Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2536-2543

  Warmus, Joseph S ^a   Quinn, Cheryl L ^a   Taylor, Clarke ^a   Murphy, Sean T ^a   Johnson, Timothy A ^a   Limberakis, Chris ^a   Ortwine, Daniel ^a   Bronstein, Joel ^a   Pagano, Paul ^a   Knafels, John D ^a   Lightle, Sandra ^a   Mochalkin, Igor ^a   Brideau, Roger ^a   Podoll, Terry ^a  

^a PFIZER INC   (United States)

Author keywords

Antibacterial; Computer aided drug design; Gram negative; Hydroxamic acid; LipE; Lipophilic efficiency; LpxC; Pseudomonas aeruginosa; Structure based drug design

Indexed keywords

BACTERIAL ENZYME; BB 78485; CHIRON090; ENZYME INHIBITOR; HYDROXAMIC ACID DERIVATIVE; LPC 011; OXAZOLINE DERIVATIVE; TU 514; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE 3 O (R 3 HYRDOXYMYRISTOYL) N ACETYL GLUCOSAMINE;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; IN VIVO STUDY; LIPOPHILICITY; NONHUMAN; PSEUDOMONAS AERUGINOSA;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; CATALYTIC DOMAIN; DRUG DESIGN; ENZYME INHIBITORS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROXAMIC ACIDS; LIPID A; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN BINDING; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS AERUGINOSA;

EID: 84858707707     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.140     Document Type: Article

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