메뉴 건너뛰기




Volumn 9, Issue 4, 2014, Pages

Predictive models of type 1 diabetes progression: Understanding T-cell cycles and their implications on autoantibody release

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; T LYMPHOCYTE RECEPTOR;

EID: 84899421060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093326     Document Type: Article
Times cited : (19)

References (54)
  • 1
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • DOI 10.1016/S0140-6736(01)05415-0
    • Atkinson MA, Eisenbarth GS (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment. The Lancet 358: 221-229. (Pubitemid 32718550)
    • (2001) Lancet , vol.358 , Issue.9277 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 2
    • 76549117468 scopus 로고    scopus 로고
    • Modeling dynamic changes in type 1 diabetes progression: Quantifying beta-cell variation after the appearance of islet-specific autoimmune responses
    • Nelson P, Smith N, Ciupe S, Zou W, Omenn GS, et al. (2009) Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses. Mathematical biosciences and engineering: MBE 6: 753-778.
    • (2009) Mathematical Biosciences and Engineering: MBE , vol.6 , pp. 753-778
    • Nelson, P.1    Smith, N.2    Ciupe, S.3    Zou, W.4    Omenn, G.S.5
  • 3
    • 0032701129 scopus 로고    scopus 로고
    • Naturally processed and presented epitopes of the islet cell autoantigen ia-2 eluted from hla-dr4
    • Peakman M, Stevens EJ, Lohmann T, Narendran P, Dromey J, et al. (1999) Naturally processed and presented epitopes of the islet cell autoantigen ia-2 eluted from hla-dr4. Journal of Clinical Investigation 104: 1449-1457.
    • (1999) Journal of Clinical Investigation , vol.104 , pp. 1449-1457
    • Peakman, M.1    Stevens, E.J.2    Lohmann, T.3    Narendran, P.4    Dromey, J.5
  • 5
    • 77954532446 scopus 로고    scopus 로고
    • Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen ia-2 heightens the risk of type 1 diabetes
    • Morran MP, Casu A, Arena VC, Pietropaolo S, Zhang YJ, et al. (2010) Humoral autoimmunity against the extracellular domain of the neuroendocrine autoantigen ia-2 heightens the risk of type 1 diabetes. Endocrinology 151: 2528-2537.
    • (2010) Endocrinology , vol.151 , pp. 2528-2537
    • Morran, M.P.1    Casu, A.2    Arena, V.C.3    Pietropaolo, S.4    Zhang, Y.J.5
  • 7
    • 0033542458 scopus 로고    scopus 로고
    • Modelling t-cell memory by genetic marking of memory t cells in vivo
    • Jacob J, Baltimore D (1999) Modelling t-cell memory by genetic marking of memory t cells in vivo. Nature 399: 593-597.
    • (1999) Nature , vol.399 , pp. 593-597
    • Jacob, J.1    Baltimore, D.2
  • 8
    • 0033118739 scopus 로고    scopus 로고
    • A kinetic basis for T cell receptor repertoire selection during an immune response
    • DOI 10.1016/S1074-7613(00)80048-5
    • Savage PA, Boniface JJ, Davis MM (1999) A kinetic basis for t cell receptor repertoire selection during an immune response. Immunity 10: 485-492. (Pubitemid 29205484)
    • (1999) Immunity , vol.10 , Issue.4 , pp. 485-492
    • Savage, P.A.1    Boniface, J.J.2    Davis, M.M.3
  • 9
    • 0029037210 scopus 로고
    • Serial triggering of many t-cell receptors by a few peptide mhc complexes
    • Valitutti S, Müller S, Cella M, Padovan E, Lanzavecchia A (1995) Serial triggering of many t-cell receptors by a few peptide mhc complexes. Nature 375: 148-151.
    • (1995) Nature , vol.375 , pp. 148-151
    • Valitutti, S.1    Müller, S.2    Cella, M.3    Padovan, E.4    Lanzavecchia, A.5
  • 11
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola A, Lanzavecchia A (1996) T cell activation determined by t cell receptor number and tunable thresholds. Science 273: 104-106. (Pubitemid 26255435)
    • (1996) Science , vol.273 , Issue.5271 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 12
    • 0031437624 scopus 로고    scopus 로고
    • Following the fate of individual t cells throughout activation and clonal expansion. Signals from t cell receptor and cd28 differentially regulate the induction and duration of a proliferative response
    • Wells A, Gudmundsdottir H, Turka L (1997) Following the fate of individual t cells throughout activation and clonal expansion. signals from t cell receptor and cd28 differentially regulate the induction and duration of a proliferative response. Journal of Clinical Investigation 100: 3173.
    • (1997) Journal of Clinical Investigation , vol.100 , pp. 3173
    • Wells, A.1    Gudmundsdottir, H.2    Turka, L.3
  • 13
    • 0030738184 scopus 로고    scopus 로고
    • Interactions of tcrs with mhc-peptide complexes: A quantitative basis for mechanistic models
    • Margulies DH (1997) Interactions of tcrs with mhc-peptide complexes: a quantitative basis for mechanistic models. Current opinion in immunology 9: 390-395.
    • (1997) Current Opinion in Immunology , vol.9 , pp. 390-395
    • Margulies, D.H.1
  • 14
    • 34249775780 scopus 로고    scopus 로고
    • Role of autoantibodies in type 1 diabetes
    • DOI 10.2741/2195
    • Miao D, Yu L, Eisenbarth GS (2007) Role of autoantibodies in type 1 diabetes. Front Biosci 12: 1889-1898. (Pubitemid 46846814)
    • (2007) Frontiers in Bioscience , vol.12 , Issue.5 , pp. 1889-1898
    • Miao, D.1    Yu, L.2    Eisenbarth, G.S.3
  • 16
    • 27844561478 scopus 로고    scopus 로고
    • + T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects
    • DOI 10.1016/j.jaut.2005.09.018, PII S0896841105001277
    • Oling V, Marttila J, Ilonen J, Kwok WW, Nepom G, et al. (2005) Gad65- and proinsulin-specific cd4+ t-cells detected by fMHCg class fIIg tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects. Journal of Autoimmunity 25: 235-243. (Pubitemid 41654469)
    • (2005) Journal of Autoimmunity , vol.25 , Issue.3 , pp. 235-243
    • Oling, V.1    Marttila, J.2    Ilonen, J.3    Kwok, W.W.4    Nepom, G.5    Knip, M.6    Simell, O.7    Reijonen, H.8
  • 17
    • 0036312395 scopus 로고    scopus 로고
    • Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects
    • Reijonen H, Novak EJ, Kochik S, Heninger A, Liu AW, et al. (2002) Detection of gad65-specific t-cells by major histocompatibility complex class ii tetramers in type 1 diabetic patients and at-risk subjects. Diabetes 51: 1375-1382. (Pubitemid 34826602)
    • (2002) Diabetes , vol.51 , Issue.5 , pp. 1375-1382
    • Reijonen, H.1    Novak, E.J.2    Kochik, S.3    Heninger, A.4    Liu, A.W.5    Kwok, W.W.6    Nepom, G.T.7
  • 18
    • 33845533220 scopus 로고    scopus 로고
    • Identification of novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives
    • DOI 10.2337/db06-0066
    • Standifer NE, Ouyang Q, Panagiotopoulos C, Verchere CB, Tan R, et al. (2006) Identification of novel hla-a*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Diabetes 55: 3061-3067. (Pubitemid 44923643)
    • (2006) Diabetes , vol.55 , Issue.11 , pp. 3061-3067
    • Standifer, N.E.1    Ouyang, Q.2    Panagiotopoulos, C.3    Verchere, C.B.4    Tan, R.5    Greenbaum, C.J.6    Pihoker, C.7    Nepom, G.T.8
  • 19
    • 77951983004 scopus 로고    scopus 로고
    • Simultaneous detection of circulating autoreactive cd8+ t-cells specific for different islet cell-associated epitopes using combinatorial mhc multimers
    • Velthuis JH, Unger WW, Abreu JR, Duinkerken G, Franken K, et al. (2010) Simultaneous detection of circulating autoreactive cd8+ t-cells specific for different islet cell-associated epitopes using combinatorial mhc multimers. Diabetes 59: 1721-1730.
    • (2010) Diabetes , vol.59 , pp. 1721-1730
    • Velthuis, J.H.1    Unger, W.W.2    Abreu, J.R.3    Duinkerken, G.4    Franken, K.5
  • 21
    • 0028801042 scopus 로고
    • Identification of protein tyrosine phosphatase-like ia2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40k autoantigen and a target of islet-cell antibodies
    • Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E (1995) Identification of protein tyrosine phosphatase-like ia2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40k autoantigen and a target of islet-cell antibodies. The Journal of Immunology 155: 5419-5426.
    • (1995) The Journal of Immunology , vol.155 , pp. 5419-5426
    • Bonifacio, E.1    Lampasona, V.2    Genovese, S.3    Ferrari, M.4    Bosi, E.5
  • 22
    • 0031438330 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus
    • Borg H, Fernlund P, Sundkvist G (1997) Protein tyrosine phosphatase-like protein ia2-antibodies plus glutamic acid decarboxylase 65 antibodies (gada) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus. Clinical chemistry 43: 2358-2363. (Pubitemid 28022973)
    • (1997) Clinical Chemistry , vol.43 , Issue.12 , pp. 2358-2363
    • Borg, H.1    Fernlund, P.2    Sundkvist, G.3
  • 23
    • 84870278243 scopus 로고    scopus 로고
    • Zinc transporter 8 (znt8) expression is reduced by ischemic insults: A potential therapeutic target to prevent ischemic retinopathy
    • DeNiro M, Al-Mohanna FA (2012) Zinc transporter 8 (znt8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy. PloS one 7: e50360.
    • (2012) PloS One , vol.7
    • DeNiro, M.1    Al-Mohanna, F.A.2
  • 24
    • 0030803535 scopus 로고    scopus 로고
    • Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes
    • Hawa M, Rowe R, Lan MS, Notkins AL, Pozzilli P, et al. (1997) Value of antibodies to islet protein tyrosine phosphatase-like molecule in predicting type 1 diabetes. Diabetes 46: 1270-1275. (Pubitemid 27315274)
    • (1997) Diabetes , vol.46 , Issue.8 , pp. 1270-1275
    • Hawa, M.1    Rowe, R.2    Lan, M.S.3    Notkins, A.L.4    Pozzilli, P.5    Christie, M.R.6    Leslie, R.D.G.7
  • 25
    • 84865613743 scopus 로고    scopus 로고
    • Znt8 and type 1 diabetes
    • Kawasaki E (2012) Znt8 and type 1 diabetes. Endocrine journal 59: 531-537.
    • (2012) Endocrine Journal , vol.59 , pp. 531-537
    • Kawasaki, E.1
  • 26
    • 0035432253 scopus 로고    scopus 로고
    • Characterization of Preparations of GAD65, Proinsulin, and the Islet Tyrosine Phosphatase IA-2 for Use in Detection of Autoreactive T-Cells in Type 1 Diabetes: Report of Phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell Assays in Type 1 Diabetes
    • Peakman M, Tree TI, Endl J, van Endert P, Atkinson MA, et al. (2001) Characterization of preparations of gad65, proinsulin, and the islet tyrosine phosphatase ia-2 for use in detection of autoreactive t-cells in type 1 diabetes report of phase ii of the second international immunology of diabetes society workshop for standardization of t-cell assays in type 1 diabetes. Diabetes 50: 1749-1754. (Pubitemid 33641592)
    • (2001) Diabetes , vol.50 , Issue.8 , pp. 1749-1754
    • Peakman, M.1    Tree, T.I.2    Endl, J.3    Van Endert, P.4    Atkinson, M.A.5    Roep, B.O.6
  • 27
    • 34248143836 scopus 로고    scopus 로고
    • The heterogeneity of diabetes: Unraveling a dispute: Is systemic inflammation related to islet autoimmunity?
    • DOI 10.2337/db06-0880
    • Pietropaolo M, Barinas-Mitchell E, Kuller LH (2007) The heterogeneity of diabetes unraveling a dispute: Is systemic inammation related to islet autoimmunity? Diabetes 56: 1189-1197. (Pubitemid 46722429)
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1189-1197
    • Pietropaolo, M.1    Barinas-Mitchell, E.2    Kuller, L.H.3
  • 28
    • 0036165756 scopus 로고    scopus 로고
    • Progression to insulin-requiring diabetes in seronegative prediabetic subjects: The role of two HLA-DQ high-risk haplotypes
    • DOI 10.1007/s125-002-8246-5
    • Pietropaolo M, Becker D, LaPorte R, Dorman J, Riboni S, et al. (2002) Progression to insulinrequiring diabetes in seronegative prediabetic subjects: the role of two hla-dq high-risk haplotypes. Diabetologia 45: 66-76. (Pubitemid 34118544)
    • (2002) Diabetologia , vol.45 , Issue.1 , pp. 66-76
    • Pietropaolo, M.1    Becker, D.J.2    LaPorte, R.E.3    Dorman, J.S.4    Riboni, S.5    Rudert, W.A.6    Mazumdar, S.7    Trucco, M.8
  • 30
  • 31
    • 57749205590 scopus 로고    scopus 로고
    • Slc30a8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes
    • Wenzlau JM, Moua O, Sarkar SA, Yu L, Rewers M, et al. (2008) Slc30a8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Annals of the New York Academy of Sciences 1150: 256-259.
    • (2008) Annals of the New York Academy of Sciences , vol.1150 , pp. 256-259
    • Wenzlau, J.M.1    Moua, O.2    Sarkar, S.A.3    Yu, L.4    Rewers, M.5
  • 32
    • 84884593099 scopus 로고    scopus 로고
    • Humoral autoimmunity in type 1 diabetes: Prediction, significance, and detection of distinct disease subtypes
    • Pietropaolo M, Towns R, Eisenbarth GS (2012) Humoral autoimmunity in type 1 diabetes: prediction, significance, and detection of distinct disease subtypes. Cold Spring Harbor perspectives in medicine: a012831.
    • (2012) Cold Spring Harbor Perspectives in Medicine
    • Pietropaolo, M.1    Towns, R.2    Eisenbarth, G.S.3
  • 33
    • 77951776390 scopus 로고    scopus 로고
    • Genetics, pathogenesis and clinical interventions in type [thinsp] 1 diabetes
    • Bluestone JA, Herold K, Eisenbarth G (2010) Genetics, pathogenesis and clinical interventions in type [thinsp] 1 diabetes. Nature 464: 1293-1300.
    • (2010) Nature , vol.464 , pp. 1293-1300
    • Bluestone, J.A.1    Herold, K.2    Eisenbarth, G.3
  • 34
    • 79955883244 scopus 로고    scopus 로고
    • Investigating the role of t-cell avidity and killing efficacy in relation to type 1 diabetes prediction
    • Khadra A, Pietropaolo M, Nepom GT, Sherman A (2011) Investigating the role of t-cell avidity and killing efficacy in relation to type 1 diabetes prediction. PloS one 6: e14796.
    • (2011) PloS One , vol.6
    • Khadra, A.1    Pietropaolo, M.2    Nepom, G.T.3    Sherman, A.4
  • 36
    • 36448978896 scopus 로고    scopus 로고
    • Type 1 diabetes as a relapsing-remitting disease?
    • DOI 10.1038/nri2192, PII NRI2192
    • von Herrath M, Sanda S, Herold K (2007) Type 1 diabetes as a relapsing-remitting disease? Nature Reviews Immunology 7: 988-994. (Pubitemid 350166057)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.12 , pp. 988-994
    • Von Herrath, M.1    Sanda, S.2    Herold, K.3
  • 38
    • 34548267062 scopus 로고    scopus 로고
    • Modeling cyclic waves of circulating T cells in autoimmune diabetes
    • DOI 10.1137/060661144
    • Mahaffy JM, Edelstein-Keshet L (2007) Modeling cyclic waves of circulating t cells in autoimmune diabetes. SIAM Journal on Applied Mathematics 67: 915-937. (Pubitemid 47317911)
    • (2007) SIAM Journal on Applied Mathematics , vol.67 , Issue.4 , pp. 915-937
    • Mahaffy, J.M.1    Edelstein-Keshet, L.2
  • 39
    • 77951168859 scopus 로고    scopus 로고
    • Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive cd4 t-cells
    • Vendrame F, Pileggi A, Laughlin E, Allende G, Martin-Pagola A, et al. (2010) Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive cd4 t-cells. Diabetes 59: 947-957.
    • (2010) Diabetes , vol.59 , pp. 947-957
    • Vendrame, F.1    Pileggi, A.2    Laughlin, E.3    Allende, G.4    Martin-Pagola, A.5
  • 40
    • 33745289128 scopus 로고    scopus 로고
    • + T cells in autoimmune diabetes: Implications for antigen-specific therapy
    • DOI 10.1093/intimm/dxl040
    • Marée AF, Santamaria P, Edelstein-Keshet L (2006) Modeling competition among autoreactive cd8 + t cells in autoimmune diabetes: implications for antigen-specific therapy. International immunology 18: 1067-1077. (Pubitemid 43923425)
    • (2006) International Immunology , vol.18 , Issue.7 , pp. 1067-1077
    • Maree, A.F.M.1    Santamaria, P.2    Edelstein-Keshet, L.3
  • 41
    • 0028987251 scopus 로고
    • Dynamics of β-cell mass in the growing rat pancreas: Estimation with a simple mathematical model
    • Finegood DT, Scaglia L, Bonner-Weir S (1995) Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 44: 249-256.
    • (1995) Diabetes , vol.44 , pp. 249-256
    • Finegood, D.T.1    Scaglia, L.2    Bonner-Weir, S.3
  • 42
    • 55849116389 scopus 로고    scopus 로고
    • Ctls are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
    • Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, et al. (2008) Ctls are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. The Journal of clinical investigation 118: 3390.
    • (2008) The Journal of Clinical Investigation , vol.118 , pp. 3390
    • Skowera, A.1    Ellis, R.J.2    Varela-Calviño, R.3    Arif, S.4    Huang, G.C.5
  • 44
    • 38949172691 scopus 로고    scopus 로고
    • Oscillations and bistability in the dynamics of cytotoxic reactions mediated by the response of immune cells to solid tumours
    • DOI 10.1016/j.mcm.2007.02.026, PII S0895717707001781
    • Lejeune O, Chaplain MA, El Akili I (2008) Oscillations and bistability in the dynamics of cytotoxic reactions mediated by the response of immune cells to solid tumours. Mathematical and Computer Modelling 47: 649-662. (Pubitemid 351210695)
    • (2008) Mathematical and Computer Modelling , vol.47 , Issue.5-6 , pp. 649-662
    • Lejeune, O.1    Chaplain, M.A.J.2    El, A.I.3
  • 45
    • 79151478290 scopus 로고    scopus 로고
    • Self-tolerance and autoimmunity in a regulatory t cell model
    • Alexander H, Wahl L (2011) Self-tolerance and autoimmunity in a regulatory t cell model. Bulletin of mathematical biology 73: 33-71.
    • (2011) Bulletin of Mathematical Biology , vol.73 , pp. 33-71
    • Alexander, H.1    Wahl, L.2
  • 46
    • 77958153648 scopus 로고    scopus 로고
    • Modeling immune complex-mediated autoimmune inammation
    • Arazi A, Neumann A (2010) Modeling immune complex-mediated autoimmune inammation. Journal of theoretical biology 267: 426-436.
    • (2010) Journal of Theoretical Biology , vol.267 , pp. 426-436
    • Arazi, A.1    Neumann, A.2
  • 47
    • 84887606996 scopus 로고    scopus 로고
    • Human systems immunology: Hypothesis-based modeling and unbiased data-driven approaches
    • Elsevier
    • Arazi A, Pendergraft WF III, Ribeiro RM, Perelson AS, Hacohen N (2013) Human systems immunology: Hypothesis-based modeling and unbiased data-driven approaches. In: Seminars in immunology. Elsevier, volume 25, pp. 193-200.
    • (2013) Seminars in Immunology , vol.25 , pp. 193-200
    • Arazi, A.1    Pendergraft III, W.F.2    Ribeiro, R.M.3    Perelson, A.S.4    Hacohen, N.5
  • 50
    • 56949090443 scopus 로고    scopus 로고
    • The role of low avidity t cells in the protection against type 1 diabetes: A modeling investigation
    • Khadra A, Santamaria S, Edelstein-Keshet L (2009) The role of low avidity t cells in the protection against type 1 diabetes: A modeling investigation. Journal of Theoretical Biology 256: 126-141.
    • (2009) Journal of Theoretical Biology , vol.256 , pp. 126-141
    • Khadra, A.1    Santamaria, S.2    Edelstein-Keshet, L.3
  • 51
    • 0003915574 scopus 로고    scopus 로고
    • Garland Science, 3d edition
    • Parham P (2009) The immune system. Garland Science, 3d edition. 608p.
    • (2009) The Immune System , pp. 608
    • Parham, P.1
  • 54
    • 33748062992 scopus 로고    scopus 로고
    • High epitope expression levels increase competition between t cells
    • Scherer A, Salathé M, Bonhoeffer S (2006) High epitope expression levels increase competition between t cells. PLoS Comput Biol 2: 1-11.
    • (2006) PLoS Comput Biol , vol.2 , pp. 1-11
    • Scherer, A.1    Salathé, M.2    Bonhoeffer, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.