Quantifying the importance of pMHC valency, total pMHC dose and frequency on nanoparticle therapeutic efficacy

Immunology and Cell Biology

Volumn 91, Issue 5, 2013, Pages 350-359

  Sugarman, Jordan ^a   Tsai, Sue ^b   Santamaria, Pere ^b,c   Khadra, Anmar ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

autoregulatory T cells; bifurcation analysis; biphasic response; mathematical model; population of model mice; T cell avidity

Indexed keywords

AUTOANTIGEN; GLUCOSE; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; AUTOREGULATORY T LYMPHOCYTE; BINDING SITE; BIOTINYLATION; CD8+ T LYMPHOCYTE; CELL CONTACT; EFFECTOR CELL; FEMALE; GLUCOSE BLOOD LEVEL; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRE T LYMPHOCYTE; STEADY STATE; T LYMPHOCYTE; TREATMENT OUTCOME; TREATMENT RESPONSE; TURNOVER TIME;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; CD8-POSITIVE T-LYMPHOCYTES; CLINICAL PROTOCOLS; COMPUTATIONAL BIOLOGY; DIABETES MELLITUS, TYPE 1; DRUG DESIGN; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MICE; MICE, INBRED NOD; MODELS, THEORETICAL; NANOPARTICLES; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, REGULATORY;

MUS;

EID: 84878532315     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2013.9     Document Type: Article

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