-
1
-
-
27844561478
-
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects
-
Oling V, Marttila J, Ilonen J et al. GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects. J Autoimmun 2005: 25: 235-243.
-
(2005)
J Autoimmun
, vol.25
, pp. 235-243
-
-
Oling, V.1
Marttila, J.2
Ilonen, J.3
-
2
-
-
0036312395
-
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects
-
Reijonen H, Novak EJ, Kochik S et al. Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects. Diabetes 2002: 51: 1375-1382.
-
(2002)
Diabetes
, vol.51
, pp. 1375-1382
-
-
Reijonen, H.1
Novak, E.J.2
Kochik, S.3
-
3
-
-
33845533220
-
Identification of novel HLA-A*0201 - restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives
-
Standifer NE, Ouyang Q, Panagiotopoulos C et al. Identification of novel HLA-A*0201 - restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Diabetes 2006: 55: 3061-3067.
-
(2006)
Diabetes
, vol.55
, pp. 3061-3067
-
-
Standifer, N.E.1
Ouyang, Q.2
Panagiotopoulos, C.3
-
4
-
-
77951983004
-
Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers
-
Velthuis JH, Unger WW, Abreu JR et al. Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes 2010: 59: 1721-1730.
-
(2010)
Diabetes
, vol.59
, pp. 1721-1730
-
-
Velthuis, J.H.1
Unger, W.W.2
Abreu, J.R.3
-
5
-
-
84866182947
-
Autoantigen Recognition Is Required for Recruitment of IGRP206-214-Autoreactive CD8+ T Cells but Is Dispensable for Tolerance
-
Wang J, Tsai S, Han B, Tailor P, Santamaria P. Autoantigen Recognition Is Required for Recruitment of IGRP206-214-Autoreactive CD8+ T Cells but Is Dispensable for Tolerance. J Immunol 2012: 189: 2975-2984.
-
(2012)
J Immunol
, vol.189
, pp. 2975-2984
-
-
Wang, J.1
Tsai, S.2
Han, B.3
Tailor, P.4
Santamaria, P.5
-
6
-
-
0842288454
-
Proinsulin expression by Hassall's corpuscles in the mouse thymus
-
Chentoufi AA, Palumbo M, Polychronakos C. Proinsulin expression by Hassall's corpuscles in the mouse thymus. Diabetes 2004: 53: 354-359.
-
(2004)
Diabetes
, vol.53
, pp. 354-359
-
-
Chentoufi, A.A.1
Palumbo, M.2
Polychronakos, C.3
-
7
-
-
0035171545
-
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
-
Derbinski J, Schulte A, Kyewski B, Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2001: 2: 1032-1039.
-
(2001)
Nat Immunol
, vol.2
, pp. 1032-1039
-
-
Derbinski, J.1
Schulte, A.2
Kyewski, B.3
Klein, L.4
-
8
-
-
84884593099
-
Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes
-
doi: 10.1101/cshperspect.a012831.
-
Pietropaolo M, Towns R, Eisenbarth GS. Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes. Cold Spring Harb Perspect Med 2012: 2: a012831. doi: 10.1101/cshperspect.a012831.
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
-
-
Pietropaolo, M.1
Towns, R.2
Eisenbarth, G.S.3
-
9
-
-
0036316723
-
Clearance of apoptotic beta-cells is reduced in neonatal autoimmune diabetes-prone rats
-
O'Brien BA, Fieldus WE, Field CJ, Finegood DT. Clearance of apoptotic beta-cells is reduced in neonatal autoimmune diabetes-prone rats. Cell Death Differ 2002: 9: 457-464.
-
(2002)
Cell Death Differ
, vol.9
, pp. 457-464
-
-
O'Brien, B.A.1
Fieldus, W.E.2
Field, C.J.3
Finegood, D.T.4
-
10
-
-
0036320896
-
Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced
-
O'Brien BA, Huang Y, Geng X, Dutz JP, Finegood DT. Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced. Diabetes 2002: 51: 2481-2488.
-
(2002)
Diabetes
, vol.51
, pp. 2481-2488
-
-
O'Brien, B.A.1
Huang, Y.2
Geng, X.3
Dutz, J.P.4
Finegood, D.T.5
-
11
-
-
0037359445
-
A role for innate immunity in type 1 diabetes?
-
Beyan H, Buckley LR, Yousaf N, Londei M, Leslie RD. A role for innate immunity in type 1 diabetes? Diabetes Metab Res Rev 2003: 19: 89-100.
-
(2003)
Diabetes Metab Res Rev
, vol.19
, pp. 89-100
-
-
Beyan, H.1
Buckley, L.R.2
Yousaf, N.3
Londei, M.4
Leslie, R.D.5
-
12
-
-
19944432792
-
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
-
Cardozo AK, Ortis F, Storling J et al. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005: 54: 452-461.
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
-
13
-
-
33749370738
-
Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid
-
Estella E, McKenzie MD, Catterall T et al. Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid. Diabetes 2006: 55: 2212-2219.
-
(2006)
Diabetes
, vol.55
, pp. 2212-2219
-
-
Estella, E.1
McKenzie, M.D.2
Catterall, T.3
-
14
-
-
79959386535
-
How does type 1 diabetes develop? The notion of homicide or beta-cell suicide revisited
-
Atkinson MA, Bluestone JA, Eisenbarth GS et al. How does type 1 diabetes develop? The notion of homicide or beta-cell suicide revisited. Diabetes 2011: 60: 1370-1379.
-
(2011)
Diabetes
, vol.60
, pp. 1370-1379
-
-
Atkinson, M.A.1
Bluestone, J.A.2
Eisenbarth, G.S.3
-
15
-
-
84859530797
-
ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes
-
O'Sullivan-Murphy B, Urano F. ER stress as a trigger for beta-cell dysfunction and autoimmunity in type 1 diabetes. Diabetes 2012: 61: 780-781.
-
(2012)
Diabetes
, vol.61
, pp. 780-781
-
-
O'Sullivan-Murphy, B.1
Urano, F.2
-
16
-
-
66749130213
-
A model of the unfolded protein response: pancreatic beta-cell as a case study
-
Schnell S. A model of the unfolded protein response: pancreatic beta-cell as a case study. Cell Physiol Biochem 2009: 23: 233-244.
-
(2009)
Cell Physiol Biochem
, vol.23
, pp. 233-244
-
-
Schnell, S.1
-
17
-
-
36849012027
-
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
-
Nejentsev S, Howson JM, Walker NM et al. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature 2007: 450: 887-892.
-
(2007)
Nature
, vol.450
, pp. 887-892
-
-
Nejentsev, S.1
Howson, J.M.2
Walker, N.M.3
-
18
-
-
0001657878
-
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study
-
Morel PA, Dorman JS, Todd JA, McDevitt HO, Trucco M. Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proc Natl Acad Sci USA 1988: 85: 8111-8115.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 8111-8115
-
-
Morel, P.A.1
Dorman, J.S.2
Todd, J.A.3
McDevitt, H.O.4
Trucco, M.5
-
19
-
-
10744228962
-
Pancreatic NOD beta cells express MHC class II protein and the frequency of I-A(g7) mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes
-
Walter U, Toepfer T, Dittmar KE et al. Pancreatic NOD beta cells express MHC class II protein and the frequency of I-A(g7) mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes. Diabetologia 2003: 46: 1106-1114.
-
(2003)
Diabetologia
, vol.46
, pp. 1106-1114
-
-
Walter, U.1
Toepfer, T.2
Dittmar, K.E.3
-
20
-
-
0034680105
-
Progression of autoimmune diabetes driven by avidity maturation of a T-cell population
-
Amrani A, Verdaguer J, Serra P, Tafuro S, Tan R, Santamaria P. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. Nature 2000: 406: 739-742.
-
(2000)
Nature
, vol.406
, pp. 739-742
-
-
Amrani, A.1
Verdaguer, J.2
Serra, P.3
Tafuro, S.4
Tan, R.5
Santamaria, P.6
-
21
-
-
26044438468
-
Soluble, dimeric HLA DR4-peptide chimeras: an approach for detection and immunoregulation of human type-1 diabetes
-
Preda I, McEvoy RC, Lin M et al. Soluble, dimeric HLA DR4-peptide chimeras: an approach for detection and immunoregulation of human type-1 diabetes. Eur J Immunol 2005: 35: 2762-2775.
-
(2005)
Eur J Immunol
, vol.35
, pp. 2762-2775
-
-
Preda, I.1
McEvoy, R.C.2
Lin, M.3
-
22
-
-
0037198420
-
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
-
Herold KC, Hagopian W, Auger JA et al. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 2002: 346: 1692-1698.
-
(2002)
N Engl J Med
, vol.346
, pp. 1692-1698
-
-
Herold, K.C.1
Hagopian, W.2
Auger, J.A.3
-
23
-
-
20544443927
-
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
-
Keymeulen B, Vandemeulebroucke E, Ziegler AG et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 2005: 352: 2598-2608.
-
(2005)
N Engl J Med
, vol.352
, pp. 2598-2608
-
-
Keymeulen, B.1
Vandemeulebroucke, E.2
Ziegler, A.G.3
-
24
-
-
36849018546
-
B cell depletion: a novel therapy for autoimmune diabetes?
-
Bour-Jordan H, Bluestone JA. B cell depletion: a novel therapy for autoimmune diabetes? J Clin Invest 2007: 117: 3642-3645.
-
(2007)
J Clin Invest
, vol.117
, pp. 3642-3645
-
-
Bour-Jordan, H.1
Bluestone, J.A.2
-
26
-
-
77951882989
-
Reversal of autoimmunity by boosting memory-like autoregulatory T cells
-
Tsai S, Shameli A, Yamanouchi J et al. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 2010: 32: 568-580.
-
(2010)
Immunity
, vol.32
, pp. 568-580
-
-
Tsai, S.1
Shameli, A.2
Yamanouchi, J.3
-
27
-
-
0036165756
-
Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes
-
Pietropaolo M, Becker DJ, LaPorte RE et al. Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes. Diabetologia 2002: 45: 66-76.
-
(2002)
Diabetologia
, vol.45
, pp. 66-76
-
-
Pietropaolo, M.1
Becker, D.J.2
LaPorte, R.E.3
-
28
-
-
0029995958
-
Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
-
Verge CF, Gianani R, Kawasaki E et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 1996: 45: 926-933.
-
(1996)
Diabetes
, vol.45
, pp. 926-933
-
-
Verge, C.F.1
Gianani, R.2
Kawasaki, E.3
-
32
-
-
0033020127
-
Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives
-
Maclaren N, Lan M, Coutant R et al. Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives. J Autoimmun 1999: 12: 279-287.
-
(1999)
J Autoimmun
, vol.12
, pp. 279-287
-
-
Maclaren, N.1
Lan, M.2
Coutant, R.3
-
33
-
-
0030716933
-
High antibody levels to prothrombin imply a risk of deep venous thrombosis and pulmonary embolism in middle-aged men - a nested case-control study
-
Palosuo T, Virtamo J, Haukka J et al. High antibody levels to prothrombin imply a risk of deep venous thrombosis and pulmonary embolism in middle-aged men - a nested case-control study. Thromb Haemost 1997: 78: 1178-1182.
-
(1997)
Thromb Haemost
, vol.78
, pp. 1178-1182
-
-
Palosuo, T.1
Virtamo, J.2
Haukka, J.3
-
34
-
-
84878847275
-
Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children
-
Achenbach P, Hummel M, Thumer L, Boerschmann H, Hofelmann D, Ziegler AG. Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children. Diabetologia 2013: 56: 1615-1622.
-
(2013)
Diabetologia
, vol.56
, pp. 1615-1622
-
-
Achenbach, P.1
Hummel, M.2
Thumer, L.3
Boerschmann, H.4
Hofelmann, D.5
Ziegler, A.G.6
-
35
-
-
84879114358
-
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
-
Ziegler AG, Rewers M, Simell O et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013: 309: 2473-2479.
-
(2013)
JAMA
, vol.309
, pp. 2473-2479
-
-
Ziegler, A.G.1
Rewers, M.2
Simell, O.3
-
36
-
-
0028584260
-
Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives
-
Bingley PJ, Christie MR, Bonifacio E et al. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 1994: 43: 1304-1310.
-
(1994)
Diabetes
, vol.43
, pp. 1304-1310
-
-
Bingley, P.J.1
Christie, M.R.2
Bonifacio, E.3
-
37
-
-
29544444313
-
Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies
-
Pietropaolo M, Yu S, Libman IM et al. Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes 2005: 6: 184-192.
-
(2005)
Pediatr Diabetes
, vol.6
, pp. 184-192
-
-
Pietropaolo, M.1
Yu, S.2
Libman, I.M.3
-
38
-
-
52649156076
-
Type 1 diabetes mellitus: primary, secondary, and tertiary prevention
-
Bollyky J, Sanda S, Greenbaum CJ. Type 1 diabetes mellitus: primary, secondary, and tertiary prevention. Mt Sinai J Med 2008: 75: 385-397.
-
(2008)
Mt Sinai J Med
, vol.75
, pp. 385-397
-
-
Bollyky, J.1
Sanda, S.2
Greenbaum, C.J.3
-
39
-
-
0032698741
-
Preservation of β-cell function in type 1 diabetes
-
Naik RG, Palmer JP. Preservation of β-cell function in type 1 diabetes. Diabetes Rev 1999: 7: 154-182.
-
(1999)
Diabetes Rev
, vol.7
, pp. 154-182
-
-
Naik, R.G.1
Palmer, J.P.2
-
40
-
-
0024542323
-
Incidence of insulin dependent diabetes in England: a study in the Oxford region, 1985-1986
-
Bingley PJ, Gale EA. Incidence of insulin dependent diabetes in England: a study in the Oxford region, 1985-1986. BMJ 1989: 298: 558-560.
-
(1989)
BMJ
, vol.298
, pp. 558-560
-
-
Bingley, P.J.1
Gale, E.A.2
-
41
-
-
0022617990
-
Type I diabetes mellitus. A chronic autoimmune disease
-
Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986: 314: 1360-1368.
-
(1986)
N Engl J Med
, vol.314
, pp. 1360-1368
-
-
Eisenbarth, G.S.1
-
42
-
-
0026603981
-
Incidence of insulin-dependent diabetes mellitus in Colorado
-
Kostraba JN, Gay EC, Cai Y et al. Incidence of insulin-dependent diabetes mellitus in Colorado. Epidemiology 1992: 3: 232-238.
-
(1992)
Epidemiology
, vol.3
, pp. 232-238
-
-
Kostraba, J.N.1
Gay, E.C.2
Cai, Y.3
-
43
-
-
0023022283
-
Pittsburgh Insulin-Dependent Diabetes Mellitus Morbidity and Mortality Study: physical activity and diabetic complications
-
LaPorte RE, Dorman JS, Tajima N et al. Pittsburgh Insulin-Dependent Diabetes Mellitus Morbidity and Mortality Study: physical activity and diabetic complications. Pediatrics 1986: 78: 1027-1033.
-
(1986)
Pediatrics
, vol.78
, pp. 1027-1033
-
-
LaPorte, R.E.1
Dorman, J.S.2
Tajima, N.3
-
44
-
-
0025940439
-
Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies
-
Barmeier H, McCulloch DK, Neifing JL et al. Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies. Diabetologia 1991: 34: 727-733.
-
(1991)
Diabetologia
, vol.34
, pp. 727-733
-
-
Barmeier, H.1
McCulloch, D.K.2
Neifing, J.L.3
-
45
-
-
0025011787
-
A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes
-
Riley WJ, Maclaren NK, Krischer J et al. A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med 1990: 323: 1167-1172.
-
(1990)
N Engl J Med
, vol.323
, pp. 1167-1172
-
-
Riley, W.J.1
Maclaren, N.K.2
Krischer, J.3
-
46
-
-
0024266274
-
How, when, and why to predict IDDM
-
Maclaren NK. How, when, and why to predict IDDM. Diabetes 1988: 37: 1591-1594.
-
(1988)
Diabetes
, vol.37
, pp. 1591-1594
-
-
Maclaren, N.K.1
-
48
-
-
0033662436
-
Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice
-
Latek RR, Suri A, Petzold SJ et al. Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice. Immunity 2000: 12: 699-710.
-
(2000)
Immunity
, vol.12
, pp. 699-710
-
-
Latek, R.R.1
Suri, A.2
Petzold, S.J.3
-
49
-
-
0023252262
-
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
-
Todd JA, Bell JI, McDevitt HO. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987: 329: 599-604.
-
(1987)
Nature
, vol.329
, pp. 599-604
-
-
Todd, J.A.1
Bell, J.I.2
McDevitt, H.O.3
-
50
-
-
0029954214
-
Insulin-dependent diabetes mellitus
-
Tisch R, McDevitt H. Insulin-dependent diabetes mellitus. Cell 1996: 85: 291-297.
-
(1996)
Cell
, vol.85
, pp. 291-297
-
-
Tisch, R.1
McDevitt, H.2
-
51
-
-
0029069963
-
Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus
-
Quartey-Papafio R, Lund T, Chandler P et al. Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus. J Immunol 1995: 154: 5567-5575.
-
(1995)
J Immunol
, vol.154
, pp. 5567-5575
-
-
Quartey-Papafio, R.1
Lund, T.2
Chandler, P.3
-
52
-
-
84885415450
-
MHC Class II polymorphisms, autoreactive T-cells, and autoimmunity
-
Tsai S, Santamaria P. MHC Class II polymorphisms, autoreactive T-cells, and autoimmunity. Front Immunol 2013: 4: 321.
-
(2013)
Front Immunol
, vol.4
, pp. 321
-
-
Tsai, S.1
Santamaria, P.2
-
53
-
-
44849130871
-
First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules
-
Suri A, Walters JJ, Rohrs HW, Gross ML, Unanue ER. First signature of islet beta-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules. J Immunol 2008: 180: 3849-3856.
-
(2008)
J Immunol
, vol.180
, pp. 3849-3856
-
-
Suri, A.1
Walters, J.J.2
Rohrs, H.W.3
Gross, M.L.4
Unanue, E.R.5
-
54
-
-
77954643719
-
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register
-
Stadinski BD, Zhang L, Crawford F, Marrack P, Eisenbarth GS, Kappler JW. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci USA 2010: 107: 10978-10983.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 10978-10983
-
-
Stadinski, B.D.1
Zhang, L.2
Crawford, F.3
Marrack, P.4
Eisenbarth, G.S.5
Kappler, J.W.6
-
55
-
-
80053628904
-
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
-
Crawford F, Stadinski B, Jin N et al. Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse. Proc Natl Acad Sci USA 2011: 108: 16729-16734.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16729-16734
-
-
Crawford, F.1
Stadinski, B.2
Jin, N.3
-
56
-
-
77949872804
-
Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes
-
Mohan JF, Levisetti MG, Calderon B, Herzog JW, Petzold SJ, Unanue ER. Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes. Nat Immunol 2010: 11: 350-354.
-
(2010)
Nat Immunol
, vol.11
, pp. 350-354
-
-
Mohan, J.F.1
Levisetti, M.G.2
Calderon, B.3
Herzog, J.W.4
Petzold, S.J.5
Unanue, E.R.6
-
57
-
-
0035424309
-
Post-translational protein modifications in antigen recognition and autoimmunity
-
Doyle HA, Mamula MJ. Post-translational protein modifications in antigen recognition and autoimmunity. Trends Immunol 2001: 22: 443-449.
-
(2001)
Trends Immunol
, vol.22
, pp. 443-449
-
-
Doyle, H.A.1
Mamula, M.J.2
-
58
-
-
7044235838
-
Post-translational modifications of self antigens: implications for autoimmunity
-
Anderton SM. Post-translational modifications of self antigens: implications for autoimmunity. Curr Opin Immunol 2004: 16: 753-758.
-
(2004)
Curr Opin Immunol
, vol.16
, pp. 753-758
-
-
Anderton, S.M.1
-
59
-
-
0028987251
-
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
-
Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 1995: 44: 249-256.
-
(1995)
Diabetes
, vol.44
, pp. 249-256
-
-
Finegood, D.T.1
Scaglia, L.2
Bonner-Weir, S.3
-
60
-
-
0033985277
-
Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?
-
Trudeau JD, Dutz JP, Arany E, Hill DJ, Fieldus WE, Finegood DT. Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes? Diabetes 2000: 49: 1-7.
-
(2000)
Diabetes
, vol.49
, pp. 1-7
-
-
Trudeau, J.D.1
Dutz, J.P.2
Arany, E.3
Hill, D.J.4
Fieldus, W.E.5
Finegood, D.T.6
-
62
-
-
0024229210
-
Mechanisms of pancreatic beta-cell destruction in type I diabetes
-
Nerup J, Mandrup-Poulsen T, Molvig J, Helqvist S, Wogensen L, Egeberg J. Mechanisms of pancreatic beta-cell destruction in type I diabetes. Diabetes Care 1988: 11 (Suppl 1): 16-23.
-
(1988)
Diabetes Care
, vol.11
, Issue.SUPPL 1
, pp. 16-23
-
-
Nerup, J.1
Mandrup-Poulsen, T.2
Molvig, J.3
Helqvist, S.4
Wogensen, L.5
Egeberg, J.6
-
63
-
-
0032830568
-
Onset of type 1 diabetes: a dynamical instability
-
Freiesleben De Blasio B, Bak P, Pociot F, Karlsen AE, Nerup J. Onset of type 1 diabetes: a dynamical instability. Diabetes 1999: 48: 1677-1685.
-
(1999)
Diabetes
, vol.48
, pp. 1677-1685
-
-
Freiesleben De Blasio, B.1
Bak, P.2
Pociot, F.3
Karlsen, A.E.4
Nerup, J.5
-
64
-
-
33748305648
-
Investigation of the age-at-onset heterogeneity in type 1 diabetes through mathematical modeling
-
Wang X, He Z, Ghosh S. Investigation of the age-at-onset heterogeneity in type 1 diabetes through mathematical modeling. Math Biosci 2006: 203: 79-99.
-
(2006)
Math Biosci
, vol.203
, pp. 79-99
-
-
Wang, X.1
He, Z.2
Ghosh, S.3
-
65
-
-
84871343233
-
Integrated model of metabolism and autoimmune response in beta-cell death and progression to type 1 diabetes
-
Marinković T, Sysi-Aho M, Oresic M. Integrated model of metabolism and autoimmune response in beta-cell death and progression to type 1 diabetes. PLoS One 2012: 7: e51909.
-
(2012)
PLoS One
, vol.7
-
-
Marinković, T.1
Sysi-Aho, M.2
Oresic, M.3
-
66
-
-
0034699781
-
A model of beta-cell mass, insulin, and glucose kinetics: pathways to diabetes
-
Topp B, Promislow K, de Vries G, Miura RM, Finegood DT. A model of beta-cell mass, insulin, and glucose kinetics: pathways to diabetes. J Theor Biol 2000: 206: 605-619.
-
(2000)
J Theor Biol
, vol.206
, pp. 605-619
-
-
Topp, B.1
Promislow, K.2
de Vries, G.3
Miura, R.M.4
Finegood, D.T.5
-
67
-
-
38349066143
-
A quantitative comparison of rates of phagocytosis and digestion of apoptotic cells by macrophages from normal (BALB/c) and diabetes-prone (NOD) mice
-
Marée AF, Komba M, Finegood DT, Edelstein-Keshet L. A quantitative comparison of rates of phagocytosis and digestion of apoptotic cells by macrophages from normal (BALB/c) and diabetes-prone (NOD) mice. J Appl Physiol 2008: 104: 157-169.
-
(2008)
J Appl Physiol
, vol.104
, pp. 157-169
-
-
Marée, A.F.1
Komba, M.2
Finegood, D.T.3
Edelstein-Keshet, L.4
-
68
-
-
14644437675
-
Quantifying macrophage defects in type 1 diabetes
-
Marée AF, Komba M, Dyck C, Labecki M, Finegood DT, Edelstein-Keshet L. Quantifying macrophage defects in type 1 diabetes. J Theor Biol 2005: 233: 533-551.
-
(2005)
J Theor Biol
, vol.233
, pp. 533-551
-
-
Marée, A.F.1
Komba, M.2
Dyck, C.3
Labecki, M.4
Finegood, D.T.5
Edelstein-Keshet, L.6
-
69
-
-
33646500349
-
Modelling the onset of type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease?
-
Marée AF, Kublik R, Finegood DT, Edelstein-Keshet L. Modelling the onset of type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease? Philos Transact A Math Phys Eng Sci 2006: 364: 1267-1282.
-
(2006)
Philos Transact A Math Phys Eng Sci
, vol.364
, pp. 1267-1282
-
-
Marée, A.F.1
Kublik, R.2
Finegood, D.T.3
Edelstein-Keshet, L.4
-
70
-
-
3242716620
-
NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells
-
Stoffels K, Overbergh L, Giulietti A et al. NOD macrophages produce high levels of inflammatory cytokines upon encounter of apoptotic or necrotic cells. J Autoimmun 2004: 23: 9-15.
-
(2004)
J Autoimmun
, vol.23
, pp. 9-15
-
-
Stoffels, K.1
Overbergh, L.2
Giulietti, A.3
-
71
-
-
77954251388
-
The pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach
-
Khadra A, Santamaria P, Edelstein-Keshet L. The pathogenicity of self-antigen decreases at high levels of autoantigenicity: a computational approach. Int Immunol 2010: 22: 571-582.
-
(2010)
Int Immunol
, vol.22
, pp. 571-582
-
-
Khadra, A.1
Santamaria, P.2
Edelstein-Keshet, L.3
-
72
-
-
0030239693
-
Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?
-
Yewdell JW, Anton LC, Bennink JR. Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules? J Immunol 1996: 157: 1823-1826.
-
(1996)
J Immunol
, vol.157
, pp. 1823-1826
-
-
Yewdell, J.W.1
Anton, L.C.2
Bennink, J.R.3
-
73
-
-
20944441042
-
Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide
-
Han B, Serra P, Amrani A et al. Prevention of diabetes by manipulation of anti-IGRP autoimmunity: high efficiency of a low-affinity peptide. Nat Med 2005: 11: 645-652.
-
(2005)
Nat Med
, vol.11
, pp. 645-652
-
-
Han, B.1
Serra, P.2
Amrani, A.3
-
74
-
-
0028031644
-
Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model
-
Aichele P, Kyburz D, Ohashi PS et al. Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model. Proc Natl Acad Sci USA 1994: 91: 444-448.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 444-448
-
-
Aichele, P.1
Kyburz, D.2
Ohashi, P.S.3
-
75
-
-
0029798058
-
Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction
-
Toes RE, Offringa R, Blom RJ, Melief CJ, Kast WM. Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction. Proc Natl Acad Sci USA 1996: 93: 7855-7860.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 7855-7860
-
-
Toes, R.E.1
Offringa, R.2
Blom, R.J.3
Melief, C.J.4
Kast, W.M.5
-
76
-
-
33745289128
-
Modeling competition among autoreactive CD8+ T cells in autoimmune diabetes: implications for antigen-specific therapy
-
Marée AF, Santamaria P, Edelstein-Keshet L. Modeling competition among autoreactive CD8+ T cells in autoimmune diabetes: implications for antigen-specific therapy. Int Immunol 2006: 18: 1067-1077.
-
(2006)
Int Immunol
, vol.18
, pp. 1067-1077
-
-
Marée, A.F.1
Santamaria, P.2
Edelstein-Keshet, L.3
-
77
-
-
0037237655
-
Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
-
Trudeau JD, Kelly-Smith C, Verchere CB et al. Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest 2003: 111: 217-223.
-
(2003)
J Clin Invest
, vol.111
, pp. 217-223
-
-
Trudeau, J.D.1
Kelly-Smith, C.2
Verchere, C.B.3
-
78
-
-
34548267062
-
Modeling cyclic waves of circulating T cells in autoimmune diabetes
-
Mahaffy JM, Edelstein-Keshet L. Modeling cyclic waves of circulating T cells in autoimmune diabetes. SIAM J Appl Math 2007: 67: 915-937.
-
(2007)
SIAM J Appl Math
, vol.67
, pp. 915-937
-
-
Mahaffy, J.M.1
Edelstein-Keshet, L.2
-
79
-
-
36448978896
-
Type 1 diabetes as a relapsing-remitting disease?
-
von Herrath M, Sanda S, Herold K. Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol 2007: 7: 988-994.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 988-994
-
-
von Herrath, M.1
Sanda, S.2
Herold, K.3
-
80
-
-
84899421060
-
Predictive models of type 1 diabetes progression: understanding T-cell cycles and their implications on autoantibody release
-
doi:10.1371/journal.pone.0093326.
-
Jaberi-Douraki M, Pietropaolo M, Khadra A. Predictive models of type 1 diabetes progression: understanding T-cell cycles and their implications on autoantibody release. PLoS One 2014: 9: e93326. doi:10.1371/journal.pone.0093326.
-
(2014)
PLoS One
, vol.9
-
-
Jaberi-Douraki, M.1
Pietropaolo, M.2
Khadra, A.3
-
81
-
-
82255163008
-
CD8+ Tregs in autoimmunity: learning "self"-control from experience
-
Tsai S, Clemente-Casares X, Santamaria P. CD8+ Tregs in autoimmunity: learning "self"-control from experience. Cell Mol Life Sci 2011: 68: 3781-3795.
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 3781-3795
-
-
Tsai, S.1
Clemente-Casares, X.2
Santamaria, P.3
-
82
-
-
56949090443
-
The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation
-
Khadra A, Santamaria P, Edelstein-Keshet L. The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation. J Theor Biol 2009: 256: 126-141.
-
(2009)
J Theor Biol
, vol.256
, pp. 126-141
-
-
Khadra, A.1
Santamaria, P.2
Edelstein-Keshet, L.3
-
83
-
-
78650661696
-
On how monospecific memory-like autoregulatory CD8+ T cells can blunt diabetogenic autoimmunity: a computational approach
-
Khadra A, Tsai S, Santamaria P, Edelstein-Keshet L. On how monospecific memory-like autoregulatory CD8+ T cells can blunt diabetogenic autoimmunity: a computational approach. J Immunol 2010: 185: 5962-5972.
-
(2010)
J Immunol
, vol.185
, pp. 5962-5972
-
-
Khadra, A.1
Tsai, S.2
Santamaria, P.3
Edelstein-Keshet, L.4
-
84
-
-
84878532315
-
Quantifying the importance of pMHC valency, total pMHC dose and frequency on nanoparticle therapeutic efficacy
-
Sugarman J, Tsai S, Santamaria P, Khadra A. Quantifying the importance of pMHC valency, total pMHC dose and frequency on nanoparticle therapeutic efficacy. Immunol Cell Biol 2013: 91: 350-359.
-
(2013)
Immunol Cell Biol
, vol.91
, pp. 350-359
-
-
Sugarman, J.1
Tsai, S.2
Santamaria, P.3
Khadra, A.4
-
85
-
-
76549117468
-
Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses
-
Nelson P, Smith N, Ciupe S, Zou W, Omenn GS, Pietropaolo M. Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses. Math Biosci Eng 2009: 6: 753-778.
-
(2009)
Math Biosci Eng
, vol.6
, pp. 753-778
-
-
Nelson, P.1
Smith, N.2
Ciupe, S.3
Zou, W.4
Omenn, G.S.5
Pietropaolo, M.6
-
86
-
-
47249124078
-
Human regulatory T cells: role in autoimmune disease and therapeutic opportunities
-
Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev 2008: 223: 371-390.
-
(2008)
Immunol Rev
, vol.223
, pp. 371-390
-
-
Brusko, T.M.1
Putnam, A.L.2
Bluestone, J.A.3
-
88
-
-
27144469301
-
Functional avidity directs T-cell fate in autoreactive CD4+ T cells
-
Mallone R, Kochik SA, Reijonen H et al. Functional avidity directs T-cell fate in autoreactive CD4+ T cells. Blood 2005: 106: 2798-2805.
-
(2005)
Blood
, vol.106
, pp. 2798-2805
-
-
Mallone, R.1
Kochik, S.A.2
Reijonen, H.3
-
89
-
-
22144482328
-
Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes
-
Han B, Serra P, Yamanouchi J et al. Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes. J Clin Invest 2005: 115: 1879-1887.
-
(2005)
J Clin Invest
, vol.115
, pp. 1879-1887
-
-
Han, B.1
Serra, P.2
Yamanouchi, J.3
-
90
-
-
84881162079
-
The impact of mathematical modeling on the understanding of diabetes and related complications
-
Ajmera I, Swat M, Laibe C, Novere NL, Chelliah V. The impact of mathematical modeling on the understanding of diabetes and related complications. CPT Pharmacometrics Syst Pharmacol 2013: 2: e54.
-
(2013)
CPT Pharmacometrics Syst Pharmacol
, vol.2
-
-
Ajmera, I.1
Swat, M.2
Laibe, C.3
Novere, N.L.4
Chelliah, V.5
|