Modeling competition among autoreactive CD8+ T cells in autoimmune diabetes: Implications for antigen-specific therapy

International Immunology

Volumn 18, Issue 7, 2006, Pages 1067-1077

  Marée, Athanasius F M ^a,c   Santamaria, Pere ^b   Edelstein Keshet, Leah ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antigen therapy; Autoimmunity; CTL; Diabetes; Mathematical modeling

Indexed keywords

CD8 ANTIGEN; EPITOPE; GLUCOSE 6 PHOSPHATE; IGRP 206214; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CELL CLONE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE COURSE; DRUG DOSE REGIMEN; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; IMMUNOREACTIVITY; INCIDENCE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MATHEMATICAL MODEL; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PANCREAS ISLET CELL; PATHOGENICITY; PREDICTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TREATMENT FAILURE; TREATMENT OUTCOME;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; EPITOPES, T-LYMPHOCYTE; GLUCOSE-6-PHOSPHATASE; HUMANS; IMMUNOTHERAPY; MICE; MICE, INBRED NOD; MODELS, BIOLOGICAL; SELF TOLERANCE; T-CELL ANTIGEN RECEPTOR SPECIFICITY;

EID: 33745289128     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxl040     Document Type: Article

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