Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase

Biochemistry

Volumn 45, Issue 26, 2006, Pages 7940-7948

  Gennadios, Heather A ^a   Whittington, Douglas A ^a,d   Li, Xuechen ^b,e   Fierke, Carol A ^c   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF MICHIGAN   (United States)

^d AMGEN INC   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOSYNTHESIS; CHELATION; CHEMICAL BONDS; HYDROXYLATION; LIGAMENTS; LIPIDS; PHOSPHATES; X RAY CRYSTALLOGRAPHY;

GRAM-NEGATIVE BACTERIAL INFECTIONS; HYDROPHOBIC TUNNEL; METAL-DEPENDENT DEACETYLASE; X-RAY CRYSTAL STRUCTURE;

ENZYMES;

1,5 ANHYDRO 2 C (CARBOXYMETHYL N HYDROXAMIDE) 2 DEOXY 3 O MYRISTOYL DEXTRO GLUCITOL; ANTIBIOTIC AGENT; BACTERIAL ENZYME; CACODYLIC ACID; CARBOXYPEPTIDASE A; CHELATE; ENZYME INHIBITOR; HISTIDINE; HYDROGEN; HYDROXAMIC ACID; IMIDAZOLE; LIGAND; LIPID A; METAL DEPENDENT DEACETYLASE; PYROPHOSPHATE; SORBITOL; THERMOLYSIN; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE [3 O (3 HYDROXYMYRISTOYL)] N ACETYLGLUCOSAMINE DEACETYLASE; WATER; ZINC ION;

ARTICLE; BINDING SITE; CATALYSIS; CATALYST; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME MECHANISM; ESCHERICHIA COLI; GEOMETRY; GRAM NEGATIVE BACTERIUM; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; LIPOGENESIS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMIDOHYDROLASES; BACTERIAL PROTEINS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; LIGANDS; LIPID A; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 33745602267     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060823m     Document Type: Article

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