Inhibition of EphA4 expression promotes Schwann cell migration and peripheral nerve regeneration

Neuroscience Letters

Volumn 548, Issue , 2013, Pages 201-205

  Wang, Yaojun ^a   Zheng, Zhao ^a   Hu, Dahai ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

EphA4; Peripheral nerve regeneration; Schwann cell migration

Indexed keywords

EPHRIN RECEPTOR A4; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; GENE INACTIVATION; NERVE FIBER GROWTH; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RNA INTERFERENCE; SCHWANN CELL; SCIATIC NERVE;

EPHA4; PERIPHERAL NERVE REGENERATION; SCHWANN CELL MIGRATION;

ANIMALS; CELL MOVEMENT; CELLS, CULTURED; GENE SILENCING; GENETIC THERAPY; MICE; NERVE REGENERATION; PERIPHERAL NERVE INJURIES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPHA4; SCHWANN CELLS;

EID: 84880132379     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.05.022     Document Type: Article

References (27)

1. Afshari F.T., Kwok J.C., Fawcett J.W. Astrocyte-produced ephrins inhibit Schwann cell migration via VAV2 signaling. J. Neurosci. 2010, 30:4246-4255.
2. Bhatheja K., Field J. Schwann cells: origins and role in axonal maintenance and regeneration. Int. J. Biochem. Cell Biol. 2006, 38:1995-1999.
3. Chen Z.L., Yu W.M., Strickland S. Peripheral regeneration. Annu. Rev. Neurosci. 2007, vol. 30:209-233. Annual Reviews, Palo Alto.
4. Cheng N., Brantley D.M., Chen J. The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 2002, 13:75-85.
5. Coonan J.R., Greferath U., Messenger J., Hartley L., Murphy M., Boyd A.W., Dottori M., Galea M.P., Bartlett P.F. Development and reorganization of corticospinal projections in EphA4 deficient mice. J. Comp. Neurol. 2001, 436:248-262.
6. Flanagan J.G., Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci. 1998, 21:309-345.
7. Geuna S., Raimondo S., Ronchi G., Di Scipio F., Tos P., Czaja K., Fornaro M. Histology of the peripheral nerve and changes occurring during nerve regeneration. Essays on Peripheral Nerve Repair and Regeneration 2009, vol. 87:27-46. Elsevier Academic Press Inc., San Diego.
8. Goldshmit Y., Spanevello M.D., Tajouri S., Li L., Rogers F., Pearse M., Galea M., Bartlett P.F., Boyd A.W., Turnley A.M. EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice. PLoS ONE 2011, 6:e24636.
9. Helmbacher F., Schneider-Maunoury S., Topilko P., Tiret L., Charnay P. Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons. Development 2000, 127:3313-3324.
10. Himanen J.P., Nikolov D.B. Eph receptors and ephrins. Int. J. Biochem. Cell Biol. 2003, 35:130-134.
11. Holland S.J., Peles E., Pawson T., Schlessinger J. Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase β. Curr. Opin. Neurobiol. 1998, 8:117-127.
12. Iiizumi M., Hosokawa M., Takehara A., Chung S., Nakamura T., Katagiri T., Eguchi H., Ohigashi H., Ishikawa O., Nakamura Y., Nakagawa H. EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth. Cancer Sci. 2006, 97:1211-1216.
13. Jessen K.R., Mirsky R. The origin and development of glial cells in peripheral nerves. Nat. Rev. Neurosci. 2005, 6:671-682.
14. Jessen K.R., Mirsky R. Schwann cells and their precursors emerge as major regulators of nerve development. Trends Neurosci. 1999, 22:402-410.
15. Klein R. Eph/ephrin signaling in morphogenesis, neural development and plasticity. Curr. Opin. Cell Biol. 2004, 16:580-589.
16. Liu X., Hawkes E., Ishimaru T., Tran T., Sretavan D.W. EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury. J. Neurosci. 2006, 26:3087-3101.
17. Madduri S., Gander B. Schwann cell delivery of neurotrophic factors for peripheral nerve regeneration. J. Peripher. Nerv. Syst. 2010, 15:93-103.
18. Madduri S., Papaloizos M., Gander B. Trophically and topographically functionalized silk fibroin nerve conduits for guided peripheral nerve regeneration. Biomaterials 2010, 31:2323-2334.
19. Miller C., Jeftinija S., Mallapragada S. Micropatterned Schwann cell-seeded biodegradable polymer substrates significantly enhance neurite alignment and outgrowth. Tissue Eng. 2001, 7:705-715.
20. Mosahebi A., Fuller P., Wiberg M., Terenghi G. Effect of allogeneic Schwann cell transplantation on peripheral nerve regeneration. Exp. Neurol. 2002, 173:213-223.
21. Parrinello S., Napoli I., Ribeiro S., Digby P.W., Fedorova M., Parkinson D.B., Doddrell R.D.S., Nakayama M., Adams R.H., Lloyd A.C. EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell 2010, 143:145-155.
22. Riethmacher D., SonnenbergRiethmacher E., Brinkmann V., Yamaai T., Lewin G.R., Birchmeier C. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 1997, 389:725-730.
23. Terenghi G. Peripheral nerve regeneration and neurotrophic factors. J. Anat. 1999, 194:1-14.
24. Terenghi G. Peripheral nerve regeneration and neurotrophic factors. J. Anat. 2002, 194:1-14.
25. Torigoe K., Hashimoto K., Lundborg G. A role of migratory Schwann cells in a conditioning effect of peripheral nerve regeneration. Exp. Neurol. 1999, 160:99-108.
26. Webber C.A., Christie K.J., Cheng C., Martinez J.A., Singh B., Singh V., Thomas D., Zochodne D.W. Schwann cells direct peripheral nerve regeneration through the Netrin 1 receptors, DCC and Unc5H2. Glia 2011, 59:1503-1517.
27. Zhang J., Hughes S.E. Role of the ephrin and Eph receptor tyrosine kinase families in angiogenesis and development of the cardiovascular system. J. Pathol. 2006, 208:453-461.