Clinical evaluation of lens culinaris agglutinin-reactive α-fetoprotein and des-γ-carboxy prothrombin in histologically proven hepatocellular carcinoma in the United States

Digestive Diseases and Sciences

Volumn 52, Issue 3, 2007, Pages 776-782

  Carr, Brian I ^a   Kanke, Futoshi ^b   Wise, Margaret ^c   Satomura, Shinji ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b FUJIFILM Wako Pure Chemical Corporation   (Japan)

^c Diagnostics Division   (United States)

Author keywords

Fetoprotein; Des carboxy prothrombin (DCP); Hepatocellular carcinoma; Lens culinaris agglutinin reactive fraction of fetoprotein; Prognosis

Indexed keywords

AGGLUTININ; ALPHA FETOPROTEIN; ANTINEOPLASTIC AGENT; DECARBOXYPROTHROMBIN;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER SURVIVAL; CLINICAL EVALUATION; FEMALE; HISTOLOGY; HUMAN; LENTIL; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; PORTAL VEIN; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE; THROMBOCYTE COUNT; UNITED STATES;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-FETOPROTEINS; BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; LENS PLANT; LIVER NEOPLASMS; MALE; MIDDLE AGED; PLANT LECTINS; PROTEIN PRECURSORS; PROTHROMBIN; SENSITIVITY AND SPECIFICITY; UNITED STATES;

EID: 33847231604     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9541-2     Document Type: Article

References (47)

1. Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden globocan 2000. Int J Cancer 94:153-156
2. El-Serag HB (2004) Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 127:S27-S34
3. Zaman SN, Melia WM, Johnson RD, Portmann BC, Johnson PJ, Williams R (1985) Risk factors in development of hepatocellular carcinoma in cirrhosis: prospective study of 613 patients. Lancet 1:1357-1360
4. Poynard T, Aubert A, Lazizi Y, et al (1991) Independent risk factors for hepatocellular carcinoma in French drinkers. Hepatology 13:896-901
5. Colombo M, Franchis Rd, Ninno ED, et al. (1991) Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med 325:675-680
6. Tsukuma H, Hiyama T, Tanaka S, et al. (1993) The factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 328:1797-1801
7. Chevret S, Trinchet JC, Mathieu D, Rached AA, Beaugrand M, Chastang C (1999) A new prognostic classification for predicting survival in patients with hepatocellular carcinoma. J Hepatol 31:133-141
8. Bruix J SMPGC, American Association for the Study of Liver Diseases (2005) Management of hepatocellular carcinoma. Hepatology 42:1208-1236
9. Shinagawa T, Ohto M, Kimura K, et al. (1984) Diagnosis and clinical features of small hepatocellular carcinoma eith emphasis on the utility of real-time ultrasonography. Gastroenterology 86:495-502
10. Ikeda K, Saitoh S, Koida I, et al. (1993) Diagnosis and follow-up of small hepatocellular carcinoma with selective intraarterial digital subtraction angiography. Hepatology 17:1003-1007
11. Oka H, Tamori A, Kuroki T, Kobayashi K, Yamamoto S (1994) Prospective study of α-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma. Hepatology 19:61-66
12. Takayasu K, Moriyama N, Muramatsu Y, et al. (1990) The diagnosis of small hepatocellular carcinoma: efficacy of various imaging procedures in 100 patients. AJR 155:49-54
13. Takayasu K, Furukawa H, Wakao F, et al. (1995) CT diagnosis of early hepatocellular carcinoma: sensitivity, findings, and CT-pathologic correlation. AJR 164:885-890
14. Ebara M, Ohto M, Watanabe Y, et al. (1986) Diagnosis of small hepatocellular carcinoma: Correlation of MR imaging and tumor histologic studies. Radiology 159:371-377
15. Daniele B, Bencivenga A, Megna AS, Tinessa V (2004) α-Fetoprotein and ultrasonography screening for hepatocellular carcinoma. Gastroenterology 127:S108-S12
16. Bruix J, Sherman M, Llovet JM, et al. (2001) Clinical management of hepatocellular carcinoma. Conclusion of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. J Hepatol 35:421-430
17. Sheu JC, Sung JL, Chen DS, et al. (1985) Early detection of hepatocellular carcinoma by real-time ultrasonography. A prospective study. Cancer 56:660-666
18. Taketa K, Sekiya C, Namiki M, et al. (1990) Lectin-reactive profiles of alpha-fetoprotein characterizing hepatocellular carcinoma and related conditions. Gastroenterology 99:508-518
19. Taketa K, Endo Y, Sekiya C, et al. (1993) A collaborative study for the evaluation of lectin-reactive a-fetoproteins in early detection of hepatocellular carcinoma. Cancer Res 53:19-23
20. Oka H, Saito A, Ito K, et al. (2001) Multicenter prospective analysis of newly diagnosed hepatocellular carcinoma with respect to the percentage of lens culinaris agglutinin-reactive a-fetoprotein. J Gastroenterol Hepatol 16:1378-1383
21. Sato Y, Nakata K, Kato Y, et al. (1993) Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein. N Engl J Med 328:1802-1806
22. Shiraki K, Takase K, Tameda Y, Hamada M, Kosaka Y, Nakano T (1995) A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients. Hepatology 22:802-807
23. Yamashita F, Tanaka M, Satomura S, Tanikawa K (1995) Monitoring of lectin-reactive a-fetoprotein in patients with hepatocellular carcinoma treated using transcatheter arterial embolization. Eur J Gastroenterol Hepatol 7:627-633
24. Yamashita F, Tanaka M, Satomura S, Tanikawa K (1996) Prognostic significance of lens culinaris agglutinin A-reactive a-fetoprotein in small hepatocellular carcinomas. Gastroenterology 111:996-1001
25. Hayashi K, Kumada T, Nakano S, et al. (1999) Usefulness of measurement of lens culinaris agglutinin-reactive fraction of α-fetoprotein as a marker of prognosis and recurrence of small hepatocellular carcinoma. Am J Gastroenterol 94:3028-3033
26. Kumada T, Nakano S, Takeda I, et al. (1999) Clinical utility of lens culinaris aggulutinin-reactive alpha-fetoprotein in small hepatocellular carcinoma: special reference to imaging diagnosis. J Hepatol 30:125-130
27. Tanaka M, Saito A, Ito K, et al. (2000) Lens culinaris agglutinin-reactive alpha-fetoprotein (AFP-L3) is the most significant prognostic factor for hepatocellular carcinoma after therapy. Hepatology 34:233A
28. Tada T, Kumada T, Toyoda H, et al. (2005) Relationship between lens culinaris agglutinin-reactive α-fetoprotein and pathologic features of hepatocellular carcinoma. Liver Int 25:1-6
29. Ono M, Ohta H, Ohhira M, Sekiya C, Namiki M (1990) Measurement of immunoreactive prothrombin precursor and vitamin-K dependent gamma-carboxylation in human hepatocellular carcinoma tissues: decreased carboxylation of prothrombin precursor as a cause of des-gamma-carboxyprothrombin synthesis. Tumor Biol 11:319-326
30. Liebman HA (1989) Isolation and characterization of a hepatoma-associated abnormal (des-gamma carboxy) prothrombin. Cancer Res 49:6493-6497
31. Aoyagi Y, Oguro M, Yanagi M, et al. (1996) Clinical significance of simultaneous determination of alpha-fetoprotein and des-gamma carboxyprothrombin inmonitoring recurrence in patientswith hepatocellular carcinoma. Cancer 77:1781-1786
32. Mita Y, Aoyagi Y, Yanagi M, Suda T, Suzuki Y, Asakura H (1998) The usefulness of determining des-gamma carboxyprothrombin by sensitive enzyme immunoassay in the early diagnosis of patients with hepatocellular carcinoma. Cancer 82:1643-1648
33. Nomura F, Ishijima M, Kuwa K, Tanaka N, Nakai T, Ohnishi K (1999) Serum des-gamma carboxyprothrombin levels determined by a new generation of sensitive immunoassay in patients with small-sized hepatocellular carcinoma. Am J Gastroenterol 94:650-654
34. Izuno K, Fujiyama S, Yamasaki K, Sato M, Sato T (1995) Early detection of hepatocellular carcinoma associated with cirrhosis by combined assay of des-gamma carboxy prothrombin and alpha-fetoprotein: a prospective study. Hepatogastroenterology 42:387-393
35. Ikoma J, Kaito M, Ishihara T, et al. (2002) Early diagnosis of hepatocellular carcinoma using a sensitive assay for serum des-gamma carboxy prothrombin: a prospective study. Hepatogastroenterology 49:235-238
36. Shimauchi Y, Tanaka M, Kuromatsu R, et al. (2000) A simultaneous monitoring of lens culinaris aggulutinin A-reactive alpha-fetoprotein and des-gamma carboxyprothrombin as an early diagnosis of hepatocellular carcinoma in the follow-up of cirrhotic patients. Oncol Rep 7:249-256
37. Ishii M, Gama H, Chida N, et al. (2000) Simultaneous measurements of serum alpha-fetoprotein and protein induced by vitamin K absence for detecting hepatocellular carcinoma. Am J Gastroenterol 95:1036-1040
38. Fujiyama S, Tanaka M, Maeda S, Ashihara H, Hirata R, Tomita K (2002) Tumor markers in early diagnosis, follow-up and management of patients with hepatocellular carcinoma. Oncology 62:57-63
39. Okuda H, Nakanishi T, Takatsu K, et al. (2002) Clinicopathologic features of patients with hepatocellular carcinoma seropositive for a-fetoprotein-L3 and seronegative for des-g-carboxy prothrombin in comparison with those seropositive for des-g-carboxy prothrombin alone. J Gastroenterol Hepatol 17:772-778
40. Okuda H, Saito A, Haruyama K, et al. (2004) Unique clinicaopathological features of patients with primary malignant hepatic tumors who are seropositive for lectin-reactive α-fetoprotein alone: report of five cases. J Gastroenterol Hepatol 19:113-119
41. Okuda H, Saito A, Shiratori K, Yamamoto M, Takasaki K, Nakano M (2005) Clinicopathologic feature of patients with primary malignant hepatic tumors seropositive for a-fetoprotein-L3 alone in comparison with other patients seropositive for a-fetoprotein-L3. J Gastroenterol Hepatol 20:759-764
42. Katoh H, Nakamura K, Tanaka T, Satomura S, Matsuura S (1998) Automatic and simultaneous analysis of Lens culinaris agglutinin-reactive alpha-fetoprotein ratio and total alpha-fetoprotein concentration. Anal Chem 70:2110-2114
43. Yamagata Y, Katoh H, Nakamura K, Tanaka T, Satomura S, Matsuura S (1998) Determination of alpha-fetoprotein concentration based on liquid-phase binding assay using anion exchange chromatography and sulfated peptide introduced antibody. J Immunol Methods 212:161-168
44. Yamagata Y, Shimizu K, Nakamura K, et al. (2003) Simultaneous determination of percentage of Lens culinaris agglutinin-reactive alpha-fetoprotein and alpha-fetoprotein concentration using the LiBASys clinical auto-analyzer. Clin Chim Acta 327:59-67
45. El-Serag HB, Mason AC, Key C (2001) Trends in survival of patients with hepatocellular carcinoma between 1977 and 1996 in the United States. Hepatology 33:62-65
46. Hamamura K, Shiratori Y, Shiina S, et al. (2000) Unique clinical characteristics of patients with hepatocellular carcinoma who present with plasma des-gamma-carboxy prothrombin and low serum alpha-fetoprotein. Cancer 88:1557-1564
47. Koike Y, Shiratori Y, Sato S, et al. (2001) Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma: a prospective analysis of 227 patients. Cancer 91:561-569