메뉴 건너뛰기




Volumn , Issue , 2009, Pages 357-384

Elimination of cancer stem cells

Author keywords

Cancer stem cells; Chemoresistance; Differentiation therapies; Hedgehog pathway; Notch pathway; Polycomb pathway; PTEN pathway; Self renewal; Targeted therapies; Wnt pathway

Indexed keywords


EID: 84900739914     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-3040-5_16     Document Type: Chapter
Times cited : (4)

References (119)
  • 2
    • 36849088519 scopus 로고    scopus 로고
    • The theoretical basis of cancerstem- cell-based therapeutics of cancer: Can it be put into practice?
    • Sanchez-Garcia I, Vicente-Duenas C and Cobaleda C (2007) The theoretical basis of cancerstem- cell-based therapeutics of cancer: can it be put into practice? Bioessays 29: 1269-1280
    • (2007) Bioessays , vol.29 , pp. 1269-1280
    • Sanchez-Garcia, I.1    Vicente-Duenas, C.2    Cobaleda, C.3
  • 3
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D and Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3: 730-737
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 4
    • 0034141934 scopus 로고    scopus 로고
    • A primitive hematopoietic cell is the target for the leukemic transformation in human philadelphia-positive acute lymphoblastic leukemia
    • Cobaleda C, Gutierrez-Cianca N, Perez-Losada J, et al. (2000) A primitive hematopoietic cell is the target for the leukemic transformation in human philadelphia-positive acute lymphoblastic leukemia. Blood 95: 1007-1013
    • (2000) Blood , vol.95 , pp. 1007-1013
    • Cobaleda, C.1    Gutierrez-Cianca, N.2    Perez-Losada, J.3
  • 5
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, et al. (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367: 645-648
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 6
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. (2003) Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100: 3983-3988
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1    Wicha, M.S.2    Benito-Hernandez, A.3
  • 7
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID, et al. (2004) Identification of human brain tumour initiating cells. Nature 432: 396-401
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 8
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P, et al. (2007) Identification of pancreatic cancer stem cells. Cancer Res 67: 1030-1037
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 9
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • Prince ME, Sivanandan R, Kaczorowski A, et al. (2007) Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 104: 973-978
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 973-978
    • Prince, M.E.1    Sivanandan, R.2    Kaczorowski, A.3
  • 10
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • Dalerba P, Dylla SJ, Park IK, et al. (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 104: 10158-10163
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10158-10163
    • Dalerba, P.1    Dylla, S.J.2    Park, I.K.3
  • 11
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • OBrien CA, Pollett A, Gallinger S, et al. (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445: 106-110
    • (2007) Nature , vol.445 , pp. 106-110
    • Obrien, C.A.1    Pollett, A.2    Gallinger, S.3
  • 12
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. (2007) Identification and expansion of human colon-cancer-initiating cells. Nature 445: 111-115
    • (2007) Nature , vol.445 , pp. 111-115
    • Ricci-Vitiani, L.1    Lombardi, D.G.2    Pilozzi, E.3
  • 13
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB, et al. (2006) Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 66: 9339-9344
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 14
    • 43749084585 scopus 로고    scopus 로고
    • Recent advances in cancer stem cells
    • Cho RW and Clarke MF (2008) Recent advances in cancer stem cells. Curr Opin Genet Dev 18: 48-53
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 48-53
    • Cho, R.W.1    Clarke, M.F.2
  • 15
    • 34547113747 scopus 로고    scopus 로고
    • Tumor growth need not be driven by rare cancer stem cells
    • Kelly PN, Dakic A, Adams JM, et al. (2007) Tumor growth need not be driven by rare cancer stem cells. Science 317: 337
    • (2007) Science , vol.317 , pp. 337
    • Kelly, P.N.1    Dakic, A.2    Adams, J.M.3
  • 17
  • 19
    • 20444424204 scopus 로고    scopus 로고
    • Stem cells for lung cancer?
    • Berns A (2005) Stem cells for lung cancer? Cell 121: 811-813
    • (2005) Cell , vol.121 , pp. 811-813
    • Berns, A.1
  • 20
    • 28744452913 scopus 로고    scopus 로고
    • A self-renewal assay for cancer stem cells
    • Clarke MF (2005) A self-renewal assay for cancer stem cells. Cancer Chemother Pharmacol 56(Suppl 1): 64-68
    • (2005) Cancer Chemother Pharmacol , vol.56 , Issue.SUPPL. 1 , pp. 64-68
    • Clarke, M.F.1
  • 21
    • 33845226457 scopus 로고    scopus 로고
    • Radiation resistance and stem-like cells in brain tumors
    • Hambardzumyan D, Squatrito M and Holland EC (2006) Radiation resistance and stem-like cells in brain tumors. Cancer Cell 10: 454-456
    • (2006) Cancer Cell , vol.10 , pp. 454-456
    • Hambardzumyan, D.1    Squatrito, M.2    Holland, E.C.3
  • 22
    • 33847296106 scopus 로고    scopus 로고
    • Targeted therapy for cancer stem cells: The patched pathway and ABC transporters
    • Lou H and Dean M (2007) Targeted therapy for cancer stem cells: the patched pathway and ABC transporters. Oncogene 26: 1357-1360
    • (2007) Oncogene , vol.26 , pp. 1357-1360
    • Lou, H.1    Dean, M.2
  • 23
    • 44649107292 scopus 로고    scopus 로고
    • Mechanisms of Disease: Cancer stem cells-targeting the evil twin
    • Trumpp A and Wiestler OD (2008) Mechanisms of Disease: cancer stem cells-targeting the evil twin. Nat Clin Pract 5: 337-347
    • (2008) Nat Clin Pract , vol.5 , pp. 337-347
    • Trumpp, A.1    Wiestler, O.D.2
  • 24
    • 33846287519 scopus 로고    scopus 로고
    • WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    • Woodward WA, Chen MS, Behbod F, et al. (2007) WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci USA 104: 618-623
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 618-623
    • Woodward, W.A.1    Chen, M.S.2    Behbod, F.3
  • 25
    • 33750584024 scopus 로고    scopus 로고
    • Tumour stem cell-targeted treatment: Elimination or differentiation
    • Massard C, Deutsch E and Soria JC (2006) Tumour stem cell-targeted treatment: elimination or differentiation. Ann Oncol 17: 1620-1624
    • (2006) Ann Oncol , vol.17 , pp. 1620-1624
    • Massard, C.1    Deutsch, E.2    Soria, J.C.3
  • 26
    • 33644520922 scopus 로고    scopus 로고
    • Target for cancer therapy: Proliferating cells or stem cells
    • Blagosklonny MV (2006) Target for cancer therapy: proliferating cells or stem cells. Leukemia 20: 385-391
    • (2006) Leukemia , vol.20 , pp. 385-391
    • Blagosklonny, M.V.1
  • 27
    • 53149105484 scopus 로고    scopus 로고
    • Cancer stem cell markers in common cancers - Therapeutic implications
    • Klonisch T, Wiechec E, Hombach-Klonisch S, et al. (2008) Cancer stem cell markers in common cancers - therapeutic implications. Trends Mol Med 14(10): 450-460
    • (2008) Trends Mol Med , vol.14 , Issue.10 , pp. 450-460
    • Klonisch, T.1    Wiechec, E.2    Hombach-Klonisch, S.3
  • 28
    • 33947433676 scopus 로고    scopus 로고
    • Cancer stem cells: At the headwaters of tumor development
    • Ward RJ and Dirks PB (2007) Cancer stem cells: at the headwaters of tumor development. Annu Rev Pathol 2: 175-189
    • (2007) Annu Rev Pathol , vol.2 , pp. 175-189
    • Ward, R.J.1    Dirks, P.B.2
  • 29
    • 33646045010 scopus 로고    scopus 로고
    • Stem cells and cancer: Two faces of eve
    • Clarke MF and Fuller M (2006) Stem cells and cancer: two faces of eve. Cell 124: 1111-1115
    • (2006) Cell , vol.124 , pp. 1111-1115
    • Clarke, M.F.1    Fuller, M.2
  • 30
    • 45749101295 scopus 로고    scopus 로고
    • Cancer stem cells: The theory and perspectives in cancer therapy
    • Gil J, Stembalska A, Pesz KA, et al. (2008) Cancer stem cells: the theory and perspectives in cancer therapy. J Appl Genet 49: 193-199
    • (2008) J Appl Genet , vol.49 , pp. 193-199
    • Gil, J.1    Stembalska, A.2    Pesz, K.A.3
  • 31
    • 16844378799 scopus 로고    scopus 로고
    • Leukaemia stem cells and the evolution of cancer-stemcell research
    • Huntly BJ and Gilliland DG (2005) Leukaemia stem cells and the evolution of cancer-stemcell research. Nat Rev Cancer 5: 311-321
    • (2005) Nat Rev Cancer , vol.5 , pp. 311-321
    • Huntly, B.J.1    Gilliland, D.G.2
  • 32
    • 84984766699 scopus 로고    scopus 로고
    • A glossary for stem-cell bioology
    • doi:10.1038/nature04954
    • Smith A (2006) A glossary for stem-cell bioology. Nature doi:10.1038/nature04954
    • (2006) Nature
    • Smith, A.1
  • 33
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • Aguirre-Ghiso JA (2007) Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 7: 834-846
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1
  • 34
    • 42349093952 scopus 로고    scopus 로고
    • Cancer stem cells: Implications for the progression and treatment of metastatic disease
    • Croker AK and Allan AL (2008) Cancer stem cells: implications for the progression and treatment of metastatic disease. J Cell Mol Med 12: 374-390
    • (2008) J Cell Mol Med , vol.12 , pp. 374-390
    • Croker, A.K.1    Allan, A.L.2
  • 35
    • 35348850693 scopus 로고    scopus 로고
    • Concise review: Roles of polycomb group proteins in development and disease: A stem cell perspective
    • Rajasekhar VK and Begemann M (2007) Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective. Stem Cells 25: 2498-2510
    • (2007) Stem Cells , vol.25 , pp. 2498-2510
    • Rajasekhar, V.K.1    Begemann, M.2
  • 36
    • 33846239456 scopus 로고    scopus 로고
    • Beyond tumorigenesis: Cancer stem cells in metastasis
    • Li F, Tiede B, Massague J, et al. (2007) Beyond tumorigenesis: cancer stem cells in metastasis. Cell Res 17: 3-14
    • (2007) Cell Res , vol.17 , pp. 3-14
    • Li, F.1    Tiede, B.2    Massague, J.3
  • 37
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann PC, Huber SL, Herrler T, et al. (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1: 313-323
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 38
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader JE and Lindeman GJ (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8: 755-768
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 39
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC and MacDonald IC (2002) Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2: 563-572
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    Macdonald, I.C.3
  • 40
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast 1889
    • Paget S (1989) The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 8: 98-101
    • (1989) Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 41
    • 33750294009 scopus 로고    scopus 로고
    • The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis
    • Ratajczak MZ, Zuba-Surma E, Kucia M, et al. (2006) The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis. Leukemia 20: 1915-1924
    • (2006) Leukemia , vol.20 , pp. 1915-1924
    • Ratajczak, M.Z.1    Zuba-Surma, E.2    Kucia, M.3
  • 42
    • 3042616145 scopus 로고    scopus 로고
    • Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4
    • Liang Z, Wu T, Lou H, et al. (2004) Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4. Cancer Res 64: 4302-4308
    • (2004) Cancer Res , vol.64 , pp. 4302-4308
    • Liang, Z.1    Wu, T.2    Lou, H.3
  • 43
    • 0034194009 scopus 로고    scopus 로고
    • Isolation and characterization of human CD34(-)Lin(-) and CD34(+)Lin(-) hematopoietic stem cells using cell surface markers AC133 and CD7
    • Gallacher L, Murdoch B, Wu DM, et al. (2000) Isolation and characterization of human CD34(-)Lin(-) and CD34(+)Lin(-) hematopoietic stem cells using cell surface markers AC133 and CD7. Blood 95: 2813-2820
    • (2000) Blood , vol.95 , pp. 2813-2820
    • Gallacher, L.1    Murdoch, B.2    Wu, D.M.3
  • 44
    • 33745020412 scopus 로고    scopus 로고
    • Killing time for cancer stem cells (CSC): Discovery and development of selective CSC inhibitors
    • Perez-Caro M and Sanchez-Garcia I (2006) Killing time for cancer stem cells (CSC): discovery and development of selective CSC inhibitors. Curr Med Chem 13: 1719-1725
    • (2006) Curr Med Chem , vol.13 , pp. 1719-1725
    • Perez-Caro, M.1    Sanchez-Garcia, I.2
  • 45
    • 2942691389 scopus 로고    scopus 로고
    • Stem cell origin of cancer and differentiation therapy
    • Sell S (2004) Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 51: 1-28
    • (2004) Crit Rev Oncol Hematol , vol.51 , pp. 1-28
    • Sell, S.1
  • 46
    • 33646106342 scopus 로고    scopus 로고
    • Cancer stem cells and differentiation therapy
    • Sell S (2006) Cancer stem cells and differentiation therapy. Tumour Biol 27: 59-70
    • (2006) Tumour Biol , vol.27 , pp. 59-70
    • Sell, S.1
  • 47
    • 0042027816 scopus 로고    scopus 로고
    • Treatment of acute promyelocytic leukemia: Strategy toward further increase of cure rate
    • Ohno R, Asou N and Ohnishi K (2003) Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate. Leukemia 17: 1454-1463
    • (2003) Leukemia , vol.17 , pp. 1454-1463
    • Ohno, R.1    Asou, N.2    Ohnishi, K.3
  • 48
    • 0031993322 scopus 로고    scopus 로고
    • Terminal differentiation of human breast cancer through PPAR gamma
    • Mueller E, Sarraf P, Tontonoz P, et al. (1998) Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell 1: 465-470
    • (1998) Mol Cell , vol.1 , pp. 465-470
    • Mueller, E.1    Sarraf, P.2    Tontonoz, P.3
  • 49
    • 12644265334 scopus 로고    scopus 로고
    • Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor
    • Tontonoz P, Singer S, Forman BM, et al. (1997) Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor. Proc Natl Acad Sci USA 94: 237-241
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 237-241
    • Tontonoz, P.1    Singer, S.2    Forman, B.M.3
  • 50
    • 22144434077 scopus 로고    scopus 로고
    • The effects of histone deacetylase inhibitors on heterochromatin: Implications for anticancer therapy?
    • Taddei A, Roche D, BickmoreWA, et al. (2005) The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? EMBO Rep 6: 520-524
    • (2005) EMBO Rep , vol.6 , pp. 520-524
    • Taddei, A.1    Bickmorewa, R.D.2
  • 51
    • 33845610993 scopus 로고    scopus 로고
    • Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    • Piccirillo SG, Reynolds BA, Zanetti N, et al. (2006) Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444: 761-765
    • (2006) Nature , vol.444 , pp. 761-765
    • Piccirillo, S.G.1    Reynolds, B.A.2    Zanetti, N.3
  • 52
    • 33750566665 scopus 로고    scopus 로고
    • Notch signaling in stem cell systems
    • Chiba S (2006) Notch signaling in stem cell systems. Stem Cells 24: 2437-2447
    • (2006) Stem Cells , vol.24 , pp. 2437-2447
    • Chiba, S.1
  • 53
    • 38449091379 scopus 로고    scopus 로고
    • Markers in normal and cancer stem cells
    • Natarajan TG and FitzGerald KT (2007) Markers in normal and cancer stem cells. Cancer Biomark 3: 211-231
    • (2007) Cancer Biomark , vol.3 , pp. 211-231
    • Natarajan, T.G.1    Fitzgerald, K.T.2
  • 54
  • 55
    • 50849111710 scopus 로고    scopus 로고
    • Rational targeting of Notch signaling in cancer
    • Rizzo P, Osipo C, Foreman K, et al. (2008) Rational targeting of Notch signaling in cancer. Oncogene 27: 5124-5131
    • (2008) Oncogene , vol.27 , pp. 5124-5131
    • Rizzo, P.1    Osipo, C.2    Foreman, K.3
  • 56
    • 52949086129 scopus 로고    scopus 로고
    • Therapeutic inhibition of Hedgehog-GLI signaling in cancer: Epithelial, stromal, or stem cell targets?
    • Ruiz i Altaba A (2008) Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets? Cancer Cell 14: 281-283
    • (2008) Cancer Cell , vol.14 , pp. 281-283
    • Ruiz, I.1    Altaba, A.2
  • 57
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo M and Taipale J (2008) Hedgehog: functions and mechanisms. Genes Dev 22: 2454-2472
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 58
    • 35348837163 scopus 로고    scopus 로고
    • Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
    • Bar EE, Chaudhry A, Lin A, et al. (2007) Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 25: 2524-2533
    • (2007) Stem Cells , vol.25 , pp. 2524-2533
    • Bar, E.E.1    Chaudhry, A.2    Lin, A.3
  • 59
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • Clement V, Sanchez P, de Tribolet N, et al. (2007) HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr Biol 17: 165-172
    • (2007) Curr Biol , vol.17 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    De Tribolet, N.3
  • 60
    • 52149119128 scopus 로고    scopus 로고
    • A paracrine requirement for hedgehog signalling in cancer
    • Yauch RL, Gould SE, Scales SJ, et al. (2008) A paracrine requirement for hedgehog signalling in cancer. Nature 455: 406-410
    • (2008) Nature , vol.455 , pp. 406-410
    • Yauch, R.L.1    Gould, S.E.2    Scales, S.J.3
  • 61
    • 34247192972 scopus 로고    scopus 로고
    • Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
    • Peacock CD, Wang Q, Gesell GS, et al. (2007) Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci USA 104: 4048-4053
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4048-4053
    • Peacock, C.D.1    Wang, Q.2    Gesell, G.S.3
  • 62
    • 0242669237 scopus 로고    scopus 로고
    • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
    • Watkins DN, Berman DM, Burkholder SG, et al. (2003) Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422: 313-317
    • (2003) Nature , vol.422 , pp. 313-317
    • Watkins, D.N.1    Berman, D.M.2    Burkholder, S.G.3
  • 63
    • 40149091426 scopus 로고    scopus 로고
    • Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure
    • Kimura H, Ng JM and Curran T (2008) Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell 13: 249-260
    • (2008) Cancer Cell , vol.13 , pp. 249-260
    • Kimura, H.1    Ng, J.M.2    Curran, T.3
  • 64
    • 0034610067 scopus 로고    scopus 로고
    • Nuclear localization and apoptotic regulation of an aminoterminal domain focal adhesion kinase fragment in endothelial cells [In Process Citation]
    • Lobo M and Zachary I (2000) Nuclear localization and apoptotic regulation of an aminoterminal domain focal adhesion kinase fragment in endothelial cells [In Process Citation]. Biochem Biophys Res Commun 276: 1068-1074
    • (2000) Biochem Biophys Res Commun , vol.276 , pp. 1068-1074
    • Lobo, M.1    Zachary, I.2
  • 65
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 66
    • 48749101937 scopus 로고    scopus 로고
    • WNT signalling in the immune system: WNT is spreading its wings
    • Staal FJ, Luis TC and Tiemessen MM (2008) WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol 8: 581-593
    • (2008) Nat Rev Immunol , vol.8 , pp. 581-593
    • Staal, F.J.1    Luis, T.C.2    Tiemessen, M.M.3
  • 67
    • 34548008809 scopus 로고    scopus 로고
    • Production of Wnt inhibitors by myeloma cells: Potential effects on canonical Wnt pathway in the bone microenvironment
    • Giuliani N, Morandi F, Tagliaferri S, et al. (2007) Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment. Cancer Res 67: 7665-7674
    • (2007) Cancer Res , vol.67 , pp. 7665-7674
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3
  • 68
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. (2003) The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 349: 2483-2494
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 69
    • 34547107319 scopus 로고    scopus 로고
    • WNT signaling pathway and stem cell signaling network
    • Katoh M and Katoh M (2007) WNT signaling pathway and stem cell signaling network. Clin Cancer Res 13: 4042-4045
    • (2007) Clin Cancer Res , vol.13 , pp. 4042-4045
    • Katoh, M.1    Katoh, M.2
  • 70
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • Barker N and Clevers H (2006) Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 5: 997-1014
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 72
    • 0037102196 scopus 로고    scopus 로고
    • The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells
    • Dimri GP, Martinez JL, Jacobs JJ, et al. (2002) The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 62: 4736-4745
    • (2002) Cancer Res , vol.62 , pp. 4736-4745
    • Dimri, G.P.1    Martinez, J.L.2    Jacobs, J.J.3
  • 73
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J and Sauvageau G (2003) Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423: 255-260
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 74
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • Molofsky AV, Pardal R, Iwashita T, et al. (2003) Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425: 962-967
    • (2003) Nature , vol.425 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3
  • 75
    • 22344449361 scopus 로고    scopus 로고
    • Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways
    • Molofsky AV, He S, Bydon M, et al. (2005) Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 19: 1432-1437
    • (2005) Genes Dev , vol.19 , pp. 1432-1437
    • Molofsky, A.V.1    He, S.2    Bydon, M.3
  • 76
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult selfrenewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M, et al. (2003) Bmi-1 is required for maintenance of adult selfrenewing haematopoietic stem cells. Nature 423: 302-305
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3
  • 77
    • 0344735881 scopus 로고    scopus 로고
    • Cancerous stem cells can arise from pediatric brain tumors
    • Hemmati HD, Nakano I, Lazareff JA, et al. (2003) Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 100: 15178-15183
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15178-15183
    • Hemmati, H.D.1    Nakano, I.2    Lazareff, J.A.3
  • 78
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
    • Jacobs JJ, Scheijen B, Voncken JW, et al. (1999) Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes Dev 13: 2678-2690
    • (1999) Genes Dev , vol.13 , pp. 2678-2690
    • Jacobs, J.J.1    Scheijen, B.2    Voncken, J.W.3
  • 79
    • 10344258563 scopus 로고    scopus 로고
    • Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
    • Iwama A, Oguro H, Negishi M, et al. (2004) Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 21: 843-851
    • (2004) Immunity , vol.21 , pp. 843-851
    • Iwama, A.1    Oguro, H.2    Negishi, M.3
  • 80
    • 20544453888 scopus 로고    scopus 로고
    • Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice
    • Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, et al. (2005) Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 19: 1438-1443
    • (2005) Genes Dev , vol.19 , pp. 1438-1443
    • Bruggeman, S.W.1    Valk-Lingbeek, M.E.2    Van Der Stoop, P.P.3
  • 81
    • 33749172559 scopus 로고    scopus 로고
    • Stem-cell ageing modified by the cyclindependent kinase inhibitor p16INK4a
    • Janzen V, Forkert R, Fleming HE, et al. (2006) Stem-cell ageing modified by the cyclindependent kinase inhibitor p16INK4a. Nature 443: 421-426
    • (2006) Nature , vol.443 , pp. 421-426
    • Janzen, V.1    Forkert, R.2    Fleming, H.E.3
  • 82
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L, et al. (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 21: 1050-1063
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3
  • 83
    • 9044241254 scopus 로고    scopus 로고
    • Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
    • Nakamura T, Largaespada DA, Lee MP, et al. (1996) Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet 12: 154-158
    • (1996) Nat Genet , vol.12 , pp. 154-158
    • Nakamura, T.1    Largaespada, D.A.2    Lee, M.P.3
  • 84
    • 13544262343 scopus 로고    scopus 로고
    • HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo
    • Fischbach NA, Rozenfeld S, Shen W, et al. (2005) HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo. Blood 105: 1456-1466
    • (2005) Blood , vol.105 , pp. 1456-1466
    • Fischbach, N.A.1    Rozenfeld, S.2    Shen, W.3
  • 85
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL and Cantley LC (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene 27: 5497-5510
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 86
    • 51849097348 scopus 로고    scopus 로고
    • The role of PTEN signaling perturbations in cancer and in targeted therapy
    • Keniry M and Parsons R (2008) The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene 27: 5477-5485
    • (2008) Oncogene , vol.27 , pp. 5477-5485
    • Keniry, M.1    Parsons, R.2
  • 87
    • 0034854091 scopus 로고    scopus 로고
    • Regulation of PTEN transcription by p53
    • Stambolic V, MacPherson D, Sas D, et al. (2001) Regulation of PTEN transcription by p53. Mol Cell 8: 317-325
    • (2001) Mol Cell , vol.8 , pp. 317-325
    • Stambolic, V.1    Macpherson, D.2    Sas, D.3
  • 88
    • 34748840281 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cellmotility and growth in three-dimensional cultures
    • Howes AL, Chiang GG, Lang ES, et al. (2007) The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cellmotility and growth in three-dimensional cultures. Mol Cancer Ther 6: 2505-2514
    • (2007) Mol Cancer Ther , vol.6 , pp. 2505-2514
    • Howes, A.L.1    Chiang, G.G.2    Lang, E.S.3
  • 89
    • 39149123820 scopus 로고    scopus 로고
    • A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
    • Garlich JR, De P, Dey N, et al. (2008) A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res 68: 206-215
    • (2008) Cancer Res , vol.68 , pp. 206-215
    • Garlich, J.R.1    De, P.2    Dey, N.3
  • 90
    • 33646447708 scopus 로고    scopus 로고
    • Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor
    • Yaguchi S, Fukui Y, Koshimizu I, et al. (2006) Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor. J Natl Cancer Inst 98: 545-556
    • (2006) J Natl Cancer Inst , vol.98 , pp. 545-556
    • Yaguchi, S.1    Fukui, Y.2    Koshimizu, I.3
  • 91
    • 42249090359 scopus 로고    scopus 로고
    • Characterization of structurally distinct, isoform-selective phosphoinositide 3-kinase inhibitors in combination with radiation in the treatment of glioblastoma
    • Chen JS, Zhou LJ, Entin-Meer M, et al. (2008) Characterization of structurally distinct, isoform-selective phosphoinositide 3-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther 7: 841-850
    • (2008) Mol Cancer Ther , vol.7 , pp. 841-850
    • Chen, J.S.1    Zhou, L.J.2    Entin-Meer, M.3
  • 92
    • 51849098272 scopus 로고    scopus 로고
    • Drug discovery approaches targeting the PI3K/Akt pathway in cancer
    • Garcia-Echeverria C and Sellers WR (2008) Drug discovery approaches targeting the PI3K/Akt pathway in cancer. Oncogene 27: 5511-5526
    • (2008) Oncogene , vol.27 , pp. 5511-5526
    • Garcia-Echeverria, C.1    Sellers, W.R.2
  • 93
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz OH, Valdez R, Theisen BK, et al. (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441: 475-482
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3
  • 94
    • 44349088690 scopus 로고    scopus 로고
    • Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
    • Guo W, Lasky JL, Chang CJ, et al. (2008) Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature 453: 529-533
    • (2008) Nature , vol.453 , pp. 529-533
    • Guo, W.1    Lasky, J.L.2    Chang, C.J.3
  • 95
    • 39749166975 scopus 로고    scopus 로고
    • DNA repair pathways as targets for cancer therapy
    • Helleday T, Petermann E, Lundin C, et al. (2008) DNA repair pathways as targets for cancer therapy. Nat Rev Cancer 8: 193-204
    • (2008) Nat Rev Cancer , vol.8 , pp. 193-204
    • Helleday, T.1    Petermann, E.2    Lundin, C.3
  • 96
    • 35948950248 scopus 로고    scopus 로고
    • The inhibitor of apoptosis proteins as therapeutic targets in cancer
    • Vucic D and Fairbrother WJ (2007) The inhibitor of apoptosis proteins as therapeutic targets in cancer. Clin Cancer Res 13: 5995-6000
    • (2007) Clin Cancer Res , vol.13 , pp. 5995-6000
    • Vucic, D.1    Fairbrother, W.J.2
  • 97
    • 0037442965 scopus 로고    scopus 로고
    • Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: Therapeutic effect of a novel polyarginine-conjugated Smac peptide
    • Yang L, Mashima T, Sato S, et al. (2003) Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res 63: 831-837
    • (2003) Cancer Res , vol.63 , pp. 831-837
    • Yang, L.1    Mashima, T.2    Sato, S.3
  • 98
    • 33749252583 scopus 로고    scopus 로고
    • Human inhibitor of apoptosis proteins: Why XIAP is the black sheep of the family
    • Eckelman BP, Salvesen GS and Scott FL (2006) Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep 7: 988-994
    • (2006) EMBO Rep , vol.7 , pp. 988-994
    • Eckelman, B.P.1    Salvesen, G.S.2    Scott, F.L.3
  • 99
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang CY, Mayo MW, Korneluk RG, et al. (1998) NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281: 1680-1683
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3
  • 100
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • Harley CB (2008) Telomerase and cancer therapeutics. Nat Rev Cancer 8: 167-179
    • (2008) Nat Rev Cancer , vol.8 , pp. 167-179
    • Harley, C.B.1
  • 101
    • 33745679352 scopus 로고    scopus 로고
    • Telomerase therapeutics for cancer: Challenges and new directions
    • Shay JW and Wright WE (2006) Telomerase therapeutics for cancer: challenges and new directions. Nat Rev Drug Discov 5: 577-584
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 577-584
    • Shay, J.W.1    Wright, W.E.2
  • 102
    • 45849139299 scopus 로고    scopus 로고
    • Cancer stem cells as targets for cancer therapy: Selected cancers as examples
    • Hombach-Klonisch S, Paranjothy T, Wiechec E, et al. (2008) Cancer stem cells as targets for cancer therapy: selected cancers as examples. Arch Immunol Ther Exp 56: 165-180
    • (2008) Arch Immunol Ther Exp , vol.56 , pp. 165-180
    • Hombach-Klonisch, S.1    Paranjothy, T.2    Wiechec, E.3
  • 103
    • 0141954014 scopus 로고    scopus 로고
    • Effects of oligonucleotide N3-P5 thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells
    • Akiyama M, Hideshima T, Shammas MA, et al. (2003) Effects of oligonucleotide N3-P5 thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells. Cancer Res 63: 6187-6194
    • (2003) Cancer Res , vol.63 , pp. 6187-6194
    • Akiyama, M.1    Hideshima, T.2    Shammas, M.A.3
  • 104
    • 0346336773 scopus 로고    scopus 로고
    • Telomerase inhibition with an oligonucleotide telomerase template antagonist: In vitro and in vivo studies in multiple myeloma and lymphoma
    • Wang ES, Wu K, Chin AC, et al. (2004) Telomerase inhibition with an oligonucleotide telomerase template antagonist: in vitro and in vivo studies in multiple myeloma and lymphoma. Blood 103: 258-266
    • (2004) Blood , vol.103 , pp. 258-266
    • Wang, E.S.1    Wu, K.2    Chin, A.C.3
  • 105
    • 33645244083 scopus 로고    scopus 로고
    • Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer
    • Gellert GC, Dikmen ZG, Wright WE, et al. (2006) Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer. Breast Cancer Res Treat 96: 73-81
    • (2006) Breast Cancer Res Treat , vol.96 , pp. 73-81
    • Gellert, G.C.1    Dikmen, Z.G.2    Wright, W.E.3
  • 106
    • 33846799020 scopus 로고    scopus 로고
    • Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells
    • Gomez-Millan J, Goldblatt EM, Gryaznov SM, et al. (2007) Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells. Int J Radiat Oncol Biol Phys 67: 897-905
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 897-905
    • Gomez-Millan, J.1    Goldblatt, E.M.2    Gryaznov, S.M.3
  • 107
    • 24744446474 scopus 로고    scopus 로고
    • In vivo inhibition of lung cancer by GRN163L: A novel human telomerase inhibitor
    • Dikmen ZG, Gellert GC, Jackson S, et al. (2005) In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res 65: 7866-7873
    • (2005) Cancer Res , vol.65 , pp. 7866-7873
    • Dikmen, Z.G.1    Gellert, G.C.2    Jackson, S.3
  • 108
    • 4344624834 scopus 로고    scopus 로고
    • Antitumor effects of specific telomerase inhibitor GRN163 in human glioblastoma xenografts
    • Ozawa T, Gryaznov SM, Hu LJ, et al. (2004) Antitumor effects of specific telomerase inhibitor GRN163 in human glioblastoma xenografts. Neuro-oncology 6: 218-226
    • (2004) Neuro-oncology , vol.6 , pp. 218-226
    • Ozawa, T.1    Gryaznov, S.M.2    Hu, L.J.3
  • 109
    • 30944442508 scopus 로고    scopus 로고
    • Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma
    • Djojosubroto MW, Chin AC, Go N, et al. (2005) Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology 42: 1127-1136
    • (2005) Hepatology , vol.42 , pp. 1127-1136
    • Djojosubroto, M.W.1    Chin, A.C.2    Go, N.3
  • 110
    • 43449139419 scopus 로고    scopus 로고
    • Telomerase targeted oligonucleotide thiophosphoramidates in T24-luc bladder cancer cells
    • Dikmen ZG, Wright WE, Shay JW, et al. (2008) Telomerase targeted oligonucleotide thiophosphoramidates in T24-luc bladder cancer cells. J Cell Biochem 104: 444-452
    • (2008) J Cell Biochem , vol.104 , pp. 444-452
    • Dikmen, Z.G.1    Wright, W.E.2    Shay, J.W.3
  • 111
    • 0042674370 scopus 로고    scopus 로고
    • A novel telomerase template antagonist (GRN163) as a potential anticancer agent
    • Asai A, Oshima Y, Yamamoto Y, et al. (2003) A novel telomerase template antagonist (GRN163) as a potential anticancer agent. Cancer Res 63: 3931-3939
    • (2003) Cancer Res , vol.63 , pp. 3931-3939
    • Asai, A.1    Oshima, Y.2    Yamamoto, Y.3
  • 112
    • 34047143340 scopus 로고    scopus 로고
    • Telomerase immunity from bench to bedside: Round one
    • Cortez-Gonzalez X and Zanetti M (2007) Telomerase immunity from bench to bedside: round one. J Transl Med 5: 12
    • (2007) J Transl Med , vol.5 , pp. 12
    • Cortez-Gonzalez, X.1    Zanetti, M.2
  • 113
    • 34248359065 scopus 로고    scopus 로고
    • Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    • Parmar K, Mauch P, Vergilio JA, et al. (2007) Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc Natl Acad Sci USA 104: 5431-5436
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5431-5436
    • Parmar, K.1    Mauch, P.2    Vergilio, J.A.3
  • 114
    • 36849083949 scopus 로고    scopus 로고
    • Cancer stem cell: Target for anti-cancer therapy
    • Tang C, Ang BT and Pervaiz S (2007) Cancer stem cell: target for anti-cancer therapy. Faseb J 21: 3777-3785
    • (2007) Faseb J , vol.21 , pp. 3777-3785
    • Tang, C.1    Ang, B.T.2    Pervaiz, S.3
  • 115
    • 37749016965 scopus 로고    scopus 로고
    • Cancer stem cells with genetic instability: The best vehicle with the best engine for cancer
    • Lagasse E (2008) Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer. Gene Ther 15: 136-142
    • (2008) Gene Ther , vol.15 , pp. 136-142
    • Lagasse, E.1
  • 116
    • 34548151293 scopus 로고    scopus 로고
    • Medical chemistry to spy cancer stem cells from outside the body
    • Herranz M and Sanchez-Garcia I (2007) Medical chemistry to spy cancer stem cells from outside the body. Mini Rev Med Chem 7: 781-791
    • (2007) Mini Rev Med Chem , vol.7 , pp. 781-791
    • Herranz, M.1    Sanchez-Garcia, I.2
  • 117
    • 4243091779 scopus 로고    scopus 로고
    • Molecular imaging of gene therapy for cancer
    • Shah K, Jacobs A, Breakefield XO, et al. (2004) Molecular imaging of gene therapy for cancer. Gene Ther 11: 1175-1187
    • (2004) Gene Ther , vol.11 , pp. 1175-1187
    • Shah, K.1    Jacobs, A.2    Breakefield, X.O.3
  • 119
    • 33750073849 scopus 로고    scopus 로고
    • RANKL-induced CCL22/ macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4
    • Nakamura ES, Koizumi K, Kobayashi M, et al. (2006) RANKL-induced CCL22/ macrophage-derived chemokine produced from osteoclasts potentially promotes the bone metastasis of lung cancer expressing its receptor CCR4. Clin Exp Metastasis 23: 9-18
    • (2006) Clin Exp Metastasis , vol.23 , pp. 9-18
    • Nakamura, E.S.1    Koizumi, K.2    Kobayashi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.