메뉴 건너뛰기




Volumn 14, Issue 5, 2014, Pages 535-548

Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma

Author keywords

AFP; Diagnosis; Dickkopfs; Hepatocellular carcinoma; Prognosis

Indexed keywords

ALPHA FETOPROTEIN; AXIN; AZACITIDINE; BETA CATENIN; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; DECARBOXYPROTHROMBIN; DICKKOPF 1 PROTEIN; DICKKOPF 2 PROTEIN; DICKKOPF 3 PROTEIN; DICKKOPF 4 PROTEIN; FLUOROURACIL; GEMCITABINE; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; MICRORNA 122; MICRORNA 155; MICRORNA 29A; UNCLASSIFIED DRUG; AFP PROTEIN, HUMAN; DKK1 PROTEIN, HUMAN; SIGNAL PEPTIDE; TUMOR MARKER;

EID: 84901271684     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2014.915747     Document Type: Review
Times cited : (13)

References (139)
  • 2
    • 63049133092 scopus 로고    scopus 로고
    • Hepatocellular carcinoma incidence. Mortality, and survival trends in the United States from 1975 to 2005
    • Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence. mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009;27(9):1485-91
    • (2009) J Clin Oncol , vol.27 , Issue.9 , pp. 1485-1491
    • Altekruse, S.F.1    McGlynn, K.A.2    Reichman, M.E.3
  • 4
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • DOI 10.1016/S0140-6736(03)14964-1
    • Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet 2003; 362(9399):1907-17 (Pubitemid 37518510
    • (2003) Lancet , vol.362 , Issue.9399 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 5
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: Incidence and risk factors
    • Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: Incidence and risk factors. Gastroenterology 2004;127(5 Suppl 1): S35-50
    • (2004) Gastroenterology , vol.127 , Issue.5 SUPPL. 1
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3    Donato, F.4
  • 6
    • 59249107797 scopus 로고    scopus 로고
    • Screening and diagnosis of hepatocellular carcinoma
    • Colombo M. Screening and diagnosis of hepatocellular carcinoma. Liver Int 2009; 29(Suppl 1):143-7
    • (2009) Liver Int , vol.29 , Issue.SUPPL. 1 , pp. 143-147
    • Colombo, M.1
  • 7
    • 82455198589 scopus 로고    scopus 로고
    • Ultrasonographic surveillance of hepatocellular carcinoma in cirrhosis: A randomized trial comparing 3-And 6-month periodicities
    • Trinchet JC, Chaffaut C, Bourcier V, et al. Ultrasonographic surveillance of hepatocellular carcinoma in cirrhosis: A randomized trial comparing 3-And 6-month periodicities. Hepatology 2011; 54(6):1987-97
    • (2011) Hepatology , vol.54 , Issue.6 , pp. 1987-1997
    • Trinchet, J.C.1    Chaffaut, C.2    Bourcier, V.3
  • 8
    • 0027458323 scopus 로고
    • Risk factors for tumor recurrence and prognosis after curative resection of hepatocellular carcinoma
    • DOI 10.1002/1097-0142(19930101)71:1<19::AID-CNCR2820710105>3.0. CO;2-I
    • Ikeda K, Saitoh S, Tsubota A, et al. Risk factors for tumor recurrence and prognosis after curative resection of hepatocellular carcinoma. Cancer 1993;71(1):19-25 (Pubitemid 23019276
    • (1993) Cancer , vol.71 , Issue.1 , pp. 19-25
    • Ikeda, K.1    Saitoh, S.2    Tsubota, A.3    Arase, Y.4    Chayama, K.5    Kumada, H.6    Watanabe, G.7    Tsurumaru, M.8
  • 9
    • 84863728651 scopus 로고    scopus 로고
    • Liver transplantation for hepatocellular cancer: UCL experience in 137 adult cirrhotic patients Alpha-foetoprotein level and locoregional treatment as refined selection criteria
    • Ciccarelli O, Lai Q, Goffette P, et al. Liver transplantation for hepatocellular cancer: UCL experience in 137 adult cirrhotic patients. Alpha-foetoprotein level and locoregional treatment as refined selection criteria. Transpl Int 2012;25(8):867-75
    • (2012) Transpl Int , vol.25 , Issue.8 , pp. 867-875
    • Ciccarelli, O.1    Lai, Q.2    Goffette, P.3
  • 10
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    • DOI 10.1053/jhep.2003.50047
    • Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology 2003;37(2):429-42 (Pubitemid 36152543
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 11
    • 80051546640 scopus 로고    scopus 로고
    • Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein as a marker of prognosis and a monitor of recurrence of hepatocellular carcinoma after curative liver resection
    • Zhang XF, Lai EC, Kang XY, et al. Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein as a marker of prognosis and a monitor of recurrence of hepatocellular carcinoma after curative liver resection. Ann Surg Oncol 2011;18(8): 2218-23
    • (2011) Ann Surg Oncol , vol.18 , Issue.8 , pp. 2218-2223
    • Zhang, X.F.1    Lai, E.C.2    Kang, X.Y.3
  • 12
    • 84867330943 scopus 로고    scopus 로고
    • Novel Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein: A biomarker of hepatocellular carcinoma recurrence in patients with low alpha-fetoprotein concentrations
    • Morimoto M, Numata K, Nozaki A, et al. Novel Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein: A biomarker of hepatocellular carcinoma recurrence in patients with low alpha-fetoprotein concentrations. Int J Clin Oncol 2012; 17(4):373-9
    • (2012) Int J Clin Oncol , vol.17 , Issue.4 , pp. 373-379
    • Morimoto, M.1    Numata, K.2    Nozaki, A.3
  • 13
    • 67650648501 scopus 로고    scopus 로고
    • Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma
    • Shirakawa H, Suzuki H, Shimomura M, et al. Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma. Cancer Sci 2009;100(8): 1403-7
    • (2009) Cancer Sci , vol.100 , Issue.8 , pp. 1403-1407
    • Shirakawa, H.1    Suzuki, H.2    Shimomura, M.3
  • 14
    • 0037698789 scopus 로고    scopus 로고
    • Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in American patients
    • DOI 10.1053/jhep.2003.50195
    • Marrero JA, Su GL, Wei W, et al. Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in American patients. Hepatology 2003;37(5): 1114-21 (Pubitemid 36538688
    • (2003) Hepatology , vol.37 , Issue.5 , pp. 1114-1121
    • Marrero, J.A.1    Su, G.L.2    Wei, W.3    Emick, D.4    Conjeevaram, H.S.5    Fontana, R.J.6    Lok, A.S.7
  • 15
    • 84866550659 scopus 로고    scopus 로고
    • Des-gamma-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma
    • Matsubara M, Shiraha H, Kataoka J, et al. Des-gamma-carboxyl prothrombin is associated with tumor angiogenesis in hepatocellular carcinoma. J Gastroenterol Hepatol 2012;27(10):1602-8
    • (2012) J Gastroenterol Hepatol , vol.27 , Issue.10 , pp. 1602-1608
    • Matsubara, M.1    Shiraha, H.2    Kataoka, J.3
  • 16
    • 78649899920 scopus 로고    scopus 로고
    • Golgi protein 73 (golph2) is a valuable serum marker for hepatocellular carcinoma
    • Mao Y, Yang H, Xu H, et al. Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma. Gut 2010; 59(12):1687-93
    • (2010) Gut , vol.59 , Issue.12 , pp. 1687-1693
    • Mao, Y.1    Yang, H.2    Xu, H.3
  • 17
    • 77950647292 scopus 로고    scopus 로고
    • Proteomics of hepatocellular carcinoma: Serum vimentin as a surrogate marker for small tumors (
    • Sun S, Poon RT, Lee NP, et al. Proteomics of hepatocellular carcinoma: Serum vimentin as a surrogate marker for small tumors (
    • (2010) J Proteome Res , vol.9 , Issue.4 , pp. 1923-1930
    • Sun, S.1    Poon, R.T.2    Lee, N.P.3
  • 18
    • 77956345377 scopus 로고    scopus 로고
    • Enhanced detection of early hepatocellular carcinoma by serum seldi-Tof proteomic signature combined with alpha-fetoprotein marker
    • Chen L, Ho DW, Lee NP, et al. Enhanced detection of early hepatocellular carcinoma by serum SELDI-TOF proteomic signature combined with alpha-fetoprotein marker. Ann Surg Oncol 2010;17(9):2518-25
    • (2010) Ann Surg Oncol , vol.17 , Issue.9 , pp. 2518-2525
    • Chen, L.1    Ho, D.W.2    Lee, N.P.3
  • 19
    • 84867081369 scopus 로고    scopus 로고
    • Combined measurement of preoperative alpha-fetoprotein and des-gamma-carboxy prothrombin predicts recurrence after curative resection in patients with hepatitis-B-related hepatocellular carcinoma
    • Chon YE, Choi GH, Lee MH, et al. Combined measurement of preoperative alpha-fetoprotein and des-gamma-carboxy prothrombin predicts recurrence after curative resection in patients with hepatitis-B-related hepatocellular carcinoma. Int J Cancer 2012;131(10):2332-41
    • (2012) Int J Cancer , vol.131 , Issue.10 , pp. 2332-2341
    • Chon, Y.E.1    Choi, G.H.2    Lee, M.H.3
  • 20
    • 84860141964 scopus 로고    scopus 로고
    • Circulating mir-15b and mir-130b in serum as potential markers for detecting hepatocellular carcinoma: A retrospective cohort study
    • Liu AM, Yao TJ, Wang W, et al. Circulating miR-15b and miR-130b in serum as potential markers for detecting hepatocellular carcinoma: A retrospective cohort study. BMJ Open 2012;2(2): E000825
    • (2012) BMJ Open , vol.2 , Issue.2
    • Liu, A.M.1    Yao, T.J.2    Wang, W.3
  • 21
    • 78649972032 scopus 로고    scopus 로고
    • Serum microrna profiles serve as novel biomarkers for hbv infection and diagnosis of hbv-positive hepatocarcinoma
    • Li LM, Hu ZB, Zhou ZX, et al. Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res 2010;70(23):9798-807
    • (2010) Cancer Res , vol.70 , Issue.23 , pp. 9798-9807
    • Li, L.M.1    Hu, Z.B.2    Zhou, Z.X.3
  • 22
    • 79952813995 scopus 로고    scopus 로고
    • Circulating microRNAs as biomarkers for hepatocellular carcinoma
    • Qu KZ, Zhang K, Li H, et al. Circulating microRNAs as biomarkers for hepatocellular carcinoma. J Clin Gastroenterol 2011;45(4): 355-60
    • (2011) J Clin Gastroenterol , vol.45 , Issue.4 , pp. 355-360
    • Qu, K.Z.1    Zhang, K.2    Li, H.3
  • 23
    • 84856229025 scopus 로고    scopus 로고
    • Dickkopfs and Wnt/beta-catenin signalling in liver cancer
    • Fatima S, Lee NP, Luk JM. Dickkopfs and Wnt/beta-catenin signalling in liver cancer. World J Clin Oncol 2011;2(8):311-25
    • (2011) World J Clin Oncol , vol.2 , Issue.8 , pp. 311-325
    • Fatima, S.1    Lee, N.P.2    Luk, J.M.3
  • 24
    • 34347341779 scopus 로고    scopus 로고
    • Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development
    • DOI 10.1242/dev.001230
    • McLin VA, Rankin SA, Zorn AM. Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 2007;134(12):2207-17 (Pubitemid 47010010
    • (2007) Development , vol.134 , Issue.12 , pp. 2207-2217
    • McLin, V.A.1    Rankin, S.A.2    Zorn, A.M.3
  • 25
    • 33644967242 scopus 로고    scopus 로고
    • Wnt signaling: Complexity at the surface
    • Cadigan KM, Liu YI. Wnt signaling: Complexity at the surface. J Cell Sci 2006; 119(Pt 3):395-402
    • (2006) J Cell Sci , vol.119 , Issue.PART 3 , pp. 395-402
    • Cadigan, K.M.1    Liu, Y.I.2
  • 26
    • 0036379830 scopus 로고    scopus 로고
    • Beta-catenin expression in hepatocellular carcinoma: A possible participation of beta-catenin in the dedifferentiation process
    • Suzuki T, Yano H, Nakashima Y, et al. Beta-catenin expression in hepatocellular carcinoma: A possible participation of beta-catenin in the dedifferentiation process. J Gastroenterol Hepatol 2002;17(9): 994-1000
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.9 , pp. 994-1000
    • Suzuki, T.1    Yano, H.2    Nakashima, Y.3
  • 27
    • 0035395236 scopus 로고    scopus 로고
    • Beta-catenin mutation and overexpression in hepatocellular carcinoma: Clinicopathologic and prognostic significance
    • DOI 10.1002/1097-0142(20010701)92:1<136::AID-CNCR1301>3.0.CO;2-R
    • Wong CM, Fan ST, Ng IO. beta-Catenin mutation and overexpression in hepatocellular carcinoma: Clinicopathologic and prognostic significance. Cancer 2001; 92(1):136-45 (Pubitemid 32623050
    • (2001) Cancer , vol.92 , Issue.1 , pp. 136-145
    • Wong, C.M.1    Fan, S.T.2    Ng, I.O.L.3
  • 28
    • 0032761853 scopus 로고    scopus 로고
    • Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection
    • Huang H, Fujii H, Sankila A, et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol 1999;155(6):1795-801
    • (1999) Am J Pathol , vol.155 , Issue.6 , pp. 1795-1801
    • Huang, H.1    Fujii, H.2    Sankila, A.3
  • 32
    • 63349098247 scopus 로고    scopus 로고
    • Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene
    • Cieply B, Zeng G, Proverbs-Singh T, et al. Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. Hepatology 2009;49(3):821-31
    • (2009) Hepatology , vol.49 , Issue.3 , pp. 821-831
    • Cieply, B.1    Zeng, G.2    Proverbs-Singh, T.3
  • 33
    • 40949086754 scopus 로고    scopus 로고
    • Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells
    • Kim M, Lee HC, Tsedensodnom O, et al. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 2008;48(5):780-91
    • (2008) J Hepatol , vol.48 , Issue.5 , pp. 780-791
    • Kim, M.1    Lee, H.C.2    Tsedensodnom, O.3
  • 36
    • 41049096579 scopus 로고    scopus 로고
    • APC promoter methylation and protein expression in hepatocellular carcinoma
    • Csepregi A, Rocken C, Hoffmann J, et al. APC promoter methylation and protein expression in hepatocellular carcinoma. J Cancer Res Clin Oncol 2008;134(5):579-89
    • (2008) J Cancer Res Clin Oncol , vol.134 , Issue.5 , pp. 579-589
    • Csepregi, A.1    Rocken, C.2    Hoffmann, J.3
  • 40
    • 33749501476 scopus 로고    scopus 로고
    • Prickle-1 negatively regulates wnt/beta-catenin pathway by promoting dishevelled ubiquitination/degradation in liver cancer
    • DOI 10.1053/j.gastro.2006.07.020, PII S0016508506016635
    • Chan DW, Chan CY, Yam JW, et al. Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer. Gastroenterology 2006;131(4): 1218-27 (Pubitemid 44515098
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1218-1227
    • Chan, D.W.1    Chan, C.2    Yam, J.W.P.3    Ching, Y.4    Ng, I.O.L.5
  • 41
    • 14944353116 scopus 로고    scopus 로고
    • HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: Involvement of methylation-mediated gene silencing
    • Yau TO, Chan CY, Chan KL, et al. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: Involvement of methylation-mediated gene silencing. Oncogene 2005;24(9):1607-14
    • (2005) Oncogene , vol.24 , Issue.9 , pp. 1607-1614
    • Yau, T.O.1    Chan, C.Y.2    Chan, K.L.3
  • 44
    • 0032556910 scopus 로고    scopus 로고
    • Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    • DOI 10.1038/34848
    • Glinka A, Wu W, Delius H, et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 1998;391(6665): 357-62 (Pubitemid 28093502
    • (1998) Nature , vol.391 , Issue.6665 , pp. 357-362
    • Glinka, A.1    Wu, W.2    Delius, H.3    Monaghan, A.P.4    Blumenstock, C.5    Niehrs, C.6
  • 46
    • 0035954281 scopus 로고    scopus 로고
    • Head inducer dickkopf-1 is a ligand for Wnt coreceptor LRP6
    • DOI 10.1016/S0960-9822(01)00290-1
    • Semenov MV, Tamai K, Brott BK, et al. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol 2001; 11(12):951-61 (Pubitemid 32589186
    • (2001) Current Biology , vol.11 , Issue.12 , pp. 951-961
    • Semenov, M.V.1    Tamai, K.2    Brott, B.K.3    Kuhl, M.4    Sokol, S.5    He, X.6
  • 47
    • 46049089076 scopus 로고    scopus 로고
    • Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of beta-Catenin Signaling
    • DOI 10.1016/j.devcel.2008.04.015, PII S1534580708001780
    • Yamamoto H, Sakane H, Michiue T, Kikuchi A. Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling. Dev Cell 2008;15(1):37-48 (Pubitemid 351895596
    • (2008) Developmental Cell , vol.15 , Issue.1 , pp. 37-48
    • Yamamoto, H.1    Sakane, H.2    Yamamoto, H.3    Michiue, T.4    Kikuchi, A.5
  • 48
    • 47949085566 scopus 로고    scopus 로고
    • Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density
    • Ellwanger K, Saito H, Clement-Lacroix P, et al. Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol 2008; 28(15):4875-82
    • (2008) Mol Cell Biol , vol.28 , Issue.15 , pp. 4875-4882
    • Ellwanger, K.1    Saito, H.2    Clement-Lacroix, P.3
  • 49
    • 53149087478 scopus 로고    scopus 로고
    • Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism
    • Wang K, Zhang Y, Li X, et al. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J Biol Chem 2008;283(34):23371-5
    • (2008) J Biol Chem , vol.283 , Issue.34 , pp. 23371-23375
    • Wang, K.1    Zhang, Y.2    Li, X.3
  • 52
    • 33847224852 scopus 로고    scopus 로고
    • The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types
    • Forget MA, Turcotte S, Beauseigle D, et al. The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types. Br J Cancer 2007;96(4):646-53
    • (2007) Br J Cancer , vol.96 , Issue.4 , pp. 646-653
    • Forget, M.A.1    Turcotte, S.2    Beauseigle, D.3
  • 53
    • 84861401445 scopus 로고    scopus 로고
    • Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype
    • Xu WH, Liu ZB, Yang C, et al. Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. PLoS One 2012; 7(5):e37624
    • (2012) PLoS One , vol.7 , Issue.5
    • Xu, W.H.1    Liu, Z.B.2    Yang, C.3
  • 54
    • 79960898036 scopus 로고    scopus 로고
    • Dickkopf-1 is frequently overexpressed in ovarian serous carcinoma and involved in tumor invasion
    • Wang S, Zhang S. Dickkopf-1 is frequently overexpressed in ovarian serous carcinoma and involved in tumor invasion. Clin Exp Metastasis 2011;28(6):581-91
    • (2011) Clin Exp Metastasis , vol.28 , Issue.6 , pp. 581-591
    • Wang, S.1    Zhang, S.2
  • 55
    • 80053997262 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of serum and tissue dickkopf-1 levels in human hepatocellular carcinoma
    • Tung EK, Mak CK, Fatima S, et al. Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma. Liver Int 2011;31(10):1494-504
    • (2011) Liver Int , vol.31 , Issue.10 , pp. 1494-1504
    • Tung, E.K.1    Mak, C.K.2    Fatima, S.3
  • 56
    • 77954374183 scopus 로고    scopus 로고
    • Wnt inhibitor dickkopf-1 as a target for passive cancer immunotherapy
    • Sato N, Yamabuki T, Takano A, et al. Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy. Cancer Res 2010; 70(13):5326-36
    • (2010) Cancer Res , vol.70 , Issue.13 , pp. 5326-5336
    • Sato, N.1    Yamabuki, T.2    Takano, A.3
  • 57
    • 0037413696 scopus 로고    scopus 로고
    • Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling
    • DOI 10.1016/S0378-1119(02)01106-X
    • Mao B, Niehrs C. Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling. Gene 2003;302(1-2): 179-83 (Pubitemid 36078410
    • (2003) Gene , vol.302 , Issue.1-2 , pp. 179-183
    • Mao, B.1    Niehrs, C.2
  • 58
    • 47949094194 scopus 로고    scopus 로고
    • DICKKOPF-4 is induced by TCF/betacatenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3
    • Pendas-Franco N, Garcia JM, Pena C, et al. DICKKOPF-4 is induced by TCF/betacatenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3. Oncogene 2008;27(32):4467-77
    • (2008) Oncogene , vol.27 , Issue.32 , pp. 4467-4477
    • Pendas-Franco, N.1    Garcia, J.M.2    Pena, C.3
  • 59
    • 64749106861 scopus 로고    scopus 로고
    • Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas
    • Yu B, Yang X, Xu Y, et al. Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. J Hepatol 2009; 50(5):948-57
    • (2009) J Hepatol , vol.50 , Issue.5 , pp. 948-957
    • Yu, B.1    Yang, X.2    Xu, Y.3
  • 62
    • 58249085555 scopus 로고    scopus 로고
    • Dkk3, downregulated in cervical cancer, functions as a negative regulator of beta-catenin
    • Lee EJ, Jo M, Rho SB, et al. Dkk3, downregulated in cervical cancer, functions as a negative regulator of beta-catenin. Int J Cancer 2009;124(2):287-97
    • (2009) Int J Cancer , vol.124 , Issue.2 , pp. 287-297
    • Lee, E.J.1    Jo, M.2    Rho, S.B.3
  • 64
    • 69549111595 scopus 로고    scopus 로고
    • Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer
    • Sheng SL, Huang G, Yu B, Qin WX. Clinical significance and prognostic value of serum Dickkopf-1 concentrations in patients with lung cancer. Clin Chem 2009;55(9): 1656-64
    • (2009) Clin Chem , vol.55 , Issue.9 , pp. 1656-1664
    • Sheng, S.L.1    Huang, G.2    Yu, B.3    Qin, W.X.4
  • 65
    • 84864484695 scopus 로고    scopus 로고
    • Clinical significance of serum and tissue dickkopf-1 levels in patients with gastric cancer
    • Lee HS, Lee HE, Park DJ, et al. Clinical significance of serum and tissue Dickkopf-1 levels in patients with gastric cancer. Clin Chim Acta 2012;413(21-22): 1753-60
    • (2012) Clin Chim Acta , vol.413 , Issue.21-22 , pp. 1753-1760
    • Lee, H.S.1    Lee, H.E.2    Park, D.J.3
  • 66
    • 73449088791 scopus 로고    scopus 로고
    • Clinical significance of serum DKK-1 in patients with gynecological cancer
    • Jiang T, Wang S, Huang L, Zhang S. Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer 2009;19(7):1177-81
    • (2009) Int J Gynecol Cancer , vol.19 , Issue.7 , pp. 1177-1181
    • Jiang, T.1    Wang, S.2    Huang, L.3    Zhang, S.4
  • 67
    • 84864359563 scopus 로고    scopus 로고
    • Serum dkk1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: A large-scale multicentre study
    • Shen Q, Fan J, Yang XR, et al. Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: A large-scale, multicentre study. Lancet Oncol 2012;13(8):817-26
    • (2012) Lancet Oncol , vol.13 , Issue.8 , pp. 817-826
    • Shen, Q.1    Fan, J.2    Yang, X.R.3
  • 70
    • 0034495080 scopus 로고    scopus 로고
    • Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis
    • Hsu HC, Jeng YM, Mao TL, et al. Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000; 157(3):763-70
    • (2000) Am J Pathol , vol.157 , Issue.3 , pp. 763-770
    • Hsu, H.C.1    Jeng, Y.M.2    Mao, T.L.3
  • 71
    • 84861958860 scopus 로고    scopus 로고
    • Hepatitis B vs. Hepatitis C infection on viral hepatitis-Associated hepatocellular carcinoma
    • Hiotis SP, Rahbari NN, Villanueva GA, et al. Hepatitis B vs. hepatitis C infection on viral hepatitis-Associated hepatocellular carcinoma. BMC Gastroenterol 2012;12:64
    • (2012) BMC Gastroenterol , vol.12 , pp. 64
    • Hiotis, S.P.1    Rahbari, N.N.2    Villanueva, G.A.3
  • 73
    • 59849104114 scopus 로고    scopus 로고
    • Distinct expression patterns in hepatitis B virus-And hepatitis C virus-infected hepatocellular carcinoma
    • Lee CF, Ling ZQ, Zhao T, Lee KR. Distinct expression patterns in hepatitis B virus-And hepatitis C virus-infected hepatocellular carcinoma. World J Gastroenterol 2008;14(39):6072-7
    • (2008) World J Gastroenterol , vol.14 , Issue.39 , pp. 6072-6077
    • Lee, C.F.1    Ling, Z.Q.2    Zhao, T.3    Lee, K.R.4
  • 75
    • 0035266345 scopus 로고    scopus 로고
    • Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: Identification of genes involved in viral carcinogenesis and tumor progression
    • Okabe H, Satoh S, Kato T, et al. Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: Identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res 2001;61(5): 2129-37 (Pubitemid 32692038
    • (2001) Cancer Research , vol.61 , Issue.5 , pp. 2129-2137
    • Okabe, H.1    Satoh, S.2    Kato, T.3    Kitahara, O.4    Yanagawa, R.5    Yamaoka, Y.6    Tsunoda, T.7    Furukawa, Y.8    Nakamura, Y.9
  • 76
    • 0030018852 scopus 로고    scopus 로고
    • Determination of serum des-gamma-carboxy prothrombin levels in patients with small-sized hepatocellular carcinoma: Comparison of the conventional enzyme immunoassay and two modified methods
    • Nomura F, Ishijima M, Horikoshi A, et al. Determination of serum des-gamma-carboxy prothrombin levels in patients with small-sized hepatocellular carcinoma: Comparison of the conventional enzyme immunoassay and two modified methods. Am J Gastroenterol 1996;91(7):1380-3 (Pubitemid 26236374
    • (1996) American Journal of Gastroenterology , vol.91 , Issue.7 , pp. 1380-1383
    • Nomura, F.1    Ishijima, M.2    Horikoshi, A.3    Nakai, T.4    Ohnishi, K.5
  • 77
    • 0034146463 scopus 로고    scopus 로고
    • A simultaneous monitoring of Lens culinaris agglutinin A-reactive alphafetoprotein and des-gamma-carboxy prothrombin as an early diagnosis of hepatocellular carcinoma in the follow-up of cirrhotic patients
    • Shimauchi Y, Tanaka M, Kuromatsu R, et al. A simultaneous monitoring of Lens culinaris agglutinin A-reactive alphafetoprotein and des-gamma-carboxy prothrombin as an early diagnosis of hepatocellular carcinoma in the follow-up of cirrhotic patients. Oncol Rep 2000;7(2): 249-56
    • (2000) Oncol Rep , vol.7 , Issue.2 , pp. 249-256
    • Shimauchi, Y.1    Tanaka, M.2    Kuromatsu, R.3
  • 78
    • 0036297393 scopus 로고    scopus 로고
    • Tumor markers in early diagnosis, follow-up and management of patients with hepatocellular carcinoma
    • DOI 10.1159/000048277
    • Fujiyama S, Tanaka M, Maeda S, et al. Tumor markers in early diagnosis, follow-up and management of patients with hepatocellular carcinoma. Oncology 2002; 62(Suppl 1):57-63 (Pubitemid 34702021
    • (2002) Oncology , vol.62 , Issue.SUPPL. . 1 , pp. 57-63
    • Fujiyama, S.1    Tanaka, M.2    Maeda, S.3    Ashihara, H.4    Hirata, R.5    Tomita, K.6
  • 79
    • 0036068640 scopus 로고    scopus 로고
    • Clinicopathologic features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein-L3 and seronegative for des-gamma-carboxy prothrombin in comparison with those seropositive for des-gamma-carboxy prothrombin alone
    • DOI 10.1046/j.1440-1746.2002.02806.x
    • Okuda H, Nakanishi T, Takatsu K, et al. Clinicopathologic features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein-L3 and seronegative for des-gamma-carboxy prothrombin in comparison with those seropositive for des-gamma-carboxy prothrombin alone. J Gastroenterol Hepatol 2002;17(7):772-8 (Pubitemid 34779738
    • (2002) Journal of Gastroenterology and Hepatology , vol.17 , Issue.7 , pp. 772-778
    • Okuda, H.1    Nakanishi, T.2    Takatsu, K.3    Saito, A.4    Hayashii, N.5    Yamamoto, M.6    Takasakii, K.7    Nakano, M.8
  • 80
    • 1642439117 scopus 로고    scopus 로고
    • Unique clinicopathological features of patients with primary malignant hepatic tumors who are seropositive for lectin-reactive alpha-fetoprotein alone: Report of five cases [1]
    • DOI 10.1111/j.1440-1746.2004.03218.x
    • Okuda H, Saito A, Haruyama K, et al. Unique clinicopathological features of patients with primary malignant hepatic tumors who are seropositive for lectin-reactive alpha-fetoprotein alone: Report of five cases. J Gastroenterol Hepatol 2004; 19(1):113-14 (Pubitemid 38130618
    • (2004) Journal of Gastroenterology and Hepatology , vol.19 , Issue.1 , pp. 113-114
    • Okuda, H.1    Saito, A.2    Haruyama, K.3    Hayashi, N.4    Yamamoto, M.5    Takasaki, K.6    Nakano, M.7
  • 81
    • 19544389853 scopus 로고    scopus 로고
    • Clinicopathologic features of patients with primary malignant hepatic tumors seropositive for alpha-fetoprotein-L3 alone in comparison with other patients seropositive for alpha-fetoprotein-L3
    • DOI 10.1111/j.1440-1746.2005.03773.x
    • Okuda H, Saito A, Shiratori K, et al. Clinicopathologic features of patients with primary malignant hepatic tumors seropositive for alpha-fetoprotein-L3 alone in comparison with other patients seropositive for alpha-fetoprotein-L3. J Gastroenterol Hepatol 2005;20(5):759-64 (Pubitemid 40733372
    • (2005) Journal of Gastroenterology and Hepatology , vol.20 , Issue.5 , pp. 759-764
    • Okuda, H.1    Saito, A.2    Shiratori, K.3    Yamamoto, M.4    Takasaki, K.5    Nakano, M.6
  • 82
    • 58049200257 scopus 로고    scopus 로고
    • Utility of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin, alone or in combination, as biomarkers for hepatocellular carcinoma
    • Sterling RK, Jeffers L, Gordon F, et al. Utility of Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxy prothrombin, alone or in combination, as biomarkers for hepatocellular carcinoma. Clin Gastroenterol Hepatol 2009;7(1):104-13
    • (2009) Clin Gastroenterol Hepatol , vol.7 , Issue.1 , pp. 104-113
    • Sterling, R.K.1    Jeffers, L.2    Gordon, F.3
  • 83
    • 67649305155 scopus 로고    scopus 로고
    • Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma
    • Marrero JA, Feng Z, Wang Y, et al. Alpha-fetoprotein, des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma. Gastroenterology 2009;137(1): 110-18
    • (2009) Gastroenterology , vol.137 , Issue.1 , pp. 110-118
    • Marrero, J.A.1    Feng, Z.2    Wang, Y.3
  • 84
    • 33847231604 scopus 로고    scopus 로고
    • Clinical evaluation of lens culinaris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States
    • Carr BI, Kanke F, Wise M, Satomura S. Clinical evaluation of lens culinaris agglutinin-reactive alpha-fetoprotein and des-gamma-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States. Dig Dis Sci 2007;52(3):776-82
    • (2007) Dig Dis Sci , vol.52 , Issue.3 , pp. 776-782
    • Carr, B.I.1    Kanke, F.2    Wise, M.3    Satomura, S.4
  • 85
    • 0041627705 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma
    • Tang W, Miki K, Kokudo N, et al. Des-gamma-carboxy prothrombin in cancer and non-cancer liver tissue of patients with hepatocellular carcinoma. Int J Oncol 2003; 22(5):969-75
    • (2003) Int J Oncol , vol.22 , Issue.5 , pp. 969-975
    • Tang, W.1    Miki, K.2    Kokudo, N.3
  • 86
    • 0034177223 scopus 로고    scopus 로고
    • Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-gamma-carboxy prothrombin and low serum alpha-fetoprotein
    • DOI 10.1002/(SICI)1097-0142(20000401)88:7<1557::AID-CNCR9>3.0.CO;2- G
    • Hamamura K, Shiratori Y, Shiina S, et al. Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-gamma-carboxy prothrombin and low serum alpha-fetoprotein. Cancer 2000;88(7): 1557-64 (Pubitemid 30183140
    • (2000) Cancer , vol.88 , Issue.7 , pp. 1557-1564
    • Hamamura, K.1    Shiratori, Y.2    Shiina, S.3    Imamura, M.4    Obi, S.5    Sato, S.6    Yoshida, H.7    Omata, M.8
  • 88
    • 21644438232 scopus 로고    scopus 로고
    • Des-gamma-carboxyprothrombin expression in cancer and/or non-cancer liver tissues: Association with survival of patients with resectable hepatocellular carcinoma
    • Tang W, Kokudo N, Sugawara Y, et al. Des-gamma-carboxyprothrombin expression in cancer and/or non-cancer liver tissues: Association with survival of patients with resectable hepatocellular carcinoma. Oncol Rep 2005;13(1):25-30
    • (2005) Oncol Rep , vol.13 , Issue.1 , pp. 25-30
    • Tang, W.1    Kokudo, N.2    Sugawara, Y.3
  • 89
    • 79960205154 scopus 로고    scopus 로고
    • Wntbetacatenin signaling activates microrna-181 expression in hepatocellular carcinoma
    • Ji J, Yamashita T, Wang XW. Wnt/betacatenin signaling activates microRNA-181 expression in hepatocellular carcinoma. Cell Biosci 2011;1(1):4
    • (2011) Cell Biosci , vol.1 , Issue.1 , pp. 4
    • Ji, J.1    Yamashita, T.2    Wang, X.W.3
  • 90
    • 84862777271 scopus 로고    scopus 로고
    • Microrna-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting wntbetacatenin pathway
    • Xu J, Zhu X, Wu L, et al. MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/betacatenin pathway. Liver Int 2012;32(5): 752-60
    • (2012) Liver Int , vol.32 , Issue.5 , pp. 752-760
    • Xu, J.1    Zhu, X.2    Wu, L.3
  • 91
    • 84868192318 scopus 로고    scopus 로고
    • Hepatitis c virus-induced upregulation of mir-155 promotes hepatocarcinogenesis by activating wnt signaling
    • Zhang Y, Wei W, Cheng N, et al. Hepatitis C. Virus-induced upregulation of miR-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology 2012; 56(5):1631-40
    • (2012) Hepatology , vol.56 , Issue.5 , pp. 1631-1640
    • Zhang, Y.1    Wei, W.2    Cheng, N.3
  • 92
    • 46249083024 scopus 로고    scopus 로고
    • MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations
    • DOI 10.1002/hep.22256
    • Ladeiro Y, Couchy G, Balabaud C, et al. MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 2008;47(6): 1955-63 (Pubitemid 351952843
    • (2008) Hepatology , vol.47 , Issue.6 , pp. 1955-1963
    • Ladeiro, Y.1    Couchy, G.2    Balabaud, C.3    Bioulac-Sage, P.4    Pelletier, L.5    Rebouissou, S.6    Zucman-Rossi, J.7
  • 94
    • 77955492538 scopus 로고    scopus 로고
    • MiR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop
    • Kapinas K, Kessler C, Ricks T, et al. miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. J Biol Chem 2010;285(33):25221-31
    • (2010) J Biol Chem , vol.285 , Issue.33 , pp. 25221-25231
    • Kapinas, K.1    Kessler, C.2    Ricks, T.3
  • 96
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    • Qiang YW, Barlogie B, Rudikoff S, Shaughnessy JD Jr. Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone 2008;42(4):669-80
    • (2008) Bone , vol.42 , Issue.4 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3    Shaughnessy Jr., J.D.4
  • 100
    • 57649158485 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment
    • Heider U, Kaiser M, Mieth M, et al. Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment. Eur J Haematol 2009;82(1):31-8
    • (2009) Eur J Haematol , vol.82 , Issue.1 , pp. 31-38
    • Heider, U.1    Kaiser, M.2    Mieth, M.3
  • 103
    • 84856421104 scopus 로고    scopus 로고
    • Relationship between clinicopathologic variables and serum and tissue levels of dickkopf-1 in patients with rectal cancer
    • Kemik O, Kemik AS, Sumer A, et al. Relationship between clinicopathologic variables and serum and tissue levels of dickkopf-1 in patients with rectal cancer. J Investig Med 2011;59(6):947-50
    • (2011) J Investig Med , vol.59 , Issue.6 , pp. 947-950
    • Kemik, O.1    Kemik, A.S.2    Sumer, A.3
  • 104
    • 84864484695 scopus 로고    scopus 로고
    • Clinical significance of serum and tissue Dickkopf-1 levels in patients with gastric cancer
    • Lee HS, Lee HE, Park do J, et al. Clinical significance of serum and tissue Dickkopf-1 levels in patients with gastric cancer. Clin Chim Acta 2012;413(21-22): 1753-60
    • (2012) Clin Chim Acta , vol.413 , Issue.21-22 , pp. 1753-1760
    • Lee, H.S.1    Lee, H.E.2    Park Do, J.3
  • 105
    • 67650431302 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T, et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 2009;114(2):371-9
    • (2009) Blood , vol.114 , Issue.2 , pp. 371-379
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 106
    • 84862908226 scopus 로고    scopus 로고
    • Active vaccination with dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma
    • Qian J, Zheng Y, Zheng C, et al. Active vaccination with Dickkopf-1 induces protective and therapeutic antitumor immunity in murine multiple myeloma. Blood 2012;119(1):161-9
    • (2012) Blood , vol.119 , Issue.1 , pp. 161-169
    • Qian, J.1    Zheng, Y.2    Zheng, C.3
  • 107
    • 76749140452 scopus 로고    scopus 로고
    • Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma
    • Yang B, Du Z, Gao YT, et al. Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma. World J Gastroenterol 2010;16(6):755-63
    • (2010) World J Gastroenterol , vol.16 , Issue.6 , pp. 755-763
    • Yang, B.1    Du, Z.2    Gao, Y.T.3
  • 109
    • 70349456794 scopus 로고    scopus 로고
    • Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways
    • Hirata H, Hinoda Y, Nakajima K, et al. Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways. Clin Cancer Res 2009;15(18): 5678-87
    • (2009) Clin Cancer Res , vol.15 , Issue.18 , pp. 5678-5687
    • Hirata, H.1    Hinoda, Y.2    Nakajima, K.3
  • 110
    • 84870327013 scopus 로고    scopus 로고
    • Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma
    • Zhu J, Zhang S, Gu L, Di W. Epigenetic silencing of DKK2 and Wnt signal pathway components in human ovarian carcinoma. Carcinogenesis 2012;33(12):2334-43
    • (2012) Carcinogenesis , vol.33 , Issue.12 , pp. 2334-2343
    • Zhu, J.1    Zhang, S.2    Gu, L.3    Di, W.4
  • 112
    • 11244323971 scopus 로고    scopus 로고
    • Dickkopf-3/REIC functions as a suppressor gene of tumor growth
    • Hsieh SY, Hsieh PS, Chiu CT, Chen WY. Dickkopf-3/REIC functions as a suppressor gene of tumor growth. Oncogene 2004; 23(57):9183-9
    • (2004) Oncogene , vol.23 , Issue.57 , pp. 9183-9189
    • Hsieh, S.Y.1    Hsieh, P.S.2    Chiu, C.T.3    Chen, W.Y.4
  • 114
    • 80053893155 scopus 로고    scopus 로고
    • Dickkopf3 overexpression inhibits pancreatic cancer cell growth in vitro
    • Gu YM, Ma YH, Zhao WG, Chen J. Dickkopf3 overexpression inhibits pancreatic cancer cell growth in vitro. World J Gastroenterol 2011;17(33):3810-17
    • (2011) World J Gastroenterol , vol.17 , Issue.33 , pp. 3810-3817
    • Gu, Y.M.1    Ma, Y.H.2    Zhao, W.G.3    Chen, J.4
  • 115
    • 68349139365 scopus 로고    scopus 로고
    • Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer
    • Veeck J, Wild PJ, Fuchs T, et al. Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. BMC Cancer 2009;9:217
    • (2009) BMC Cancer , vol.9 , pp. 217
    • Veeck, J.1    Wild, P.J.2    Fuchs, T.3
  • 116
    • 58949084494 scopus 로고    scopus 로고
    • Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer
    • Yu J, Tao Q, Cheng YY, et al. Promoter methylation of the Wnt/beta-catenin signaling antagonist Dkk-3 is associated with poor survival in gastric cancer. Cancer 2009;115(1):49-60
    • (2009) Cancer , vol.115 , Issue.1 , pp. 49-60
    • Yu, J.1    Tao, Q.2    Cheng, Y.Y.3
  • 117
    • 47249111724 scopus 로고    scopus 로고
    • Epigenetic alteration of wnt pathway antagonists in progressive glandular neoplasia of the lung
    • DOI 10.1093/carcin/bgn017
    • Licchesi JD, Westra WH, Hooker CM, et al. Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis 2008; 29(5):895-904 (Pubitemid 351982232
    • (2008) Carcinogenesis , vol.29 , Issue.5 , pp. 895-904
    • Licchesi, J.D.F.1    Westra, W.H.2    Hooker, C.M.3    Machida, E.O.4    Baylin, S.B.5    Herman, J.G.6
  • 119
    • 38349133630 scopus 로고    scopus 로고
    • Dickkopf-3 as a new potential marker for neoangiogenesis in colorectal cancer: Expression in cancer tissue and adjacent non-cancerous tissue
    • Zitt M, Untergasser G, Amberger A, et al. Dickkopf-3 as a new potential marker for neoangiogenesis in colorectal cancer: Expression in cancer tissue and adjacent non-cancerous tissue. Dis Markers 2008; 24(2):101-9
    • (2008) Dis Markers , vol.24 , Issue.2 , pp. 101-109
    • Zitt, M.1    Untergasser, G.2    Amberger, A.3
  • 120
    • 67650666507 scopus 로고    scopus 로고
    • Dkk-3 expression in the tumor endothelium: A novel prognostic marker of pancreatic adenocarcinomas
    • Fong D, Hermann M, Untergasser G, et al. Dkk-3 expression in the tumor endothelium: A novel prognostic marker of pancreatic adenocarcinomas. Cancer Sci 2009;100(8):1414-20
    • (2009) Cancer Sci , vol.100 , Issue.8 , pp. 1414-1420
    • Fong, D.1    Hermann, M.2    Untergasser, G.3
  • 121
    • 77954895848 scopus 로고    scopus 로고
    • Clinical significance of serum Dkk-3 in patients with gynecological cancer
    • Jiang T, Huang L, Wang S, Zhang S. Clinical significance of serum Dkk-3 in patients with gynecological cancer. J Obstet Gynaecol Res 2010;36(4):769-73
    • (2010) J Obstet Gynaecol Res , vol.36 , Issue.4 , pp. 769-773
    • Jiang, T.1    Huang, L.2    Wang, S.3    Zhang, S.4
  • 122
    • 80755159355 scopus 로고    scopus 로고
    • Elevated levels of Dickkopf-related protein 3 in seminal plasma of prostate cancer patients
    • Zenzmaier C, Heitz M, Klocker H, et al. Elevated levels of Dickkopf-related protein 3 in seminal plasma of prostate cancer patients. J Transl Med 2011;9:193
    • (2011) J Transl Med , vol.9 , pp. 193
    • Zenzmaier, C.1    Heitz, M.2    Klocker, H.3
  • 123
    • 41849139333 scopus 로고    scopus 로고
    • Dysregulation of Dkk-3 expression in benign and malignant prostatic tissue
    • DOI 10.1002/pros.20711
    • Zenzmaier C, Untergasser G, Hermann M, et al. Dysregulation of Dkk-3 expression in benign and malignant prostatic tissue. Prostate 2008;68(5):540-7 (Pubitemid 351500214
    • (2008) Prostate , vol.68 , Issue.5 , pp. 540-547
    • Zenzmaier, C.1    Untergasser, G.2    Hermann, M.3    Dirnhofer, S.4    Sampson, N.5    Berger, P.6
  • 124
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells
    • Jahr S, Hentze H, Englisch S, et al. DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001;61(4):1659-65 (Pubitemid 34292602
    • (2001) Cancer Research , vol.61 , Issue.4 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3    Hardt, D.4    Fackelmayer, F.O.5    Hesch, R.-D.6    Knippers, R.7
  • 125
    • 84872168031 scopus 로고    scopus 로고
    • Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening
    • Kloten V, Becker B, Winner K, et al. Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening. Breast Cancer Res 2013;15(1):R4
    • (2013) Breast Cancer Res , vol.15 , Issue.1
    • Kloten, V.1    Becker, B.2    Winner, K.3
  • 127
    • 83155177127 scopus 로고    scopus 로고
    • Plasma DNA methylation of Wnt antagonists predicts recurrence of esophageal squamous cell carcinoma
    • Liu JB, Qiang FL, Dong J, et al. Plasma DNA methylation of Wnt antagonists predicts recurrence of esophageal squamous cell carcinoma. World J Gastroenterol 2011; 17(44):4917-21
    • (2011) World J Gastroenterol , vol.17 , Issue.44 , pp. 4917-4921
    • Liu, J.B.1    Qiang, F.L.2    Dong, J.3
  • 128
    • 84866549389 scopus 로고    scopus 로고
    • Dickkopf 4 (dkk4) acts on wntbetacatenin pathway by influencing beta-catenin in hepatocellular carcinoma
    • Fatima S, Lee NP, Tsang FH, et al. Dickkopf 4 (DKK4) acts on Wnt/betacatenin pathway by influencing beta-catenin in hepatocellular carcinoma. Oncogene 2012;31(38):4233-44
    • (2012) Oncogene , vol.31 , Issue.38 , pp. 4233-4244
    • Fatima, S.1    Lee, N.P.2    Tsang, F.H.3
  • 129
    • 70349602255 scopus 로고    scopus 로고
    • DICKKOPF-4 and-2 genes are upregulated in human colorectal cancer
    • Matsui A, Yamaguchi T, Maekawa S, et al. DICKKOPF-4 and-2 genes are upregulated in human colorectal cancer. Cancer Sci 2009;100(10):1923-30
    • (2009) Cancer Sci , vol.100 , Issue.10 , pp. 1923-1930
    • Matsui, A.1    Yamaguchi, T.2    Maekawa, S.3
  • 130
    • 60849116411 scopus 로고    scopus 로고
    • Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells
    • Baehs S, Herbst A, Thieme SE, et al. Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells. Cancer Lett 2009;276(2):152-9
    • (2009) Cancer Lett , vol.276 , Issue.2 , pp. 152-159
    • Baehs, S.1    Herbst, A.2    Thieme, S.E.3
  • 131
    • 79953798397 scopus 로고    scopus 로고
    • Dickkopf-4 activates the noncanonical c-jun-nh2 kinase signaling pathway while inhibiting the wnt-canonical pathway in human renal cell carcinoma
    • Hirata H, Hinoda Y, Majid S, et al. DICKKOPF-4 activates the noncanonical c-Jun-NH2 kinase signaling pathway while inhibiting the Wnt-canonical pathway in human renal cell carcinoma. Cancer 2011; 117(8):1649-60
    • (2011) Cancer , vol.117 , Issue.8 , pp. 1649-1660
    • Hirata, H.1    Hinoda, Y.2    Majid, S.3
  • 132
    • 38749095527 scopus 로고    scopus 로고
    • Validation of biomarkers associated with 5-fiuorouracil and thymidylate synthase in colorectal cancer
    • Xi Y, Formentini A, Nakajima G, et al. Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer. Oncol Rep 2008;19(1): 257-62 (Pubitemid 351176158
    • (2008) Oncology Reports , vol.19 , Issue.1 , pp. 257-262
    • Xi, Y.1    Formentini, A.2    Nakajima, G.3    Kornmann, M.4    Ju, J.5
  • 133
    • 84855755065 scopus 로고    scopus 로고
    • Tfap2e-dkk4 and chemoresistance in colorectal cancer
    • Ebert MP, Tanzer M, Balluff B, et al. TFAP2E-DKK4 and chemoresistance in colorectal cancer. N Engl J Med 2012; 366(1):44-53
    • (2012) N Engl J Med , vol.366 , Issue.1 , pp. 44-53
    • Ebert, M.P.1    Tanzer, M.2    Balluff, B.3
  • 134
    • 67349198077 scopus 로고    scopus 로고
    • Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-Alpha/5-fluorouracil combination therapy for hepatocellular carcinoma
    • Noda T, Nagano H, Takemasa I, et al. Activation of Wnt/beta-catenin signalling pathway induces chemoresistance to interferon-Alpha/5-fluorouracil combination therapy for hepatocellular carcinoma. Br J Cancer 2009;100(10):1647-58
    • (2009) Br J Cancer , vol.100 , Issue.10 , pp. 1647-1658
    • Noda, T.1    Nagano, H.2    Takemasa, I.3
  • 135
    • 36448942509 scopus 로고    scopus 로고
    • Interferon-Alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules
    • DOI 10.1002/cncr.23033
    • Nagano H, Miyamoto A, Wada H, et al. Interferon-Alpha and 5-fluorouracil combination therapy after palliative hepatic resection in patients with advanced hepatocellular carcinoma, portal venous tumor thrombus in the major trunk, and multiple nodules. Cancer 2007;110(11): 2493-501 (Pubitemid 350174935
    • (2007) Cancer , vol.110 , Issue.11 , pp. 2493-2501
    • Nagano, H.1    Miyamoto, A.2    Wada, H.3    Ota, H.4    Marubashi, S.5    Takeda, Y.6    Dono, K.7    Umeshita, K.8    Sakon, M.9    Monden, M.10
  • 136
    • 0034122117 scopus 로고    scopus 로고
    • Sensitivity of commonly available screening tests in detecting hepatocellular carcinoma in cirrhotic patients undergoing liver transplantation
    • DOI 10.1016/S0002-9270(00)00883-2, PII S0002927000008832
    • Gambarin-Gelwan M, Wolf DC, Shapiro R, et al. Sensitivity of commonly available screening tests in detecting hepatocellular carcinoma in cirrhotic patients undergoing liver transplantation. Am J Gastroenterol 2000;95(6):1535-8 (Pubitemid 30396316
    • (2000) American Journal of Gastroenterology , vol.95 , Issue.6 , pp. 1535-1538
    • Gambarin-Gelwan, M.1    Wolf, D.C.2    Shapiro, R.3    Schwartz, M.E.4    Min, A.D.5
  • 138
    • 82255185608 scopus 로고    scopus 로고
    • Diagnostic accuracy of alpha-fetoprotein and des-gamma-carboxy prothrombin in screening for hepatocellular carcinoma in liver transplant candidates
    • Yamashiki N, Sugawara Y, Tamura S, et al. Diagnostic accuracy of alpha-fetoprotein and des-gamma-carboxy prothrombin in screening for hepatocellular carcinoma in liver transplant candidates. Hepatol Res 2011;41(12):1199-207
    • (2011) Hepatol Res , vol.41 , Issue.12 , pp. 1199-1207
    • Yamashiki, N.1    Sugawara, Y.2    Tamura, S.3
  • 139
    • 77957558765 scopus 로고    scopus 로고
    • Diagnostic value of glypican-3 in serum and liver for primary hepatocellular carcinoma
    • Liu H, Li P, Zhai Y, et al. Diagnostic value of glypican-3 in serum and liver for primary hepatocellular carcinoma. World J Gastroenterol 2010;16(35):4410-15
    • (2010) World J Gastroenterol , vol.16 , Issue.35 , pp. 4410-4415
    • Liu, H.1    Li, P.2    Zhai, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.