Inhibition of PAX2 gene expression by siRNA (polyethylenimine) in experimental model of obstructive nephropathy

Renal Failure

Volumn 34, Issue 10, 2012, Pages 1288-1296

  Li, Li ^a,b   Wu, Yubin ^a   Wang, Changshan ^b   Zhang, Weiguo ^c  

^a CHINA MEDICAL UNIVERSITY   (China)

^b JIAMUSI UNIVERSITY   (China)

^c Cardiovascular and Neurological Institutes   (United States)

Author keywords

Interstitial fibrosis; Obstructive nephropathy; PAX2; RNA interference; Small interfering RNA

Indexed keywords

POLYETHYLENEIMINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR PAX2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; MALE; NONHUMAN; OBSTRUCTIVE NEPHROPATHY; PRIORITY JOURNAL; RAT; RNA INTERFERENCE; URETER OBSTRUCTION;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; KIDNEY DISEASES; MALE; PAX2 TRANSCRIPTION FACTOR; RATS; RATS, WISTAR; RNA, SMALL INTERFERING; URETERAL OBSTRUCTION;

EID: 84867700390     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/0886022X.2012.723662     Document Type: Article

References (30)

1. Chen F. Genetic and developmental basis for urinary tract obstruction. Pediatr Nephrol. 2009;24(9):1621-"1632.
2. Chevalier RL, Thornhill BA, Forbes MS, Kiley SC. Mechanisms of renal injury and progression of renal disease in congenital obstructive nephropathy. Pediatr Nephrol. 2010; 25(4):687-"697.
3. Picard N, Baum O, Vogetseder A, Kaissling B, Le Hir M. Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat. Histochem Cell Biol. 2008;130(1):141-"155.
4. Narlis M, Grote D, Gaitan Y, Boualia SK, Bouchard M. PAX2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol. 2007;18(4):1121-"1129. (Pubitemid 46536898)
5. Lindoso RS, Verdoorn KS, Einicker-Lamas M. Renal recovery after injury: The role of Pax-2. Nephrol Dial Transplant. 2009;24(9):2628-"2633.
6. Cohen T, Loutochin O, Amin M, Capolicchio JP, Goodyer P, Jednak R. PAX2 is reactivated in urinary tract obstruction and partially protects collecting duct cells from programmed cell death. Am J Physiol Renal Physiol. 2007;292(4):F1267-"F1273. (Pubitemid 46572446)
7. Li L, Wu Y, Zhang W. PAX2 re-expression in renal tubular epithelial cells and correlation with renal interstitial fibrosis of rats with obstructive nephropathy. Ren Fail. 2010;32(5): 603-"611.
8. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391(6669): 806-"811. (Pubitemid 28099681)
9. Hueber PA, Waters P, Clark P, Eccles M, Goodyer P. PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells. Kidney Int. 2006;69(7):1139-"1145.
10. Qing L, Quan K, Song W, et al. Selection and validation of optimal siRNA target sites for RNAi-mediated gene silencing. Gene. 2007;395(1-"2):160- "169. (Pubitemid 46670640)
11. Taal MW, Zandi-Nejad K, Weening B, et al. Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney. Kidney Int. 2000;58(4):1664-"1676.
12. Mizuguchi Y, Miyajima A, Kosaka T, Asano T, Asano T, Hayakawa M. Atrovastatin ameliorates renal tissue damage in unilateral ureteral obstruction. J Urol. 2004;172(6 Pt 1): 2456-"2459. (Pubitemid 39507552)
13. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T)method. Nat Protoc. 2008;3(6): 1101-"1108. (Pubitemid 351818697)
14. Moffat J, Sabatini DM. Building mammalian signalling pathways with RNAi screens. Nat Rev Mol Cell Biol. 2006;7 (3):177-"187.
15. Kumar LD, Clarke AR. Gene manipulation through the use of small interfering RNA (siRNA): From in vitro to in vivo applications. Adv Drug Deliver Rev. 2007;59(2-"3):87-"100. (Pubitemid 46770901)
16. Wilson R, Purcell D, Netter HJ, Revill PA. Does RNA interference provide new hope for control of chronic hepatitis B infection? Antivir Ther. 2009;14(7):879-"889.
17. Bramsen JB, Laursen MB, Nielsen AF, et al. A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res. 2009;37(9):2867-"2881.
18. Ui-Tei K, Naito Y, Zenno S, et al. Functional dissection of siRNA sequence by systematic DNA substitution: Modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. Nucleic Acids Res. 2008;36(7):2136-"2151. (Pubitemid 351566989)
19. Choung S, Kim YJ, Kim S, Park HO, Choi YC. Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem Biophys Res Commun. 2006;342(3):919-"927. (Pubitemid 43320485)
20. Pecot CV, Calin GA, Coleman RL, Lopez-Berestein G, Sood AK. RNA interference in the clinic: Challenges and future directions. Nat Rev Cancer. 2011;11(1):59-"67.
21. Duan Y, Zhang S, Wang B, Yang B, Zhi D. The biological routes of gene delivery mediated by lipid-based non-viral vectors. Expert Opin Drug Deliv. 2009;6(12):1351-"1361.
22. Zaiss AK, Muruve DA. Immune responses to adeno-Associated virus vectors. Curr Gene Ther. 2005;5(3):323-"331. (Pubitemid 40895016)
23. Karmali PP, Chaudhuri A. Cationic liposomes as non-viral carriers of gene medicines: Resolved issues, open questions, and future promises. Med Res Rev. 2007;27(5):696-"722. (Pubitemid 47282449)
24. Behlke MA. Progress towards in vivo use of siRNAs. Mol Ther. 2006;13(4):644-"670.
25. Nimesh S, Chandra R. Polyethylenimine nanoparticles as an efficient in vitro siRNA delivery system. Eur J Pharm Biopharm. 2009;73(1):43-"49.
26. Jere D, Jiang HL, Arote R, et al. Degradable polyethylenimines as DNA and small interfering RNA carriers. Expert Opin Drug Deliv. 2009;6(8):827- "834.
27. Hassani Z, Francois JC, Alfama G, et al. A hybrid CMV-H1 construct improves efficiency of PEI-delivered shRNA in the mouse brain. Nucleic Acids Res. 2007;35(9):e65.
28. Liao HW, Yau KW. In vivo gene delivery in the retina using poly-ethyleneimine. Biotechniques. 2007;42(3):285-"6, 288.
29. Bolcato-Bellemin AL, Bonnet ME, Creusat G, Erbacher P, Behr JP. Sticky overhangs enhance siRNA-mediated gene silencing. Proc Natl Acad Sci USA. 2007;104(41):16050-"16055. (Pubitemid 350099361)
30. Yoshinari K, Miyagishi M, Taira K. Effects on RNAi of the tight structure, sequence and position of the targeted region. Nucleic Acids Res. 2004;32(2):691-"699. (Pubitemid 38263060)