APC promoter methylation and protein expression in hepatocellular carcinoma

Journal of Cancer Research and Clinical Oncology

Volumn 134, Issue 5, 2008, Pages 579-589

  Csepregi, Antal ^a   Röcken, Christoph ^b   Hoffmann, Juliane ^a   Gu, Ping ^a   Saliger, Stephan ^a   Müller, Oliver ^c   Schneider Stock, Regine ^a   Kutzner, Nadine ^c   Roessner, Albert ^a   Malfertheiner, Peter ^a   Ebert, Matthias P A ^d  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

APC; Hepatocellular carcinoma; Methylight assay; Promoter methylation; Protein

Indexed keywords

APC PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DNA METHYLATION; DNA SEQUENCE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; WESTERN BLOTTING;

ADENOMATOUS POLYPOSIS COLI PROTEIN; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS (GENETICS);

EID: 41049096579     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-007-0321-y     Document Type: Article

References (21)

1. Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, Wirtz R, Kuhl M, Wedlich D, Birchmeier W (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280:596-599
2. Bird A (1992) The essentials of DNA methylation. Cell 70:5-8
3. Bosch X, Ribes J, Borras J (1999) Epidemiology of primary liver cancer. Semin Liver Dis 19:271-285
4. Chen J, Rocken C, Lofton-Day C, Schulz HU, Muller O, Kutzner N, Malfertherine P, Ebert MP (2005) Molecular analysis of APC promoter methylation and protein expression in colorectal cancer metastasis. Carcinogenesis 26:37-43
5. Eads CA, Lord RV, Kurumboor SK, Wickramasinghe K, Skinner ML, Long TI, Peters JH, DeMeester TR, Danenberg KD, Danenberg PV, Laird PW, Skinner KA (2000) Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res 60:5021-5026
6. Ebert MP, Yu J, Hoffmann J, Rocco A, Rocken C, Kahmann S, Muller O, Korc M, Sung JJ, Malfertheiner P (2003) Loss of beta-catenin expression in metastatic gastric cancer. J Clin Oncol 21:1708-1714
7. Esteller M, Corn PG, Baylin SB, Herman JG (2001) A gene hypermethylation profile of human cancer. Cancer Res 6:3225-3229
8. Esteller M, Sparks A, Toyota M, Sanchez-Cespedes M, Capella G, Peinando MA, Gonzalez S, Tarafa G, Sidransky D, Meltzer SJ, Baylin SB, Herman JG (2000) Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res 60:4366-4371
9. Hiltunen MO, Alhonen L, Koistinaho J, Myohanen S, Paakkonen M, Marin S, Kosma VM, Janne J (1997) Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. Int J Cancer 70:644-648
10. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween RN (1995) Histological grading and staging of chronic hepatitis. J Hepatol 22:696-699
11. Kahmann S, Herter P, Kuhnen C, Muller KM, Muhr G, Martin D, Soddemann M, Muller O (2002) A non-radioactive protein truncation test for the sensitive detection of all stop and frameshift mutations. Hum Mutat 19:165-172
12. Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, Brensinger JD, Vogelstein B, Kinzler KW (1997) Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet 17:79-83
13. Lee S, Lee HJ, Kim JH, Lee HS, Jang JJ, Kang GH (2003) Aberrant CpG island hypermethylation along multistep hepatocarcinogenesis. Am J Pathol 163:1371-1378
14. Lehmann U, Berg-Ribbe I, Wingen LU, Brakensiek K, Becker T, Klempnauer J, Schlegerberger B, Kreipe H, Flemming P (2005) Distinc methylation pattern of benign and malignant liver tumors revealed by quantitative methylation profiling. Clin Cancer Res 11:3654-3660
15. Lewis CM, Cler LR, Bu DW, Jochbauer-Muller S, Milchgrub S, Naftalis EZ, Leitch AM, Minna JD, Euhus DM (2005) Promoter hypermethylation in benign breast epithelium in relation to predicted breast cancer risk. Clin Cancer Res 11:166-172
16. Llovet JM, Burroughs A, Bruix J (2003) Hepatocellular carcinoma. Lancet 362:1907-1917
17. MacSween RNM, Burt AD, Portman BC (eds) (2002) Pathology of the liver. London Churchill Livingstone, Edinburgh
18. Tsuchiya T, Tamura G, Sato K, Endoh Y, Sakata K, Jin Z et al (2000) Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia. Oncogene 19:3642-3646
19. Yang B, Guo M, Herman JG, Clark DP (2003) Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol 163:1101-1107
20. Yu J, Ni M, Xu J, Zhang H, Gao B, Gu J, Chen J, Zhang L, Wu M, Zhen S, Zhu J (2002) Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer 2:29
21. Zysman M, Saka A, Millar A, Knight J, Chapman W, Bapat B (2002) Methylation of adenomatous polyposis coli in endometrial cancer occurs more frequently in tumors with microsatellite instability phenotype. Cancer Res 62:3663-3666