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Volumn 306, Issue 10, 2014, Pages

Silencing of hypoxia-inducible factor-1α gene attenuates chronic ischemic renal injury in two-kidney, one-clip rats

Author keywords

Chronic kidney diseases; Collagen; Renal fibrosis; smooth muscle actin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SHORT HAIRPIN RNA;

EID: 84900826353     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00673.2013     Document Type: Article
Times cited : (57)

References (70)
  • 2
    • 0037675044 scopus 로고    scopus 로고
    • The role of angiotensin II-stimulated renal tubular transport in hypertension
    • Burns KD, Li N. The role of angiotensin II-stimulated renal tubular transport in hypertension. Curr Hypertens Rep 5: 165-171, 2003.
    • (2003) Curr Hypertens Rep , vol.5 , pp. 165-171
    • Burns, K.D.1    Li, N.2
  • 3
    • 34250733867 scopus 로고    scopus 로고
    • The role of tubular epithelialmesenchymal transition in progressive kidney disease
    • Burns WC, Kantharidis P, Thomas MC. The role of tubular epithelialmesenchymal transition in progressive kidney disease. Cells Tissues Organs 185: 222-231, 2007.
    • (2007) Cells Tissues Organs , vol.185 , pp. 222-231
    • Burns, W.C.1    Kantharidis, P.2    Thomas, M.C.3
  • 5
    • 84884417754 scopus 로고    scopus 로고
    • Inhibition of prolyl hydroxylase domain-containing protein on hypertension/renal injury induced by high salt diet and nitric oxide withdrawal
    • Dallatu MK, Choi M, Oyekan AO. Inhibition of prolyl hydroxylase domain-containing protein on hypertension/renal injury induced by high salt diet and nitric oxide withdrawal. J Hypertens, 2013.
    • (2013) J Hypertens
    • Dallatu, M.K.1    Choi, M.2    Oyekan, A.O.3
  • 7
    • 51849094304 scopus 로고    scopus 로고
    • Chronic hypoxia as a mechanism of progression of chronic kidney diseases: From hypothesis to novel therapeutics
    • Fine LG, Norman JT. Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Kidney Int 74: 867-872, 2008.
    • (2008) Kidney Int , vol.74 , pp. 867-872
    • Fine, L.G.1    Norman, J.T.2
  • 8
    • 67649865399 scopus 로고    scopus 로고
    • The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice
    • Gao S, Dagnaes-Hansen F, Nielsen EJ, Wengel J, Besenbacher F, Howard KA, Kjems J. The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice. Mol Ther 17: 1225-1233, 2009.
    • (2009) Mol Ther , vol.17 , pp. 1225-1233
    • Gao, S.1    Dagnaes-Hansen, F.2    Nielsen, E.J.3    Wengel, J.4    Besenbacher, F.5    Howard, K.A.6    Kjems, J.7
  • 9
    • 69849113833 scopus 로고    scopus 로고
    • HIF in kidney disease and development
    • Gunaratnam L, Bonventre JV. HIF in kidney disease and development. J Am Soc Nephrol 20: 1877-1887, 2009.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1877-1887
    • Gunaratnam, L.1    Bonventre, J.V.2
  • 10
    • 84880966482 scopus 로고    scopus 로고
    • Hypoxia-inducible factor signaling in the development of kidney fibrosis
    • Haase VH. Hypoxia-inducible factor signaling in the development of kidney fibrosis. Fibrogenesis Tissue Repair 5, Suppl 1: S16, 2012.
    • (2012) Fibrogenesis Tissue Repair , vol.5 , Issue.SUPPL. 1
    • Haase, V.H.1
  • 11
    • 68949204214 scopus 로고    scopus 로고
    • Oxygen regulates epithelial-to-mesenchymal transition: Insights into molecular mechanisms and relevance to disease
    • Haase VH. Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease. Kidney Int 76: 492-499, 2009.
    • (2009) Kidney Int , vol.76 , pp. 492-499
    • Haase, V.H.1
  • 12
    • 70350389951 scopus 로고    scopus 로고
    • Pathophysiological consequences of HIF activation
    • Haase VH. Pathophysiological consequences of HIF activation. Ann NY Acad Sci 1177: 57-65, 2009.
    • (2009) Ann NY Acad Sci , vol.1177 , pp. 57-65
    • Haase, V.H.1
  • 13
    • 84875790987 scopus 로고    scopus 로고
    • Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells
    • Han WQ, Zhu Q, Hu J, Li PL, Zhang F, Li N. Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Biochim Biophys Acta 1833: 1454-1462, 2013.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 1454-1462
    • Han, W.Q.1    Zhu, Q.2    Hu, J.3    Li, P.L.4    Zhang, F.5    Li, N.6
  • 14
    • 33745360875 scopus 로고    scopus 로고
    • Angiotensin II-induced calcium signaling in the afferent arteriole from rats with two-kidney, one-clip hypertension
    • Helle F, Vagnes OB, Iversen BM. Angiotensin II-induced calcium signaling in the afferent arteriole from rats with two-kidney, one-clip hypertension. Am J Physiol Renal Physiol 291: F140-F147, 2006.
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Helle, F.1    Vagnes, O.B.2    Iversen, B.M.3
  • 16
    • 44349140101 scopus 로고    scopus 로고
    • Hypoxia-inducible factor signaling in the development of tissue fibrosis
    • Higgins DF, Kimura K, Iwano M, Haase VH. Hypoxia-inducible factor signaling in the development of tissue fibrosis. Cell Cycle 7: 1128-1132, 2008.
    • (2008) Cell Cycle , vol.7 , pp. 1128-1132
    • Higgins, D.F.1    Kimura, K.2    Iwano, M.3    Haase, V.H.4
  • 17
    • 42149140586 scopus 로고    scopus 로고
    • Hypertensive nephrosclerosis
    • Hill GS. Hypertensive nephrosclerosis. Curr Opin Nephrol Hypertens 17: 266-270, 2008.
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , pp. 266-270
    • Hill, G.S.1
  • 19
    • 0037390050 scopus 로고    scopus 로고
    • Ultrasound enhances the transfection of plasmid DNA by non-viral vectors
    • Hosseinkhani H, Aoyama T, Ogawa O, Tabata Y. Ultrasound enhances the transfection of plasmid DNA by non-viral vectors. Curr Pharm Biotechnol 4: 109-122, 2003.
    • (2003) Curr Pharm Biotechnol , vol.4 , pp. 109-122
    • Hosseinkhani, H.1    Aoyama, T.2    Ogawa, O.3    Tabata, Y.4
  • 20
    • 78149409458 scopus 로고    scopus 로고
    • Hypoxia-inducible factors as essential regulators of inflammation
    • Imtiyaz HZ, Simon MC. Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol 345: 105-120, 2010.
    • (2010) Curr Top Microbiol Immunol , vol.345 , pp. 105-120
    • Imtiyaz, H.Z.1    Simon, M.C.2
  • 22
    • 24344438196 scopus 로고    scopus 로고
    • Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression
    • Kietzmann T, Görlach A. Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression. Semin Cell Dev Biol 16: 474-486, 2005.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 474-486
    • Kietzmann, T.1    Görlach, A.2
  • 24
    • 0037374219 scopus 로고    scopus 로고
    • Progression of chronic renal disease
    • Klahr S, Morrissey J. Progression of chronic renal disease. Am J Kidney Dis 41: S3-S7, 2003.
    • (2003) Am J Kidney Dis , vol.41
    • Klahr, S.1    Morrissey, J.2
  • 27
    • 0037498439 scopus 로고    scopus 로고
    • Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model
    • Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol 14: 1535-1548, 2003.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1535-1548
    • Lan, H.Y.1    Mu, W.2    Tomita, N.3    Huang, X.R.4    Li, J.H.5    Zhu, H.J.6    Morishita, R.7    Johnson, R.J.8
  • 28
    • 0015092830 scopus 로고
    • A solid silver clip for induction of predictable levels of renal hypertension in the rat
    • Leenen FH, de Jong W. A solid silver clip for induction of predictable levels of renal hypertension in the rat. J Appl Physiol 31: 142-144, 1971.
    • (1971) J Appl Physiol , vol.31 , pp. 142-144
    • Leenen, F.H.1    de Jong, W.2
  • 29
    • 84867700390 scopus 로고    scopus 로고
    • Inhibition of PAX2 gene expression by siRNA (polyethylenimine) in experimental model of obstructive nephropathy
    • Li L, Wu Y, Wang C, Zhang W. Inhibition of PAX2 gene expression by siRNA (polyethylenimine) in experimental model of obstructive nephropathy. Ren Fail 34: 1288-1296, 2012.
    • (2012) Ren Fail , vol.34 , pp. 1288-1296
    • Li, L.1    Wu, Y.2    Wang, C.3    Zhang, W.4
  • 30
    • 43449128852 scopus 로고    scopus 로고
    • Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1α in the renal medulla
    • Li N, Chen L, Yi F, Xia M, Li PL. Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1α in the renal medulla. Circ Res 102: 1101-1108, 2008.
    • (2008) Circ Res , vol.102 , pp. 1101-1108
    • Li, N.1    Chen, L.2    Yi, F.3    Xia, M.4    Li, P.L.5
  • 31
    • 33847622900 scopus 로고    scopus 로고
    • Role of renal medullary heme oxygenase in the regulation of pressure natriuresis and arterial blood pressure
    • Li N, Yi F, dos Santos EA, Donley DK, Li PL. Role of renal medullary heme oxygenase in the regulation of pressure natriuresis and arterial blood pressure. Hypertension 49: 148-154, 2007.
    • (2007) Hypertension , vol.49 , pp. 148-154
    • Li, N.1    Yi, F.2    dos Santos, E.A.3    Donley, D.K.4    Li, P.L.5
  • 33
    • 0347993932 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention
    • Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15: 1-12, 2004.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1-12
    • Liu, Y.1
  • 34
    • 57749107579 scopus 로고    scopus 로고
    • Renal medullary 11β-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension
    • Liu Y, Singh RJ, Usa K, Netzel BC, Liang M. Renal medullary 11β-hydroxysteroid dehydrogenase type 1 in Dahl salt-sensitive hypertension. Physiol Genomics 36: 52-58, 2008.
    • (2008) Physiol Genomics , vol.36 , pp. 52-58
    • Liu, Y.1    Singh, R.J.2    Usa, K.3    Netzel, B.C.4    Liang, M.5
  • 36
    • 33645452371 scopus 로고    scopus 로고
    • Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure
    • Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 17: 17-25, 2006.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 17-25
    • Nangaku, M.1
  • 37
    • 36849049298 scopus 로고    scopus 로고
    • Hypoxia and the HIF system in kidney disease
    • Nangaku M, Eckardt KU. Hypoxia and the HIF system in kidney disease. J Mol Med 85: 1325-1330, 2007.
    • (2007) J Mol Med , vol.85 , pp. 1325-1330
    • Nangaku, M.1    Eckardt, K.U.2
  • 38
    • 39049119220 scopus 로고    scopus 로고
    • Activation of the renin-angiotensin system and chronic hypoxia of the kidney
    • Nangaku M, Fujita T. Activation of the renin-angiotensin system and chronic hypoxia of the kidney. Hypertens Res 31: 175-184, 2008.
    • (2008) Hypertens Res , vol.31 , pp. 175-184
    • Nangaku, M.1    Fujita, T.2
  • 40
    • 33847768717 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Ultrasound for gene transfer
    • Newman CMH, Bettinger T. Gene therapy progress and prospects: ultrasound for gene transfer. Gene Ther 14: 465-475, 2007.
    • (2007) Gene Ther , vol.14 , pp. 465-475
    • Newman, C.M.H.1    Bettinger, T.2
  • 41
    • 15944368868 scopus 로고    scopus 로고
    • Blockade of NF[kappa] B activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney
    • Ng YY, Hou CC, Wang W, Huang XR, Lan HY. Blockade of NF[kappa] B activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney. Kidney Int 67: S83-S91, 2005.
    • (2005) Kidney Int , vol.67
    • Ng, Y.Y.1    Hou, C.C.2    Wang, W.3    Huang, X.R.4    Lan, H.Y.5
  • 42
    • 0033662026 scopus 로고    scopus 로고
    • Hypoxia promotes fibrogenesis in human renal fibroblasts
    • Norman JT, Clark IM, Garcia PL. Hypoxia promotes fibrogenesis in human renal fibroblasts. Kidney Int 58: 2351-2366, 2000.
    • (2000) Kidney Int , vol.58 , pp. 2351-2366
    • Norman, J.T.1    Clark, I.M.2    Garcia, P.L.3
  • 43
    • 0032703190 scopus 로고    scopus 로고
    • Hypoxia-induced changes in extracellular matrix metabolism in renal cells
    • Norman JT, Orphanides C, Garcia P, Fine LG. Hypoxia-induced changes in extracellular matrix metabolism in renal cells. Exp Nephrol 7: 463-469, 1999.
    • (1999) Exp Nephrol , vol.7 , pp. 463-469
    • Norman, J.T.1    Orphanides, C.2    Garcia, P.3    Fine, L.G.4
  • 44
    • 0033924915 scopus 로고    scopus 로고
    • Renal tubulointerstitial fibrosis. New thoughts on its development and progression
    • O'Donnell MP. Renal tubulointerstitial fibrosis. New thoughts on its development and progression. Postgrad Med 108: 159-162, 165, 171-152, 2000.
    • (2000) Postgrad Med , vol.108 , pp. 159-162
    • O'Donnell, M.P.1
  • 46
    • 80051549232 scopus 로고    scopus 로고
    • Interactions between nitric oxide and hypoxiainducible factor signaling pathways in inflammatory disease
    • Olson N, van der Vliet A. Interactions between nitric oxide and hypoxiainducible factor signaling pathways in inflammatory disease. Nitric Oxide 25: 125-137, 2011.
    • (2011) Nitric Oxide , vol.25 , pp. 125-137
    • Olson, N.1    van der Vliet, A.2
  • 47
    • 38749106115 scopus 로고    scopus 로고
    • Hypoxiainducible factor-1α stabilization in nonhypoxic conditions: Role of oxidation and intracellular ascorbate depletion
    • Page EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxiainducible factor-1α stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell 19: 86-94, 2008.
    • (2008) Mol Biol Cell , vol.19 , pp. 86-94
    • Page, E.L.1    Chan, D.A.2    Giaccia, A.J.3    Levine, M.4    Richard, D.E.5
  • 48
    • 38549110053 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats
    • Palm F, Connors SG, Mendonca M, Welch WJ, Wilcox CS. Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats. Hypertension 51: 345-351, 2008.
    • (2008) Hypertension , vol.51 , pp. 345-351
    • Palm, F.1    Connors, S.G.2    Mendonca, M.3    Welch, W.J.4    Wilcox, C.S.5
  • 49
    • 74949137792 scopus 로고    scopus 로고
    • Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats: Effects of tempol and Angiotensin blockade
    • Palm F, Onozato M, Welch WJ, Wilcox CS. Blood pressure, blood flow, and oxygenation in the clipped kidney of chronic 2-kidney, 1-clip rats: effects of tempol and Angiotensin blockade. Hypertension 55: 298-304, 2010.
    • (2010) Hypertension , vol.55 , pp. 298-304
    • Palm, F.1    Onozato, M.2    Welch, W.J.3    Wilcox, C.S.4
  • 50
    • 0021179653 scopus 로고
    • Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats
    • Raij L, Azar S, Keane W. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats. Kidney Int 26: 137-143, 1984.
    • (1984) Kidney Int , vol.26 , pp. 137-143
    • Raij, L.1    Azar, S.2    Keane, W.3
  • 54
    • 0038115172 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1α (HIF-1α) accumulation via redox-dependent mechanisms
    • Shatrov VA, Sumbayev VV, Zhou J, Brüne B. Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1α (HIF-1α) accumulation via redox-dependent mechanisms. Blood 101: 4847-4849, 2003.
    • (2003) Blood , vol.101 , pp. 4847-4849
    • Shatrov, V.A.1    Sumbayev, V.V.2    Zhou, J.3    Brüne, B.4
  • 56
    • 60749137389 scopus 로고    scopus 로고
    • EMT and proteinuria as progression factors
    • Strutz FM. EMT and proteinuria as progression factors. Kidney Int 75: 475-481, 2009.
    • (2009) Kidney Int , vol.75 , pp. 475-481
    • Strutz, F.M.1
  • 58
    • 25144475141 scopus 로고    scopus 로고
    • Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model
    • Tanaka T, Kojima I, Ohse T, Ingelfinger JR, Adler S, Fujita T, Nangaku M. Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model. Lab Invest 85: 1292-1307, 2005.
    • (2005) Lab Invest , vol.85 , pp. 1292-1307
    • Tanaka, T.1    Kojima, I.2    Ohse, T.3    Ingelfinger, J.R.4    Adler, S.5    Fujita, T.6    Nangaku, M.7
  • 59
    • 32844456187 scopus 로고    scopus 로고
    • Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis
    • Tanaka T, Matsumoto M, Inagi R, Miyata T, Kojima I, Ohse T, Fujita T, Nangaku M. Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis. Kidney Int 68: 2714-2725, 2005.
    • (2005) Kidney Int , vol.68 , pp. 2714-2725
    • Tanaka, T.1    Matsumoto, M.2    Inagi, R.3    Miyata, T.4    Kojima, I.5    Ohse, T.6    Fujita, T.7    Nangaku, M.8
  • 60
    • 33748513032 scopus 로고    scopus 로고
    • Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice
    • Turnberg D, Lewis M, Moss J, Xu Y, Botto M, Cook HT. Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice. J Immunol 177: 4094-4102, 2006.
    • (2006) J Immunol , vol.177 , pp. 4094-4102
    • Turnberg, D.1    Lewis, M.2    Moss, J.3    Xu, Y.4    Botto, M.5    Cook, H.T.6
  • 61
    • 78651395628 scopus 로고    scopus 로고
    • Hypoxiainducible factor-1alpha contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells
    • Wang Z, Tang L, Zhu Q, Yi F, Zhang F, Li PL, Li N. Hypoxiainducible factor-1alpha contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int 79: 300-310, 2011.
    • (2011) Kidney Int , vol.79 , pp. 300-310
    • Wang, Z.1    Tang, L.2    Zhu, Q.3    Yi, F.4    Zhang, F.5    Li, P.L.6    Li, N.7
  • 62
    • 77951463662 scopus 로고    scopus 로고
    • Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla
    • Wang Z, Zhu Q, Xia M, Li PL, Hinton SJ, Li N. Hypoxia-inducible factor prolyl-hydroxylase 2 senses high-salt intake to increase hypoxia inducible factor 1alpha levels in the renal medulla. Hypertension 55: 1129-1136, 2010.
    • (2010) Hypertension , vol.55 , pp. 1129-1136
    • Wang, Z.1    Zhu, Q.2    Xia, M.3    Li, P.L.4    Hinton, S.J.5    Li, N.6
  • 64
    • 0034782480 scopus 로고    scopus 로고
    • Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice
    • Yang J, Dai C, Liu Y. Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in mice. Gene Ther 8: 1470-1479, 2001.
    • (2001) Gene Ther , vol.8 , pp. 1470-1479
    • Yang, J.1    Dai, C.2    Liu, Y.3
  • 65
    • 58149395046 scopus 로고    scopus 로고
    • Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats
    • Yi F, Xia M, Li N, Zhang C, Tang L, Li PL. Contribution of guanine nucleotide exchange factor Vav2 to hyperhomocysteinemic glomerulosclerosis in rats. Hypertension 53: 90-96, 2009.
    • (2009) Hypertension , vol.53 , pp. 90-96
    • Yi, F.1    Xia, M.2    Li, N.3    Zhang, C.4    Tang, L.5    Li, P.L.6
  • 66
    • 1642379154 scopus 로고    scopus 로고
    • The role of epithelial-to-mesenchymal transition in renal fibrosis
    • Zeisberg M, Kalluri R. The role of epithelial-to-mesenchymal transition in renal fibrosis. J Mol Med 82: 175-181, 2004.
    • (2004) J Mol Med , vol.82 , pp. 175-181
    • Zeisberg, M.1    Kalluri, R.2
  • 68
    • 84868115582 scopus 로고    scopus 로고
    • Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension
    • Zhu Q, Liu M, Han WQ, Li PL, Wang Z, Li N. Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension. J Cell Mol Med 16: 2701-2707, 2012.
    • (2012) J Cell Mol Med , vol.16 , pp. 2701-2707
    • Zhu, Q.1    Liu, M.2    Han, W.Q.3    Li, P.L.4    Wang, Z.5    Li, N.6
  • 69
    • 84859042920 scopus 로고    scopus 로고
    • Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats
    • Zhu Q, Wang Z, Xia M, Li PL, Zhang F, Li N. Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats. Biochim Biophys Acta 1822: 936-941, 2012.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 936-941
    • Zhu, Q.1    Wang, Z.2    Xia, M.3    Li, P.L.4    Zhang, F.5    Li, N.6
  • 70
    • 80053564265 scopus 로고    scopus 로고
    • Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin ii-induced renal injury in Sprague-Dawley rats
    • Zhu Q, Wang Z, Xia M, Li PL, Van Tassell BW, Abbate A, Dhaduk R, Li N. Silencing of hypoxia-inducible factor-1α gene attenuated angiotensin ii-induced renal injury in Sprague-Dawley rats. Hypertension 58: 657-664, 2011.
    • (2011) Hypertension , vol.58 , pp. 657-664
    • Zhu, Q.1    Wang, Z.2    Xia, M.3    Li, P.L.4    Van Tassell, B.W.5    Abbate, A.6    Dhaduk, R.7    Li, N.8


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