-
1
-
-
0037779439
-
Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons
-
Angelastro JM, Ignatova TN, Kukekov VG, Steindler DA, Stengren GB, Mendelsohn C, Greene LA (2003) Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. J Neurosci 23:4590-4600.
-
(2003)
J Neurosci
, vol.23
, pp. 4590-4600
-
-
Angelastro, J.M.1
Ignatova, T.N.2
Kukekov, V.G.3
Steindler, D.A.4
Stengren, G.B.5
Mendelsohn, C.6
Greene, L.A.7
-
2
-
-
27644493692
-
Globular amyloid b-peptide 1-42 oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease
-
Barghorn S, Nimmrich V, Striebinger A, Krantz C, Keller P, Janson B, Bahr M, Schmidt M, Bitner RS, Harlan J, Barlow E, Ebert U, Hillen H (2005) Globular amyloid b-peptide 1-42 oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. J Neurochem 95:834-847.
-
(2005)
J Neurochem
, vol.95
, pp. 834-847
-
-
Barghorn, S.1
Nimmrich, V.2
Striebinger, A.3
Krantz, C.4
Keller, P.5
Janson, B.6
Bahr, M.7
Schmidt, M.8
Bitner, R.S.9
Harlan, J.10
Barlow, E.11
Ebert, U.12
Hillen, H.13
-
3
-
-
5444234359
-
Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis
-
Becker EB, Howell J, Kodama Y, Barker PA, Bonni A (2004) Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. J Neurosci 24:8762-8770.
-
(2004)
J Neurosci
, vol.24
, pp. 8762-8770
-
-
Becker, E.B.1
Howell, J.2
Kodama, Y.3
Barker, P.A.4
Bonni, A.5
-
4
-
-
0035923665
-
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
-
Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM, Anderson DW (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98:13681-13686.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13681-13686
-
-
Bennett, B.L.1
Sasaki, D.T.2
Murray, B.W.3
O'Leary, E.C.4
Sakata, S.T.5
Xu, W.6
Leisten, J.C.7
Motiwala, A.8
Pierce, S.9
Satoh, Y.10
Bhagwat, S.S.11
Manning, A.M.12
Anderson, D.W.13
-
5
-
-
0037147122
-
Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation
-
Biswas SC, Greene LA (2002) Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation. J Biol Chem 277:49511-49516.
-
(2002)
J Biol Chem
, vol.277
, pp. 49511-49516
-
-
Biswas, S.C.1
Greene, L.A.2
-
6
-
-
24944474714
-
Bim is a direct target of a neuronal E2F-dependent apoptotic pathway
-
Biswas SC, Liu DX, Greene LA (2005) Bim is a direct target of a neuronal E2F-dependent apoptotic pathway. J Neurosci 25:8349-8358.
-
(2005)
J Neurosci
, vol.25
, pp. 8349-8358
-
-
Biswas, S.C.1
Liu, D.X.2
Greene, L.A.3
-
7
-
-
0032522911
-
Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
-
Busser J, Geldmacher DS, Herrup K (1998) Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 18:2801-2807.
-
(1998)
J Neurosci
, vol.18
, pp. 2801-2807
-
-
Busser, J.1
Geldmacher, D.S.2
Herrup, K.3
-
8
-
-
0029912056
-
Mechanisms of neuronal death in Alzheimer's disease
-
Cotman CW, Su JH (1996) Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol 6:493-506.
-
(1996)
Brain Pathol
, vol.6
, pp. 493-506
-
-
Cotman, C.W.1
Su, J.H.2
-
9
-
-
0028609874
-
Possible role of apoptosis in Alzheimer's disease
-
Cotman CW, Whittemore ER, Watt JA, Anderson AJ, Loo DT (1994) Possible role of apoptosis in Alzheimer's disease. Ann NY Acad Sci 747:36-49.
-
(1994)
Ann NY Acad Sci
, vol.747
, pp. 36-49
-
-
Cotman, C.W.1
Whittemore, E.R.2
Watt, J.A.3
Anderson, A.J.4
Loo, D.T.5
-
10
-
-
0035805391
-
Expression of apoptosis related proteins in brains of patients with Alzheimer's disease
-
Engidawork E, Gulesserian T, Seidl R, Cairns N, Lubec G (2001) Expression of apoptosis related proteins in brains of patients with Alzheimer's disease. Neurosci Lett 303:79-82.
-
(2001)
Neurosci Lett
, vol.303
, pp. 79-82
-
-
Engidawork, E.1
Gulesserian, T.2
Seidl, R.3
Cairns, N.4
Lubec, G.5
-
11
-
-
0030808462
-
Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction
-
Estus S, Tucker HM, van Rooyen C, Wright S, Brigham EF, Wogulis M, Rydel RE (1997) Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction. J Neurosci 17:7736-7745.
-
(1997)
J Neurosci
, vol.17
, pp. 7736-7745
-
-
Estus, S.1
Tucker, H.M.2
van Rooyen, C.3
Wright, S.4
Brigham, E.F.5
Wogulis, M.6
Rydel, R.E.7
-
12
-
-
0033516567
-
Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F X DP, in B-amyloid-induced neuronal death
-
Giovanni A, Wirtz-Brugger F, Keramaris E, Slack R, Park DS (1999) Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F X DP, in B-amyloid-induced neuronal death. J Biol Chem 274:19011-19016.
-
(1999)
J Biol Chem
, vol.274
, pp. 19011-19016
-
-
Giovanni, A.1
Wirtz-Brugger, F.2
Keramaris, E.3
Slack, R.4
Park, D.S.5
-
13
-
-
0034697299
-
E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3
-
Giovanni A, Keramaris E, Morris EJ, Hou ST, O'Hare M, Dyson N, Robertson GS, Slack RS, Park DS (2000) E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3. J Biol Chem 275:11553-11560.
-
(2000)
J Biol Chem
, vol.275
, pp. 11553-11560
-
-
Giovanni, A.1
Keramaris, E.2
Morris, E.J.3
Hou, S.T.4
O'Hare, M.5
Dyson, N.6
Robertson, G.S.7
Slack, R.S.8
Park, D.S.9
-
14
-
-
1642433100
-
Cell cycle molecules and vertebrate neuron death: E2F at the hub
-
Greene LA, Biswas SC, Liu DX (2004) Cell cycle molecules and vertebrate neuron death: E2F at the hub. Cell Death Differ 11:49-60.
-
(2004)
Cell Death Differ
, vol.11
, pp. 49-60
-
-
Greene, L.A.1
Biswas, S.C.2
Liu, D.X.3
-
15
-
-
23044458127
-
BH3-only proteins: Key regulators of neuronal apoptosis
-
Ham J, Towers E, Gilley J, Terzano S, Randall R (2005) BH3-only proteins: key regulators of neuronal apoptosis. Cell Death Differ 12:1015-1020.
-
(2005)
Cell Death Differ
, vol.12
, pp. 1015-1020
-
-
Ham, J.1
Towers, E.2
Gilley, J.3
Terzano, S.4
Randall, R.5
-
16
-
-
0031052381
-
Amyloid, the presenilins and Alzheimer's disease
-
Hardy J (1997) Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 20:154-159.
-
(1997)
Trends Neurosci
, vol.20
, pp. 154-159
-
-
Hardy, J.1
-
17
-
-
21544468846
-
Treatment with an amyloid-β antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease
-
Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, Holtzman DM (2005) Treatment with an amyloid-β antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J Neurosci 25:6213-6220.
-
(2005)
J Neurosci
, vol.25
, pp. 6213-6220
-
-
Hartman, R.E.1
Izumi, Y.2
Bales, K.R.3
Paul, S.M.4
Wozniak, D.F.5
Holtzman, D.M.6
-
18
-
-
7044237034
-
Divide and die: Cell cycle events as triggers of nerve cell death
-
Herrup K, Neve R, Ackerman SL, Copani A (2004) Divide and die: cell cycle events as triggers of nerve cell death. J Neurosci 24:9232-9239.
-
(2004)
J Neurosci
, vol.24
, pp. 9232-9239
-
-
Herrup, K.1
Neve, R.2
Ackerman, S.L.3
Copani, A.4
-
19
-
-
0030569357
-
Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells
-
Li YP, Bushnell AF, Lee CM, Perlmutter LS, Wong SK (1996) Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells. Brain Res 738:196-204.
-
(1996)
Brain Res
, vol.738
, pp. 196-204
-
-
Li, Y.P.1
Bushnell, A.F.2
Lee, C.M.3
Perlmutter, L.S.4
Wong, S.K.5
-
20
-
-
0036850972
-
Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons
-
Linseman DA, Phelps RA, Bouchard RJ, Le SS, Laessig TA, McClure ML, Heidenreich KA (2002) Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons. J Neurosci 22:9287-9297.
-
(2002)
J Neurosci
, vol.22
, pp. 9287-9297
-
-
Linseman, D.A.1
Phelps, R.A.2
Bouchard, R.J.3
Le, S.S.4
Laessig, T.A.5
McClure, M.L.6
Heidenreich, K.A.7
-
21
-
-
0035829650
-
Regulation of neuronal survival and death by E2F-dependent gene repression and derepression
-
Liu DX, Greene LA (2001) Regulation of neuronal survival and death by E2F-dependent gene repression and derepression. Neuron 32:425-438.
-
(2001)
Neuron
, vol.32
, pp. 425-438
-
-
Liu, D.X.1
Greene, L.A.2
-
22
-
-
5444227823
-
B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage
-
Liu DX, Biswas SC, Greene LA (2004) B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage. J Neurosci 24:8720-8725.
-
(2004)
J Neurosci
, vol.24
, pp. 8720-8725
-
-
Liu, D.X.1
Biswas, S.C.2
Greene, L.A.3
-
23
-
-
15444379011
-
Regulation of neuron survival and death by p130 and associated chromatin modifiers
-
Liu DX, Nath N, Chellappan SP, Greene LA (2005) Regulation of neuron survival and death by p130 and associated chromatin modifiers. Genes Dev 19:719-732.
-
(2005)
Genes Dev
, vol.19
, pp. 719-732
-
-
Liu, D.X.1
Nath, N.2
Chellappan, S.P.3
Greene, L.A.4
-
24
-
-
0022156464
-
Neuronal origin of a cerebral amyloid: Neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels
-
Masters CL, Multhaup G, Simms G, Pottgiesser J, Martins RN, Beyreuther K (1985) Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J 4:2757-2763.
-
(1985)
EMBO J
, vol.4
, pp. 2757-2763
-
-
Masters, C.L.1
Multhaup, G.2
Simms, G.3
Pottgiesser, J.4
Martins, R.N.5
Beyreuther, K.6
-
25
-
-
0032547801
-
Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents
-
Park DS, Morris EJ, Padmanabhan J, Shelanski ML, Geller HM, Greene LA (1998) Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents. J Cell Biol 143:457-467.
-
(1998)
J Cell Biol
, vol.143
, pp. 457-467
-
-
Park, D.S.1
Morris, E.J.2
Padmanabhan, J.3
Shelanski, M.L.4
Geller, H.M.5
Greene, L.A.6
-
26
-
-
0025733411
-
Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures
-
Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991) Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur J Pharmacol 207:367-368.
-
(1991)
Eur J Pharmacol
, vol.207
, pp. 367-368
-
-
Pike, C.J.1
Walencewicz, A.J.2
Glabe, C.G.3
Cotman, C.W.4
-
27
-
-
0035053624
-
Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis
-
Putcha GV, Moulder KL, Golden JP, Bouillet P, Adams JA, Strasser A, Johnson EM (2001) Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Neuron 29:615-628.
-
(2001)
Neuron
, vol.29
, pp. 615-628
-
-
Putcha, G.V.1
Moulder, K.L.2
Golden, J.P.3
Bouillet, P.4
Adams, J.A.5
Strasser, A.6
Johnson, E.M.7
-
28
-
-
0037860975
-
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis
-
Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B, Alix S, Youle RJ, LaMarche A, Maroney AC, Johnson Jr EM (2003) JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38:899-914.
-
(2003)
Neuron
, vol.38
, pp. 899-914
-
-
Putcha, G.V.1
Le, S.2
Frank, S.3
Besirli, C.G.4
Clark, K.5
Chu, B.6
Alix, S.7
Youle, R.J.8
LaMarche, A.9
Maroney, A.C.10
Johnson Jr, E.M.11
-
29
-
-
0036097786
-
Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
-
Puthalakath H, Strasser A (2002) Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 9:505-512.
-
(2002)
Cell Death Differ
, vol.9
, pp. 505-512
-
-
Puthalakath, H.1
Strasser, A.2
-
30
-
-
0034849106
-
Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis
-
Ranganathan S, Scudiere S, Bowser R (2001) Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis. J Alzheimers Dis 3:377-385.
-
(2001)
J Alzheimers Dis
, vol.3
, pp. 377-385
-
-
Ranganathan, S.1
Scudiere, S.2
Bowser, R.3
-
31
-
-
0042696985
-
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
-
Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS (2003) Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 5:733-740.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 733-740
-
-
Reginato, M.J.1
Mills, K.R.2
Paulus, J.K.3
Lynch, D.K.4
Sgroi, D.C.5
Debnath, J.6
Muthuswamy, S.K.7
Brugge, J.S.8
-
32
-
-
0033600274
-
Translating cell biology into therapeutic advances in Alzheimer's disease
-
Selkoe DJ (1999) Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399:A23-A31.
-
(1999)
Nature
, vol.399
-
-
Selkoe, D.J.1
-
33
-
-
0035081475
-
Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein
-
Selkoe DJ (2001) Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J Alzheimers Dis 3:75-80.
-
(2001)
J Alzheimers Dis
, vol.3
, pp. 75-80
-
-
Selkoe, D.J.1
-
34
-
-
6344282962
-
Neuronal structure is altered by amyloid plaques
-
Spires TL, Hyman BT (2004) Neuronal structure is altered by amyloid plaques. Rev Neurosci 15:267-278.
-
(2004)
Rev Neurosci
, vol.15
, pp. 267-278
-
-
Spires, T.L.1
Hyman, B.T.2
-
35
-
-
0032747486
-
Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death
-
Stadelmann C, Deckwerth TL, Srinivasan A, Bancher C, Bruck W, Jellinger K, Lassmann H (1999) Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. Am J Pathol 155:1459-1466.
-
(1999)
Am J Pathol
, vol.155
, pp. 1459-1466
-
-
Stadelmann, C.1
Deckwerth, T.L.2
Srinivasan, A.3
Bancher, C.4
Bruck, W.5
Jellinger, K.6
Lassmann, H.7
-
36
-
-
0034652232
-
Caspase-2 mediates neuronal cell death induced by β-amyloid
-
Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML (2000) Caspase-2 mediates neuronal cell death induced by β-amyloid. J Neurosci 20:1386-1392.
-
(2000)
J Neurosci
, vol.20
, pp. 1386-1392
-
-
Troy, C.M.1
Rabacchi, S.A.2
Friedman, W.J.3
Frappier, T.F.4
Brown, K.5
Shelanski, M.L.6
-
37
-
-
0035076483
-
β-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation
-
Troy CM, Rabacchi SA, Xu Z, Maroney AC, Connors TJ, Shelanski ML, Greene LA (2001) β-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation. J Neurochem 77:157-164.
-
(2001)
J Neurochem
, vol.77
, pp. 157-164
-
-
Troy, C.M.1
Rabacchi, S.A.2
Xu, Z.3
Maroney, A.C.4
Connors, T.J.5
Shelanski, M.L.6
Greene, L.A.7
-
38
-
-
0028853478
-
An improved approach to prepare human brains for research
-
Vonsattel JP, Aizawa H, Ge P, DiFiglia M, McKee AC, MacDonald M, Gusella JF, Landwehrmeyer GB, Bird ED, Richardson Jr EP, Hedley-Whyte ET (1995) An improved approach to prepare human brains for research. J Neuropathol Exp Neurol 54:42-56.
-
(1995)
J Neuropathol Exp Neurol
, vol.54
, pp. 42-56
-
-
Vonsattel, J.P.1
Aizawa, H.2
Ge, P.3
DiFiglia, M.4
McKee, A.C.5
MacDonald, M.6
Gusella, J.F.7
Landwehrmeyer, G.B.8
Bird, E.D.9
Richardson Jr, E.P.10
Hedley-Whyte, E.T.11
-
39
-
-
24344476294
-
The cell cycle in Alzheimer disease: A unique target for neuropharmacology
-
Webber KM, Raina AK, Marlatt MW, Zhu X, Prat MI, Morelli L, Casadesus G, Perry G, Smith MA (2005) The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mech Ageing Dev 126:1019-1025.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 1019-1025
-
-
Webber, K.M.1
Raina, A.K.2
Marlatt, M.W.3
Zhu, X.4
Prat, M.I.5
Morelli, L.6
Casadesus, G.7
Perry, G.8
Smith, M.A.9
-
40
-
-
0035049449
-
Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release
-
Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J (2001) Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29:629-643.
-
(2001)
Neuron
, vol.29
, pp. 629-643
-
-
Whitfield, J.1
Neame, S.J.2
Paquet, L.3
Bernard, O.4
Ham, J.5
-
42
-
-
0029896354
-
Mechanisms of neuronal degeneration in Alzheimer's disease
-
Yankner BA (1996) Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16:921-932.
-
(1996)
Neuron
, vol.16
, pp. 921-932
-
-
Yankner, B.A.1
-
43
-
-
13944275183
-
β-Amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w
-
Yao M, Nguyen TV, Pike CJ (2005) β-Amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J Neurosci 25:1149-1158.
-
(2005)
J Neurosci
, vol.25
, pp. 1149-1158
-
-
Yao, M.1
Nguyen, T.V.2
Pike, C.J.3
-
44
-
-
0037112194
-
Amyloid-β induces Smac release via AP-1/Bim activation in cerebral endothelial cells
-
Yin KJ, Lee JM, Chen SD, Xu J, Hsu CY (2002) Amyloid-β induces Smac release via AP-1/Bim activation in cerebral endothelial cells. J Neurosci 22:9764-9770.
-
(2002)
J Neurosci
, vol.22
, pp. 9764-9770
-
-
Yin, K.J.1
Lee, J.M.2
Chen, S.D.3
Xu, J.4
Hsu, C.Y.5
|