Pancreatic NOD beta cells express MHC class II protein and the frequency of I-Ag7 mRNA-expressing beta cells strongly increases during progression to autoimmune diabetes

Diabetologia

Volumn 46, Issue 8, 2003, Pages 1106-1114

  Walter, U ^a,b,c   Toepfer, T ^a   Dittmar, K E J ^a   Kretschmer, K ^a   Lauber, J ^a   Weiss, S ^a   Servos, G ^b   Lechner, O ^a   Scherbaum, W A ^b   Bornstein, S R ^b   Von Boehmer, H ^d   Buer, J ^a,e  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c INSERM   (France)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Beta cell; MHC class II; NOD mice; Single cell multiplex RT PCR; Type 1 diabetes mellitus

Indexed keywords

AUTOANTIGEN; CD45 ANTIGEN; IA ANTIGEN; IA G7 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; PREPROINSULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; IMMUNOFLUORESCENCE; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTIC INFILTRATION; MOUSE; MOUSE STRAIN; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; GENE EXPRESSION REGULATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; MICE, SCID; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 10744228962     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1164-y     Document Type: Article

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