Polyglutamine-rich suppressors of huntingtin toxicity act upstream of Hsp70 and Sti1 in spatial quality control of amyloid-like proteins

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Wolfe, Katie J ^a   Ren, Hong Yu ^a   Trepte, Philipp ^b   Cyr, Douglas M ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; CHAPERONE; DNA FRAGMENT; GENOMIC DNA; HEAT SHOCK PROTEIN 70; HUNTINGTIN; NUCLEAR PROTEIN; POLYGLUTAMINE; PROTEIN CBK1; PROTEIN NAB3; PROTEIN POP2; PROTEIN STI1; UNCLASSIFIED DRUG; CBK1 PROTEIN, S CEREVISIAE; HEAT SHOCK PROTEIN; HTT PROTEIN, HUMAN; NAB3 PROTEIN, S CEREVISIAE; NERVE PROTEIN; NUCLEAR LOCALIZATION SIGNAL; PEPTIDE; POP2 PROTEIN, S CEREVISIAE; PROTEIN AGGREGATE; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; RNA BINDING PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; SIGNAL PEPTIDE; STI1 PROTEIN, S CEREVISIAE;

AGGRESOME; ARTICLE; BIOACCUMULATION; CELL NUCLEUS; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOWN REGULATION; GENE DOSAGE; GENE OVEREXPRESSION; NONHUMAN; PROLINE RICH PROTEIN DOMAIN; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; QUALITY CONTROL; RNA PROCESSING; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; CHEMISTRY; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HUNTINGTON CHOREA; METABOLISM; MOLECULAR GENETICS; NUCLEAR LOCALIZATION SIGNAL; PATHOLOGY; PLASMID; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; TRANSGENE;

AMINO ACID SEQUENCE; AMYLOIDOGENIC PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HUNTINGTON DISEASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NUCLEAR LOCALIZATION SIGNALS; NUCLEAR PROTEINS; PEPTIDES; PLASMIDS; PROTEIN AGGREGATES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; RIBONUCLEASES; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANSGENES;

EID: 84901309564     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0095914     Document Type: Article

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