Huntingtin toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

Journal of Cell Biology

Volumn 157, Issue 6, 2002, Pages 997-1004

  Meriin, Anatoli B ^a   Zhang, Xiaoqian ^a   He, Xiangwei ^c   Newnam, Gary P ^a   Chernoff, Yury O ^b   Sherman, Michael Y ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aggregation; Polyglutamine; Prions; Toxicity; Yeast

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 104; HUNTINGTIN; MUTANT PROTEIN; POLYGLUTAMINE; PRION PROTEIN; PROTEIN RNQ1; PROTEIN SIS1; PROTEIN SSA1; PROTEIN SSA2; PROTEIN YDJ1 151; UNCLASSIFIED DRUG; FUNGAL PROTEIN; GREEN FLUORESCENT PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN; PEPTIDE; PHOTOPROTEIN; POLYGLUTAMIC ACID; RNQ1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE MODEL; DISEASE PREDISPOSITION; GENE DELETION; GENE MUTATION; GENETIC COMPLEMENTATION; HUNTINGTON CHOREA; INHERITANCE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEFICIENCY; PROTEIN DOMAIN; PROTEIN EXPRESSION; RNQ1 GENE; SPONTANEOUS MUTATION; SUPPRESSOR GENE; WILD TYPE; BIOLOGICAL MODEL; CHEMISTRY; CROSS BREEDING; CULTURE MEDIUM; GENE FREQUENCY; GENE REPRESSION; GENETICS; GENOTYPE; METABOLISM; MUTATION; PHENOTYPE; PHYSIOLOGY; PRION; PROMOTER REGION; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SOLUBILITY;

ANIMALIA;

CROSSES, GENETIC; CULTURE MEDIA; FUNGAL PROTEINS; GENE DELETION; GENE FREQUENCY; GENOTYPE; GREEN FLUORESCENT PROTEINS; HUNTINGTON DISEASE; LUMINESCENT PROTEINS; MODELS, BIOLOGICAL; MOLECULAR CHAPERONES; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PHENOTYPE; POLYGLUTAMIC ACID; PRIONS; PROMOTER REGIONS (GENETICS); PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SOLUBILITY; SUPPRESSION, GENETIC;

EID: 0037053566     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200112104     Document Type: Article

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