메뉴 건너뛰기




Volumn 1846, Issue 1, 2014, Pages 142-151

Mucins and tumor resistance to chemotherapeutic drugs

Author keywords

Apoptosis; Cancer; Chemotherapeutic drug; Mucin; Prognosis biomarker; Resistance

Indexed keywords

ANTINEOPLASTIC AGENT; BORTEZOMIB; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DEOXYGLUCOSE; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; GEMCITABINE; LAPATINIB; METHOTREXATE; MUCIN; MUCIN 1; MUCIN 2; MUCIN 3; MUCIN 4; MUCIN 5AC; MUCIN 5B; PACLITAXEL; PLATINUM DERIVATIVE; RHODAMINE 123; TAMOXIFEN; TAXANE DERIVATIVE; TRASTUZUMAB; VINBLASTINE;

EID: 84901413878     PISSN: 0304419X     EISSN: 18792561     Source Type: Journal    
DOI: 10.1016/j.bbcan.2014.04.008     Document Type: Review
Times cited : (83)

References (143)
  • 4
    • 43549093774 scopus 로고    scopus 로고
    • Structure and function of the polymeric mucins in airways mucus
    • Thornton D.J., Rousseau K., McGuckin M.A. Structure and function of the polymeric mucins in airways mucus. Annu. Rev. Physiol. 2008, 70:459-486.
    • (2008) Annu. Rev. Physiol. , vol.70 , pp. 459-486
    • Thornton, D.J.1    Rousseau, K.2    McGuckin, M.A.3
  • 6
    • 2942682904 scopus 로고    scopus 로고
    • MUC1 and the MUCs: a family of human mucins with impact in cancer biology
    • Baldus S.E., Engelmann K., Hanisch F.G. MUC1 and the MUCs: a family of human mucins with impact in cancer biology. Crit. Rev. Clin. Lab. Sci. 2004, 41:189-231.
    • (2004) Crit. Rev. Clin. Lab. Sci. , vol.41 , pp. 189-231
    • Baldus, S.E.1    Engelmann, K.2    Hanisch, F.G.3
  • 7
    • 84874817783 scopus 로고    scopus 로고
    • Mucin-type O-glycosylation during development
    • Tran D.T., Ten Hagen K.G. Mucin-type O-glycosylation during development. J. Biol. Chem. 2013, 288:6921-6929.
    • (2013) J. Biol. Chem. , vol.288 , pp. 6921-6929
    • Tran, D.T.1    Ten Hagen, K.G.2
  • 9
    • 65849285123 scopus 로고    scopus 로고
    • Mucin CYS domains are ancient and highly conserved modules that evolved in concert
    • Desseyn J.L. Mucin CYS domains are ancient and highly conserved modules that evolved in concert. Mol. Phylogenet. Evol. 2009, 52:284-292.
    • (2009) Mol. Phylogenet. Evol. , vol.52 , pp. 284-292
    • Desseyn, J.L.1
  • 11
    • 84880934560 scopus 로고    scopus 로고
    • Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains
    • Backstrom M., Ambort D., Thomsson E., Johansson M.E., Hansson G.C. Increased understanding of the biochemistry and biosynthesis of MUC2 and other gel-forming mucins through the recombinant expression of their protein domains. Mol. Biotechnol. 2013, 54:250-256.
    • (2013) Mol. Biotechnol. , vol.54 , pp. 250-256
    • Backstrom, M.1    Ambort, D.2    Thomsson, E.3    Johansson, M.E.4    Hansson, G.C.5
  • 12
    • 43549126011 scopus 로고    scopus 로고
    • Structure and function of the cell surface (tethered) mucins
    • Hattrup C.L., Gendler S.J. Structure and function of the cell surface (tethered) mucins. Annu. Rev. Physiol. 2008, 70:431-457.
    • (2008) Annu. Rev. Physiol. , vol.70 , pp. 431-457
    • Hattrup, C.L.1    Gendler, S.J.2
  • 13
    • 84877769538 scopus 로고    scopus 로고
    • Membrane-bound mucin modular domains: from structure to function
    • Jonckheere N., Skrypek N., Frenois F., Van Seuningen I. Membrane-bound mucin modular domains: from structure to function. Biochimie 2013, 95:1077-1086.
    • (2013) Biochimie , vol.95 , pp. 1077-1086
    • Jonckheere, N.1    Skrypek, N.2    Frenois, F.3    Van Seuningen, I.4
  • 14
    • 66349096961 scopus 로고    scopus 로고
    • The membrane-bound mucins: how large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene-based and immunotherapies
    • Jonckheere N., Van Seuningen I. The membrane-bound mucins: how large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene-based and immunotherapies. Crit. Rev. Oncog. 2008, 14:177-196.
    • (2008) Crit. Rev. Oncog. , vol.14 , pp. 177-196
    • Jonckheere, N.1    Van Seuningen, I.2
  • 15
    • 39249084422 scopus 로고    scopus 로고
    • Architecture of the large membrane-bound mucins
    • Desseyn J.L., Tetaert D., Gouyer V. Architecture of the large membrane-bound mucins. Gene 2008, 410:215-222.
    • (2008) Gene , vol.410 , pp. 215-222
    • Desseyn, J.L.1    Tetaert, D.2    Gouyer, V.3
  • 16
    • 54249101068 scopus 로고    scopus 로고
    • Focus on molecules: human mucin MUC16
    • Perez B.H., Gipson I.K. Focus on molecules: human mucin MUC16. Exp. Eye Res. 2008, 87:400-401.
    • (2008) Exp. Eye Res. , vol.87 , pp. 400-401
    • Perez, B.H.1    Gipson, I.K.2
  • 17
    • 72149108714 scopus 로고    scopus 로고
    • The membrane-bound mucins: from cell signalling to transcriptional regulation and expression in epithelial cancers
    • Jonckheere N., Van Seuningen I. The membrane-bound mucins: from cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie 2010, 92:1-11.
    • (2010) Biochimie , vol.92 , pp. 1-11
    • Jonckheere, N.1    Van Seuningen, I.2
  • 18
    • 0035490435 scopus 로고    scopus 로고
    • Transcriptional regulation of the 11p15 mucin genes. Towards new biological tools in human therapy, in inflammatory diseases and cancer?
    • Van Seuningen I., Pigny P., Perrais M., Porchet N., Aubert J.P. Transcriptional regulation of the 11p15 mucin genes. Towards new biological tools in human therapy, in inflammatory diseases and cancer?. Front. Biosci. 2001, 6:D1216-D1234.
    • (2001) Front. Biosci. , vol.6
    • Van Seuningen, I.1    Pigny, P.2    Perrais, M.3    Porchet, N.4    Aubert, J.P.5
  • 20
    • 79960260638 scopus 로고    scopus 로고
    • Tumour-associated antigens of mucin O-glycans. Clinical relevance of glycobiology in cancer and inflammatory diseases of the epithelium
    • Research Signpost, Kerala, India, I. Van Seuningen (Ed.)
    • Robbe-Masselot C., Michalski J.C., Capon C. Tumour-associated antigens of mucin O-glycans. Clinical relevance of glycobiology in cancer and inflammatory diseases of the epithelium. The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases 2008, 55-74. Research Signpost, Kerala, India. I. Van Seuningen (Ed.).
    • (2008) The Epithelial Mucins: Structure/Function. Roles in Cancer and Inflammatory Diseases , pp. 55-74
    • Robbe-Masselot, C.1    Michalski, J.C.2    Capon, C.3
  • 21
    • 84856346939 scopus 로고    scopus 로고
    • Assessing mucin expression and function in human ocular surface epithelia in vivo and in vitro
    • Argueso P., Gipson I.K. Assessing mucin expression and function in human ocular surface epithelia in vivo and in vitro. Methods Mol. Biol. 2012, 842:313-325.
    • (2012) Methods Mol. Biol. , vol.842 , pp. 313-325
    • Argueso, P.1    Gipson, I.K.2
  • 22
    • 0347123435 scopus 로고    scopus 로고
    • Mucins in cancer: protection and control of the cell surface
    • Hollingsworth M.A., Swanson B.J. Mucins in cancer: protection and control of the cell surface. Nat. Rev. Cancer 2004, 4:45-60.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 45-60
    • Hollingsworth, M.A.1    Swanson, B.J.2
  • 25
    • 70450247207 scopus 로고    scopus 로고
    • Mucins in cancer: function, prognosis and therapy
    • Kufe D.W. Mucins in cancer: function, prognosis and therapy. Nat. Rev. Cancer 2009, 9:874-885.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 874-885
    • Kufe, D.W.1
  • 27
    • 84866995203 scopus 로고    scopus 로고
    • MUC5B leads to aggressive behavior of breast cancer MCF7 cells
    • Valque H., Gouyer V., Gottrand F., Desseyn J.L. MUC5B leads to aggressive behavior of breast cancer MCF7 cells. PLoS ONE 2012, 7:e46699.
    • (2012) PLoS ONE , vol.7
    • Valque, H.1    Gouyer, V.2    Gottrand, F.3    Desseyn, J.L.4
  • 28
    • 77952452039 scopus 로고    scopus 로고
    • RNA interference suppression of mucin 5AC (MUC5AC) reduces the adhesive and invasive capacity of human pancreatic cancer cells
    • Yamazoe S., Tanaka H., Sawada T., Amano R., Yamada N., Ohira M., Hirakawa K. RNA interference suppression of mucin 5AC (MUC5AC) reduces the adhesive and invasive capacity of human pancreatic cancer cells. J. Exp. Clin. Cancer Res. 2010, 29:53.
    • (2010) J. Exp. Clin. Cancer Res. , vol.29 , pp. 53
    • Yamazoe, S.1    Tanaka, H.2    Sawada, T.3    Amano, R.4    Yamada, N.5    Ohira, M.6    Hirakawa, K.7
  • 30
    • 79956000989 scopus 로고    scopus 로고
    • Mucin 13: structure, function, and potential roles in cancer pathogenesis
    • Maher D.M., Gupta B.K., Nagata S., Jaggi M., Chauhan S.C. Mucin 13: structure, function, and potential roles in cancer pathogenesis. Mol. Cancer Res. 2011, 9:531-537.
    • (2011) Mol. Cancer Res. , vol.9 , pp. 531-537
    • Maher, D.M.1    Gupta, B.K.2    Nagata, S.3    Jaggi, M.4    Chauhan, S.C.5
  • 31
    • 84857118144 scopus 로고    scopus 로고
    • MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells
    • Lakshmanan I., Ponnusamy M.P., Das S., Chakraborty S., Haridas D., Mukhopadhyay P., Lele S.M., Batra S.K. MUC16 induced rapid G2/M transition via interactions with JAK2 for increased proliferation and anti-apoptosis in breast cancer cells. Oncogene 2012, 31:805-817.
    • (2012) Oncogene , vol.31 , pp. 805-817
    • Lakshmanan, I.1    Ponnusamy, M.P.2    Das, S.3    Chakraborty, S.4    Haridas, D.5    Mukhopadhyay, P.6    Lele, S.M.7    Batra, S.K.8
  • 33
    • 0026669773 scopus 로고
    • Expression and characterization of mucins associated with the resistance to methotrexate of human colonic adenocarcinoma cell line HT29
    • Dahiya R., Lesuffleur T., Kwak K.S., Byrd J.C., Barbat A., Zweibaum A., Kim Y.S. Expression and characterization of mucins associated with the resistance to methotrexate of human colonic adenocarcinoma cell line HT29. Cancer Res. 1992, 52:4655-4662.
    • (1992) Cancer Res. , vol.52 , pp. 4655-4662
    • Dahiya, R.1    Lesuffleur, T.2    Kwak, K.S.3    Byrd, J.C.4    Barbat, A.5    Zweibaum, A.6    Kim, Y.S.7
  • 34
    • 0027437938 scopus 로고
    • Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations
    • Lesuffleur T., Porchet N., Aubert J.P., Swallow D., Gum J.R., Kim Y.S., Real F.X., Zweibaum A. Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations. J. Cell Sci. 1993, 106(Pt 3):771-783.
    • (1993) J. Cell Sci. , vol.106 , Issue.Pt 3 , pp. 771-783
    • Lesuffleur, T.1    Porchet, N.2    Aubert, J.P.3    Swallow, D.4    Gum, J.R.5    Kim, Y.S.6    Real, F.X.7    Zweibaum, A.8
  • 35
    • 1642381066 scopus 로고    scopus 로고
    • Differential mucin expression in colon carcinoma HT-29 clones with variable resistance to 5-fluorouracil and methotrexate
    • Leteurtre E., Gouyer V., Rousseau K., Moreau O., Barbat A., Swallow D., Huet G., Lesuffleur T. Differential mucin expression in colon carcinoma HT-29 clones with variable resistance to 5-fluorouracil and methotrexate. Biol. Cell. 2004, 96:145-151.
    • (2004) Biol. Cell. , vol.96 , pp. 145-151
    • Leteurtre, E.1    Gouyer, V.2    Rousseau, K.3    Moreau, O.4    Barbat, A.5    Swallow, D.6    Huet, G.7    Lesuffleur, T.8
  • 36
    • 70349895167 scopus 로고    scopus 로고
    • MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells
    • Fessler S.P., Wotkowicz M.T., Mahanta S.K., Bamdad C. MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells. Breast Cancer Res. Treat. 2009, 118:113-124.
    • (2009) Breast Cancer Res. Treat. , vol.118 , pp. 113-124
    • Fessler, S.P.1    Wotkowicz, M.T.2    Mahanta, S.K.3    Bamdad, C.4
  • 37
    • 84877122771 scopus 로고    scopus 로고
    • Effect of MUC1 siRNA on drug resistance of gastric cancer cells to trastuzumab
    • Deng M., Jing D.D., Meng X.J. Effect of MUC1 siRNA on drug resistance of gastric cancer cells to trastuzumab. Asian Pac. J. Cancer Prev. 2013, 14:127-131.
    • (2013) Asian Pac. J. Cancer Prev. , vol.14 , pp. 127-131
    • Deng, M.1    Jing, D.D.2    Meng, X.J.3
  • 38
    • 84878026061 scopus 로고    scopus 로고
    • Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression
    • Shi M., Yang Z., Hu M., Liu D., Hu Y., Qian L., Zhang W., Chen H., Guo L., Yu M., Song L., Ma Y., Guo N. Catecholamine-Induced beta2-adrenergic receptor activation mediates desensitization of gastric cancer cells to trastuzumab by upregulating MUC4 expression. J. Immunol. 2013, 190:5600-5608.
    • (2013) J. Immunol. , vol.190 , pp. 5600-5608
    • Shi, M.1    Yang, Z.2    Hu, M.3    Liu, D.4    Hu, Y.5    Qian, L.6    Zhang, W.7    Chen, H.8    Guo, L.9    Yu, M.10    Song, L.11    Ma, Y.12    Guo, N.13
  • 40
    • 70349653064 scopus 로고    scopus 로고
    • Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin
    • Bafna S., Kaur S., Momi N., Batra S.K. Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin. Br. J. Cancer 2009, 101:1155-1161.
    • (2009) Br. J. Cancer , vol.101 , pp. 1155-1161
    • Bafna, S.1    Kaur, S.2    Momi, N.3    Batra, S.K.4
  • 41
    • 77950828177 scopus 로고    scopus 로고
    • MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies
    • Mimeault M., Johansson S.L., Senapati S., Momi N., Chakraborty S., Batra S.K. MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies. Cancer Lett. 2010, 295:69-84.
    • (2010) Cancer Lett. , vol.295 , pp. 69-84
    • Mimeault, M.1    Johansson, S.L.2    Senapati, S.3    Momi, N.4    Chakraborty, S.5    Batra, S.K.6
  • 42
    • 84875887000 scopus 로고    scopus 로고
    • The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family
    • Skrypek N., Duchene B., Hebbar M., Leteurtre E., van Seuningen I., Jonckheere N. The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. Oncogene 2013, 32:1714-1723.
    • (2013) Oncogene , vol.32 , pp. 1714-1723
    • Skrypek, N.1    Duchene, B.2    Hebbar, M.3    Leteurtre, E.4    van Seuningen, I.5    Jonckheere, N.6
  • 43
    • 84860266586 scopus 로고    scopus 로고
    • Mucin production determines sensitivity to bortezomib and gemcitabine in pancreatic cancer cells
    • Wissniowski T.T., Meister S., Hahn E.G., Kalden J.R., Voll R., Ocker M. Mucin production determines sensitivity to bortezomib and gemcitabine in pancreatic cancer cells. Int. J. Oncol. 2012, 40:1581-1589.
    • (2012) Int. J. Oncol. , vol.40 , pp. 1581-1589
    • Wissniowski, T.T.1    Meister, S.2    Hahn, E.G.3    Kalden, J.R.4    Voll, R.5    Ocker, M.6
  • 44
    • 0038403798 scopus 로고    scopus 로고
    • Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells
    • Hu Y.P., Haq B., Carraway K.L., Savaraj N., Lampidis T.J. Multidrug resistance correlates with overexpression of Muc4 but inversely with P-glycoprotein and multidrug resistance related protein in transfected human melanoma cells. Biochem. Pharmacol. 2003, 65:1419-1425.
    • (2003) Biochem. Pharmacol. , vol.65 , pp. 1419-1425
    • Hu, Y.P.1    Haq, B.2    Carraway, K.L.3    Savaraj, N.4    Lampidis, T.J.5
  • 46
    • 84862528416 scopus 로고    scopus 로고
    • The differences in the histological types of breast cancer and the response to neoadjuvant chemotherapy: the relationship between the outcome and the clinicopathological characteristics
    • Nagao T., Kinoshita T., Hojo T., Tsuda H., Tamura K., Fujiwara Y. The differences in the histological types of breast cancer and the response to neoadjuvant chemotherapy: the relationship between the outcome and the clinicopathological characteristics. Breast 2012, 21:289-295.
    • (2012) Breast , vol.21 , pp. 289-295
    • Nagao, T.1    Kinoshita, T.2    Hojo, T.3    Tsuda, H.4    Tamura, K.5    Fujiwara, Y.6
  • 48
    • 77956821072 scopus 로고    scopus 로고
    • Pathologic response rate after concomitant neo-adjuvant radiotherapy and chemotherapy for adenocarcinoma of the uterine cervix: a retrospective multicentric study
    • Poujade O., Morice P., Rouzier R., Madelenat P., Lecuru F., Muray J.M., Mathevet P., Alran S., Salmon R.J., Reyal F. Pathologic response rate after concomitant neo-adjuvant radiotherapy and chemotherapy for adenocarcinoma of the uterine cervix: a retrospective multicentric study. Int. J. Gynecol. Cancer 2010, 20:815-820.
    • (2010) Int. J. Gynecol. Cancer , vol.20 , pp. 815-820
    • Poujade, O.1    Morice, P.2    Rouzier, R.3    Madelenat, P.4    Lecuru, F.5    Muray, J.M.6    Mathevet, P.7    Alran, S.8    Salmon, R.J.9    Reyal, F.10
  • 49
    • 80255125997 scopus 로고    scopus 로고
    • The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study
    • (discussion 693)
    • Messager M., Lefevre J.H., Pichot-Delahaye V., Souadka A., Piessen G., Mariette C. The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. Ann. Surg. 2011, 254:684-693. (discussion 693).
    • (2011) Ann. Surg. , vol.254 , pp. 684-693
    • Messager, M.1    Lefevre, J.H.2    Pichot-Delahaye, V.3    Souadka, A.4    Piessen, G.5    Mariette, C.6
  • 51
    • 65249127544 scopus 로고    scopus 로고
    • MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment
    • Pitroda S.P., Khodarev N.N., Beckett M.A., Kufe D.W., Weichselbaum R.R. MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:5837-5841.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 5837-5841
    • Pitroda, S.P.1    Khodarev, N.N.2    Beckett, M.A.3    Kufe, D.W.4    Weichselbaum, R.R.5
  • 52
    • 16644362068 scopus 로고    scopus 로고
    • Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer
    • Takano M., Fujii K., Kita T., Kikuchi Y., Uchida K. Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer. Oncol. Rep. 2004, 12:1177-1182.
    • (2004) Oncol. Rep. , vol.12 , pp. 1177-1182
    • Takano, M.1    Fujii, K.2    Kita, T.3    Kikuchi, Y.4    Uchida, K.5
  • 53
    • 84878438650 scopus 로고    scopus 로고
    • Chemoresistance is associated with MUC1 and Lewis y antigen expression in ovarian epithelial cancers
    • Zhang D., Gao J., Zhu L., Hu Z., Hou R., Liu S., Tan M., Liu J., Lin B. Chemoresistance is associated with MUC1 and Lewis y antigen expression in ovarian epithelial cancers. Int. J. Mol. Sci. 2013, 14:11024-11033.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 11024-11033
    • Zhang, D.1    Gao, J.2    Zhu, L.3    Hu, Z.4    Hou, R.5    Liu, S.6    Tan, M.7    Liu, J.8    Lin, B.9
  • 54
    • 0029979921 scopus 로고    scopus 로고
    • Drug diffusion through cystic fibrotic mucus: steady-state permeation, rheologic properties, and glycoprotein morphology
    • Bhat P.G., Flanagan D.R., Donovan M.D. Drug diffusion through cystic fibrotic mucus: steady-state permeation, rheologic properties, and glycoprotein morphology. J. Pharm. Sci. 1996, 85:624-630.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 624-630
    • Bhat, P.G.1    Flanagan, D.R.2    Donovan, M.D.3
  • 55
    • 12344314225 scopus 로고    scopus 로고
    • The influence of excipients on the diffusion of ibuprofen and paracetamol in gastric mucus
    • Shaw L.R., Irwin W.J., Grattan T.J., Conway B.R. The influence of excipients on the diffusion of ibuprofen and paracetamol in gastric mucus. Int. J. Pharm. 2005, 290:145-154.
    • (2005) Int. J. Pharm. , vol.290 , pp. 145-154
    • Shaw, L.R.1    Irwin, W.J.2    Grattan, T.J.3    Conway, B.R.4
  • 58
    • 34948826922 scopus 로고    scopus 로고
    • Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: overcoming cellular barriers for therapeutic gain
    • Kalra A.V., Campbell R.B. Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: overcoming cellular barriers for therapeutic gain. Br. J. Cancer 2007, 97:910-918.
    • (2007) Br. J. Cancer , vol.97 , pp. 910-918
    • Kalra, A.V.1    Campbell, R.B.2
  • 59
    • 0037372855 scopus 로고    scopus 로고
    • Induction of a storage phenotype and abnormal intracellular localization of apical glycoproteins are two independent responses to GalNAcalpha-O-bn
    • Leteurtre E., Gouyer V., Delacour D., Hemon B., Pons A., Richet C., Zanetta J.P., Huet G. Induction of a storage phenotype and abnormal intracellular localization of apical glycoproteins are two independent responses to GalNAcalpha-O-bn. J. Histochem. Cytochem. 2003, 51:349-361.
    • (2003) J. Histochem. Cytochem. , vol.51 , pp. 349-361
    • Leteurtre, E.1    Gouyer, V.2    Delacour, D.3    Hemon, B.4    Pons, A.5    Richet, C.6    Zanetta, J.P.7    Huet, G.8
  • 60
    • 57649171078 scopus 로고    scopus 로고
    • Mucin overexpression limits the effectiveness of 5-FU by reducing intracellular drug uptake and antineoplastic drug effects in pancreatic tumours
    • Kalra A.V., Campbell R.B. Mucin overexpression limits the effectiveness of 5-FU by reducing intracellular drug uptake and antineoplastic drug effects in pancreatic tumours. Eur. J. Cancer 2009, 45:164-173.
    • (2009) Eur. J. Cancer , vol.45 , pp. 164-173
    • Kalra, A.V.1    Campbell, R.B.2
  • 61
    • 33847656731 scopus 로고    scopus 로고
    • Diffusion of nutrients molecules and model drug carriers through mucin layer investigated by magnetic resonance imaging with chemical shift resolution
    • Lafitte G., Thuresson K., Soderman O. Diffusion of nutrients molecules and model drug carriers through mucin layer investigated by magnetic resonance imaging with chemical shift resolution. J. Pharm. Sci. 2007, 96:258-263.
    • (2007) J. Pharm. Sci. , vol.96 , pp. 258-263
    • Lafitte, G.1    Thuresson, K.2    Soderman, O.3
  • 63
    • 0033135026 scopus 로고    scopus 로고
    • Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells
    • Komatsu M., Yee L., Carraway K.L. Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells. Cancer Res. 1999, 59:2229-2236.
    • (1999) Cancer Res. , vol.59 , pp. 2229-2236
    • Komatsu, M.1    Yee, L.2    Carraway, K.L.3
  • 65
    • 0037142184 scopus 로고    scopus 로고
    • Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance
    • Price-Schiavi S.A., Jepson S., Li P., Arango M., Rudland P.S., Yee L., Carraway K.L. Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance. Int. J. Cancer 2002, 99:783-791.
    • (2002) Int. J. Cancer , vol.99 , pp. 783-791
    • Price-Schiavi, S.A.1    Jepson, S.2    Li, P.3    Arango, M.4    Rudland, P.S.5    Yee, L.6    Carraway, K.L.7
  • 66
    • 12544250996 scopus 로고    scopus 로고
    • Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line
    • Nagy P., Friedlander E., Tanner M., Kapanen A.I., Carraway K.L., Isola J., Jovin T.M. Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line. Cancer Res. 2005, 65:473-482.
    • (2005) Cancer Res. , vol.65 , pp. 473-482
    • Nagy, P.1    Friedlander, E.2    Tanner, M.3    Kapanen, A.I.4    Carraway, K.L.5    Isola, J.6    Jovin, T.M.7
  • 68
    • 13844262819 scopus 로고    scopus 로고
    • Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
    • Wei X., Xu H., Kufe D. Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 2005, 7:167-178.
    • (2005) Cancer Cell , vol.7 , pp. 167-178
    • Wei, X.1    Xu, H.2    Kufe, D.3
  • 69
    • 84862304215 scopus 로고    scopus 로고
    • The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function
    • Ahmad R., Alam M., Rajabi H., Kufe D. The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J. Biol. Chem. 2012, 287:20866-20875.
    • (2012) J. Biol. Chem. , vol.287 , pp. 20866-20875
    • Ahmad, R.1    Alam, M.2    Rajabi, H.3    Kufe, D.4
  • 70
    • 33748055445 scopus 로고    scopus 로고
    • MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage
    • Raina D., Ahmad R., Kumar S., Ren J., Yoshida K., Kharbanda S., Kufe D. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J. 2006, 25:3774-3783.
    • (2006) EMBO J. , vol.25 , pp. 3774-3783
    • Raina, D.1    Ahmad, R.2    Kumar, S.3    Ren, J.4    Yoshida, K.5    Kharbanda, S.6    Kufe, D.7
  • 72
    • 36749092728 scopus 로고    scopus 로고
    • MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling
    • Ahmad R., Raina D., Trivedi V., Ren J., Rajabi H., Kharbanda S., Kufe D. MUC1 oncoprotein activates the IkappaB kinase beta complex and constitutive NF-kappaB signalling. Nat. Cell Biol. 2007, 9:1419-1427.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1419-1427
    • Ahmad, R.1    Raina, D.2    Trivedi, V.3    Ren, J.4    Rajabi, H.5    Kharbanda, S.6    Kufe, D.7
  • 73
    • 51049090388 scopus 로고    scopus 로고
    • MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8
    • Agata N., Ahmad R., Kawano T., Raina D., Kharbanda S., Kufe D. MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8. Cancer Res. 2008, 68:6136-6144.
    • (2008) Cancer Res. , vol.68 , pp. 6136-6144
    • Agata, N.1    Ahmad, R.2    Kawano, T.3    Raina, D.4    Kharbanda, S.5    Kufe, D.6
  • 75
    • 43449100667 scopus 로고    scopus 로고
    • Reactive oxygen species: current knowledge and applications in cancer research and therapeutic
    • Lau A.T., Wang Y., Chiu J.F. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J. Cell. Biochem. 2008, 104:657-667.
    • (2008) J. Cell. Biochem. , vol.104 , pp. 657-667
    • Lau, A.T.1    Wang, Y.2    Chiu, J.F.3
  • 76
    • 17244367828 scopus 로고    scopus 로고
    • Reactive oxygen species in tumor progression
    • Storz P. Reactive oxygen species in tumor progression. Front. Biosci. 2005, 10:1881-1896.
    • (2005) Front. Biosci. , vol.10 , pp. 1881-1896
    • Storz, P.1
  • 77
    • 0042818006 scopus 로고    scopus 로고
    • Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress
    • Yin L., Li Y., Ren J., Kuwahara H., Kufe D. Human MUC1 carcinoma antigen regulates intracellular oxidant levels and the apoptotic response to oxidative stress. J. Biol. Chem. 2003, 278:35458-35464.
    • (2003) J. Biol. Chem. , vol.278 , pp. 35458-35464
    • Yin, L.1    Li, Y.2    Ren, J.3    Kuwahara, H.4    Kufe, D.5
  • 78
    • 7944230166 scopus 로고    scopus 로고
    • MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress
    • Yin L., Huang L., Kufe D. MUC1 oncoprotein activates the FOXO3a transcription factor in a survival response to oxidative stress. J. Biol. Chem. 2004, 279:45721-45727.
    • (2004) J. Biol. Chem. , vol.279 , pp. 45721-45727
    • Yin, L.1    Huang, L.2    Kufe, D.3
  • 79
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygen species: a breath of life or death?
    • Fruehauf J.P., Meyskens F.L. Reactive oxygen species: a breath of life or death?. Clin. Cancer Res. 2007, 13:789-794.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens, F.L.2
  • 81
    • 34248218177 scopus 로고    scopus 로고
    • MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins
    • Chaturvedi P., Singh A.P., Moniaux N., Senapati S., Chakraborty S., Meza J.L., Batra S.K. MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins. Mol. Cancer Res. 2007, 5:309-320.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 309-320
    • Chaturvedi, P.1    Singh, A.P.2    Moniaux, N.3    Senapati, S.4    Chakraborty, S.5    Meza, J.L.6    Batra, S.K.7
  • 83
    • 77952140698 scopus 로고    scopus 로고
    • Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies
    • Torres M.P., Ponnusamy M.P., Chakraborty S., Smith L.M., Das S., Arafat H.A., Batra S.K. Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol. Cancer Ther. 2010, 9:1419-1431.
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1419-1431
    • Torres, M.P.1    Ponnusamy, M.P.2    Chakraborty, S.3    Smith, L.M.4    Das, S.5    Arafat, H.A.6    Batra, S.K.7
  • 85
    • 0035945663 scopus 로고    scopus 로고
    • Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor
    • Komatsu M., Jepson S., Arango M.E., Carothers Carraway C.A., Carraway K.L. Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor. Oncogene 2001, 20:461-470.
    • (2001) Oncogene , vol.20 , pp. 461-470
    • Komatsu, M.1    Jepson, S.2    Arango, M.E.3    Carothers Carraway, C.A.4    Carraway, K.L.5
  • 86
    • 0037168129 scopus 로고    scopus 로고
    • Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways
    • Jepson S., Komatsu M., Haq B., Arango M.E., Huang D., Carraway C.A., Carraway K.L. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene 2002, 21:7524-7532.
    • (2002) Oncogene , vol.21 , pp. 7524-7532
    • Jepson, S.1    Komatsu, M.2    Haq, B.3    Arango, M.E.4    Huang, D.5    Carraway, C.A.6    Carraway, K.L.7
  • 87
    • 66149143976 scopus 로고    scopus 로고
    • The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms
    • Workman H.C., Sweeney C., Carraway K.L. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer Res. 2009, 69:2845-2852.
    • (2009) Cancer Res. , vol.69 , pp. 2845-2852
    • Workman, H.C.1    Sweeney, C.2    Carraway, K.L.3
  • 91
    • 40949121607 scopus 로고    scopus 로고
    • ABC multidrug transporters: structure, function and role in chemoresistance
    • Sharom F.J. ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics 2008, 9:105-127.
    • (2008) Pharmacogenomics , vol.9 , pp. 105-127
    • Sharom, F.J.1
  • 92
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves M., Maley C.C. Clonal evolution in cancer. Nature 2012, 481:306-313.
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.C.2
  • 93
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., Lander E.S. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659.
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6    Lander, E.S.7
  • 94
    • 84886695948 scopus 로고    scopus 로고
    • MUC1-C oncoprotein activates ERK→C/EBPbeta signaling and induction of aldehyde dehydrogenase 1A1 in breast cancer cells
    • Alam M., Ahmad R., Rajabi H., Kharbanda A., Kufe D. MUC1-C oncoprotein activates ERK→C/EBPbeta signaling and induction of aldehyde dehydrogenase 1A1 in breast cancer cells. J. Biol. Chem. 2013, 288:30892-30903.
    • (2013) J. Biol. Chem. , vol.288 , pp. 30892-30903
    • Alam, M.1    Ahmad, R.2    Rajabi, H.3    Kharbanda, A.4    Kufe, D.5
  • 96
    • 79955105128 scopus 로고    scopus 로고
    • MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells
    • Ponnusamy M.P., Seshacharyulu P., Vaz A., Dey P., Batra S.K. MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells. J. Ovarian Res. 2011, 4:7.
    • (2011) J. Ovarian Res. , vol.4 , pp. 7
    • Ponnusamy, M.P.1    Seshacharyulu, P.2    Vaz, A.3    Dey, P.4    Batra, S.K.5
  • 99
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 100
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 2006, 7:131-142.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 101
    • 84877928478 scopus 로고    scopus 로고
    • Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs
    • Lamouille S., Subramanyam D., Blelloch R., Derynck R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr. Opin. Cell Biol. 2013, 25:200-207.
    • (2013) Curr. Opin. Cell Biol. , vol.25 , pp. 200-207
    • Lamouille, S.1    Subramanyam, D.2    Blelloch, R.3    Derynck, R.4
  • 102
    • 84857119664 scopus 로고    scopus 로고
    • Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression
    • Wendt M.K., Tian M., Schiemann W.P. Deconstructing the mechanisms and consequences of TGF-beta-induced EMT during cancer progression. Cell Tissue Res. 2012, 347:85-101.
    • (2012) Cell Tissue Res. , vol.347 , pp. 85-101
    • Wendt, M.K.1    Tian, M.2    Schiemann, W.P.3
  • 103
    • 77952855239 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer
    • Ahmed N., Abubaker K., Findlay J., Quinn M. Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer. Curr. Cancer Drug Targets 2010, 10:268-278.
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 268-278
    • Ahmed, N.1    Abubaker, K.2    Findlay, J.3    Quinn, M.4
  • 104
    • 84879171839 scopus 로고    scopus 로고
    • SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance
    • Lim S., Becker A., Zimmer A., Lu J., Buettner R., Kirfel J. SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS ONE 2013, 8:e66558.
    • (2013) PLoS ONE , vol.8
    • Lim, S.1    Becker, A.2    Zimmer, A.3    Lu, J.4    Buettner, R.5    Kirfel, J.6
  • 105
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic
    • Voulgari A., Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim. Biophys. Acta 2009, 1796:75-90.
    • (2009) Biochim. Biophys. Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 107
    • 79952704437 scopus 로고    scopus 로고
    • Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH:OVCAR3 ovarian carcinoma cells
    • Comamala M., Pinard M., Theriault C., Matte I., Albert A., Boivin M., Beaudin J., Piche A., Rancourt C. Downregulation of cell surface CA125/MUC16 induces epithelial-to-mesenchymal transition and restores EGFR signalling in NIH:OVCAR3 ovarian carcinoma cells. Br. J. Cancer 2011, 104:989-999.
    • (2011) Br. J. Cancer , vol.104 , pp. 989-999
    • Comamala, M.1    Pinard, M.2    Theriault, C.3    Matte, I.4    Albert, A.5    Boivin, M.6    Beaudin, J.7    Piche, A.8    Rancourt, C.9
  • 108
    • 64049093492 scopus 로고    scopus 로고
    • ERK and PI3K regulate different aspects of the epithelial to mesenchymal transition of mammary tumor cells induced by truncated MUC1
    • Horn G., Gaziel A., Wreschner D.H., Smorodinsky N.I., Ehrlich M. ERK and PI3K regulate different aspects of the epithelial to mesenchymal transition of mammary tumor cells induced by truncated MUC1. Exp. Cell Res. 2009, 315:1490-1504.
    • (2009) Exp. Cell Res. , vol.315 , pp. 1490-1504
    • Horn, G.1    Gaziel, A.2    Wreschner, D.H.3    Smorodinsky, N.I.4    Ehrlich, M.5
  • 110
    • 77958451128 scopus 로고    scopus 로고
    • MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells
    • Ponnusamy M.P., Lakshmanan I., Jain M., Das S., Chakraborty S., Dey P., Batra S.K. MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. Oncogene 2010, 29:5741-5754.
    • (2010) Oncogene , vol.29 , pp. 5741-5754
    • Ponnusamy, M.P.1    Lakshmanan, I.2    Jain, M.3    Das, S.4    Chakraborty, S.5    Dey, P.6    Batra, S.K.7
  • 111
    • 84898014554 scopus 로고    scopus 로고
    • MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition
    • Rajabi H., Alam M., Takahashi H., Kharbanda A., Guha M., Ahmad R., Kufe D. MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene 2014, 33:1680-1689.
    • (2014) Oncogene , vol.33 , pp. 1680-1689
    • Rajabi, H.1    Alam, M.2    Takahashi, H.3    Kharbanda, A.4    Guha, M.5    Ahmad, R.6    Kufe, D.7
  • 113
    • 84899092745 scopus 로고    scopus 로고
    • Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis
    • Gao L., Liu J., Zhang B., Zhang H., Wang D., Zhang T., Liu Y., Wang C. Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Tumour Biol. 2014, 35:1335-1341.
    • (2014) Tumour Biol. , vol.35 , pp. 1335-1341
    • Gao, L.1    Liu, J.2    Zhang, B.3    Zhang, H.4    Wang, D.5    Zhang, T.6    Liu, Y.7    Wang, C.8
  • 114
    • 84898790695 scopus 로고    scopus 로고
    • Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press
    • Jonckheere N., Van Seuningen I. Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press. Tumour Biol. 2014, 35:3941-3942.
    • (2014) Tumour Biol. , vol.35 , pp. 3941-3942
    • Jonckheere, N.1    Van Seuningen, I.2
  • 115
    • 84874501842 scopus 로고    scopus 로고
    • ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression
    • Fujii T., Shimada K., Anai S., Fujimoto K., Konishi N. ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression. Cancer Sci. 2013, 104:321-327.
    • (2013) Cancer Sci. , vol.104 , pp. 321-327
    • Fujii, T.1    Shimada, K.2    Anai, S.3    Fujimoto, K.4    Konishi, N.5
  • 117
    • 84897029728 scopus 로고    scopus 로고
    • Clinical impact of genetic variants of drug transporters in different ethnic groups within and across regions
    • Ono C., Kikkawa H., Suzuki A., Suzuki M., Yamamoto Y., Ichikawa K., Fukae M., Ieiri I. Clinical impact of genetic variants of drug transporters in different ethnic groups within and across regions. Pharmacogenomics 2013, 14:1745-1764.
    • (2013) Pharmacogenomics , vol.14 , pp. 1745-1764
    • Ono, C.1    Kikkawa, H.2    Suzuki, A.3    Suzuki, M.4    Yamamoto, Y.5    Ichikawa, K.6    Fukae, M.7    Ieiri, I.8
  • 118
    • 79960535705 scopus 로고    scopus 로고
    • Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs
    • Sai K., Saito Y. Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs. Expert Opin. Drug Metab. Toxicol. 2011, 7:967-988.
    • (2011) Expert Opin. Drug Metab. Toxicol. , vol.7 , pp. 967-988
    • Sai, K.1    Saito, Y.2
  • 124
    • 84856347243 scopus 로고    scopus 로고
    • Gel-forming and cell-associated mucins: preparation for structural and functional studies
    • Davies J.R., Wickstrom C., Thornton D.J. Gel-forming and cell-associated mucins: preparation for structural and functional studies. Methods Mol. Biol. 2012, 842:27-47.
    • (2012) Methods Mol. Biol. , vol.842 , pp. 27-47
    • Davies, J.R.1    Wickstrom, C.2    Thornton, D.J.3
  • 125
    • 77954897999 scopus 로고    scopus 로고
    • Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function
    • Yin L., Ahmad R., Kosugi M., Kufe T., Vasir B., Avigan D., Kharbanda S., Kufe D. Survival of human multiple myeloma cells is dependent on MUC1 C-terminal transmembrane subunit oncoprotein function. Mol. Pharmacol. 2010, 78:166-174.
    • (2010) Mol. Pharmacol. , vol.78 , pp. 166-174
    • Yin, L.1    Ahmad, R.2    Kosugi, M.3    Kufe, T.4    Vasir, B.5    Avigan, D.6    Kharbanda, S.7    Kufe, D.8
  • 126
    • 84880534957 scopus 로고    scopus 로고
    • Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer
    • Kharbanda A., Rajabi H., Jin C., Raina D., Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol. Cancer Res. 2013, 11:714-723.
    • (2013) Mol. Cancer Res. , vol.11 , pp. 714-723
    • Kharbanda, A.1    Rajabi, H.2    Jin, C.3    Raina, D.4    Kufe, D.5
  • 128
    • 84873481897 scopus 로고    scopus 로고
    • Inhibition of the MUC1-C oncoprotein is synergistic with cytotoxic agents in the treatment of breast cancer cells
    • Uchida Y., Raina D., Kharbanda S., Kufe D. Inhibition of the MUC1-C oncoprotein is synergistic with cytotoxic agents in the treatment of breast cancer cells. Cancer Biol. Ther. 2013, 14:127-134.
    • (2013) Cancer Biol. Ther. , vol.14 , pp. 127-134
    • Uchida, Y.1    Raina, D.2    Kharbanda, S.3    Kufe, D.4
  • 130
    • 51349164401 scopus 로고    scopus 로고
    • Strategies used for MUC1 immunotherapy: preclinical studies
    • Tang C.K., Apostolopoulos V. Strategies used for MUC1 immunotherapy: preclinical studies. Expert Rev. Vaccines 2008, 7:951-962.
    • (2008) Expert Rev. Vaccines , vol.7 , pp. 951-962
    • Tang, C.K.1    Apostolopoulos, V.2
  • 131
    • 51349116036 scopus 로고    scopus 로고
    • Strategies used for MUC1 immunotherapy: human clinical studies
    • Tang C.K., Katsara M., Apostolopoulos V. Strategies used for MUC1 immunotherapy: human clinical studies. Expert Rev. Vaccines 2008, 7:963-975.
    • (2008) Expert Rev. Vaccines , vol.7 , pp. 963-975
    • Tang, C.K.1    Katsara, M.2    Apostolopoulos, V.3
  • 134
    • 84866883611 scopus 로고    scopus 로고
    • Reversal of paclitaxel resistance in epithelial ovarian carcinoma cells by a MUC1 aptamer-let-7i chimera
    • Liu N., Zhou C., Zhao J., Chen Y. Reversal of paclitaxel resistance in epithelial ovarian carcinoma cells by a MUC1 aptamer-let-7i chimera. Cancer Investig. 2012, 30:577-582.
    • (2012) Cancer Investig. , vol.30 , pp. 577-582
    • Liu, N.1    Zhou, C.2    Zhao, J.3    Chen, Y.4
  • 135
    • 84886091090 scopus 로고    scopus 로고
    • The anti-chemoresistant effect and mechanism of MUC1 aptamer-miR-29b chimera in ovarian cancer
    • Dai F., Zhang Y., Zhu X., Shan N., Chen Y. The anti-chemoresistant effect and mechanism of MUC1 aptamer-miR-29b chimera in ovarian cancer. Gynecol. Oncol. 2013, 131:451-459.
    • (2013) Gynecol. Oncol. , vol.131 , pp. 451-459
    • Dai, F.1    Zhang, Y.2    Zhu, X.3    Shan, N.4    Chen, Y.5
  • 136
    • 84871722734 scopus 로고    scopus 로고
    • Tumor markers in clinical practice: a review focusing on common solid cancers
    • Duffy M.J. Tumor markers in clinical practice: a review focusing on common solid cancers. Med. Princ. Pract. 2013, 22:4-11.
    • (2013) Med. Princ. Pract. , vol.22 , pp. 4-11
    • Duffy, M.J.1
  • 138
    • 77449146259 scopus 로고    scopus 로고
    • Clinical significance of acellular mucin in rectal adenocarcinoma patients with a pathologic complete response to preoperative chemoradiation
    • Smith K.D., Tan D., Das P., Chang G.J., Kattepogu K., Feig B.W., Skibber J.M., Rodriguez-Bigas M.A. Clinical significance of acellular mucin in rectal adenocarcinoma patients with a pathologic complete response to preoperative chemoradiation. Ann. Surg. 2010, 251:261-264.
    • (2010) Ann. Surg. , vol.251 , pp. 261-264
    • Smith, K.D.1    Tan, D.2    Das, P.3    Chang, G.J.4    Kattepogu, K.5    Feig, B.W.6    Skibber, J.M.7    Rodriguez-Bigas, M.A.8
  • 142
    • 80052312067 scopus 로고    scopus 로고
    • Kinetics of CEA and CA15-3 correlate with treatment response in patients undergoing chemotherapy for metastatic breast cancer (MBC)
    • Di Gioia D., Heinemann V., Nagel D., Untch M., Kahlert S., Bauerfeind I., Koehnke T., Stieber P. Kinetics of CEA and CA15-3 correlate with treatment response in patients undergoing chemotherapy for metastatic breast cancer (MBC). Tumour Biol. 2011, 32:777-785.
    • (2011) Tumour Biol. , vol.32 , pp. 777-785
    • Di Gioia, D.1    Heinemann, V.2    Nagel, D.3    Untch, M.4    Kahlert, S.5    Bauerfeind, I.6    Koehnke, T.7    Stieber, P.8
  • 143
    • 79954466229 scopus 로고    scopus 로고
    • MUC1-positive circulating tumor cells and MUC1 protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer
    • Cheng J.P., Yan Y., Wang X.Y., Lu Y.L., Yuan Y.H., Jia J., Ren J. MUC1-positive circulating tumor cells and MUC1 protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer. Chin. J. Cancer 2011, 30:54-61.
    • (2011) Chin. J. Cancer , vol.30 , pp. 54-61
    • Cheng, J.P.1    Yan, Y.2    Wang, X.Y.3    Lu, Y.L.4    Yuan, Y.H.5    Jia, J.6    Ren, J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.