Relationship between clinicopathologic variables and serum and tissue levels of dickkopf-1 in patients with rectal cancer

Journal of Investigative Medicine

Volumn 59, Issue 6, 2011, Pages 947-950

  Kemik, Ozgur ^a   Kemik, Ahu Sarbay ^b   Sumer, Aziz ^a   Begenik, Huseyin ^a   Purisa, Sevim ^c   Tuzun, Sefa ^d   Kotan, Cetin ^a  

^a YUZUNCU YIL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

^d HASEKI EDUCATION AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Clinicopathologic variables; Dickkopf 1; Rectal cancer

Indexed keywords

DICKKOPF 1 PROTEIN;

ADULT; ARTICLE; BLOOD LEVEL; CANCER GROWTH; CANCER INVASION; CANCER STAGING; CLINICAL FEATURE; FEMALE; HISTOPATHOLOGY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; RECTUM CANCER; TISSUE LEVEL; TUMOR DIFFERENTIATION;

EID: 84856421104     PISSN: 17088267     EISSN: 17088267     Source Type: Journal    
DOI: 10.2310/jim.0b013e318224d8e4     Document Type: Article

References (34)

1. Colon and rectal cancer. National Cancer Institute. Web page.
2. Chen Y, Zheng S, Yiu J, et al. Artificial neural networks analysis of surface-enhanced laser desorption/ionization mass spectra of serum protein pattern distinguishes colorectal cancer from healthy population. Clin Cancer Res. 2004;10:8380-8384.
3. Zhang Z, Barnhill SD, Zhang H, et al. Combination of multiple serum markers using an artificial neural network to improve specificity in discriminating malignant from benign pelvic masses. Gynecol Oncol. 1999;73:56-61. (Pubitemid 29177600)
4. Van de Vijver MJ, He YD, et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med. 2002;347:1999-2009. (Pubitemid 35461656)
5. Li J, Zhang Z, Rosenzweig J, et al. Proteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer. Clin Chem. 2002;48:1296-1304. (Pubitemid 34809839)
6. Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma. N Engl J Med. 2002;346:1937-1947. (Pubitemid 34651353)
7. Zhang Z, Bast R, Yu Y, et al. Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer. Cancer Res. 2004;64:5882-5890. (Pubitemid 39095590)
8. Yamabuki T, Takano A, Hayama S, et al. DNkkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas. Cancer Res. 2007;67:2518-2525.
9. Niida K, Hiroko T, Kasai M, et al. DKK-1, a negative regulator of Wnt signaling, is a target of the A-catenin/TCF pathway. Oncogene. 2004;23:8520-8526. (Pubitemid 39540802)
10. Gonzalez-Sancho JM, Aguilera O, Garcia JM, et al. The Wnt antagonist DICKKOPF-1 gene is a downstream target of A-catenin/TCF and is downregulated in human colon cancer. Oncogene. 2005;24:1098-1103. (Pubitemid 40313887)
11. Lee DK, Nathan GR, Trachte AL, et al. Activation of the canonical Wnt/beta-catenin pathway enhances monocyte adhesion to endothelial cells. Biochem Biophys Res Commun. 2006;347:109-116. (Pubitemid 44015656)
12. Masckauchan TN, Shawber CJ, Funahashi Y, et al. Wnt/beta-catenin signaling induces proliferation, survival and IL-8 in human endothelial cells. Angiogenesis. 2005;8:43-51. (Pubitemid 41223838)
13. Zerlin M, Julius MA, Kitajewski J. Wnt/Frizzled signaling in angiogenesis. Angiogenesis. 2008;11:63-69.
14. Ueland T, Otterdal K, Lekva T, et al. Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis. Arteriosc Thromb Vasc Biology. 2009;29:1228-1234.
15. Von Marschall Z, Fisher LW. Secreted Frizzled-related protein-2 augments canonical Wnt3a-induced signaling. Biochem Biophys Res Commun. 2010;400(3):299-304.
16. Takahashi N, Fukushima T, Yorita K, et al. DKK-1 is overexpressed in human pancreatic ductal adenocarcinoma cells in and is involved in invasive growth. Int J Cancer. 2010;126(7):1611-1620.
17. Yu B, Yang X, Xu Y, et al. Elevated expression of DKK-1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. J Hepatol. 2009;50(5):948-957.
18. Mikheev AM, Mikheeva SA, Maxwell JP, et al. Dickkopf-1 mediated tumor suppression in human breast carcinoma cells. Breast Cancer Res Treat. 2008;112(2):263-273.
19. Jass JR, Sobin LH. Histological Typing of Intestinal Tumors (International Histological Classifications of Tumors Series). 2nd ed. Berlin: Springer-Verlag; 1989.
20. Horn A, Dahl O, Morild I. Venous and neural invasion as predictors of recurrence in rectal adenocarcinoma. Dis Colon Rectum. 1991;34(9):798-804.
21. Zhou XL, Qin XR, Zhang XD, et al. Down-regulation of DKK-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. Acta Pharmacol Sin. 2010;31(2):202-210.
22. Fedi P, Bafico A, Nieto Soria A, et al. Isolation and biochemical characterization of the human DKK-1 homologue, a novel inhibitor mammalian Wnt signalling. J Biol Chem. 1999;274:19465-19472.
23. Mao B, Wu W, Davidson G, et al. Kremen proteins are dickkopf receptors that regulate Wnt/beta-catenin signaling. Nature. 2002;417:664-667. (Pubitemid 34614827)
24. Glinka A, Wu W, Delius H, et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998;391:357-362. (Pubitemid 28093502)
25. Mao B, Wu W, Li Y, et al. Ldl-receptor-related protein 6 is a receptor for DKK-1 proteins. Nature. 2001;411:321-325. (Pubitemid 32467039)
26. Krupnik VE, Sharp JD, Jiang C, et al. Functional and structural diversity of the human DKK gene family. Gene. 1999;238:301-313. (Pubitemid 29447031)
27. Aung PP, Que N, Mitani Y, et al. Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase 10 are novel prognostic factors in patients with gastric cancer. Oncogene. 2006;25:2546-2557.
28. Wirths O, Waha A, Weggen S, et al. Overexpression of human DKK-1, an antagonist of wingless/Wnt signaling, in human hepatoblastomas and Wilms' tumors. Lab Invest. 2003;83:429-434. (Pubitemid 36351004)
29. Patil MA, Chua MS, Pan KH, et al. An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma. Oncogene. 2005;24:3737-3747. (Pubitemid 40826873)
30. Hsieh JC, Kodjabachian L, Rebbert ML, et al. A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999;398:431-436. (Pubitemid 29180376)
31. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol. 1998;14:59-88. (Pubitemid 29001449)
32. Cebrat M, Strzadala L, Kisielow P. Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells. Cancer Lett. 2004;206:107-113. (Pubitemid 38281260)
33. Sato N, Yamabuki T, Takano A, et al. Wnt inhibitor DKK-1 as a target for passive cancer immunotherapy. Cancer Res. 2010;70:5326-5336.
34. Aquilera O, Fraga MF, Ballestar E, et al. Epigenetic inactivation of the Wnt antagonist DKK-1 gene in human colon cancer. Oncogene. 2006;25:4116-4121. (Pubitemid 44024874)