-
1
-
-
0034569866
-
Obesity: Preventing and managing the global epidemic. Report of a WHO consultation
-
Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser, 2000. 894: p. i-xii, 1-253.
-
(2000)
World Health Organ Tech Rep Ser
, vol.894
-
-
-
2
-
-
78349272089
-
Mediators of inflammation in obesity and its comorbidities
-
Gualillo, O., Mediators of inflammation in obesity and its comorbidities. Mediators Inflamm, 2010. 2010.
-
(2010)
Mediators Inflamm
, vol.2010
-
-
Gualillo, O.1
-
3
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn, S.E., R.L. Hull, and K.M. Utzschneider, Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature, 2006. 444 (7121): p. 840-6.
-
(2006)
Nature
, vol.444
, Issue.7121
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
4
-
-
81855225795
-
Molecular mechanisms of cancer development in obesity
-
Khandekar, M.J., P. Cohen, and B.M. Spiegelman, Molecular mechanisms of cancer development in obesity. Nat Rev Cancer, 2011. 11 (12): p. 886-95.
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.12
, pp. 886-895
-
-
Khandekar, M.J.1
Cohen, P.2
Spiegelman, B.M.3
-
5
-
-
84875679556
-
Nonalcoholic fatty liver disease: An emerging threat to obese and diabetic individuals
-
Masuoka, H.C. and N. Chalasani, Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals. Ann N Y Acad Sci, 2013. 1281 : p. 106-22.
-
(2013)
Ann N Y Acad Sci
, vol.1281
, pp. 106-122
-
-
Masuoka, H.C.1
Chalasani, N.2
-
6
-
-
84865472821
-
Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease
-
Rask-Madsen, C. and C.R. Kahn, Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease. Arterioscler Thromb Vasc Biol, 2012. 32 (9): p. 2052-9.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, Issue.9
, pp. 2052-2059
-
-
Rask-Madsen, C.1
Kahn, C.R.2
-
7
-
-
2342466734
-
Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
-
Wild, S., et al., Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 2004. 27 (5): p. 1047-53.
-
(2004)
Diabetes Care
, vol.27
, Issue.5
, pp. 1047-1053
-
-
Wild, S.1
-
8
-
-
84860256182
-
Structural and biochemical characteristics of various white adipose tissue depots
-
Oxf
-
Wronska, A. and Z. Kmiec, Structural and biochemical characteristics of various white adipose tissue depots. Acta Physiol (Oxf), 2012. 205 (2): p. 194-208.
-
(2012)
Acta Physiol
, vol.205
, Issue.2
, pp. 194-208
-
-
Wronska, A.1
Kmiec, Z.2
-
9
-
-
62849107819
-
Metabolic dysregulation and adipose tissue fibrosis: Role of collagen VI
-
Khan, T., et al., Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol, 2009. 29 (6): p. 1575-91.
-
(2009)
Mol Cell Biol
, vol.29
, Issue.6
, pp. 1575-1591
-
-
Khan, T.1
-
10
-
-
79955044996
-
Architecture and the extracellular matrix: The still unappreciated components of the adipose tissue
-
Divoux, A. and K. Clement, Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue. Obes Rev, 2011. 12 (5): p. e494-503.
-
(2011)
Obes Rev
, vol.12
, Issue.5
-
-
Divoux, A.1
Clement, K.2
-
11
-
-
78650474024
-
Human adipose-derived stem cells: Current challenges and clinical perspectives
-
Yarak, S. and O.K. Okamoto, Human adipose-derived stem cells: current challenges and clinical perspectives. An Bras Dermatol, 2010. 85 (5): p. 647-56.
-
(2010)
An Bras Dermatol
, vol.85
, Issue.5
, pp. 647-656
-
-
Yarak, S.1
Okamoto, O.K.2
-
12
-
-
84868029397
-
Membrane-tethered delta-like 1 homolog (DLK1) restricts adipose tissue size by inhibiting preadipocyte proliferation
-
Mortensen, S.B., et al., Membrane-tethered delta-like 1 homolog (DLK1) restricts adipose tissue size by inhibiting preadipocyte proliferation. Diabetes, 2012. 61 (11): p. 2814-22.
-
(2012)
Diabetes
, vol.61
, Issue.11
, pp. 2814-2822
-
-
Mortensen, S.B.1
-
13
-
-
29244465509
-
Human fat cell lipolysis: Biochemistry, regulation and clinical role
-
Arner, P., Human fat cell lipolysis: biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab, 2005. 19 (4): p. 471-82.
-
(2005)
Best Pract Res Clin Endocrinol Metab
, vol.19
, Issue.4
, pp. 471-482
-
-
Arner, P.1
-
14
-
-
33947502786
-
Relationship between adipocyte size and adipokine expression and secretion
-
Skurk, T., et al., Relationship between adipocyte size and adipokine expression and secretion. J Clin EndocrinolMetab, 2007. 92 (3): p. 1023-33.
-
(2007)
J Clin EndocrinolMetab
, vol.92
, Issue.3
, pp. 1023-1033
-
-
Skurk, T.1
-
15
-
-
84900334046
-
Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity
-
Meyer, L.K., et al., Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity. Adipocyte, 2013. 2 (4): p. 217-26.
-
(2013)
Adipocyte
, vol.2
, Issue.4
, pp. 217-226
-
-
Meyer, L.K.1
-
16
-
-
84890464817
-
Preadipocytes proliferate and differentiate under the guidance ofDelta-like 1 homolog (DLK1)
-
Traustadottir, G.A., et al., Preadipocytes proliferate and differentiate under the guidance ofDelta-like 1 homolog (DLK1). Adipocyte, 2013. 2 (4): p. 272-5.
-
(2013)
Adipocyte
, vol.2
, Issue.4
, pp. 272-275
-
-
Traustadottir, G.A.1
-
17
-
-
44849132591
-
Dynamics of fat cell turnover in humans
-
Spalding, K.L., et al., Dynamics of fat cell turnover in humans. Nature, 2008. 453 (7196): p. 783-7.
-
(2008)
Nature
, vol.453
, Issue.7196
, pp. 783-787
-
-
Spalding, K.L.1
-
18
-
-
73249117062
-
Adipose tissue collagen VI in obesity
-
Pasarica, M., et al., Adipose tissue collagen VI in obesity. J Clin Endocrinol Metab, 2009. 94 (12): p. 5155-62.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, Issue.12
, pp. 5155-5162
-
-
Pasarica, M.1
-
19
-
-
77950618036
-
Adipocyte extracellular matrix composition, dynamics and role in obesity
-
Mariman, E.C. and P. Wang, Adipocyte extracellular matrix composition, dynamics and role in obesity. Cell Mol Life Sci, 2010. 67 (8): p. 1277-92.
-
(2010)
Cell Mol Life Sci
, vol.67
, Issue.8
, pp. 1277-1292
-
-
Mariman, E.C.1
Wang, P.2
-
20
-
-
79551553120
-
alpha3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues
-
Huang, G., et al., alpha3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues. J Clin Invest, 2011. 121 (2): p. 769-83.
-
(2011)
J Clin Invest
, vol.121
, Issue.2
, pp. 769-783
-
-
Huang, G.1
-
21
-
-
58849088969
-
Ectopic lipids and organ function
-
Szendroedi, J. and M. Roden, Ectopic lipids and organ function. Curr Opin Lipidol, 2009. 20 (1): p. 50-6.
-
(2009)
Curr Opin Lipidol
, vol.20
, Issue.1
, pp. 50-56
-
-
Szendroedi, J.1
Roden, M.2
-
22
-
-
77954348590
-
Adipose tissue inflammation: Novel insight into the role of macrophages and lymphocytes
-
Sell, H. and J. Eckel, Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes. Curr Opin Clin Nutr Metab Care, 2010. 13 (4): p. 366-70.
-
(2010)
Curr Opin Clin Nutr Metab Care
, vol.13
, Issue.4
, pp. 366-370
-
-
Sell, H.1
Eckel, J.2
-
23
-
-
34848851922
-
Angiogenesis modulates adipogenesis and obesity
-
Cao, Y., Angiogenesis modulates adipogenesis and obesity. J Clin Invest, 2007. 117 (9): p. 2362-8.
-
(2007)
J Clin Invest
, vol.117
, Issue.9
, pp. 2362-2368
-
-
Cao, Y.1
-
24
-
-
75849165542
-
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
-
Cao, Y., Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nat Rev Drug Discov, 2010. 9 (2): p. 107-15.
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.2
, pp. 107-115
-
-
Cao, Y.1
-
25
-
-
3042786130
-
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice
-
Brakenhielm, E., et al., Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res, 2004. 94 (12): p. 1579-88.
-
(2004)
Circ Res
, vol.94
, Issue.12
, pp. 1579-1588
-
-
Brakenhielm, E.1
-
26
-
-
81055146759
-
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys
-
Barnhart, K.F., et al., A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med, 2011. 3 (108): p. 108ra112.
-
(2011)
Sci Transl Med
, vol.3
, Issue.108
-
-
Barnhart, K.F.1
-
27
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil, G.S., N.S. Shargill, and B.M. Spiegelman, Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science, 1993. 259 (5091): p. 87-91.
-
(1993)
Science
, vol.259
, Issue.5091
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
28
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg, S.P., et al., Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest, 2003. 112 (12): p. 1796-808.
-
(2003)
J Clin Invest
, vol.112
, Issue.12
, pp. 1796-1808
-
-
Weisberg, S.P.1
-
29
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu, H., et al., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest, 2003. 112 (12): p. 1821-30.
-
(2003)
J Clin Invest
, vol.112
, Issue.12
, pp. 1821-1830
-
-
Xu, H.1
-
30
-
-
80355133234
-
Macrophage-mediated inflammation in metabolic disease
-
Chawla, A., K.D. Nguyen, and Y.P. Goh, Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol, 2011. 11 (11): p. 738-49.
-
(2011)
Nat Rev Immunol
, vol.11
, Issue.11
, pp. 738-749
-
-
Chawla, A.1
Nguyen, K.D.2
Goh, Y.P.3
-
31
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky, J.M. and C.K. Glass, Macrophages, inflammation, and insulin resistance. Annu Rev Physiol, 2010. 72 : p. 219-46.
-
(2010)
Annu Rev Physiol
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
32
-
-
84878785347
-
Immunological goings-on in visceral adipose tissue
-
Mathis, D., Immunological goings-on in visceral adipose tissue. Cell Metab, 2013. 17 (6): p. 851-9.
-
(2013)
Cell Metab
, vol.17
, Issue.6
, pp. 851-859
-
-
Mathis, D.1
-
33
-
-
84857985148
-
The cellular and signaling networks linking the immune system and metabolism in disease
-
Osborn, O. and J.M. Olefsky, The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med, 2012. 18 (3): p. 363-74.
-
(2012)
Nat Med
, vol.18
, Issue.3
, pp. 363-374
-
-
Osborn, O.1
Olefsky, J.M.2
-
34
-
-
68349160704
-
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
-
Liu, J., et al., Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med, 2009. 15 (8): p. 940-5.
-
(2009)
Nat Med
, vol.15
, Issue.8
, pp. 940-945
-
-
Liu, J.1
-
35
-
-
53149119231
-
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
-
Elgazar-Carmon, V., et al., Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res, 2008. 49 (9): p. 1894-903.
-
(2008)
J Lipid Res
, vol.49
, Issue.9
, pp. 1894-1903
-
-
Elgazar-Carmon, V.1
-
36
-
-
84868671526
-
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
-
Talukdar, S., et al., Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med, 2012.
-
(2012)
Nat Med
-
-
Talukdar, S.1
-
37
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer, S., et al., Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med, 2009. 15 (8): p. 921-9.
-
(2009)
Nat Med
, vol.15
, Issue.8
, pp. 921-929
-
-
Winer, S.1
-
38
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
Nishimura, S., et al., CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med, 2009. 15 (8): p. 914-20.
-
(2009)
Nat Med
, vol.15
, Issue.8
, pp. 914-920
-
-
Nishimura, S.1
-
39
-
-
85027938385
-
B cells promote insulin resistance through modulation of Tcells and production of pathogenic IgG antibodies
-
Winer, D.A., et al., B cells promote insulin resistance through modulation of Tcells and production of pathogenic IgG antibodies. Nat Med, 2011. 17 (5): p. 610-7.
-
(2011)
Nat Med
, vol.17
, Issue.5
, pp. 610-617
-
-
Winer, D.A.1
-
40
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer, M., et al., Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med, 2009. 15 (8): p. 930-9.
-
(2009)
Nat Med
, vol.15
, Issue.8
, pp. 930-939
-
-
Feuerer, M.1
-
41
-
-
79953815551
-
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
-
Wu, D., et al., Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science, 2011. 332 (6026): p. 243-7.
-
(2011)
Science
, vol.332
, Issue.6026
, pp. 243-247
-
-
Wu, D.1
-
42
-
-
84876746655
-
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
-
Molofsky, A.B., et al., Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med, 2013. 210 (3): p. 535-49.
-
(2013)
J Exp Med
, vol.210
, Issue.3
, pp. 535-549
-
-
Molofsky, A.B.1
-
43
-
-
79958715229
-
Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
-
Jenkins, S.J., et al., Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science, 2011. 332 (6035): p. 1284-1288.
-
(2011)
Science
, vol.332
, Issue.6035
, pp. 1284-1288
-
-
Jenkins, S.J.1
-
44
-
-
84886816349
-
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1
-
Jenkins, S.J., et al., IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1. The Journal of Experimental Medicine, 2013.
-
(2013)
The Journal of Experimental Medicine
-
-
Jenkins, S.J.1
-
45
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng, C.N., J.L. Bodzin, and A.R. Saltiel, Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest, 2007. 117 (1): p. 175-84.
-
(2007)
J Clin Invest
, vol.117
, Issue.1
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
46
-
-
33847073149
-
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
-
Lumeng, C.N., et al., Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes, 2007. 56 (1): p. 16-23.
-
(2007)
Diabetes
, vol.56
, Issue.1
, pp. 16-23
-
-
Lumeng, C.N.1
-
47
-
-
34347354309
-
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
-
Odegaard, J.I., et al., Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature, 2007. 447 (7148): p. 1116-20.
-
(2007)
Nature
, vol.447
, Issue.7148
, pp. 1116-1120
-
-
Odegaard, J.I.1
-
48
-
-
84884254187
-
Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions
-
Kawakami, T., et al., Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. J Immunol, 2013. 191 (6): p. 3358-72.
-
(2013)
J Immunol
, vol.191
, Issue.6
, pp. 3358-3372
-
-
Kawakami, T.1
-
49
-
-
53049093989
-
Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue
-
Stienstra, R., et al., Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue. J Biol Chem, 2008. 283 (33): p. 22620-7.
-
(2008)
J Biol Chem
, vol.283
, Issue.33
, pp. 22620-22627
-
-
Stienstra, R.1
-
50
-
-
84875611758
-
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages
-
Satoh, T., et al., Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature, 2013. 495 (7442): p. 524-8.
-
(2013)
Nature
, vol.495
, Issue.7442
, pp. 524-528
-
-
Satoh, T.1
-
51
-
-
84877841706
-
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice
-
Aouadi, M., et al., Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice. Proc Natl Acad Sci U S A, 2013. 110 (20): p. 8278-83.
-
(2013)
Proc Natl Acad Sci U S a
, vol.110
, Issue.20
, pp. 8278-8283
-
-
Aouadi, M.1
-
52
-
-
84872142459
-
JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
-
Han, M.S., et al., JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science, 2013. 339 (6116): p. 218-22.
-
(2013)
Science
, vol.339
, Issue.6116
, pp. 218-222
-
-
Han, M.S.1
-
53
-
-
1542287347
-
Neutrophil extracellular traps kill bacteria
-
Brinkmann, V., et al., Neutrophil extracellular traps kill bacteria. Science, 2004. 303 (5663): p. 1532-5.
-
(2004)
Science
, vol.303
, Issue.5663
, pp. 1532-1535
-
-
Brinkmann, V.1
-
54
-
-
77956396699
-
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance
-
Yang, H., et al., Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J Immunol, 2010. 185 (3): p. 1836- 45.
-
(2010)
J Immunol
, vol.185
, Issue.3
, pp. 1836-1845
-
-
Yang, H.1
-
55
-
-
77957108166
-
T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice
-
Strissel, K.J., et al., T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice. Obesity (Silver Spring), 2010. 18 (10): p. 1918-25.
-
(2010)
Obesity (Silver Spring)
, vol.18
, Issue.10
, pp. 1918-1925
-
-
Strissel, K.J.1
-
56
-
-
70450277113
-
Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
-
McGillicuddy, F.C., et al., Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem, 2009. 284 (46): p. 31936-44.
-
(2009)
J Biol Chem
, vol.284
, Issue.46
, pp. 31936-31944
-
-
McGillicuddy, F.C.1
-
57
-
-
84900310755
-
Signal transducer and activator of transcription (STAT) 4 deficiency reduces obesity induced insulin resistance and adipose tissue inflammation
-
Dobrian, A.D., et al., Signal transducer and activator of transcription (STAT) 4 deficiency reduces obesity induced insulin resistance and adipose tissue inflammation. Diabetes, 2013.
-
(2013)
Diabetes
-
-
Dobrian, A.D.1
-
58
-
-
84878800136
-
Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice
-
Morris, D.L., et al., Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice. Diabetes, 2013. 62 (8): p. 2762-72.
-
(2013)
Diabetes
, vol.62
, Issue.8
, pp. 2762-2772
-
-
Morris, D.L.1
-
59
-
-
65649117802
-
Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
-
Duffaut, C., et al., Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun, 2009. 384 (4): p. 482-5.
-
(2009)
Biochem Biophys Res Commun
, vol.384
, Issue.4
, pp. 482-485
-
-
Duffaut, C.1
-
60
-
-
77955653584
-
Toll-like receptors regulate B cell cytokine production in patients with diabetes
-
Jagannathan, M., et al., Toll-like receptors regulate B cell cytokine production in patients with diabetes. Diabetologia, 2010. 53 (7): p. 1461-71.
-
(2010)
Diabetologia
, vol.53
, Issue.7
, pp. 1461-1471
-
-
Jagannathan, M.1
-
61
-
-
84875548030
-
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
-
DeFuria, J., et al., B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A, 2013. 110 (13): p. 5133-8.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.13
, pp. 5133-5138
-
-
DeFuria, J.1
-
62
-
-
82755182907
-
Tissular T(regs): A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism
-
Cipolletta, D., et al., Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. Semin Immunol, 2011. 23 (6): p. 431-7.
-
(2011)
Semin Immunol
, vol.23
, Issue.6
, pp. 431-437
-
-
Cipolletta, D.1
-
63
-
-
37649015079
-
CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
-
Tiemessen, M.M., et al., CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci U S A, 2007. 104 (49): p. 19446-51.
-
(2007)
Proc Natl Acad Sci U S a
, vol.104
, Issue.49
, pp. 19446-19451
-
-
Tiemessen, M.M.1
-
64
-
-
77953110535
-
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
-
Ilan, Y., et al., Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proceedings of the National Academy of Sciences, 2010. 107 (21): p. 9765-9770.
-
(2010)
Proceedings of the National Academy of Sciences
, vol.107
, Issue.21
, pp. 9765-9770
-
-
Ilan, Y.1
-
65
-
-
84862986986
-
PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells
-
Cipolletta, D., et al., PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature, 2012. 486 (7404): p. 549-53.
-
(2012)
Nature
, vol.486
, Issue.7404
, pp. 549-553
-
-
Cipolletta, D.1
-
66
-
-
84881452345
-
Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance
-
Priceman, S.J., et al., Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance. Proc Natl Acad Sci U S A, 2013. 110 (32): p. 13079-84.
-
(2013)
Proc Natl Acad Sci U S a
, vol.110
, Issue.32
, pp. 13079-13084
-
-
Priceman, S.J.1
-
67
-
-
84887419072
-
Adipose natural regulatory B cells negatively control adipose tissue inflammation
-
Nishimura, S., et al., Adipose natural regulatory B cells negatively control adipose tissue inflammation. Cell metabolism, 2013.
-
(2013)
Cell Metabolism
-
-
Nishimura, S.1
-
68
-
-
84870243493
-
Recognition of CD1d-restricted antigens by natural killer T cells
-
Rossjohn, J., et al., Recognition of CD1d-restricted antigens by natural killer T cells. Nat Rev Immunol, 2012. 12 (12): p. 845-57.
-
(2012)
Nat Rev Immunol
, vol.12
, Issue.12
, pp. 845-857
-
-
Rossjohn, J.1
-
69
-
-
84859997837
-
Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity
-
Ji, Y., et al., Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J Biol Chem, 2012. 287 (17): p. 13561-71.
-
(2012)
J Biol Chem
, vol.287
, Issue.17
, pp. 13561-13571
-
-
Ji, Y.1
-
70
-
-
84865992180
-
Natural killer Tcells in adipose tissue prevent insulin resistance
-
Schipper, H.S., et al., Natural killer Tcells in adipose tissue prevent insulin resistance. J Clin Invest, 2012. 122 (9): p. 3343-54.
-
(2012)
J Clin Invest
, vol.122
, Issue.9
, pp. 3343-3354
-
-
Schipper, H.S.1
-
71
-
-
84866520055
-
Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
-
Lynch, L., et al., Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity, 2012. 37 (3): p. 574-87.
-
(2012)
Immunity
, vol.37
, Issue.3
, pp. 574-587
-
-
Lynch, L.1
-
72
-
-
84884148202
-
Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice
-
Subramanian, S., et al., Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice. J Lipid Res, 2013. 54 (10): p. 2831-41.
-
(2013)
J Lipid Res
, vol.54
, Issue.10
, pp. 2831-2841
-
-
Subramanian, S.1
-
73
-
-
84860794660
-
Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice
-
Wu, L., et al., Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice. Proc Natl Acad Sci U S A, 2012. 109 (19): p. E1143-52.
-
(2012)
Proc Natl Acad Sci U S a
, vol.109
, Issue.19
-
-
Wu, L.1
-
74
-
-
69249155107
-
Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity
-
Lynch, L., et al., Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity. Eur J Immunol, 2009. 39 (7): p. 1893-901.
-
(2009)
Eur J Immunol
, vol.39
, Issue.7
, pp. 1893-1901
-
-
Lynch, L.1
-
75
-
-
84861732299
-
Strategy of lipid recognition by invariant natural killer T cells: ' one for all and all for one'
-
Mallevaey, T. and T. Selvanantham, Strategy of lipid recognition by invariant natural killer T cells: ' one for all and all for one'. Immunology, 2012. 136 (3): p. 273-82.
-
(2012)
Immunology
, vol.136
, Issue.3
, pp. 273-282
-
-
Mallevaey, T.1
Selvanantham, T.2
-
76
-
-
33646016323
-
Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping
-
Elinav, E., et al., Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping. J Pathol, 2006. 209 (1): p. 121-8.
-
(2006)
J Pathol
, vol.209
, Issue.1
, pp. 121-128
-
-
Elinav, E.1
-
77
-
-
79958022995
-
Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity
-
Mantell, B.S., et al., Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity. PLoS One, 2011. 6 (6): p. e19831.
-
(2011)
PLoS One
, vol.6
, Issue.6
-
-
Mantell, B.S.1
-
78
-
-
80053324882
-
Impact of CD1d deficiency on metabolism
-
Kotas, M.E., et al., Impact of CD1d deficiency on metabolism. PLoS One, 2011. 6 (9): p. e25478.
-
(2011)
PLoS One
, vol.6
, Issue.9
-
-
Kotas, M.E.1
-
79
-
-
84857470273
-
Type II NKTcells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance
-
Satoh,M., et al., Type II NKTcells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance. PLoS One, 2012. 7 (2): p. e30568.
-
(2012)
PLoS One
, vol.7
, Issue.2
-
-
Satoh, M.1
-
80
-
-
84863808516
-
Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4
-
Ji, Y., et al., Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4. J Biol Chem, 2012. 287 (29): p. 24378-86.
-
(2012)
J Biol Chem
, vol.287
, Issue.29
, pp. 24378-24386
-
-
Ji, Y.1
-
81
-
-
84873473809
-
Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance
-
Wu, L. and L.Van Kaer, Contribution of lipid-reactive natural killer T cells to obesity-associated inflammation and insulin resistance. Adipocyte, 2013. 2 (1): p. 12-16.
-
(2013)
Adipocyte
, vol.2
, Issue.1
, pp. 12-16
-
-
Wu, L.1
Van Kaer, L.2
-
82
-
-
27444437321
-
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
-
Cinti, S., et al., Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. Journal of Lipid Research, 2005. 46 (11): p. 2347-2355.
-
(2005)
Journal of Lipid Research
, vol.46
, Issue.11
, pp. 2347-2355
-
-
Cinti, S.1
-
83
-
-
79952437112
-
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice
-
Prieur, X., et al., Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 2011. 60 (3): p. 797-809.
-
(2011)
Diabetes
, vol.60
, Issue.3
, pp. 797-809
-
-
Prieur, X.1
-
84
-
-
84874863882
-
Adipose tissue foam cells are present in human obesity
-
Shapiro, H., et al., Adipose tissue foam cells are present in human obesity. J Clin Endocrinol Metab, 2013. 98 (3): p. 1173-81.
-
(2013)
J Clin Endocrinol Metab
, vol.98
, Issue.3
, pp. 1173-1181
-
-
Shapiro, H.1
-
85
-
-
36849012057
-
Adipocyte death, adipose tissue remodeling, and obesity complications
-
Strissel, K.J., et al., Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes, 2007. 56 (12): p. 2910-8.
-
(2007)
Diabetes
, vol.56
, Issue.12
, pp. 2910-2918
-
-
Strissel, K.J.1
-
86
-
-
84883157734
-
Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis
-
Giordano, A., et al., Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis. J Lipid Res, 2013. 54 (9): p. 2423-36.
-
(2013)
J Lipid Res
, vol.54
, Issue.9
, pp. 2423-2436
-
-
Giordano, A.1
-
87
-
-
84880046877
-
Time course of histomorphological changes in adipose tissue upon acute lipoatrophy
-
Murano, I., et al., Time course of histomorphological changes in adipose tissue upon acute lipoatrophy. NutrMetab Cardiovasc Dis, 2013. 23 (8): p. 723-31.
-
(2013)
NutrMetab Cardiovasc Dis
, vol.23
, Issue.8
, pp. 723-731
-
-
Murano, I.1
-
88
-
-
78449269290
-
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
-
Miao, E.A., et al., Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol, 2010. 11 (12): p. 1136-1142.
-
(2010)
Nat Immunol
, vol.11
, Issue.12
, pp. 1136-1142
-
-
Miao, E.A.1
-
89
-
-
84255210700
-
Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012
-
Galluzzi, L., et al., Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ, 2012. 19 (1): p. 107-20.
-
(2012)
Cell Death Differ
, vol.19
, Issue.1
, pp. 107-120
-
-
Galluzzi, L.1
-
90
-
-
34047119110
-
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation
-
Hosogai, N., et al., Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes, 2007. 56 (4): p. 901-11.
-
(2007)
Diabetes
, vol.56
, Issue.4
, pp. 901-911
-
-
Hosogai, N.1
-
91
-
-
35148854599
-
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
-
Ye, J., et al., Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab, 2007. 293 (4): p. E1118-28.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
, Issue.4
-
-
Ye, J.1
-
92
-
-
38149142633
-
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
-
Lond
-
Rausch, M.E., et al., Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond), 2008. 32 (3): p. 451-63.
-
(2008)
Int J Obes
, vol.32
, Issue.3
, pp. 451-463
-
-
Rausch, M.E.1
-
93
-
-
79960359853
-
Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation
-
Goossens, G.H., et al., Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation, 2011. 124 (1): p. 67-76.
-
(2011)
Circulation
, vol.124
, Issue.1
, pp. 67-76
-
-
Goossens, G.H.1
-
94
-
-
0028985547
-
β-adrenergic stimulation and abdominal subcutaneous fat blood flow in lean, obese, and reduced-obese subjects
-
Blaak, E.E., et al., β-adrenergic stimulation and abdominal subcutaneous fat blood flow in lean, obese, and reduced-obese subjects. Metabolism, 1995. 44 (2): p. 183-187.
-
(1995)
Metabolism
, vol.44
, Issue.2
, pp. 183-187
-
-
Blaak, E.E.1
-
95
-
-
84872290190
-
Hypoxia and adipose tissue function and dysfunction in obesity
-
Trayhurn, P., Hypoxia and adipose tissue function and dysfunction in obesity. Physiological Reviews, 2013. 93 (1): p. 1-21.
-
(2013)
Physiological Reviews
, vol.93
, Issue.1
, pp. 1-21
-
-
Trayhurn, P.1
-
96
-
-
62749167010
-
Reduced adipose tissue oxygenation in human obesity: Evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response
-
Pasarica, M., et al., Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes, 2009. 58 (3): p. 718-725.
-
(2009)
Diabetes
, vol.58
, Issue.3
, pp. 718-725
-
-
Pasarica, M.1
-
97
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi, T., et al., The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med, 2001. 7 (8): p. 941-6.
-
(2001)
Nat Med
, vol.7
, Issue.8
, pp. 941-946
-
-
Yamauchi, T.1
-
98
-
-
52749091008
-
Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
-
Boden, G., et al., Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes, 2008. 57 (9): p. 2438-44.
-
(2008)
Diabetes
, vol.57
, Issue.9
, pp. 2438-2444
-
-
Boden, G.1
-
99
-
-
62749178966
-
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
-
Gregor, M.F., et al., Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes, 2009. 58 (3): p. 693-700.
-
(2009)
Diabetes
, vol.58
, Issue.3
, pp. 693-700
-
-
Gregor, M.F.1
-
100
-
-
31444447850
-
Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes
-
Chen, B., et al., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochem Biophys Res Commun, 2006. 341 (2): p. 549-56.
-
(2006)
Biochem Biophys Res Commun
, vol.341
, Issue.2
, pp. 549-556
-
-
Chen, B.1
-
101
-
-
0142057126
-
Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes
-
Lolmede, K., et al., Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord, 2003. 27 (10): p. 1187-95.
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, Issue.10
, pp. 1187-1195
-
-
Lolmede, K.1
-
102
-
-
0027210562
-
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
-
Wang, G.L. and G.L. Semenza, General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci U S A, 1993. 90 (9): p. 4304-8.
-
(1993)
Proc Natl Acad Sci U S a
, vol.90
, Issue.9
, pp. 4304-4308
-
-
Wang, G.L.1
Semenza, G.L.2
-
103
-
-
80053408653
-
Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice
-
Jiang, C., et al., Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes, 2011. 60 (10): p. 2484-2495.
-
(2011)
Diabetes
, vol.60
, Issue.10
, pp. 2484-2495
-
-
Jiang, C.1
-
104
-
-
84872166765
-
Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
-
Odegaard, J.I. and A. Chawla, Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science, 2013. 339 (6116): p. 172-7.
-
(2013)
Science
, vol.339
, Issue.6116
, pp. 172-177
-
-
Odegaard, J.I.1
Chawla, A.2
-
105
-
-
84872290190
-
Hypoxia and adipose tissue function and dysfunction in obesity
-
Trayhurn, P., Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev, 2013. 93 (1): p. 1-21.
-
(2013)
Physiol Rev
, vol.93
, Issue.1
, pp. 1-21
-
-
Trayhurn, P.1
|