Functional and selective RNA interference in developing axons and growth cones

Journal of Neuroscience

Volumn 26, Issue 21, 2006, Pages 5727-5732

  Hengst, Ulrich ^a   Cox, Llewellyn J ^a   Macosko, Evan Z ^a   Jaffrey, Samie R ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Axons; Dicer; Fragile X mental retardation protein; Growth cones; RhoA; RNA interference; Small interfering RNA

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; NERVE PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GROWTH CONE; NERVE GROWTH; NEUROTRANSMITTER RELEASE; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; RNA INTERFERENCE; RNA TRANSLATION; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; NERVE FIBER; PHYSIOLOGY; POSTERIOR HORN CELL; PRENATAL DEVELOPMENT; ULTRASTRUCTURE;

ANIMALS; AXONS; GROWTH CONES; NERVE TISSUE PROTEINS; POSTERIOR HORN CELLS; RATS; RNA INTERFERENCE;

EID: 33745007605     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5229-05.2006     Document Type: Article

References (32)

1. Antar LN, Dictenberg JB, Plociniak M, Afroz R, Bassell GJ (2005) Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons. Genes Brain Behav 4:350-359.
2. Bagni C, Greenough WT (2005) From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat Rev Neurosci 6:376-387.
3. Bassell GJ, Zhang H, Byrd AL, Femino AM, Singer RH, Taneja KL, Lifshitz LM, Herman IM, Kosik KS (1998) Sorting of β-actin mRNA and protein to neurites and growth cones in culture. J Neurosci 18:251-265.
4. Brittis PA, Lu Q, Flanagan JG (2002) Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target. Cell 110:223-235.
5. Campbell DS, Holt CE (2001) Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32:1013-1026.
6. Campenot RB (1977) Local control of neurite development by nerve growth factor. Proc Natl Acad Sci USA 74:4516-4519.
7. Caudy AA, Myers M, Hannon GJ, Hammond SM (2002) Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev 16:2491-2496.
8. Chen L, Yun SW, Seto J, Liu W, Toth M (2003) The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U-rich target sequences. Neuroscience 120:1005-1017.
9. Eng H, Lund K, Campenot RB (1999) Synthesis of β-tubulin, actin, and other proteins in axons of sympathetic neurons in compartmented cultures. J Neurosci 19:1-9.
10. Feng Y, Gutekunst CA, Eberhart DE, Yi H, Warren ST, Hersch SM (1997) Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J Neurosci 17:1539-1547.
11. Giraldez AJ, Cinalli RM, Glasner ME, Enright AJ, Thomson JM, Baskerville S, Hammond SM, Bartel DP, Schier AF (2005) MicroRNAs regulate brain morphogenesis in zebrafish. Science 308:833-838.
12. Irvin-Wilson CV, Chaudhuri G (2005) Alternative initiation and splicing in dicer gene expression in human breast cells. Breast Cancer Res 7:R563-R569.
13. Ishizuka A, Siomi MC, Siomi H (2002) A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev 16:2497-2508.
14. Jin P, Alisch RS, Warren ST (2004a) RNA and microRNAs in fragile X mental retardation. Nat Cell Biol 6:1048-1053.
15. Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST (2004b) Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci 7:113-117.
16. Kanai Y, Dohmae N, Hirokawa N (2004) Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron 43:513-525.
17. Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G (2004) Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci USA 101:360-365.
18. Kleiman R, Banker G, Steward O (1994) Development of subcellular mRNA compartmentation in hippocampal neurons in culture. J Neurosci 14:1130-1140.
19. Krichevsky AM, Kosik KS (2001) Neuronal RNA granules: a link between RNA localization and stimulation-dependent translation. Neuron 32:683-696.
20. Krichevsky AM, King KS, Donahue CP, Khrapko K, Kosik KS (2003) A microRNA array reveals extensive regulation of microRNAs during brain development. RNA 9:1274-1281.
21. Lyles V, Zhao Y, Martin KC (2006) Synapse formation and mRNA localization in cultured Aplysia neurons. Neuron 49:349-356.
22. Mello CC, Conte Jr D (2004) Revealing the world of RNA interference. Nature 431:338-342.
23. Ming GL, Wong ST, Henley J, Yuan XB, Song HJ, Spitzer NC, Poo MM (2002) Adaptation in the chemotactic guidance of nerve growth cones. Nature 417:411-418.
24. Olink-Coux M, Hollenbeck PJ (1996) Localization and active transport of mRNA in axons of sympathetic neurons in culture. J Neurosci 16:1346-1358.
25. Piper M, Anderson R, Dwivedy A, Weinl C, van Horck F, Leung KM, Cogill E, Holt C (2006) Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones. Neuron 49:215-228.
26. Steward O (2002) Translating axon guidance cues. Cell 110:537-540.
27. Tanaka Hall TM (2005) Structure and function of argonaute proteins. Structure 13:1403-1408.
28. Taylor AM, Blurton-Jones M, Rhee SW, Cribbs DH, Cotman CW, Jeon NL (2005) A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods 2:599-605.
29. Weiler IJ, Irwin SA, Klintsova AY, Spencer CM, Brazelton AD, Miyashiro K, Comery TA, Patel B, Eberwine J, Greenough WT (1997) Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation. Proc Natl Acad Sci USA 94:5395-5400.
30. Wu K, Hengst U, Cox LJ, Macosko EZ, Jeromin A, Urquhart ER, Jaffrey SR (2005) Local translation of RhoA regulates growth cone collapse. Nature 436:1020-1024.
31. Yamada KM, Spooner BS, Wessells NK (1971) Ultrastructure and function of growth cones and axons of cultured nerve cells. J Cell Biol 49:614-635.
32. Zhang X, Poo MM (2002) Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon. Neuron 36:675-688.