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Volumn 15, Issue 2, 2008, Pages 136-142

Cancer stem cells with genetic instability: The best vehicle with the best engine for cancer

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IMATINIB;

EID: 37749016965     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3303068     Document Type: Review
Times cited : (65)

References (76)
  • 1
    • 84956427297 scopus 로고
    • A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
    • Till JE, McCulloch EA. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 1961; 14: 213-223.
    • (1961) Radiat Res , vol.14 , pp. 213-223
    • Till, J.E.1    McCulloch, E.A.2
  • 3
    • 0023922373 scopus 로고
    • Purification and characterization of mouse hematopoietic stem cells
    • Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science (Washington DC) 1988; 241: 58-62.
    • (1988) Science (Washington DC) , vol.241 , pp. 58-62
    • Spangrude, G.J.1    Heimfeld, S.2    Weissman, I.L.3
  • 5
  • 6
    • 0035038390 scopus 로고    scopus 로고
    • Stem cells and pattern formation in the nervous system: The possible versus the actual
    • Anderson DJ. Stem cells and pattern formation in the nervous system: The possible versus the actual. Neuron 2001; 30: 19-35.
    • (2001) Neuron , vol.30 , pp. 19-35
    • Anderson, D.J.1
  • 7
    • 5444244267 scopus 로고    scopus 로고
    • Epigenetic control of neural stem cell fate
    • Hsieh J, Gage FH. Epigenetic control of neural stem cell fate. Curr Opin Genet Dev 2004; 14: 461-469.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 461-469
    • Hsieh, J.1    Gage, F.H.2
  • 9
    • 0142052965 scopus 로고    scopus 로고
    • Stem cells. Stemness' genes still elusive
    • Vogel G. Stem cells. Stemness' genes still elusive. Science 2003; 302: 371
    • (2003) Science , vol.302 , pp. 371
    • Vogel, G.1
  • 11
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003; 423: 302-305.
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3    Becker, M.W.4    Pihalja, M.5    Weissman, I.L.6
  • 12
    • 0025727771 scopus 로고
    • Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice
    • Haupt Y, Alexander WS, Barri G, Klinken SP, Adams JM. Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. Cell 1991; 65: 753-763.
    • (1991) Cell , vol.65 , pp. 753-763
    • Haupt, Y.1    Alexander, W.S.2    Barri, G.3    Klinken, S.P.4    Adams, J.M.5
  • 13
    • 34547194433 scopus 로고    scopus 로고
    • Bud-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells
    • Hosen N, Yamane T, Muijtjens M, Pharn K, Clarke MF, Weissman IL. Bud-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells 2007, 25: 1635-1644.
    • (2007) Stem Cells , vol.25 , pp. 1635-1644
    • Hosen, N.1    Yamane, T.2    Muijtjens, M.3    Pharn, K.4    Clarke, M.F.5    Weissman, I.L.6
  • 14
    • 33746459740 scopus 로고    scopus 로고
    • Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors
    • Pardal R, Molofsky AV, He S, Morrison SJ. Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors. Cold Spring Harb Symp Quant Biol 2005; 70: 177-185.
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 177-185
    • Pardal, R.1    Molofsky, A.V.2    He, S.3    Morrison, S.J.4
  • 15
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • Morrison SJ, Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 2006, 441: 1068-1074.
    • (2006) Nature , vol.441 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 16
    • 27144555447 scopus 로고    scopus 로고
    • Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
    • Caussinus E, Gonzalez C. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 2005; 37: 1125-1129.
    • (2005) Nat Genet , vol.37 , pp. 1125-1129
    • Caussinus, E.1    Gonzalez, C.2
  • 17
    • 33751579138 scopus 로고    scopus 로고
    • Origins and consequences of centrosome aberrations in human cancers
    • Nigg EA. Origins and consequences of centrosome aberrations in human cancers. Int J Cancer 2006; 119: 2717-2723.
    • (2006) Int J Cancer , vol.119 , pp. 2717-2723
    • Nigg, E.A.1
  • 19
    • 0035951482 scopus 로고    scopus 로고
    • Centrosome abnormalities, genomic instability and carcinogenic progression
    • Duensing S, Munger. K. Centrosome abnormalities, genomic instability and carcinogenic progression. Biochim Biophys Acta 2001; 1471: M81-M88.
    • (2001) Biochim Biophys Acta , vol.1471
    • Duensing, S.1    Munger, K.2
  • 20
    • 34247527731 scopus 로고    scopus 로고
    • Male and female Drosophila germline stem cells: Two versions of immortality
    • Fuller MT, Spradling AC. Male and female Drosophila germline stem cells: Two versions of immortality. Science 2007; 316: 402-404.
    • (2007) Science , vol.316 , pp. 402-404
    • Fuller, M.T.1    Spradling, A.C.2
  • 21
    • 12544252115 scopus 로고    scopus 로고
    • Gene circuitry controlling a stem cell niche
    • Chen D, McKearin D. Gene circuitry controlling a stem cell niche. Curr Biol 2005; 15: 179-184.
    • (2005) Curr Biol , vol.15 , pp. 179-184
    • Chen, D.1    McKearin, D.2
  • 22
    • 34248564820 scopus 로고    scopus 로고
    • Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma
    • Fukino K, Shen L, Patocs A, Mutter GL, Eng C. Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma. JAMA 2007; 297: 2103-2111.
    • (2007) JAMA , vol.297 , pp. 2103-2111
    • Fukino, K.1    Shen, L.2    Patocs, A.3    Mutter, G.L.4    Eng, C.5
  • 23
    • 33646249638 scopus 로고    scopus 로고
    • Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas
    • Ishiguro K, Yoshida T, Yagishita H, Numata Y, Okayasu T. Epithelial and stromal genetic instability contributes to genesis of colorectal adenomas. Gut 2006; 55: 695-702.
    • (2006) Gut , vol.55 , pp. 695-702
    • Ishiguro, K.1    Yoshida, T.2    Yagishita, H.3    Numata, Y.4    Okayasu, T.5
  • 24
    • 0342264492 scopus 로고    scopus 로고
    • Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis
    • Moinfar F, Man YG, Arnould L, Bratthauer GL, Ratschek M, Tavassoli FA. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: Implications for tumorigenesis. Cancer Res 2000; 60: 2562-2566.
    • (2000) Cancer Res , vol.60 , pp. 2562-2566
    • Moinfar, F.1    Man, Y.G.2    Arnould, L.3    Bratthauer, G.L.4    Ratschek, M.5    Tavassoli, F.A.6
  • 25
    • 0018583976 scopus 로고
    • Clonal origin of human tumors
    • Fialkow PJ. Clonal origin of human tumors. Annu Rev Med 1979; 30:135-143.
    • (1979) Annu Rev Med , vol.30 , pp. 135-143
    • Fialkow, P.J.1
  • 26
    • 0021992165 scopus 로고
    • Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors
    • Vogelstein B, Fearorr ER, Hamilton SR, Feinberg AP. Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. Science 1985; 227: 642-645.
    • (1985) Science , vol.227 , pp. 642-645
    • Vogelstein, B.1    Fearorr, E.R.2    Hamilton, S.R.3    Feinberg, A.P.4
  • 27
    • 84965820581 scopus 로고
    • The transmission of leukemia of mice with a single cell
    • Furth J, Kahn Jr JB. The transmission of leukemia of mice with a single cell. Am J Cancer 1936; 31: 276-282.
    • (1936) Am J Cancer , vol.31 , pp. 276-282
    • Furth, J.1    Kahn Jr, J.B.2
  • 28
    • 0000286732 scopus 로고
    • A minute chromosome in human chromic granulocytic leukemia
    • Nowell P, Hungerford D. A minute chromosome in human chromic granulocytic leukemia. Science 1960; 132: 1497.
    • (1960) Science , vol.132 , pp. 1497
    • Nowell, P.1    Hungerford, D.2
  • 29
    • 0036376720 scopus 로고    scopus 로고
    • Tumor progression: A brief historical perspective
    • Nowell PC. Tumor progression: A brief historical perspective. Semin Cancer Biol 2002; 12: 261-266.
    • (2002) Semin Cancer Biol , vol.12 , pp. 261-266
    • Nowell, P.C.1
  • 30
    • 0028807126 scopus 로고
    • Lymphomatoid papulosis followed by Ki-1 positive anaplastic large cell lymphoma: Proliferation of a common T-cell clone
    • Amagai M, Kawakubo Y, Tsuyuki A, Harada R. Lymphomatoid papulosis followed by Ki-1 positive anaplastic large cell lymphoma: Proliferation of a common T-cell clone. J Dermatol 1995; 22: 743-746.
    • (1995) J Dermatol , vol.22 , pp. 743-746
    • Amagai, M.1    Kawakubo, Y.2    Tsuyuki, A.3    Harada, R.4
  • 31
    • 0034014831 scopus 로고    scopus 로고
    • The clonal origin and clonal evolution of epithelial tumours
    • Garcia SB, Novelli M, Wright NA. The clonal origin and clonal evolution of epithelial tumours. Int J Exp Pathol 2000; 81: 89-116.
    • (2000) Int J Exp Pathol , vol.81 , pp. 89-116
    • Garcia, S.B.1    Novelli, M.2    Wright, N.A.3
  • 32
    • 0015250479 scopus 로고
    • Genes which increase chromosomal instability in somatic cells and predispose to cancer
    • German J. Genes which increase chromosomal instability in somatic cells and predispose to cancer. Prog Med Genet 1972; 8: 61-101.
    • (1972) Prog Med Genet , vol.8 , pp. 61-101
    • German, J.1
  • 34
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10: 789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 35
    • 0017785769 scopus 로고
    • Primary bioassay of human tumor stem cells
    • Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science 1977; 197: 461-463.
    • (1977) Science , vol.197 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 37
    • 0017704436 scopus 로고
    • Metastasis results from preexisting variant cells within a malignant tumor
    • Fidler IJ, Kripke ML. Metastasis results from preexisting variant cells within a malignant tumor. Science 1977; 197: 893-895.
    • (1977) Science , vol.197 , pp. 893-895
    • Fidler, I.J.1    Kripke, M.L.2
  • 38
    • 0019941487 scopus 로고
    • Biological diversity in metastatic neoplasms: Origins and implications
    • Fidler IJ, Hart IR. Biological diversity in metastatic neoplasms: origins and implications. Science 1982; 217: 998-1003.
    • (1982) Science , vol.217 , pp. 998-1003
    • Fidler, I.J.1    Hart, I.R.2
  • 39
    • 0038105499 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations in neuroblastoma
    • Tonini GP, Romani M. Genetic and epigenetic alterations in neuroblastoma. Cancer Lett 2003; 197: 69-73.
    • (2003) Cancer Lett , vol.197 , pp. 69-73
    • Tonini, G.P.1    Romani, M.2
  • 40
    • 0037386583 scopus 로고    scopus 로고
    • Breast cancer stem cells revealed
    • Dick JE. Breast cancer stem cells revealed. Proc Natl Acad Sci USA 2003; 100: 3547-3549.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3547-3549
    • Dick, J.E.1
  • 41
    • 0016692602 scopus 로고
    • Mutation selection and the natural history of cancer
    • Cairns J. Mutation selection and the natural history of cancer. Nature 1975; 255: 197-200.
    • (1975) Nature , vol.255 , pp. 197-200
    • Cairns, J.1
  • 42
    • 0021689859 scopus 로고
    • Perspectives on clonogenic tumor cells, stem cells, and oncogenes
    • Buick RN, Pollak MN. Perspectives on clonogenic tumor cells, stem cells, and oncogenes. Cancer Res 1984; 44: 4909-4918.
    • (1984) Cancer Res , vol.44 , pp. 4909-4918
    • Buick, R.N.1    Pollak, M.N.2
  • 43
    • 0028294877 scopus 로고
    • Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers
    • Sell S, Pierce GB. Maturation arrest of stem cell differentiation is a common pathway for the cellular origin of teratocarcinomas and epithelial cancers. Lab Invest 1994; 70: 6-22.
    • (1994) Lab Invest , vol.70 , pp. 6-22
    • Sell, S.1    Pierce, G.B.2
  • 45
    • 0021905418 scopus 로고
    • Two-stage tumor promotion in mouse skin: An alternative interpretation
    • Hennings H, Yuspa SH. Two-stage tumor promotion in mouse skin: An alternative interpretation. J Natl Cancer Inst 1985; 74: 735-740.
    • (1985) J Natl Cancer Inst , vol.74 , pp. 735-740
    • Hennings, H.1    Yuspa, S.H.2
  • 46
    • 21644485644 scopus 로고    scopus 로고
    • A perspective on keratinocybe stem cells as targets for skin carcinogenesis
    • Morris RJ. A perspective on keratinocybe stem cells as targets for skin carcinogenesis. Differentiation 2004, 72: 381-386.
    • (2004) Differentiation , vol.72 , pp. 381-386
    • Morris, R.J.1
  • 47
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3: 730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 48
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • Galli R, Binds E, Orfanelli U, Cipelletti B, Gritti A, De Vitis S et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004; 64: 7011-7021.
    • (2004) Cancer Res , vol.64 , pp. 7011-7021
    • Galli, R.1    Binds, E.2    Orfanelli, U.3    Cipelletti, B.4    Gritti, A.5    De Vitis, S.6
  • 53
    • 0031663494 scopus 로고    scopus 로고
    • Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells transformed with c-myc and H-ras form high-grade glioma after stereotactic injection into the rat brain
    • Barnett SC, Robertson L, Graham D, Allan D, Rampling R. Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells transformed with c-myc and H-ras form high-grade glioma after stereotactic injection into the rat brain. Carcinogenesis 1998; 19: 1529-1537.
    • (1998) Carcinogenesis , vol.19 , pp. 1529-1537
    • Barnett, S.C.1    Robertson, L.2    Graham, D.3    Allan, D.4    Rampling, R.5
  • 54
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    • Passegue E, Jamieson CH, Ailles LE, Weissman IL. Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci USA 2003; 100 (Suppl 1): 11842-11849.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.SUPPL. 1 , pp. 11842-11849
    • Passegue, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 55
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C, Kinzler KW, Vogelstein B. Genetic instabilities in human cancers. Nature 1998; 396: 643-649.
    • (1998) Nature , vol.396 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 56
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Bayhn SB. The epigenomics of cancer. Cell 2007; 128 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Bayhn, S.B.2
  • 60
    • 33846008439 scopus 로고    scopus 로고
    • Colorectal cancer: A model for epigenetic tumorigenesis
    • Wong JJ, Hawkins NJ, Ward RL. Colorectal cancer: A model for epigenetic tumorigenesis. Gut 2007; 56: 140-148.
    • (2007) Gut , vol.56 , pp. 140-148
    • Wong, J.J.1    Hawkins, N.J.2    Ward, R.L.3
  • 61
    • 0037069469 scopus 로고    scopus 로고
    • Multistage carcinogenesis and the incidence of colorectal cancer
    • Luebeck EG, Moolgavkar SH. Multistage carcinogenesis and the incidence of colorectal cancer. Proc Natl Acad Sci USA 2002; 99: 15095-15100.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15095-15100
    • Luebeck, E.G.1    Moolgavkar, S.H.2
  • 62
    • 0037445248 scopus 로고    scopus 로고
    • Role of DNA mismatch repair defects in the pathogenesis of human cancer
    • Peltomaki P. Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol 2003; 21: 1174-1179.
    • (2003) J Clin Oncol , vol.21 , pp. 1174-1179
    • Peltomaki, P.1
  • 63
    • 34547095240 scopus 로고    scopus 로고
    • Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastorna
    • Shiras A, Chettiar ST, Shepal V, Rajendran G, Prasad GR, Shastry P. Spontaneous transformation of human adult nontumorigenic stem cells to cancer stem cells is driven by genomic instability in a human model of glioblastorna. Stem Cells 2007; 25: 1478-1489.
    • (2007) Stem Cells , vol.25 , pp. 1478-1489
    • Shiras, A.1    Chettiar, S.T.2    Shepal, V.3    Rajendran, G.4    Prasad, G.R.5    Shastry, P.6
  • 64
    • 34249676964 scopus 로고    scopus 로고
    • Chronic myeloid leukaemia as a model of disease evolution in human cancer
    • Melo JV, Barnes DJ. Chronic myeloid leukaemia as a model of disease evolution in human cancer. Nat Rev Cancer 2007, 7: 441-453.
    • (2007) Nat Rev Cancer , vol.7 , pp. 441-453
    • Melo, J.V.1    Barnes, D.J.2
  • 65
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • Sawyers C. Targeted cancer therapy. Nature 2004; 432: 294-297.
    • (2004) Nature , vol.432 , pp. 294-297
    • Sawyers, C.1
  • 68
    • 0029593313 scopus 로고
    • 5-Fluorouracil-resistant CD34+ cell population from peripheral blood of CML patients contains BCR-ABL-negative progenitor cells
    • Jazwiec: B, Mahon FX, Pigneux A, Pigeonnier V, Reiffers J. 5-Fluorouracil-resistant CD34+ cell population from peripheral blood of CML patients contains BCR-ABL-negative progenitor cells. Exp Hematol 1995; 23: 1509-1514.
    • (1995) Exp Hematol , vol.23 , pp. 1509-1514
    • Jazwiec, B.1    Mahon, F.X.2    Pigneux, A.3    Pigeonnier, V.4    Reiffers, J.5
  • 69
    • 13344262695 scopus 로고    scopus 로고
    • Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis
    • Sirard C, Lapidot T, Vormoor J, Cashman JD, Doedens M, Murdoch B et al. Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood 1996; 87: 1539-1548.
    • (1996) Blood , vol.87 , pp. 1539-1548
    • Sirard, C.1    Lapidot, T.2    Vormoor, J.3    Cashman, J.D.4    Doedens, M.5    Murdoch, B.6
  • 70
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the AN tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S et al. Effects of a selective inhibitor of the AN tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2: 561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3    Ohno, S.4    Segal, G.M.5    Fanning, S.6
  • 71
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344 1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3    Peng, B.4    Buchdunger, E.5    Ford, J.M.6
  • 72
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to ST1571 in vitro
    • Graham SM, Jorgensen HG, Allan E, Pearson C, Aldorn MJ, Richmond L et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to ST1571 in vitro. Blood 2002; 99: 319-325.
    • (2002) Blood , vol.99 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Aldorn, M.J.5    Richmond, L.6
  • 73
    • 4644341516 scopus 로고    scopus 로고
    • Discontinuation of imatinib therapy after achieving a moleculqr response
    • Cortes J, O'Brien S, Kantarjian H. Discontinuation of imatinib therapy after achieving a moleculqr response. Blood 2004; 104: 2204-2205.
    • (2004) Blood , vol.104 , pp. 2204-2205
    • Cortes, J.1    O'Brien, S.2    Kantarjian, H.3
  • 74
    • 37049003546 scopus 로고    scopus 로고
    • Cortes J, Jabbour E, Kantarjian H, Yin CC, Shan J, O'Brien S et al. Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 2007 (prepublished online September 4).
    • Cortes J, Jabbour E, Kantarjian H, Yin CC, Shan J, O'Brien S et al. Dynamics of BCR-ABL kinase domain mutations in chronic myeloid leukemia after sequential treatment with multiple tyrosine kinase inhibitors. Blood 2007 (prepublished online September 4).
  • 75
    • 3242800443 scopus 로고    scopus 로고
    • Clonal evolution in chronic myelogenous leukemia
    • Cortes J, O'Dwyer ME. Clonal evolution in chronic myelogenous leukemia. Hematol Oncol Clin North Am 2004; 18: 671-684.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 671-684
    • Cortes, J.1    O'Dwyer, M.E.2
  • 76
    • 33750202014 scopus 로고    scopus 로고
    • The population dynamics of cancer: A Darwinian perspective
    • Vineis P, Berwick M. The population dynamics of cancer: A Darwinian perspective. Int J Epidemiol 2006; 35: 1151-1159.
    • (2006) Int J Epidemiol , vol.35 , pp. 1151-1159
    • Vineis, P.1    Berwick, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.