Joint use of a chitosan/PLGA scaffold and MSCs to bridge an extra large gap in dog sciatic nerve

Neurorehabilitation and Neural Repair

Volumn 26, Issue 1, 2012, Pages 96-106

  Xue, Chengbin ^a,b   Hu, Nan ^a   Gu, Yun ^a   Yang, Yumin ^a   Liu, Yan ^a   Liu, Jie ^a   Ding, Fei ^a   Gu, Xiaosong ^a,b  

^a NANTONG UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

bone marrow mesenchymal stem cells; chitosan; dog sciatic nerve; nerve grafts; peripheral nerve regeneration; poly(lactic co glycolic acid)

Indexed keywords

CHITOSAN; FLUOROGOLD; POLYGLACTIN; TISSUE SCAFFOLD;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOGRAFT; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BEHAVIOR; CONTROLLED STUDY; EXPERIMENTAL DOG; FEASIBILITY STUDY; HINDLIMB; HISTOPATHOLOGY; ISOTOPE TRACING; MALE; MESENCHYMAL STEM CELL; MORPHOMETRICS; MOTOR PERFORMANCE; NERVE GRAFT; NERVE REGENERATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; PERIPHERAL NERVE; PERIPHERAL NERVE INJURY; SCIATIC NERVE; SCIATIC NERVE GAP; TISSUE ENGINEERED NERVE GRAFT; TISSUE ENGINEERING;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE MARROW; CHITOSAN; DOGS; LACTIC ACID; MESENCHYMAL STEM CELL TRANSPLANTATION; NERVE REGENERATION; PERIPHERAL NERVE INJURIES; POLYGLYCOLIC ACID; SCIATIC NERVE; TISSUE ENGINEERING; TISSUE SCAFFOLDS; TISSUE TRANSPLANTATION; WOUND HEALING;

EID: 84862946246     PISSN: 15459683     EISSN: 15526844     Source Type: Journal    
DOI: 10.1177/1545968311420444     Document Type: Article

References (39)

1. Gu X, Ding F, Yang Y, Liu J. Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Prog Neurobiol. 2011 ; 93: 204-230
2. Hudson TW, Evans GR, Schmidt CE. Engineering strategies for peripheral nerve repair. Orthop Clin North Am. 2000 ; 31: 485-498
3. Schmidt CE, Leach JB. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng. 2003 ; 5: 293-347 (Pubitemid 40125315)
4. Jiang X, Lim SH, Mao HQ, Chew SY. Current applications and future perspectives of artificial nerve conduits. Exp Neurol. 2010 ; 223: 86-101
5. Johnson EO, Soucacos PN. Nerve repair: experimental and clinical evaluation of biodegradable artificial nerve guides. Injury. 2008 ; 39: S30 - S36
6. Wang X, Hu W, Cao Y, Yao J, Wu J, Gu X. Dog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial nerve graft. Brain. 2005 ; 128: 1897-1910 (Pubitemid 41373662)
7. Fan W, Gu J, Hu W, et al. Repairing a 35-mm-long median nerve defect with a chitosan/PGA artificial nerve graft in the human: a case study. Microsurgery. 2008 ; 28: 238-242 (Pubitemid 351770165)
8. Aubert I, Ridet JL, Gage FH. Regeneration in the adult mammalian CNS: guided by development. Curr Opin Neurobiol. 1995 ; 5: 625-635
9. Domeniconi M, Filbin MT. Overcoming inhibitors in myelin to promote axonal regeneration. J Neurol Sci. 2005 ; 233: 43-47 (Pubitemid 40804814)
10. Sandvig A, Berry M, Barrett LB, Butt A, Logan A. Myelin-, reactive glia-, and scar-derived CNS axon growth inhibitors: expression, receptor signaling, and correlation with axon regeneration. Glia. 2004 ; 46: 225-251 (Pubitemid 38679204)
11. Schwab JM, Bernard F, Moreau-Fauvarque C, Chedotal A. Injury reactive myelin/oligodendrocyte-derived axon growth inhibition in the adult mammalian central nervous system. Brain Res Brain Res Rev. 2005 ; 49: 295-299 (Pubitemid 41160397)
12. Hood B, Levene HB, Levi AD. Transplantation of autologous Schwann cells for the repair of segmental peripheral nerve defects. Neurosurg Focus. 2009 ; 26: E4
13. Mosahebi A, Woodward B, Wiberg M, Martin R, Terenghi G. Retroviral labeling of Schwann cells: in vitro characterization and in vivo transplantation to improve peripheral nerve regeneration. Glia. 2001 ; 34: 8-17 (Pubitemid 32329027)
14. Morrissey TK, Kleitman N, Bunge RP. Isolation and functional characterization of Schwann cells derived from adult peripheral nerve. J Neurosci. 1991 ; 11: 2433-2442
15. Calderon-Martinez D, Garavito Z, Spinel C, Hurtado H. Schwann cell-enriched cultures from adult human peripheral nerve: a technique combining short enzymatic dissociation and treatment with cytosine arabinoside (Ara-C). J Neurosci Methods. 2002 ; 114: 1-8 (Pubitemid 34163242)
16. McKay Hart A, Brannstrom T, Wiberg M, Terenghi G. Primary sensory neurons and satellite cells after peripheral axotomy in the adult rat: timecourse of cell death and elimination. Exp Brain Res. 2002 ; 142: 308-318 (Pubitemid 34117811)
17. Keilhoff G, Stang F, Goihl A, Wolf G, Fansa H. Transdifferentiated mesenchymal stem cells as alternative therapy in supporting nerve regeneration and myelination. Cell Mol Neurobiol. 2006 ; 26: 1235-1252 (Pubitemid 44924044)
18. Abdallah BM, Kassem M. Human mesenchymal stem cells: from basic biology to clinical applications. Gene Ther. 2008 ; 15: 109-116
19. Bianco P, Riminucci M, Gronthos S, Robey PG. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells. 2001 ; 19: 180-192 (Pubitemid 32524539)
20. Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells. 2007 ; 25: 2896-2902 (Pubitemid 350127874)
21. Deryugina EI, Muller-Sieburg CE. Stromal cells in long-term cultures: keys to the elucidation of hematopoietic development?. Crit Rev Immunol. 1993 ; 13: 115-150 (Pubitemid 24251324)
22. Johnson A, Dorshkind K. Stromal cells in myeloid and lymphoid long-term bone marrow cultures can support multiple hemopoietic lineages and modulate their production of hemopoietic growth factors. Blood. 1986 ; 68: 1348-1354 (Pubitemid 17228814)
23. Dezawa M, Takahashi I, Esaki M, Takano M, Sawada H. Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells. Eur J Neurosci. 2001 ; 14: 1771-1776 (Pubitemid 35463694)
24. Cuevas P, Carceller F, Dujovny M, et al. Peripheral nerve regeneration by bone marrow stromal cells. Neurol Res. 2002 ; 24: 634-638
25. Dezawa M, Kanno H, Hoshino M, et al. Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation. J Clin Invest. 2004 ; 113: 1701-1710 (Pubitemid 39071662)
26. Dezawa M, Hoshino M, Ide C. Treatment of neurodegenerative diseases using adult bone marrow stromal cell-derived neurons. Expert Opin Biol Ther. 2005 ; 5: 427-435 (Pubitemid 40593327)
27. Wang D, Liu XL, Zhu JK, et al. Bridging small-gap peripheral nerve defects using acellular nerve allograft implanted with autologous bone marrow stromal cells in primates. Brain Res. 2008 ; 1188: 44-53 (Pubitemid 350296052)
28. Hu J, Zhu QT, Liu XL, Xu YB, Zhu JK. Repair of extended peripheral nerve lesions in rhesus monkeys using acellular allogenic nerve grafts implanted with autologous mesenchymal stem cells. Exp Neurol. 2007 ; 204: 658-666 (Pubitemid 46497053)
29. Chen X, Wang XD, Chen G, Lin WW, Yao J, Gu XS. Study of in vivo differentiation of rat bone marrow stromal cells into Schwann cell-like cells. Microsurgery. 2006 ; 26: 111-115
30. Ding F, Wu J, Yang Y, et al. Use of tissue-engineered nerve grafts consisting of a chitosan/poly(lactic-co-glycolic acid) -based scaffold included with bone marrow mesenchymal cells for bridging 50-mm dog sciatic nerve gaps. Tissue Eng Part A. 2010 ; 16: 3779-3790
31. Bartunek J, Croissant JD, Wijns W, et al. Pretreatment of adult bone marrow mesenchymal stem cells with cardiomyogenic growth factors and repair of the chronically infarcted myocardium. Am J Physiol Heart Circ Physiol. 2007 ; 292: H1095 - H1104
32. Millis DL, Levine D, Taylor RA Canine Rehabilitation & Physical Therapy. Philadelphia, PA: Saunders ; 2004
33. Yang Y, Ding F, Wu J, et al. Development and evaluation of silk fibroin-based nerve grafts used for peripheral nerve regeneration. Biomaterials. 2007 ; 28: 5526-5535 (Pubitemid 47610691)
34. Lin W, Chen X, Wang X, Liu J, Gu X. Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro. In Vitro Cell Dev Biol Anim. 2008 ; 44: 31-40
35. Mackinnon SE, Dellon AL, Hudson AR, Hunter DA. Nerve regeneration through a pseudosynovial sheath in a primate model. Plast Reconstr Surg. 1985 ; 75: 833-841
36. Hashimoto T, Suzuki Y, Kitada M, et al. Peripheral nerve regeneration through alginate gel: analysis of early outgrowth and late increase in diameter of regenerating axons. Exp Brain Res. 2002 ; 146: 356-368
37. Chamberlain LJ, Yannas IV, Hsu HP, Strichartz G, Spector M. Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft. Exp Neurol. 1998 ; 154: 315-329 (Pubitemid 29044204)
38. Fansa H, Keilhoff G, Wolf G, Schneider W, Gold BG. Tissue engineering of peripheral nerves: a comparison of venous and acellular muscle grafts with cultured Schwann cells. Plast Reconstr Surg. 2001 ; 107: 495-496 (Pubitemid 32125292)
39. Valero-Cabre A, Tsironis K, Skouras E, Perego G, Navarro X, Neiss WF. Superior muscle reinnervation after autologous nerve graft or poly-L-lactide-epsilon-caprolactone (PLC) tube implantation in comparison to silicone tube repair. J Neurosci Res. 2001 ; 63: 214-223 (Pubitemid 32041873)