The pathogenicity of self-antigen decreases at high levels of autoantigenicity: A computational approach

International Immunology

Volumn 22, Issue 7, 2010, Pages 571-582

  Khadra, Anmar ^a   Santamaria, Pere ^b   Edelstein Keshet, Leah ^c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Autoimmunity; CD8+ T cells; Mathematical model; P MHC efficiency; Protein allocation

Indexed keywords

AUTOANTIGEN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGENICITY; ARTICLE; AUTOIMMUNE DISEASE; CROSS PRESENTATION; CYTOLYSIS; DENDRITIC CELL; IMMUNOPATHOGENESIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN SYNTHESIS; T LYMPHOCYTE ACTIVATION; TARGET CELL;

AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; COMPUTER SIMULATION; CROSS-PRIMING; DENDRITIC CELLS; MAJOR HISTOCOMPATIBILITY COMPLEX; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 77954251388     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq041     Document Type: Article

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