Post-translational modifications of self antigens: Implications for autoimmunity

Current Opinion in Immunology

Volumn 16, Issue 6, 2004, Pages 753-758

  Anderton, Stephen M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; ARGININE; AUTOANTIBODY; AUTOANTIGEN; CITRULLINE; EPITOPE; FIBRIN; FILAGGRIN; GLIADIN; GRANZYME B; PEPTIDE; PROTEIN ARGININE DEIMINASE; PROTEINASE; T LYMPHOCYTE RECEPTOR; VIMENTIN;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELLULAR IMMUNITY; DEAMINATION; ENCEPHALITIS; ENZYME ACTIVITY; HUMAN; IMMUNE SYSTEM; IMMUNIZATION; INFLAMMATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROCESSING; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; ARGININE; AUTOANTIGENS; AUTOIMMUNITY; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; T-LYMPHOCYTES;

EID: 7044235838     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.09.001     Document Type: Review

References (45)

1. M.J. van Stipdonk, A.A. Willems, S. Amor, C. Persoon-Deen, P.J. Travers, C.J. Boog, and J.M. van Noort T cells discriminate between differentially phosphorylated forms of alphaB-crystallin, a major central nervous system myelin antigen Int Immunol 10 1998 943 950
2. E. Michaelsson, V. Malmstrom, S. Reis, A. Engstrom, H. Burkhardt, and R. Holmdahl T cell recognition of carbohydrates on type II collagen J Exp Med 180 1994 745 749
3. A. Corthay, J. Backlund, J. Broddefalk, E. Michaelsson, T.J. Goldschmidt, J. Kihlberg, and R. Holmdahl Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis Eur J Immunol 28 1998 2580 2590
4. J. Backlund, A. Treschow, R. Bockermann, B. Holm, L. Holm, S. Issazadeh-Navikas, J. Kihlberg, and R. Holmdahl Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis Eur J Immunol 32 2002 3776 3784
5. L. Fugger, J.B. Rothbard, and G. Sonderstrup-McDevitt Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen Eur J Immunol 26 1996 928 933
6. J. Backlund, S. Carlsen, T. Hoger, B. Holm, L. Fugger, J. Kihlberg, H. Burkhardt, and R. Holmdahl Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis Proc Natl Acad Sci USA 99 2002 9960 9965
7. O. Molberg, S.N. McAdam, R. Korner, H. Quarsten, C. Kristiansen, L. Madsen, L. Fugger, H. Scott, O. Noren, and P. Roepstorff Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease Nat Med 4 1998 713 717
8. H. Arentz-Hansen, R. Korner, O. Molberg, H. Quarsten, W. Vader, Y.M. Kooy, K.E. Lundin, F. Koning, P. Roepstorff, and L.M. Sollid The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase J Exp Med 191 2000 603 612
9. H. Quarsten, O. Molberg, L. Fugger, S.N. McAdam, and L.M. Sollid HLA binding and T cell recognition of a tissue transglutaminase-modified gliadin epitope Eur J Immunol 29 1999 2506 2514
10. N.J. Viner, C.A. Nelson, B. Deck, and E.R. Unanue Complexes generated by the binding of free peptides to class II MHC molecules are antigenically diverse compared with those generated by intracellular processing J Immunol 156 1996 2365 2368
11. S.N. McAdam, B. Fleckenstein, I.B. Rasmussen, D.G. Schmid, I. Sandlie, B. Bogen, N.J. Viner, and L.M. Sollid T cell recognition of the dominant I-A(k)-restricted hen egg lysozyme epitope: critical role for asparagine deamidation J Exp Med 193 2001 1239 1246
12. T.P. Cirrito, Z. Pu, M.B. Deck, and E.R. Unanue Deamidation of asparagine in a major histocompatibility complex-bound peptide affects T cell recognition but does not explain type B reactivity J Exp Med 194 2001 1165 1170
13. M.J. Mamula, R.J. Gee, J.I. Elliott, A. Sette, S. Southwood, P.J. Jones, and P.R. Blier Isoaspartyl post-translational modification triggers autoimmune responses to self-proteins J Biol Chem 274 1999 22321 22327
14. H. Brahms, J. Raymackers, A. Union, F. de Keyser, L. Meheus, and R. Luhrmann The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies J Biol Chem 275 2000 17122 17129
15. M.A. van Boekel, and W.J. van Venrooij Modifications of arginines and their role in autoimmunity Autoimmun Rev 2 2003 57 62
16. M.A. van Boekel, E.R. Vossenaar, F.H. van den Hoogen, and W.J. van Venrooij Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value Arthritis Res 4 2002 87 93
17. G.A. Schellekens, B.A. de Jong, F.H. van den Hoogen, L.B. van de Putte, and W.J. van Venrooij Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies J Clin Invest 101 1998 273 281
18. G.A. Schellekens, H. Visser, B.A. de Jong, F.H. van den Hoogen, J.M. Hazes, F.C. Breedveld, and W.J. van Venrooij The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide Arthritis Rheum 43 2000 155 163
19. F.A. van Gaalen, S.P. Linn-Rasker, W.J. van Venrooij, B.A. de Jong, F.C. Breedveld, C.L. Verweij, R.E. Toes, and T.W. Huizinga Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study Arthritis Rheum 50 2004 709 715 Together within 20, these studies highlight the strengths of testing for anti-citrulline antibodies in predicting disease progression in RA.
20. •].
21. E.R. Vossenaar, S. Nijenhuis, M.M. Helsen, A. van der Heijden, T. Senshu, W.B. van den Berg, W.J. van Venrooij, and L.A. Joosten Citrullination of synovial proteins in murine models of rheumatoid arthritis Arthritis Rheum 48 2003 2489 2500
22. C.C. Reparon-Schuijt, W.J. van Esch, C. van Kooten, G.A. Schellekens, B.A. de Jong, W.J. van Venrooij, F.C. Breedveld, and C.L. Verweij Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis Arthritis Rheum 44 2001 41 47
23. J.A. Hill, S. Southwood, A. Sette, A.M. Jevnikar, D.A. Bell, and E. Cairns Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule J Immunol 171 2003 538 541 Using HLA-DR transgenic mice, this study shows T cell recognition of citrullinated, but not native vimentin peptide. The effect of citrullination is to increase peptide binding specifically to the shared epitope HLA-DR alleles associated with RA.
24. M.A. Moscarello, D.D. Wood, C. Ackerley, and C. Boulias Myelin in multiple sclerosis is developmentally immature J Clin Invest 94 1994 146 154
25. D.D. Wood, J.M. Bilbao, P. O'Connors, and M.A. Moscarello Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein Ann Neurol 40 1996 18 24
26. M.A. Moscarello, L. Pritzker, F.G. Mastronardi, and D.D. Wood Peptidylarginine deiminase: a candidate factor in demyelinating disease J Neurochem 81 2002 335 343
27. J. De Keyser, M. Schaaf, and A. Teelken Peptidylarginine deiminase activity in postmortem white matter of patients with multiple sclerosis Neurosci Lett 260 1999 74 76
28. L.R. Tranquill, L. Cao, N.C. Ling, H. Kalbacher, R.M. Martin, and J.N. Whitaker Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients Mult Scler 6 2000 220 225
29. J. de Seze, S. Dubucquoi, D. Lefranc, F. Virecoulon, I. Nuez, V. Dutoit, P. Vermersch, and L. Prin IgG reactivity against citrullinated myelin basic protein in multiple sclerosis J Neuroimmunol 117 2001 149 155
30. S.-R. Zhou, M.A. Moscarello, and J.N. Whitaker The effects of citrullination or variable amino-terminus acylation on the encephalitogenicity of human myelin basic protein in the PL/J mouse J Neuroimmunol 62 1995 147 152
31. L. Cao, D. Sun, and J.N. Whitaker Citrullinated myelin basic protein induces experimental autoimmune encephalomyelitis in Lewis rats through a diverse T cell repertoire J Neuroimmunol 88 1998 21 29
32. R. Nissinen, L. Paimela, H. Julkunen, P.J. Tienari, M. Leirisalo-Repo, T. Palosuo, and O. Vaarala Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjogren syndrome Scand J Rheumatol 32 2003 337 342
33. E.R. Einstein, J. Csejtey, K.B. Dalal, C.W. Adams, O.B. Bayliss, and J.F. Hallpike Proteolytic activity and basic protein loss in and around multiple sclerosis plaques: combined biochemical and histochemical observations J Neurochem 19 1972 653 662
34. L. Cao, R. Goodin, D. Wood, M.A. Moscarello, and J.N. Whitaker Rapid release and unusual stability of immunodominant peptide 45-89 from citrullinated myelin basic protein Biochemistry 38 1999 6157 6163
35. L.B. Pritzker, S. Joshi, J.J. Gowan, G. Harauz, and M.A. Moscarello Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D Biochemistry 39 2000 5374 5381
36. L.B. Pritzker, S. Joshi, G. Harauz, and M.A. Moscarello Deimination of myelin basic protein. 2. Effect of methylation of MBP on its deimination by peptidylarginine deiminase Biochemistry 39 2000 5382 5388
37. A.L. Young, W.G. Carter, H.A. Doyle, M.J. Mamula, and D.W. Aswad Structural integrity of histone H2B in vivo requires the activity of protein L-isoaspartate O-methyltransferase, a putative protein repair enzyme J Biol Chem 276 2001 37161 37165
38. L. Gahring, N.G. Carlson, E.L. Meyer, and S.W. Rogers Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation J Immunol 166 2001 1433 1438
39. P. Wood, and T. Elliott Glycan-regulated antigen processing of a protein in the endoplasmic reticulum can uncover cryptic cytotoxic T cell epitopes J Exp Med 188 1998 773 778
40. M. Krogsgaard, K.W. Wucherpfennig, B. Cannella, B.E. Hansen, A. Svejgaard, J. Pyrdol, H. Ditzel, C. Raine, J. Engberg, and L. Fugger Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex J Exp Med 191 2000 1395 1412
41. B. Manoury, E.W. Hewitt, N. Morrice, P.M. Dando, A.J. Barrett, and C. Watts An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation Nature 396 1998 695 699
42. B. Manoury, D. Mazzeo, L. Fugger, N. Viner, M. Ponsford, H. Streeter, G. Mazza, D.C. Wraith, and C. Watts Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP Nat Immunol 3 2002 169 174
43. H. Ito, K. Okamoto, H. Nakayama, T. Isobe, and K. Kato Phosphorylation of alpha B-Crystallin in Response to Various Types of Stress J Biol Chem 272 1997 29934 29941
44. F.M. Scott, W. Prime, M. Walshaw, L. Turnbull, and J.K. Field Peptide amidating activity in human bronchoalveolar lavage fluid: relationship to lung cancer, inflammation and infection Int J Oncol 16 2000 327 332
45. M. Griffin, R. Casadio, and C.M. Bergamini Transglutaminases: nature's biological glues Biochem J 368 2002 377 396