Deliv Rev 2011, 63:300-311.
231. Hobson M.I., Brown R., Green C.J., Terenghi G. Inter-relationships between angiogenesis and nerve regeneration: a histochemical study. Br J Plast Surg 1997, 50:125-131.
232. Kakinoki R., Nishijima N., Ueba Y., Oka M., Yamamuro T. Relationship between axonal regeneration and vascularity in tubulation-an experimental study in rats. Neurosci Res 1995, 23:35-45.
233. Kakinoki R., Nishijima N., Ueba Y., Oka M., Yamamuro T., Nakamura T. Nerve regeneration over a 25 mm gap in rat sciatic nerves using tubes containing blood vessels: the possibility of clinical application. Int Orthop 1997, 21:332-336.
234. Harrison D.G. Cellular and molecular mechanisms of endothelial cell dysfunction. JClin Invest 1997, 100:2153.
235. González-Hernández T., Rustioni A. Expression of three forms of nitric oxide synthase in peripheral nerve regeneration. JNeurosci Res 1999, 55:198-207.
236. Keilhoff G., Wolf G., Fansa H. NOS-mediated differences in peripheral nerve graft revascularization and regeneration. Neuroreport 2002, 13:1463-1468.
237. Goligorsky M.S., Budzikowski A.S., Tsukahara H., Noiri E. Co-operation between endothelin and nitric oxide in promoting endothelial cell migration and angiogenesis. Clin Exp Pharmacol Physiol 1999, 26:269-271.
238. Ferrara N. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 1999, 56:794-814.
239. Sondell M., Lundborg G., Kanje M. Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system. JNeurosci 1999, 19:5731-5740.
240. Hobson M.I., Green C.J., Terenghi G. VEGF enhances intraneural angiogenesis and improves nerve regeneration after axotomy. JAnat 2000, 197:591-605.
241. Wongtrakul S., Bishop A.T., Friedrich P.F. Vascular endothelial growth factor promotion of neoangiogenesis in conventional nerve grafts. JHand Surg Am 2002, 27:277-285.
242. Pola R., Aprahamian T.R., Bosch-Marcé M., Curry C., Gaetani E., Flex A., et al. Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves. Neurobiol Aging 2004, 25:1361-1368.
243. Aizawa Y., Wylie R., Shoichet M. Endothelial cell guidance in 3D patterned scaffolds. Adv Mater 2010, 22:4831-4835.
244. Hobson M.I. Increased vascularisation enhances axonal regeneration within an acellular nerve conduit. Ann R Coll Surg Engl 2002, 84:47-53.
245. Lee Y.B., Polio S., Lee W., Dai G., Menon L., Carroll R.S., et al. Bio-printing of collagen and VEGF-releasing fibrin gel scaffolds for neural stem cell culture. Exp Neurol 2010, 223:645-652.
246. Ravichandran R., Sundarrajan S., Venugopal J.R., Mukherjee S., Ramakrishna S. Applications of conducting polymers and their issues in biomedical engineering. JR Soc Interface 2007, 7(Suppl.5):S559-S579.
247. Schmidt C.E., Shastri V.R., Vacanti J.P., Langer R. Stimulation of neurite outgrowth using an electrically conducting polymer. Proc Natl Acad Sci U S A 1997, 94:8948-8953.
248. Runge M.B., Dadsetan M., Baltrusaitis J., Knight A.M., Ruesink T., Lazcano E.A., et al. The development of electrically conductive polycaprolactone fumarate-polypyrrole composite materials for nerve regeneration. Biomaterials 2010, 31:5916-5926.
249. Marquardt L.M., Sakiyama-Elbert S.E. Engineering peripheral nerve repair. Curr Opin Biotechnol 2013, 10.1016/j.bbr.2011.03.031.
250. Fine E.G., Valentini R.F., Bellamkonda R., Aebischer P. Improved nerve regeneration through piezoelectric vinylidenefluoride-trifluoroethylene copolymer guidance channels. Biomaterials 1991, 12:775-780.
251. Ghasemi-Mobarakeh L., Prabhakaran M.P., Morshed M., Nasr-Esfahani M.H., Baharvand H., Kiani S., et al. Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering. JTissue Eng Regen Med 2011, 5:e17-e35.
252. McCaig C.D., Rajnicek A.M., Song B., Zhao M. Controlling cell behavior electrically: current views and future potential. Physiol Rev 2005, 85:943-978.
253. Yao L., McCaig C.D., Zhao M. Electrical signals polarize neuronal organelles, direct neuron migration, and orient cell division. Hippocampus 2009, 19:855-868.
254. Yao L., Pandit A., Yao S., McCaig C.D. Electric field-guided neuron migration: a novel approach in neurogenesis. Tissue Eng Part B 2011, 17:143-153.
255. Nguyen H.T., Wei C., Chow J.K., Nguy L., Nguyen H.K., Schmidt C.E. Electric field stimulation through a substrate influences Schwann cell and extracellular matrix structure. JNeural Eng 2013, 10:046011.
256. Al-Majed A.A., Neumann C.M., Brushart T.M., Gordon T. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. JNeurosci 2000, 20:2602-2608.
257. Brushart T.M., Hoffman P.N., Royall R.M., Murinson B.B., Witzel C., Gordon T. Electrical stimulation promotes motoneuron regeneration without increasing its speed or conditioning the neuron. JNeurosci 2002, 22:6631-6638.
258. Brushart T.M., Jari R., Verge V., Rohde C., Gordon T. Electrical stimulation restores the specificity of sensory axon regeneration. Exp Neurol 2005, 194:221-229.
259. Geremia N.M., Gordon T., Brushart T.M., Al-Majed A.A., Verge V.M. Electrical stimulation promotes sensory neuron regeneration and growth-associated gene expression. Exp Neurol 2007, 205:347-359.
260. Gordon T., Amirjani N., Edwards D.C., Chan K.M. Brief post-surgical electrical stimulation accelerates axon regeneration and muscle reinnervation without affecting the functional measures in carpal tunnel syndrome patients. Exp Neurol 2010, 223:192-202.
261. Mendonça A.C., Barbieri C.H., Mazzer N. Directly applied low intensity direct electric current enhances peripheral nerve regeneration in rats. JNeurosci Meth 2003, 129:183-190.
262. Yeh C.-C., Lin Y.-C., Tsai F.-J., Huang C.-Y., Yao C.-H., Chen Y.-S. Timing of applying electrical stimulation is an important factor deciding the success rate and maturity of regenerating rat sciatic nerves. Neurorehab Neural Repair 2010, 24:730-735.
263. Lu M.-C., Ho C.-Y., Hsu S.-F., Lee H.-C., Lin J.-H., Yao C.-H., et al. Effects of electrical stimulation at different frequencies on regeneration of transected peripheral nerve. Neurorehab Neural Re 2008, 22:367-373.
264. Kiefer R., Kieseier B.C., Stoll G., Hartung H.P. The role of macrophages in immune-mediated damage to the peripheral nervous system. Prog Neurobiol 2001, 64:109-127.
265. Wang Y., Tang X., Yu B., Gu Y., Yuan Y., Yao D., et al. Gene network revealed involvements of birc2, birc3 and tnfrsf1a in anti-apoptosis of injured peripheral nerves. PloS One 2002, 7:e43436.
266. Camara-Lemarroy C.R., Guzman-de la Garza F.J., Fernandez-Garza N.E. Molecular inflammatory mediators in peripheral nerve degeneration and regeneration. Neuroimmunomodulation 2010, 17:314-324.
267. Tang X., Wang Y., Zhou S., Qian T., Gu X. Signaling pathways regulating dose-dependent dual effects of TNF-alpha on primary cultured Schwann cells. Mol Cell Biochem 2013, 378:237-246.
268. Schense J.C., Bloch J., Aebischer P., Hubbell J.A. Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension. Nat Biotechnol 2000, 18:415-419.
269. Cheng Q., Yuan Y., Sun C., Gu X., Cao Z., Ding F. Neurotrophic and neuroprotective actions of Achyranthes bidentata polypeptides on cultured dorsal root ganglia of rats and on crushed common peroneal nerve of rabbits. Neurosci Lett 2014, 562:7-12.
270. Shen Y., Fan Y., Dai H., Fu Q., Hu W., Chen Z. Neuroprotective effect of carnosine on necrotic cell death in PC12 cells. Neurosci Lett 2007, 414:145-149.
271. Wilson A.D., Hart A., Brannstrom T., Wiberg M., Terenghi G. Delayed acetyl-L-carnitine administration and its effect on sensory neuronal rescue after peripheral nerve injury. JPlast Reconstr Aesthet Surg 2007, 60:114-118.
272. Tang X., Xue C., Wang Y., Ding F., Yang Y., Gu X. Bridging peripheral nerve defects with a tissue engineered nerve graft composed of an invitro cultured nerve equivalent and a silk fibroin-based scaffold. Biomaterials 2012, 33:3860-3867.
273. Navarro X., Vivo M., Valero-Cabre A. Neural plasticity after peripheral nerve injury and regeneration. Prog Neurobiol 2007, 82:163-201.
274. Raimondo S., Fornaro M., Tos P., Battiston B., Giacobini-Robecchi M.G., Geuna S. Perspectives in regeneration and tissue engineering of peripheral nerves. Ann Anat 2011, 193:334-340.
275. Napoli I., Noon L.A., Ribeiro S., Kerai A.P., Parrinello S., Rosenberg L.H., et al. Acentral role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration invivo. Neuron 2012, 73:729-742.
276. Fricker F.R., Antunes-Martins A., Galino J., Paramsothy R., La Russa F., Perkins J., et al. Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination. Brain 2013, 136:2279-2297.
277. Lin M.Y., Manzano G., Gupta R. Nerve allografts and conduits in peripheral nerve repair. Hand Clin 2013, 29:331-348.
278. Rinkel W.D., Huisstede B.M., van der Avoort D.J., Coert H.J., Hovius S.E. What is evidence based in the reconstruction of digital nerves? A systematic review. JPlast Reconstr Aesthet Surg 2013, 66:151-164.
279. Zhang P., Han N., Wang T., Xue F., Kou Y., Wang Y., et al. Biodegradable conduit small gap tubulization for peripheral nerve mutilation: a substitute for traditional epineurial neurorrhaphy. Int J Med Sci 2013, 10:171-175.