메뉴 건너뛰기




Volumn 7, Issue 7, 2008, Pages 963-975

Strategies used for MUC1 immunotherapy: Human clinical studies

Author keywords

Antigen delivery; Cancer; Clinical trial; Human study; Immunotherapy; MUC1; Mucin; Vaccine

Indexed keywords

BCG VACCINE; BLP 25; CANCER VACCINE; CARCINOEMBRYONIC ANTIGEN; CD164 ANTIGEN; CD34 ANTIBODY; CELL ADHESION MOLECULE; COMPLEMENTARY DNA; CYCLOPHOSPHAMIDE; DIPHTHERIA TOXOID; GLUTATHIONE TRANSFERASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; INTERLEUKIN 2; KEYHOLE LIMPET HEMOCYANIN; LEUKOSIALIN; MANNAN; METRONIDAZOLE; MUCIN 1; MUCIN VNTR PEPTIDE; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; PLACEBO; QS 21; SIALOMUCIN; TAMOXIFEN; TG 1031; TG 4010; TG 5058; THERATOPE; TRICOM VACCINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 51349116036     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.7.7.963     Document Type: Review
Times cited : (67)

References (109)
  • 2
    • 0029801151 scopus 로고    scopus 로고
    • Breast cancer immunotherapy: Current status and future prospects
    • Apostolopoulos V, McKenzie IF, Pietersz GA. Breast cancer immunotherapy: current status and future prospects. Immunol. Cell Biol. 74(5), 457-464 (1996).
    • (1996) Immunol. Cell Biol , vol.74 , Issue.5 , pp. 457-464
    • Apostolopoulos, V.1    McKenzie, I.F.2    Pietersz, G.A.3
  • 5
    • 37549051721 scopus 로고    scopus 로고
    • Identification and expression of human epiglycanin/MUC21: A novel transmembrane mucin
    • Itoh Y, Kamata-Sakurai M, Denda-Nagai K et al. Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. Glycobiology 18(1), 74-83 (2008).
    • (2008) Glycobiology , vol.18 , Issue.1 , pp. 74-83
    • Itoh, Y.1    Kamata-Sakurai, M.2    Denda-Nagai, K.3
  • 7
    • 42049109699 scopus 로고    scopus 로고
    • MCF7 side population cells with characteristics of cancer stem/progenitor cells express the tumor antigen MUC1
    • Engelmann K, Shen H, Finn OJ. MCF7 side population cells with characteristics of cancer stem/progenitor cells express the tumor antigen MUC1. Cancer Res. 68(7), 2419-2426 (2008).
    • (2008) Cancer Res , vol.68 , Issue.7 , pp. 2419-2426
    • Engelmann, K.1    Shen, H.2    Finn, O.J.3
  • 8
    • 24744434192 scopus 로고    scopus 로고
    • MUC1 as a target antigen for cancer immunotherapy
    • Acres B, Limacher JM. MUC1 as a target antigen for cancer immunotherapy. Expert Rev. Vaccines 4(4), 493-502 (2005).
    • (2005) Expert Rev. Vaccines , vol.4 , Issue.4 , pp. 493-502
    • Acres, B.1    Limacher, J.M.2
  • 10
    • 51349164401 scopus 로고    scopus 로고
    • Strategies used for MUC1 immunotherapy: Preclinical studies
    • Tang C-K, Apostolopoulos V. Strategies used for MUC1 immunotherapy: preclinical studies. Expert Rev. Vaccines 7(7), 951-962 (2008).
    • (2008) Expert Rev. Vaccines , vol.7 , Issue.7 , pp. 951-962
    • Tang, C.-K.1    Apostolopoulos, V.2
  • 12
    • 0029035766 scopus 로고
    • Phase I study of synthetic MUC1 peptides in breast cancer
    • First paper demonstrating that MUC1 peptides in humans are safe and induce immune responses, •
    • Xing PX, Michael M, Apostolopoulos V et al. Phase I study of synthetic MUC1 peptides in breast cancer. Int. J. Oncol. 6, 1283-1289 (1995). • First paper demonstrating that MUC1 peptides in humans are safe and induce immune responses.
    • (1995) Int. J. Oncol , vol.6 , pp. 1283-1289
    • Xing, P.X.1    Michael, M.2    Apostolopoulos, V.3
  • 13
    • 0030000007 scopus 로고    scopus 로고
    • A Phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma
    • Goydos JS, Elder E, Whiteside TL, Finn OJ, Lotze MT. A Phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma. J. Surg. Res. 63(1), 298-304 (1996).
    • (1996) J. Surg. Res , vol.63 , Issue.1 , pp. 298-304
    • Goydos, J.S.1    Elder, E.2    Whiteside, T.L.3    Finn, O.J.4    Lotze, M.T.5
  • 14
    • 0032503501 scopus 로고    scopus 로고
    • Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide
    • Reddish M, MacLean GD, Koganty RR et al. Anti-MUC1 class I restricted CTLs in metastatic breast cancer patients immunized with a synthetic MUC1 peptide. Int. J. Cancer 76(6), 817-823 (1998).
    • (1998) Int. J. Cancer , vol.76 , Issue.6 , pp. 817-823
    • Reddish, M.1    MacLean, G.D.2    Koganty, R.R.3
  • 15
    • 0031457133 scopus 로고    scopus 로고
    • Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein
    • Karanikas V, Hwang LA, Pearson J et al. Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein. J. Clin. Invest. 100(11), 2783-2792 (1997).
    • (1997) J. Clin. Invest , vol.100 , Issue.11 , pp. 2783-2792
    • Karanikas, V.1    Hwang, L.A.2    Pearson, J.3
  • 16
    • 33344473830 scopus 로고    scopus 로고
    • Expression of aberrantly glycosylated tumor mucin-1 on human DC after transduction with a fiber-modified adenoviral vector
    • van Leeuwen EB, Cloosen S, Senden-Gijsbers BL et al. Expression of aberrantly glycosylated tumor mucin-1 on human DC after transduction with a fiber-modified adenoviral vector. Cytotherapy 8(1), 24-35 (2006).
    • (2006) Cytotherapy , vol.8 , Issue.1 , pp. 24-35
    • van Leeuwen, E.B.1    Cloosen, S.2    Senden-Gijsbers, B.L.3
  • 17
    • 33344469054 scopus 로고    scopus 로고
    • Transduction with a fiber-modified adenoviral vector is superior to non-viral nucleofection for expressing tumor-associated Ag mucin-1 in human DC
    • van Leeuwen EB, Cloosen S, Senden-Gijsbers BL, Germeraad WT, Bos GM. Transduction with a fiber-modified adenoviral vector is superior to non-viral nucleofection for expressing tumor-associated Ag mucin-1 in human DC. Cytotherapy 8(1), 36-46 (2006).
    • (2006) Cytotherapy , vol.8 , Issue.1 , pp. 36-46
    • van Leeuwen, E.B.1    Cloosen, S.2    Senden-Gijsbers, B.L.3    Germeraad, W.T.4    Bos, G.M.5
  • 18
    • 0034766337 scopus 로고    scopus 로고
    • Transduction of human dendritic cells with a recombinant modified vaccinia Ankara virus encoding MUC1 and IL-2
    • Trevor KT, Hersh EM, Brailey J, Balloul JM, Acres B. Transduction of human dendritic cells with a recombinant modified vaccinia Ankara virus encoding MUC1 and IL-2. Cancer Immunol. Immunother. 50(8), 397-407 (2001).
    • (2001) Cancer Immunol. Immunother , vol.50 , Issue.8 , pp. 397-407
    • Trevor, K.T.1    Hersh, E.M.2    Brailey, J.3    Balloul, J.M.4    Acres, B.5
  • 19
    • 0034856787 scopus 로고    scopus 로고
    • Adenovirus-mediated MUC1 gene transduction into human blood-derived dendritic cells
    • Maruyama K, Akiyama Y, Nara-Ashizawa N et al. Adenovirus-mediated MUC1 gene transduction into human blood-derived dendritic cells. J. Immunother. 24(4), 345-353 (2001).
    • (2001) J. Immunother , vol.24 , Issue.4 , pp. 345-353
    • Maruyama, K.1    Akiyama, Y.2    Nara-Ashizawa, N.3
  • 20
    • 0035152442 scopus 로고    scopus 로고
    • Mucin gene () transfer into human dendritic cells by cationic liposomes and recombinant adenovirus, 214A, 2591-2596
    • Pecher G, Spahn G, Schirrmann T et al. Mucin gene (MUC1) transfer into human dendritic cells by cationic liposomes and recombinant adenovirus. Anticancer Res. 21(4A), 2591-2596 (2001).
    • (2001) Anticancer Res , vol.MUC1
    • Pecher, G.1    Spahn, G.2    Schirrmann, T.3
  • 21
    • 27744491292 scopus 로고    scopus 로고
    • Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells
    • Koido S, Hara E, Homma S et al. Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells. Clin. Cancer Res. 11(21), 7891-7900 (2005).
    • (2005) Clin. Cancer Res , vol.11 , Issue.21 , pp. 7891-7900
    • Koido, S.1    Hara, E.2    Homma, S.3
  • 22
    • 46149093317 scopus 로고    scopus 로고
    • Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells
    • Koido S, Hara E, Homma S et al. Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells. J. Immunol. 179(7), 4874-4883 (2007).
    • (2007) J. Immunol , vol.179 , Issue.7 , pp. 4874-4883
    • Koido, S.1    Hara, E.2    Homma, S.3
  • 23
    • 34548593215 scopus 로고    scopus 로고
    • Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells
    • Napoletano C, Rughetti A, Agervig Tarp MP et al. Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells. Cancer Res. 67(17), 8358-8367 (2007).
    • (2007) Cancer Res , vol.67 , Issue.17 , pp. 8358-8367
    • Napoletano, C.1    Rughetti, A.2    Agervig Tarp, M.P.3
  • 24
    • 33847177614 scopus 로고    scopus 로고
    • Methods of delivery to antigen-presenting cells: Development of new and improved vaccines
    • Apostolopoulos V. Methods of delivery to antigen-presenting cells: development of new and improved vaccines. Mol. Pharm. 4(1), 1-3 (2007).
    • (2007) Mol. Pharm , vol.4 , Issue.1 , pp. 1-3
    • Apostolopoulos, V.1
  • 26
    • 33847230184 scopus 로고    scopus 로고
    • Receptor-mediated delivery of antigens to dendritic cells: Anticancer applications
    • Proudfoot O, Apostolopoulos V, Pietersz GA. Receptor-mediated delivery of antigens to dendritic cells: anticancer applications. Mol. Pharm. 4(1), 58-72 (2007).
    • (2007) Mol. Pharm , vol.4 , Issue.1 , pp. 58-72
    • Proudfoot, O.1    Apostolopoulos, V.2    Pietersz, G.A.3
  • 27
    • 51349091474 scopus 로고    scopus 로고
    • Protein/peptide and DNA vaccine delivery by targeting C-type lectin receptors
    • Tang C-K, Sheng K-C, Apostolopoulos V, Pietersz GA. Protein/peptide and DNA vaccine delivery by targeting C-type lectin receptors. Expert Rev. Vaccines 7(7), 1005-1018 (2008).
    • (2008) Expert Rev. Vaccines , vol.7 , Issue.7 , pp. 1005-1018
    • Tang, C.-K.1    Sheng, K.-C.2    Apostolopoulos, V.3    Pietersz, G.A.4
  • 28
    • 0034662394 scopus 로고    scopus 로고
    • Ex vivo targeting of the macrophage mannose receptor generates anti-tumor CTL responses
    • Apostolopoulos V, Barnes N, Pietersz GA, McKenzie IF. Ex vivo targeting of the macrophage mannose receptor generates anti-tumor CTL responses. Vaccine 18(27), 3174-3184 (2000).
    • (2000) Vaccine , vol.18 , Issue.27 , pp. 3174-3184
    • Apostolopoulos, V.1    Barnes, N.2    Pietersz, G.A.3    McKenzie, I.F.4
  • 29
    • 0035468913 scopus 로고    scopus 로고
    • Role of the mannose receptor in the immune response
    • Apostolopoulos V, McKenzie IF. Role of the mannose receptor in the immune response. Curr. Mol. Med. 1(4), 469-474 (2001).
    • (2001) Curr. Mol. Med , vol.1 , Issue.4 , pp. 469-474
    • Apostolopoulos, V.1    McKenzie, I.F.2
  • 30
    • 0030723225 scopus 로고    scopus 로고
    • MUC1 peptide epitopes associated with five different H-2 class I molecules
    • Apostolopoulos V, Haurum JS, McKenzie IF. MUC1 peptide epitopes associated with five different H-2 class I molecules. Eur. J. Immunol. 27(10), 2579-2587 (1997).
    • (1997) Eur. J. Immunol , vol.27 , Issue.10 , pp. 2579-2587
    • Apostolopoulos, V.1    Haurum, J.S.2    McKenzie, I.F.3
  • 31
    • 0031297362 scopus 로고    scopus 로고
    • Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen
    • Apostolopoulos V, Karanikas V, Haurum JS, McKenzie IF. Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen. J. Immunol. 159(11), 5211-5218 (1997).
    • (1997) J. Immunol , vol.159 , Issue.11 , pp. 5211-5218
    • Apostolopoulos, V.1    Karanikas, V.2    Haurum, J.S.3    McKenzie, I.F.4
  • 34
    • 0033658867 scopus 로고    scopus 로고
    • Generation of MUC1 cytotoxic T-cells in mice and epitope mapping
    • Apostolopoulos V, McKenzie IF, Pietersz GA. Generation of MUC1 cytotoxic T-cells in mice and epitope mapping. Methods Mol. Biol. 125, 455-462 (2000).
    • (2000) Methods Mol. Biol , vol.125 , pp. 455-462
    • Apostolopoulos, V.1    McKenzie, I.F.2    Pietersz, G.A.3
  • 36
    • 0030174878 scopus 로고    scopus 로고
    • Cell-mediated immune responses to MUC1 fusion protein coupled to mannan
    • Apostolopoulos V, Pietersz GA, McKenzie IF. Cell-mediated immune responses to MUC1 fusion protein coupled to mannan. Vaccine 14(9), 930-938 (1996).
    • (1996) Vaccine , vol.14 , Issue.9 , pp. 930-938
    • Apostolopoulos, V.1    Pietersz, G.A.2    McKenzie, I.F.3
  • 37
    • 0031938432 scopus 로고    scopus 로고
    • Cyclophosphamide enhances the CTL precursor frequency in mice immunized with MUC1-mannan fusion protein (M-FP)
    • Apostolopoulos V, Popovski V, McKenzie IF. Cyclophosphamide enhances the CTL precursor frequency in mice immunized with MUC1-mannan fusion protein (M-FP). J. Immunother. 21(2), 109-113 (1998).
    • (1998) J. Immunother , vol.21 , Issue.2 , pp. 109-113
    • Apostolopoulos, V.1    Popovski, V.2    McKenzie, I.F.3
  • 38
    • 0036311017 scopus 로고    scopus 로고
    • Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: A new approach for vaccine design
    • Apostolopoulos V, Yu M, Corper AL et al. Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design. J. Mol. Biol. 318(5), 1293-1305 (2002).
    • (2002) J. Mol. Biol , vol.318 , Issue.5 , pp. 1293-1305
    • Apostolopoulos, V.1    Yu, M.2    Corper, A.L.3
  • 40
    • 0034666716 scopus 로고    scopus 로고
    • Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice
    • Lees CJ, Apostolopoulos V, Acres B et al. Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice. Vaccine 19(2-3), 158-162 (2000).
    • (2000) Vaccine , vol.19 , Issue.2-3 , pp. 158-162
    • Lees, C.J.1    Apostolopoulos, V.2    Acres, B.3
  • 41
    • 0033403460 scopus 로고    scopus 로고
    • Cytokine production from murine CD4 and CD8 cells after mannan-MUC1 immunization
    • Lees CJ, Apostolopoulos V, McKenzie IF. Cytokine production from murine CD4 and CD8 cells after mannan-MUC1 immunization. J. Interferon Cytokine Res. 19(12), 1373-1379 (1999).
    • (1999) J. Interferon Cytokine Res , vol.19 , Issue.12 , pp. 1373-1379
    • Lees, C.J.1    Apostolopoulos, V.2    McKenzie, I.F.3
  • 42
    • 0030611550 scopus 로고    scopus 로고
    • Induction of T1 (cytotoxic lymphocyte) and/or T2 (antibody) responses to a mucin-1 tumour antigen
    • Lofthouse SA, Apostolopoulos V, Pietersz GA, Li W, McKenzie IF. Induction of T1 (cytotoxic lymphocyte) and/or T2 (antibody) responses to a mucin-1 tumour antigen. Vaccine 15(14), 1586-1593 (1997).
    • (1997) Vaccine , vol.15 , Issue.14 , pp. 1586-1593
    • Lofthouse, S.A.1    Apostolopoulos, V.2    Pietersz, G.A.3    Li, W.4    McKenzie, I.F.5
  • 43
    • 0032524481 scopus 로고    scopus 로고
    • Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses
    • McKenzie IF, Apostolopoulos V, Lees C et al. Oxidised mannan antigen conjugates preferentially stimulate T1 type immune responses. Vet. Immunol. Immunopathol. 63(1-2), 185-190 (1998).
    • (1998) Vet. Immunol. Immunopathol , vol.63 , Issue.1-2 , pp. 185-190
    • McKenzie, I.F.1    Apostolopoulos, V.2    Lees, C.3
  • 46
    • 0345166825 scopus 로고    scopus 로고
    • A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor
    • Apostolopoulos V, Yuriev E, Ramsland PA et al. A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor. Proc. Natl Acad. Sci. USA 100(25), 15029-15034 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.25 , pp. 15029-15034
    • Apostolopoulos, V.1    Yuriev, E.2    Ramsland, P.A.3
  • 47
    • 0034103551 scopus 로고    scopus 로고
    • Flow cytometric measurement of intracellular cytokines detects immune responses in MUC1 immunotherapy
    • Karanikas V, Lodding J, Maino VC, McKenzie IF. Flow cytometric measurement of intracellular cytokines detects immune responses in MUC1 immunotherapy. Clin. Cancer Res. 6(3), 829-837 (2000).
    • (2000) Clin. Cancer Res , vol.6 , Issue.3 , pp. 829-837
    • Karanikas, V.1    Lodding, J.2    Maino, V.C.3    McKenzie, I.F.4
  • 48
    • 0035126975 scopus 로고    scopus 로고
    • Mannan mucin-1 peptide immunization: Influence of cyclophosphamide and the route of injection
    • Karanikas V, Thynne G, Mitchell P et al. Mannan mucin-1 peptide immunization: influence of cyclophosphamide and the route of injection. J. Immunother. 24(2), 172-183 (2001).
    • (2001) J. Immunother , vol.24 , Issue.2 , pp. 172-183
    • Karanikas, V.1    Thynne, G.2    Mitchell, P.3
  • 49
    • 33745126667 scopus 로고    scopus 로고
    • Pilot Phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]
    • Pilot Phase III study demonstrating that in early breast cancer patients with no evidence of disease, MUC1 immunotherapy is beneficial. Patients injected with MUC1 vaccine are protected against recurrence compared with placebo-controlled cohorts, ••
    • Apostolopoulos V, Pietersz GA, Tsibanis A et al. Pilot Phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]. Breast Cancer Res. 8(3), R27 (2006). •• Pilot Phase III study demonstrating that in early breast cancer patients with no evidence of disease, MUC1 immunotherapy is beneficial. Patients injected with MUC1 vaccine are protected against recurrence compared with placebo-controlled cohorts.
    • (2006) Breast Cancer Res , vol.8 , Issue.3
    • Apostolopoulos, V.1    Pietersz, G.A.2    Tsibanis, A.3
  • 52
    • 0031889940 scopus 로고    scopus 로고
    • MUC1 cross-reactive Gal a(1,3)Gal antibodies in humans switch immune responses from cellular to humoral
    • Apostolopoulos V, Osinski C, McKenzie IF. MUC1 cross-reactive Gal a(1,3)Gal antibodies in humans switch immune responses from cellular to humoral. Nat. Med. 4(3), 315-320 (1998).
    • (1998) Nat. Med , vol.4 , Issue.3 , pp. 315-320
    • Apostolopoulos, V.1    Osinski, C.2    McKenzie, I.F.3
  • 53
    • 0032825352 scopus 로고    scopus 로고
    • Mimics and cross reactions of relevance to tumour immunotherapy
    • Apostolopoulos V, Sandrin MS, McKenzie IF. Mimics and cross reactions of relevance to tumour immunotherapy. Vaccine 18(3-4), 268-275 (1999).
    • (1999) Vaccine , vol.18 , Issue.3-4 , pp. 268-275
    • Apostolopoulos, V.1    Sandrin, M.S.2    McKenzie, I.F.3
  • 54
    • 0032968911 scopus 로고    scopus 로고
    • Carbohydrate/peptide mimics: Effect on MUC1 cancer immunotherapy
    • Apostolopoulos V, Sandrin MS, McKenzie IF. Carbohydrate/peptide mimics: effect on MUC1 cancer immunotherapy. J. Mol. Med. 77(5), 427-436 (1999).
    • (1999) J. Mol. Med , vol.77 , Issue.5 , pp. 427-436
    • Apostolopoulos, V.1    Sandrin, M.S.2    McKenzie, I.F.3
  • 55
    • 32944475905 scopus 로고    scopus 로고
    • Mannan-MUC1-pulsed dendritic cell immunotherapy: A Phase I trial in patients with adenocarcinoma
    • Ex vivo-cultured monocyte derived dendritic cells (moDCs) pulsed with mannan-MUC1 induce strong cellular responses in advanced adenocarcinoma patients, ••
    • Loveland BE, Zhao A, White S et al. Mannan-MUC1-pulsed dendritic cell immunotherapy: a Phase I trial in patients with adenocarcinoma. Clin. Cancer Res. 12(3 Pt 1), 869-877 (2006). •• Ex vivo-cultured monocyte derived dendritic cells (moDCs) pulsed with mannan-MUC1 induce strong cellular responses in advanced adenocarcinoma patients.
    • (2006) Clin. Cancer Res , vol.12 , Issue.3 PART 1 , pp. 869-877
    • Loveland, B.E.1    Zhao, A.2    White, S.3
  • 56
    • 0036348644 scopus 로고    scopus 로고
    • Dendritic cells in vaccination therapies of malignant diseases
    • Brossart P. Dendritic cells in vaccination therapies of malignant diseases. Transfus. Apher. Sci. 27(2), 183-186 (2002).
    • (2002) Transfus. Apher. Sci , vol.27 , Issue.2 , pp. 183-186
    • Brossart, P.1
  • 57
    • 0034331218 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
    • Ex vivo-grown moDCs pulsed with MUC1 peptide induce immune responses in patients with cancer, •
    • Brossart P, Wirths S, Stuhler G, Reichardt VL, Kanz L, Brugger W. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 96(9), 3102-3108 (2000). • Ex vivo-grown moDCs pulsed with MUC1 peptide induce immune responses in patients with cancer.
    • (2000) Blood , vol.96 , Issue.9 , pp. 3102-3108
    • Brossart, P.1    Wirths, S.2    Stuhler, G.3    Reichardt, V.L.4    Kanz, L.5    Brugger, W.6
  • 58
    • 28944437160 scopus 로고    scopus 로고
    • Dendritic cell-based cancer immunotherapy targeting MUC-1
    • Wierecky J, Mueller M, Brossart P. Dendritic cell-based cancer immunotherapy targeting MUC-1. Cancer Immunol. Immunother. 55(1), 63-67 (2006).
    • (2006) Cancer Immunol. Immunother , vol.55 , Issue.1 , pp. 63-67
    • Wierecky, J.1    Mueller, M.2    Brossart, P.3
  • 59
    • 33745247366 scopus 로고    scopus 로고
    • Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients
    • Immunization of patients with ex vivo-cultured DCs pulsed with MUC1 peptides and re-injected into advanced renal cell carcinoma patients offers immune responses in patients, •
    • Wierecky J, Muller MR, Wirths S et al. Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients. Cancer Res. 66(11), 5910-5918 (2006). • Immunization of patients with ex vivo-cultured DCs pulsed with MUC1 peptides and re-injected into advanced renal cell carcinoma patients offers immune responses in patients.
    • (2006) Cancer Res , vol.66 , Issue.11 , pp. 5910-5918
    • Wierecky, J.1    Muller, M.R.2    Wirths, S.3
  • 60
    • 1942481506 scopus 로고    scopus 로고
    • Dendritic cell vaccine immunotherapy of cancer targeting MUC1 mucin
    • Kontani K, Taguchi O, Ozaki Y et al. Dendritic cell vaccine immunotherapy of cancer targeting MUC1 mucin. Int. J. Mol. Med. 12(4), 493-502 (2003).
    • (2003) Int. J. Mol. Med , vol.12 , Issue.4 , pp. 493-502
    • Kontani, K.1    Taguchi, O.2    Ozaki, Y.3
  • 61
    • 0036453668 scopus 로고    scopus 로고
    • Mucin gene (MUC1) transfected dendritic cells as vaccine: Results of a Phase I/II clinical trial
    • MUC1 cDNA-transfected DCs injected into patients induce immune responses, •
    • Pecher G, Haring A, Kaiser L, Thiel E. Mucin gene (MUC1) transfected dendritic cells as vaccine: results of a Phase I/II clinical trial. Cancer Immunol. Immunother. 51(11-12), 669-673 (2002). • MUC1 cDNA-transfected DCs injected into patients induce immune responses.
    • (2002) Cancer Immunol. Immunother , vol.51 , Issue.11-12 , pp. 669-673
    • Pecher, G.1    Haring, A.2    Kaiser, L.3    Thiel, E.4
  • 62
    • 21244461557 scopus 로고    scopus 로고
    • Dendritic cells: Activation and maturation - applications for cancer immunotherapy
    • Sheng KC, Pietersz GA, Wright MD, Apostolopoulos V. Dendritic cells: activation and maturation - applications for cancer immunotherapy. Curr. Med. Chem. 12(15), 1783-1800 (2005).
    • (2005) Curr. Med. Chem , vol.12 , Issue.15 , pp. 1783-1800
    • Sheng, K.C.1    Pietersz, G.A.2    Wright, M.D.3    Apostolopoulos, V.4
  • 63
    • 40549097760 scopus 로고    scopus 로고
    • Kondo H, Hazama S, Kawaoka T et al. Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Anticancer Res. 28(1B), 379-387 (2008). •• First demonstration that injection of both MUC1 DCs and MUC1 cytotoxic T-lymphocytes in advanced pancreatic cancer patients induces immune and clinical responses in patients.
    • Kondo H, Hazama S, Kawaoka T et al. Adoptive immunotherapy for pancreatic cancer using MUC1 peptide-pulsed dendritic cells and activated T lymphocytes. Anticancer Res. 28(1B), 379-387 (2008). •• First demonstration that injection of both MUC1 DCs and MUC1 cytotoxic T-lymphocytes in advanced pancreatic cancer patients induces immune and clinical responses in patients.
  • 64
    • 51349099842 scopus 로고    scopus 로고
    • Cell fusion: From hybridoma to dendritic cell-based vaccine
    • Gong J, Koido S, Calderwood SK. Cell fusion: from hybridoma to dendritic cell-based vaccine. Expert Rev. Vaccines 7(7), 1055-1068 (2008).
    • (2008) Expert Rev. Vaccines , vol.7 , Issue.7 , pp. 1055-1068
    • Gong, J.1    Koido, S.2    Calderwood, S.K.3
  • 65
    • 4644354179 scopus 로고    scopus 로고
    • Avigan D. Dendritic cell-tumor fusion vaccines for renal cell carcinoma. Clin. Cancer Res. 10(18 Pt 2), 6347S-6352S (2004). •• DC-tumor fusion vaccine in patients with kidney cancer induces immune responses.
    • Avigan D. Dendritic cell-tumor fusion vaccines for renal cell carcinoma. Clin. Cancer Res. 10(18 Pt 2), 6347S-6352S (2004). •• DC-tumor fusion vaccine in patients with kidney cancer induces immune responses.
  • 66
    • 3242666031 scopus 로고    scopus 로고
    • Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses
    • Avigan D, Vasir B, Gong J et al. Fusion cell vaccination of patients with metastatic breast and renal cancer induces immunological and clinical responses. Clin. Cancer Res. 10(14), 4699-4708 (2004).
    • (2004) Clin. Cancer Res , vol.10 , Issue.14 , pp. 4699-4708
    • Avigan, D.1    Vasir, B.2    Gong, J.3
  • 67
    • 13444311549 scopus 로고    scopus 로고
    • A pilot clinical trial of vaccination with dendritic cells pulsed with autologous tumor cells derived from malignant pleural effusion in patients with late-stage lung carcinoma
    • Chang GC, Lan HC, Juang SH et al. A pilot clinical trial of vaccination with dendritic cells pulsed with autologous tumor cells derived from malignant pleural effusion in patients with late-stage lung carcinoma. Cancer 103(4), 763-771 (2005).
    • (2005) Cancer , vol.103 , Issue.4 , pp. 763-771
    • Chang, G.C.1    Lan, H.C.2    Juang, S.H.3
  • 68
    • 0034071575 scopus 로고    scopus 로고
    • Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21
    • Use of MUC1 variable number tandem repeats peptide-keyhole limpet hemocyanin (KLH) mixed with QS21 as a vaccine, •
    • Gilewski T, Adluri S, Ragupathi G et al. Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21. Clin. Cancer Res. 6(5), 1693-1701 (2000). • Use of MUC1 variable number tandem repeats peptide-keyhole limpet hemocyanin (KLH) mixed with QS21 as a vaccine.
    • (2000) Clin. Cancer Res , vol.6 , Issue.5 , pp. 1693-1701
    • Gilewski, T.1    Adluri, S.2    Ragupathi, G.3
  • 70
    • 19944433959 scopus 로고    scopus 로고
    • Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer
    • Ramanathan RK, Lee KM, McKolanis J et al. Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer. Cancer Immunol. Immunother. 54(3), 254-264 (2005).
    • (2005) Cancer Immunol. Immunother , vol.54 , Issue.3 , pp. 254-264
    • Ramanathan, R.K.1    Lee, K.M.2    McKolanis, J.3
  • 71
    • 23344445706 scopus 로고    scopus 로고
    • MUC1 peptide vaccination in patients with advanced pancreas or biliary tract cancer
    • Yamamoto K, Ueno T, Kawaoka T et al. MUC1 peptide vaccination in patients with advanced pancreas or biliary tract cancer. Anticancer Res. 25(5), 3575-3579 (2005).
    • (2005) Anticancer Res , vol.25 , Issue.5 , pp. 3575-3579
    • Yamamoto, K.1    Ueno, T.2    Kawaoka, T.3
  • 72
    • 0034789572 scopus 로고    scopus 로고
    • Phase I study of the BLP25 (MUC1 peptide) liposomal vaccine for active specific immunotherapy in stage IIIB/IV non-small-cell lung cancer
    • Palmer M, Parker J, Modi S et al. Phase I study of the BLP25 (MUC1 peptide) liposomal vaccine for active specific immunotherapy in stage IIIB/IV non-small-cell lung cancer. Clinical Lung Cancer 3(1), 49-57 (2001).
    • (2001) Clinical Lung Cancer , vol.3 , Issue.1 , pp. 49-57
    • Palmer, M.1    Parker, J.2    Modi, S.3
  • 73
    • 27244449289 scopus 로고    scopus 로고
    • Randomized Phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
    • Results of L-BLP-25 vaccine in advanced non-small-cell lung cancer patients, •
    • Butts C, Murray N, Maksymiuk A et al. Randomized Phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer. J. Clin. Oncol. 23(27), 6674-6681 (2005). • Results of L-BLP-25 vaccine in advanced non-small-cell lung cancer patients.
    • (2005) J. Clin. Oncol , vol.23 , Issue.27 , pp. 6674-6681
    • Butts, C.1    Murray, N.2    Maksymiuk, A.3
  • 74
    • 33744546327 scopus 로고    scopus 로고
    • A pilot study of the liposomal MUC1 vaccine BLP25 in prostate specific antigen failures after radical prostatectomy
    • Results of L-BLP-25 vaccine in advanced prostate cancer patients, •
    • North SA, Graham K, Bodnar D, Venner P. A pilot study of the liposomal MUC1 vaccine BLP25 in prostate specific antigen failures after radical prostatectomy. J. Urol. 176(1), 91-95 (2006). • Results of L-BLP-25 vaccine in advanced prostate cancer patients.
    • (2006) J. Urol , vol.176 , Issue.1 , pp. 91-95
    • North, S.A.1    Graham, K.2    Bodnar, D.3    Venner, P.4
  • 75
    • 34547661985 scopus 로고    scopus 로고
    • L-BLP25: A peptide vaccine strategy in non small cell lung cancer
    • Sangha R, Butts C. L-BLP25: a peptide vaccine strategy in non small cell lung cancer. Clin. Cancer Res. 13(15 Pt 2), S4652-S4654 (2007).
    • (2007) Clin. Cancer Res , vol.13 , Issue.15 PART 2
    • Sangha, R.1    Butts, C.2
  • 76
    • 36048986266 scopus 로고    scopus 로고
    • L-BLP25: A MUC1-targeted peptide vaccine therapy in prostate cancer
    • Sangha R, North S. L-BLP25: a MUC1-targeted peptide vaccine therapy in prostate cancer. Expert Opin. Biol. Ther. 7(11), 1723-1730 (2007).
    • (2007) Expert Opin. Biol. Ther , vol.7 , Issue.11 , pp. 1723-1730
    • Sangha, R.1    North, S.2
  • 77
    • 0033989671 scopus 로고    scopus 로고
    • MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines
    • Acres B, Apostolopoulos V, Balloul JM et al. MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines. Cancer Immunol. Immunother. 48(10), 588-594 (2000).
    • (2000) Cancer Immunol. Immunother , vol.48 , Issue.10 , pp. 588-594
    • Acres, B.1    Apostolopoulos, V.2    Balloul, J.M.3
  • 78
    • 0033852076 scopus 로고    scopus 로고
    • Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer
    • Scholl SM, Balloul JM, Le Goc G et al. Recombinant vaccinia virus encoding human MUC1 and IL2 as immunotherapy in patients with breast cancer. J. Immunother. 23(5), 570-580 (2000).
    • (2000) J. Immunother , vol.23 , Issue.5 , pp. 570-580
    • Scholl, S.M.1    Balloul, J.M.2    Le Goc, G.3
  • 79
    • 0742324611 scopus 로고    scopus 로고
    • Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen-specific immunotherapy in patients with MUC1-positive advanced cancer
    • Rochlitz C, Figlin R, Squiban P et al. Phase I immunotherapy with a modified vaccinia virus (MVA) expressing human MUC1 as antigen-specific immunotherapy in patients with MUC1-positive advanced cancer. J. Gene Med. 5(8), 690-699 (2003).
    • (2003) J. Gene Med , vol.5 , Issue.8 , pp. 690-699
    • Rochlitz, C.1    Figlin, R.2    Squiban, P.3
  • 80
    • 4344713204 scopus 로고    scopus 로고
    • Phase I trial of antigen-specific gene therapy using a recombinant vaccinia virus encoding MUC-1 and IL-2 in MUC-1-positive patients with advanced prostate cancer
    • Use of vaccinia virus carrying MUC1 and IL-2 genes induces immune responses in patients with prostate cancer, •
    • Pantuck AJ, van Ophoven A, Gitlitz BJ et al. Phase I trial of antigen-specific gene therapy using a recombinant vaccinia virus encoding MUC-1 and IL-2 in MUC-1-positive patients with advanced prostate cancer. J. Immunother. 27(3), 240-253 (2004). • Use of vaccinia virus carrying MUC1 and IL-2 genes induces immune responses in patients with prostate cancer.
    • (2004) J. Immunother , vol.27 , Issue.3 , pp. 240-253
    • Pantuck, A.J.1    van Ophoven, A.2    Gitlitz, B.J.3
  • 81
    • 51349124402 scopus 로고    scopus 로고
    • Clinical development of MVA-based therapeutic cancer vaccines
    • Acres B, Bonnefoy JY. Clinical development of MVA-based therapeutic cancer vaccines. Expert Rev. Vaccines 7(7), 889-893 (2008).
    • (2008) Expert Rev. Vaccines , vol.7 , Issue.7 , pp. 889-893
    • Acres, B.1    Bonnefoy, J.Y.2
  • 82
    • 34047159281 scopus 로고    scopus 로고
    • PANVAC-VF: Poxviral-based vaccine therapy targeting CEA and MUC1 in carcinoma
    • Madan RA, Arlen PM, Gulley JL. PANVAC-VF: poxviral-based vaccine therapy targeting CEA and MUC1 in carcinoma. Expert Opin. Biol. Ther. 7(4), 543-554 (2007).
    • (2007) Expert Opin. Biol. Ther , vol.7 , Issue.4 , pp. 543-554
    • Madan, R.A.1    Arlen, P.M.2    Gulley, J.L.3
  • 83
    • 38849160991 scopus 로고    scopus 로고
    • Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer
    • Kaufman HL, Kim-Schulze S, Manson K et al. Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer. J. Transl. Med. 5, 60 (2007).
    • (2007) J. Transl. Med , vol.5 , pp. 60
    • Kaufman, H.L.1    Kim-Schulze, S.2    Manson, K.3
  • 84
    • 49649090374 scopus 로고    scopus 로고
    • Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma
    • Gulley JL, Arlen PM, Tsang KY et al. Pilot study of vaccination with recombinant CEA-MUC-1-TRICOM poxviral-based vaccines in patients with metastatic carcinoma. Clin. Cancer Res. 14(10), 3060-3069 (2008).
    • (2008) Clin. Cancer Res , vol.14 , Issue.10 , pp. 3060-3069
    • Gulley, J.L.1    Arlen, P.M.2    Tsang, K.Y.3
  • 85
    • 0027219075 scopus 로고
    • Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody
    • Hird V, Maraveyas A, Snook D et al. Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody. Br. J. Cancer 68(2), 403-406 (1993).
    • (1993) Br. J. Cancer , vol.68 , Issue.2 , pp. 403-406
    • Hird, V.1    Maraveyas, A.2    Snook, D.3
  • 86
    • 0033955509 scopus 로고    scopus 로고
    • Targeting superficial bladder cancer by the intravesical administration of copper-67-labeled anti-MUC1 mucin monoclonal antibody C595
    • Hughes OD, Bishop MC, Perkins AC et al. Targeting superficial bladder cancer by the intravesical administration of copper-67-labeled anti-MUC1 mucin monoclonal antibody C595. J. Clin. Oncol. 18(2), 363-370 (2000).
    • (2000) J. Clin. Oncol , vol.18 , Issue.2 , pp. 363-370
    • Hughes, O.D.1    Bishop, M.C.2    Perkins, A.C.3
  • 87
    • 4344712401 scopus 로고    scopus 로고
    • A Phase I trial of idiotypic vaccination with HMFG1 in ovarian cancer
    • Nicholson S, Bomphray CC, Thomas H et al. A Phase I trial of idiotypic vaccination with HMFG1 in ovarian cancer. Cancer Immunol. Immunother. 53(9), 809-816 (2004).
    • (2004) Cancer Immunol. Immunother , vol.53 , Issue.9 , pp. 809-816
    • Nicholson, S.1    Bomphray, C.C.2    Thomas, H.3
  • 89
    • 0033522823 scopus 로고    scopus 로고
    • Induction of humoral and cellular responses in cynomolgus monkeys immunised with mannan-human MUC1 conjugates
    • Vaughan HA, Ho DW, Karanikas VA et al. Induction of humoral and cellular responses in cynomolgus monkeys immunised with mannan-human MUC1 conjugates. Vaccine 17(20-21), 2740-2752 (1999).
    • (1999) Vaccine , vol.17 , Issue.20-21 , pp. 2740-2752
    • Vaughan, H.A.1    Ho, D.W.2    Karanikas, V.A.3
  • 92
    • 2642679252 scopus 로고    scopus 로고
    • Mouse mucin 1 (MUC1) defined by monoclonal antibodies
    • Xing PX, Lees C, Lodding J et al. Mouse mucin 1 (MUC1) defined by monoclonal antibodies. Int. J. Cancer 76(6), 875-883 (1998).
    • (1998) Int. J. Cancer , vol.76 , Issue.6 , pp. 875-883
    • Xing, P.X.1    Lees, C.2    Lodding, J.3
  • 94
    • 45849143648 scopus 로고    scopus 로고
    • + T cells in mice. Gives evidence that autoimmunity can be induced when using self antigens for cancer immunotherapy studies.
    • + T cells in mice. Gives evidence that autoimmunity can be induced when using self antigens for cancer immunotherapy studies.
  • 95
    • 17344392248 scopus 로고    scopus 로고
    • Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin
    • Demonstration that antibodies to MUC1 in patients with breast cancer enhances long-term survival, •
    • von Mensdorff-Pouilly S, Verstraeten AA, Kenemans P et al. Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin. J. Clin. Oncol. 18(3), 574-583 (2000). • Demonstration that antibodies to MUC1 in patients with breast cancer enhances long-term survival.
    • (2000) J. Clin. Oncol , vol.18 , Issue.3 , pp. 574-583
    • von Mensdorff-Pouilly, S.1    Verstraeten, A.A.2    Kenemans, P.3
  • 96
    • 0028875822 scopus 로고
    • Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin
    • Domenech N, Henderson RA, Finn OJ. Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin. J. Immunol. 155(10), 4766-4774 (1995).
    • (1995) J. Immunol , vol.155 , Issue.10 , pp. 4766-4774
    • Domenech, N.1    Henderson, R.A.2    Finn, O.J.3
  • 97
    • 0033563771 scopus 로고    scopus 로고
    • Presentation of MUC1 tumor antigen by class I MHC and CTL function correlate with the glycosylation state of the protein taken up by dendritic cells
    • Hiltbold EM, Alter MD, Ciborowski P, Finn OJ. Presentation of MUC1 tumor antigen by class I MHC and CTL function correlate with the glycosylation state of the protein taken up by dendritic cells. Cell. Immunol. 194(2), 143-149 (1999).
    • (1999) Cell. Immunol , vol.194 , Issue.2 , pp. 143-149
    • Hiltbold, E.M.1    Alter, M.D.2    Ciborowski, P.3    Finn, O.J.4
  • 98
    • 0034004294 scopus 로고    scopus 로고
    • Definition of MHC-restricted CTL epitopes from non-variable number of tandem repeat sequence of MUC1
    • Pietersz GA, Li W, Osinski C, Apostolopoulos V, McKenzie IF. Definition of MHC-restricted CTL epitopes from non-variable number of tandem repeat sequence of MUC1. Vaccine 18(19), 2059-2071 (2000).
    • (2000) Vaccine , vol.18 , Issue.19 , pp. 2059-2071
    • Pietersz, G.A.1    Li, W.2    Osinski, C.3    Apostolopoulos, V.4    McKenzie, I.F.5
  • 99
    • 42249104403 scopus 로고    scopus 로고
    • Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo
    • Sheng KC, Kalkanidis M, Pouniotis DS et al. Delivery of antigen using a novel mannosylated dendrimer potentiates immunogenicity in vitro and in vivo. Eur. J. Immunol. 38(2), 424-436 (2008).
    • (2008) Eur. J. Immunol , vol.38 , Issue.2 , pp. 424-436
    • Sheng, K.C.1    Kalkanidis, M.2    Pouniotis, D.S.3
  • 100
    • 33745218281 scopus 로고    scopus 로고
    • Mannan derivatives induce phenotypic and functional maturation of mouse dendritic cells
    • Sheng KC, Pouniotis DS, Wright MD et al. Mannan derivatives induce phenotypic and functional maturation of mouse dendritic cells. Immunology 118(3), 372-383 (2006).
    • (2006) Immunology , vol.118 , Issue.3 , pp. 372-383
    • Sheng, K.C.1    Pouniotis, D.S.2    Wright, M.D.3
  • 101
    • 34848896345 scopus 로고    scopus 로고
    • Slovin SF, Ragupathi G, Fernandez C et al. A polyvalent vaccine for high-risk prostate patients: 'are more antigens better, Cancer Immunol. Immunother. 56(12, 1921-1930 2007, • Multivalent vaccine comprising six to eight antigens for immunotherapy of prostate cancer. Do more antigens included in the vaccine improve the responses? Results are discussed in this paper
    • Slovin SF, Ragupathi G, Fernandez C et al. A polyvalent vaccine for high-risk prostate patients: 'are more antigens better?' Cancer Immunol. Immunother. 56(12), 1921-1930 (2007). • Multivalent vaccine comprising six to eight antigens for immunotherapy of prostate cancer. Do more antigens included in the vaccine improve the responses? Results are discussed in this paper.
  • 102
    • 38049089743 scopus 로고    scopus 로고
    • Preclinical and clinical studies of recombinant poxvirus vaccines for carcinoma therapy
    • Arlen PM, Gulley JL, Madan RA, Hodge JW, Schlom J. Preclinical and clinical studies of recombinant poxvirus vaccines for carcinoma therapy. Crit. Rev. Immunol. 27(5), 451-462 (2007).
    • (2007) Crit. Rev. Immunol , vol.27 , Issue.5 , pp. 451-462
    • Arlen, P.M.1    Gulley, J.L.2    Madan, R.A.3    Hodge, J.W.4    Schlom, J.5
  • 103
    • 34748847470 scopus 로고    scopus 로고
    • Enhancing efficacy of therapeutic vaccinations by combination with other modalities
    • Gulley JL, Madan RA, Arlen PM. Enhancing efficacy of therapeutic vaccinations by combination with other modalities. Vaccine 25(Suppl. 2), B89-B96 (2007).
    • (2007) Vaccine , vol.25 , Issue.SUPPL. 2
    • Gulley, J.L.1    Madan, R.A.2    Arlen, P.M.3
  • 104
    • 0346994560 scopus 로고    scopus 로고
    • The role of cancer vaccines following autologous stem cell rescue in breast and ovarian cancer patients: Experience with the STn-KLH vaccine (Theratope)
    • Holmberg LA, Oparin DV, Gooley T, Sandmaier BM. The role of cancer vaccines following autologous stem cell rescue in breast and ovarian cancer patients: experience with the STn-KLH vaccine (Theratope). Clin. Breast Cancer 3(Suppl. 4), S144-S151 (2003).
    • (2003) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 4
    • Holmberg, L.A.1    Oparin, D.V.2    Gooley, T.3    Sandmaier, B.M.4
  • 106
    • 9644265336 scopus 로고    scopus 로고
    • Holmberg LA, Sandmaier BM. Vaccination with Theratope (STn-KLH) as treatment for breast cancer. Expert Rev. Vaccines 3(6), 655-663 (2004). • Nice review of the Theratope® (STn-KLH) vaccine.
    • Holmberg LA, Sandmaier BM. Vaccination with Theratope (STn-KLH) as treatment for breast cancer. Expert Rev. Vaccines 3(6), 655-663 (2004). • Nice review of the Theratope® (STn-KLH) vaccine.
  • 107
    • 0346994554 scopus 로고    scopus 로고
    • Clinical development of the STn-KLH vaccine (Theratope)
    • Ibrahim NK, Murray JL. Clinical development of the STn-KLH vaccine (Theratope). Clin. Breast Cancer 3(Suppl. 4), S139-S143 (2003).
    • (2003) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 4
    • Ibrahim, N.K.1    Murray, J.L.2
  • 108
    • 0346364653 scopus 로고    scopus 로고
    • Rationale for the clinical development of STn-KLH (Theratope) and anti-MUC-1 vaccines in breast cancer
    • Miles D, Papazisis K. Rationale for the clinical development of STn-KLH (Theratope) and anti-MUC-1 vaccines in breast cancer. Clin. Breast Cancer 3(Suppl. 4), S134-S138 (2003).
    • (2003) Clin. Breast Cancer , vol.3 , Issue.SUPPL. 4
    • Miles, D.1    Papazisis, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.