Ablation of dicer from murine Schwann cells increases their proliferation while blocking myelination

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Bremer, Juliane ^a   O'Connor, Tracy ^a   Tiberi, Cinzia ^a   Rehrauer, Hubert ^b   Weis, Joachim ^c   Aguzzi, Adriano ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DICER; MICRORNA; DEAD BOX PROTEIN; DICER1 PROTEIN, MOUSE; RIBONUCLEASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; MICROARRAY ANALYSIS; MOUSE; MYELINATION; NERVE FIBER; NONHUMAN; PERIPHERAL NERVE; PROTEIN DEPLETION; SCHWANN CELL; UPREGULATION; ANIMAL; CYTOLOGY; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MYELIN SHEATH; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MURINAE;

ANIMALS; CELL PROLIFERATION; DEAD-BOX RNA HELICASES; ENDORIBONUCLEASES; GENE DELETION; GENE EXPRESSION REGULATION; MICE; MICRORNAS; MYELIN SHEATH; SCHWANN CELLS; SIGNAL TRANSDUCTION;

EID: 77957897322     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0012450     Document Type: Article

References (33)

1. Suter U, Scherer SS (2003) Disease mechanisms in inherited neuropathies. Nat Rev Neurosci 4: 714-726.
2. Heuß D (2008) Diagnostik bei Polyneuropathien. DGN guideline.
3. Jessen KR, Mirsky R (2005) The origin and development of glial cells in peripheral nerves. Nat Rev Neurosci 6: 671-682.
4. Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854.
5. Bernstein E, Caudy AA, Hammond SM, Hannon GJ (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409: 363-366.
6. Carthew RW, Sontheimer EJ (2009) Origins and Mechanisms of miRNAs and siRNAs. Cell 136: 642-655.
7. Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, et al. (2003) Dicer is essential for mouse development. Nat Genet 35: 215-217.
8. Lewis MA, Steel KP (2010) MicroRNAs in mouse development and disease. Semin Cell Dev Biol.
9. Schaefer A, O'Carroll D, Tan CL, Hillman D, Sugimori M, et al. (2007) Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med 204: 1553-1558.
10. Davis TH, Cuellar TL, Koch SM, Barker AJ, Harfe BD, et al. (2008) Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci 28: 4322-4330.
11. Dugas JC, Cuellar TL, Scholze A, Ason B, Ibrahim A, et al. (2010) Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron 65: 597-611.
12. Zhao X, He X, Han X, Yu Y, Ye F, et al. (2010) MicroRNA-mediated control of oligodendrocyte differentiation. Neuron 65: 612-626.
13. Lau P, Verrier JD, Nielsen JA, Johnson KR, Notterpek L, et al. (2008) Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes. J Neurosci 28: 11720-11730.
14. Pereira JA, Baumann R, Norrmen C, Somandin C, Miehe M, et al. (2010) Dicer in Schwann cells is required for myelination and axonal integrity. J Neurosci 30: 6763-6775.
15. Woodhoo A, Alonso MB, Droggiti A, Turmaine M, D'Antonio M, et al. (2009) Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci 12: 839-847.
16. Ebenezer GJ, McArthur JC, Thomas D, Murinson B, Hauer P, et al. (2007) Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies. Brain 130: 2703-2714.
17. Harfe BD, McManus MT, Mansfield JH, Hornstein E, Tabin CJ (2005) The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A 102: 10898-10903.
18. Murchison EP, Partridge JF, Tam OH, Cheloufi S, Hannon GJ (2005) Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A 102: 12135-12140.
19. Naiche LA, Papaioannou VE (2007) Cre activity causes widespread apoptosis and lethal anemia during embryonic development. Genesis 45: 768-775.
20. Letzen BS, Liu C, Thakor NV, Gearhart JD, All AH, et al. (2010) MicroRNA expression profiling of oligodendrocyte differentiation from human embryonic stem cells. PLoS One 5: e10480.
21. Verrier JD, Lau P, Hudson L, Murashov AK, Renne R, et al. (2009) Peripheral myelin protein 22 is regulated post-transcriptionally by miRNA-29a. Glia 57: 1265-1279.
22. Li Y, Guessous F, Zhang Y, Dipierro C, Kefas B, et al. (2009) MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res 69: 7569-7576.
23. Guessous F, Zhang Y, Kofman A, Catania A, Li Y, et al. (2010) microRNA-34a is tumor suppressive in brain tumors and glioma stem cells. Cell Cycle 9.
24. Subramanian S, Thayanithy V, West RB, Lee CH, Beck AH, et al. (2010) Genome-wide transcriptome analyses reveal p53 inactivation mediated loss of miR-34a expression in malignant peripheral nerve sheath tumours. J Pathol 220: 58-70.
25. Cheng AM, Byrom MW, Shelton J, Ford LP (2005) Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 33: 1290-1297.
26. Henson BJ, Bhattacharjee S, O'Dee DM, Feingold E, Gollin SM (2009) Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer 48: 569-582.
27. Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW, et al. (2004) The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation. EMBO J 23: 3061-3071.
28. Tapinos N, Rambukkana A (2005) Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli. Proc Natl Acad Sci U S A 102: 9188-9193.
29. Ridley AJ, Paterson HF, Noble M, Land H (1988) Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation. EMBO J 7: 1635-1645.
30. Kim HA, Rosenbaum T, Marchionni MA, Ratner N, DeClue JE (1995) Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes. Oncogene 11: 325-335.
31. Pang RT, Leung CO, Ye TM, Liu W, Chiu PC, et al. (2010) MicroRNA-34a suppresses invasion through down-regulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis.
32. Ogata T, Iijima S, Hoshikawa S, Miura T, Yamamoto S, et al. (2004) Opposing extracellular signal-regulated kinase and Akt pathways control Schwann cell myelination. J Neurosci 24: 6724-6732.
33. Lindeboom F, Gillemans N, Karis A, Jaegle M, Meijer D, et al. (2003) A tissuespecific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse. Nucleic Acids Res 31: 5405-5412.