Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism

Journal of Biological Chemistry

Volumn 283, Issue 34, 2008, Pages 23371-23375

  Wang, Ke ^a,b   Zhang, Yazhou ^b,d   Li, Xiaofeng ^b,d   Chen, Lijun ^c   Wang, He ^b   Wu, Jianguo ^a   Zheng, Jie ^c   Wu, Dianqing ^b  

^a WUHAN UNIVERSITY   (China)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d Enzon Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; PROTEINS; THREE DIMENSIONAL;

BINDING RESIDUES; BINDING SURFACES; COEXPRESSED; DIMENSIONAL STRUCTURES; LOW DENSITY LIPOPROTEIN RECEPTORS; PATHOPHYSIOLOGICAL PROCESSES; TRANSMEMBRANE PROTEINS;

BINDING SITES;

ARGININE; DICKKOPF 1 PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYSINE; MEMBRANE PROTEIN; MUTANT PROTEIN; PROTEIN DKK2; PROTEIN KREMEN; SERINE; UNCLASSIFIED DRUG; WNT PROTEIN; DKK1 PROTEIN, HUMAN; DKK1 PROTEIN, MOUSE; KREMEN PROTEIN, MOUSE; KREMEN1 PROTEIN, HUMAN; LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LRP6 PROTEIN, HUMAN; LRP6 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; WILD TYPE; ANIMAL; CHEMISTRY; CONFORMATION; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANIMALS; BINDING SITES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LDL-RECEPTOR RELATED PROTEINS; MEMBRANE PROTEINS; MICE; MOLECULAR CONFORMATION; PROTEIN STRUCTURE, TERTIARY; WNT PROTEINS;

EID: 53149087478     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802376200     Document Type: Article

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