메뉴 건너뛰기




Volumn 12, Issue 12, 2012, Pages 845-857

Recognition of CD1d-restricted antigens by natural killer T cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD1D ANTIGEN; CYTOKINE; GLYCOLIPID; LIPID; PHOSPHOLIPID; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

EID: 84870243493     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri3328     Document Type: Review
Times cited : (361)

References (131)
  • 1
    • 2542448243 scopus 로고    scopus 로고
    • CD1: Antigen presentation and T cell function
    • DOI 10.1146/annurev.immunol.22.012703.104608
    • Brigl, M. & Brenner, M. B. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22, 817-890 (2004). (Pubitemid 38680443)
    • (2004) Annual Review of Immunology , vol.22 , pp. 817-890
    • Brigl, M.1    Brenner, M.B.2
  • 2
    • 84865369721 scopus 로고    scopus 로고
    • T cells specific for lipid antigens
    • Mori, L. & De Libero, G. T cells specific for lipid antigens. Immunol. Res. 53, 191-199 (2012).
    • (2012) Immunol. Res , vol.53 , pp. 191-199
    • Mori, L.1    De Libero, G.2
  • 5
    • 10044286529 scopus 로고    scopus 로고
    • Going both ways: Immune regulation via CD1d-dependent NKT cells
    • DOI 10.1172/JCI200423594
    • Godfrey, D. I. & Kronenberg, M. Going both ways: immune regulation via CD1d-dependent NKT cells. J. Clin. Invest. 114, 1379-1388 (2004). (Pubitemid 40385565)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.10 , pp. 1379-1388
    • Godfrey, D.I.1    Kronenberg, M.2
  • 6
    • 45449103839 scopus 로고    scopus 로고
    • Cd1d-restricted inkt cells the 'swiss-army knife' of the immune system
    • Matsuda, J. L., Mallevaey, T., Scott-Browne, J. & Gapin, L. CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr. Opin. Immunol. 20, 358-368 (2008).
    • (2008) Curr. Opin. Immunol , vol.20 , pp. 358-368
    • Matsuda, J.L.1    Mallevaey, T.2    Scott-Browne, J.3    Gapin, L.4
  • 7
    • 79251497664 scopus 로고    scopus 로고
    • Presumed guilty: Natural killer t cell defects and human disease
    • Berzins, S. P., Smyth, M. J. & Baxter, A. G. Presumed guilty: natural killer T cell defects and human disease. Nature Rev. Immunol. 11, 131-142 (2011).
    • (2011) Nature Rev. Immunol , vol.11 , pp. 131-142
    • Berzins, S.P.1    Smyth, M.J.2    Baxter, A.G.3
  • 8
    • 77953539101 scopus 로고    scopus 로고
    • Synthetic inkt cell-agonists as vaccine adjuvants - finding the balance
    • Cerundolo, V., Barral, P. & Batista, F. D. Synthetic iNKT cell-agonists as vaccine adjuvants - finding the balance. Curr. Opin. Immunol. 22, 417-424 (2010).
    • (2010) Curr. Opin. Immunol , vol.22 , pp. 417-424
    • Cerundolo, V.1    Barral, P.2    Batista, F.D.3
  • 9
  • 10
    • 77949271519 scopus 로고    scopus 로고
    • Antigen recognition by cd1d-restricted nkt t cell receptors
    • Godfrey, D. I. et al. Antigen recognition by CD1d-restricted NKT T cell receptors. Semin. Immunol. 22, 61-67 (2010).
    • (2010) Semin. Immunol , vol.22 , pp. 61-67
    • Godfrey, D.I.1
  • 11
    • 79958251746 scopus 로고    scopus 로고
    • New ways to turn on nkt cells
    • Godfrey, D. I. & Rossjohn, J. New ways to turn on NKT cells. J. Exp. Med. 208, 1121-1125 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1121-1125
    • Godfrey, D.I.1    Rossjohn, J.2
  • 12
    • 79958281073 scopus 로고    scopus 로고
    • Invariant nkt cells are required for airway inflammation induced by environmental antigens
    • Wingender, G. et al. Invariant NKT cells are required for airway inflammation induced by environmental antigens. J. Exp. Med. 208, 1151-1162 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1151-1162
    • Wingender, G.1
  • 13
    • 77649231838 scopus 로고    scopus 로고
    • Lipid and glycolipid antigens of cd1d-restricted natural killer t cells
    • Venkataswamy, M. M. & Porcelli, S. A. Lipid and glycolipid antigens of CD1d-restricted natural killer T cells. Semin. Immunol. 22, 68-78 (2010).
    • (2010) Semin. Immunol , vol.22 , pp. 68-78
    • Venkataswamy, M.M.1    Porcelli, S.A.2
  • 14
    • 0028169443 scopus 로고
    • An invariant vα24-jαq/vβ11 t cell receptor is expressed in all individuals by clonally expanded cd4-8- t cells
    • Dellabona, P., Padovan, E., Casorati, G., Brockhaus, M. & Lanzavecchia, A. An invariant Vα24-JαQ/Vβ11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells. J. Exp. Med. 180, 1171-1176 (1994).
    • (1994) J. Exp. Med , vol.180 , pp. 1171-1176
    • Dellabona, P.1    Padovan, E.2    Casorati, G.3    Brockhaus, M.4    Lanzavecchia, A.5
  • 15
    • 0027178514 scopus 로고
    • - α/β T cells demonstrates preferential use of several Vβ genes and an invariant TCR α chain
    • Porcelli, S., Yockey, C. E., Brenner, M. B. & Balk, S. P. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- α/β T cells demonstrates preferential use of several Vβ genes and an invariant TCR α chain. J. Exp. Med. 178, 1-16 (1993). (Pubitemid 23173239)
    • (1993) Journal of Experimental Medicine , vol.178 , Issue.1 , pp. 1-16
    • Porcelli, S.1    Yockey, C.E.2    Brenner, M.B.3    Balk, S.P.4
  • 16
    • 0028025074 scopus 로고
    • - T cells in mice and humans
    • DOI 10.1084/jem.180.3.1097
    • Lantz, O. & Bendelac, A. An invariant T cell receptor α chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J. Exp. Med. 180, 1097-1106 (1994). (Pubitemid 24256622)
    • (1994) Journal of Experimental Medicine , vol.180 , Issue.3 , pp. 1097-1106
    • Lantz, O.1    Bendelac, A.2
  • 17
    • 23944482509 scopus 로고    scopus 로고
    • CD1d antigen presentation: Treats for NKT cells
    • DOI 10.1038/ni0805-754, PII N0805754
    • Godfrey, D. I., McCluskey, J. & Rossjohn, J. CD1d antigen presentation: treats for NKT cells. Nature Immunol. 6, 754-756 (2005). (Pubitemid 43090459)
    • (2005) Nature Immunology , vol.6 , Issue.8 , pp. 754-756
    • Godfrey, D.I.1    McCluskey, J.2    Rossjohn, J.3
  • 18
    • 33645083481 scopus 로고    scopus 로고
    • A structural basis for selection and cross-species reactivity of the semi-invariant nkt cell receptor in cd1d/glycolipid recognition
    • Kjer-Nielsen, L. et al. A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition. J. Exp. Med. 203, 661-673 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 661-673
    • Kjer-Nielsen, L.1
  • 20
    • 0030613856 scopus 로고    scopus 로고
    • Requirement for vα14 nkt cells in il-12-mediated rejection of tumors
    • Cui, J. Q. et al. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science 278, 1623-1626 (1997).
    • (1997) Science , vol.278 , pp. 1623-1626
    • Cui, J.Q.1
  • 21
    • 84864116698 scopus 로고    scopus 로고
    • Lower tcr repertoire diversity in traj18-deficient mice
    • Bedel, R. et al. Lower TCR repertoire diversity in Traj18-deficient mice. Nature Immunol. 13, 705-706 (2012).
    • (2012) Nature Immunol , vol.13 , pp. 705-706
    • Bedel, R.1
  • 23
    • 77950092257 scopus 로고    scopus 로고
    • Inkt cell autoreactivity: What is 'self' and how is it recognized?
    • Gapin, L. iNKT cell autoreactivity: what is 'self' and how is it recognized? Nature Rev. Immunol. 10, 272-277 (2010).
    • (2010) Nature Rev. Immunol , vol.10 , pp. 272-277
    • Gapin, L.1
  • 25
    • 0034730119 scopus 로고    scopus 로고
    • Structural requirements for antigen presentation by mouse cd1
    • This study characterizes α-galactosylceramide as a ligand for type I NKT cells
    • This study characterizes α-galactosylceramide as a ligand for type I NKT cells. 25. Burdin, N. et al. Structural requirements for antigen presentation by mouse CD1. Proc. Natl Acad. Sci. USA 97, 10156-10161 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 10156-10161
    • Burdin, N.1
  • 26
    • 0032193207 scopus 로고    scopus 로고
    • Selective ability of mouse cd1 to present glycolipids: Galactosylceramide specifically stimulates vα14+ nk t lymphocytes
    • Burdin, N. et al. Selective ability of mouse CD1 to present glycolipids: α-galactosylceramide specifically stimulates Vα14+ NK T lymphocytes. J. Immunol. 161, 3271-3281 (1998).
    • (1998) J. Immunol , vol.161 , pp. 3271-3281
    • Burdin, N.1
  • 27
    • 84865399909 scopus 로고    scopus 로고
    • Immunomodulatory type ii natural killer t (nkt) lymphocytes in health and disease
    • Rhost, S., Sedimbi, S., Kadri, N. & Cardell, S. L. Immunomodulatory type II natural killer T (NKT) lymphocytes in health and disease. Scand. J. Immunol. 76, 246-255 (2012).
    • (2012) Scand. J. Immunol , vol.76 , pp. 246-255
    • Rhost, S.1    Sedimbi, S.2    Kadri, N.3    Cardell, S.L.4
  • 28
    • 1842682026 scopus 로고    scopus 로고
    • Prevention of Autoimmunity by Targeting a Distinct, Noninvariant CD1d-reactive T Cell Population Reactive to Sulfatide
    • DOI 10.1084/jem.20031389
    • Jahng, A. et al. Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide. J. Exp. Med. 199, 947-957 (2004). (Pubitemid 38481086)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.7 , pp. 947-957
    • Jahng, A.1    Maricic, I.2    Aguilera, C.3    Cardell, S.4    Halder, R.C.5    Kumar, V.6
  • 29
    • 0029112507 scopus 로고
    • Cd1-restricted cd4+ t cells in major histocompatibility complex class ii-deficient mice
    • Cardell, S. et al. CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice. J. Exp. Med. 182, 993-1004 (1995).
    • (1995) J. Exp. Med , vol.182 , pp. 993-1004
    • Cardell, S.1
  • 30
    • 77954628293 scopus 로고    scopus 로고
    • Oligoclonality and innate-like features in the tcr repertoire of type ii nkt cells reactive to a β-linked self-glycolipid
    • Arrenberg, P., Halder, R., Dai, Y., Maricic, I. & Kumar, V. Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a β-linked self-glycolipid. Proc. Natl Acad. Sci. USA 107, 10984-10989 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 10984-10989
    • Arrenberg, P.1    Halder, R.2    Dai, Y.3    Maricic, I.4    Kumar, V.5
  • 31
    • 0035896733 scopus 로고    scopus 로고
    • The mouse cd1d-restricted repertoire is dominated by a few autoreactive t cell receptor families
    • Park, S. H. et al. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families. J. Exp. Med. 193, 893-904 (2001).
    • (2001) J. Exp. Med , vol.193 , pp. 893-904
    • Park, S.H.1
  • 32
    • 84865762611 scopus 로고    scopus 로고
    • The majority of cd1d-sulfatide-specific t cells in human blood use a semiinvariant vδ1 tcr
    • Bai, L. et al. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR. Eur. J. Immunol. 42, 2505-2510 (2012).
    • (2012) Eur. J. Immunol , vol.42 , pp. 2505-2510
    • Bai, L.1
  • 33
    • 0036591697 scopus 로고    scopus 로고
    • + T lymphocytes
    • Gadola, S. D., Dulphy, N., Salio, M. & Cerundolo, V. Vα24-JαQ-independent, CD1d-restricted recognition of α-galactosylceramide by human CD4+ and CD8αβ+ T lymphocytes. J. Immunol. 168, 5514-5520 (2002). (Pubitemid 34556130)
    • (2002) Journal of Immunology , vol.168 , Issue.11 , pp. 5514-5520
    • Gadola, S.D.1    Dulphy, N.2    Salio, M.3    Cerundolo, V.4
  • 34
    • 33645074941 scopus 로고    scopus 로고
    • Structure and binding kinetics of three different human cd1d-α-galactosylceramide-specific t cell receptors
    • Gadola, S. D. et al. Structure and binding kinetics of three different human CD1d-α-galactosylceramide-specific T cell receptors. J. Exp. Med. 203, 699-710 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 699-710
    • Gadola, S.D.1
  • 36
    • 79960419019 scopus 로고    scopus 로고
    • Naive-like population of human cd1d-restricted t cells expressing intermediate levels of promyelocytic leukemia zinc finger
    • Constantinides, M. G., Picard, D., Savage, A. K. & Bendelac, A. A. Naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger. J. Immunol. 187, 309-315 (2011).
    • (2011) J. Immunol , vol.187 , pp. 309-315
    • Constantinides, M.G.1    Picard, D.2    Savage, A.K.3    Bendelac, A.A.4
  • 37
    • 79959375627 scopus 로고    scopus 로고
    • A semi-invariant vα10+ t cell antigen receptor defines a population of natural killer t cells with distinct glycolipid antigen-recognition properties
    • Uldrich, A. P. et al. A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. Nature Immunol. 12, 616-623 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 616-623
    • Uldrich, A.P.1
  • 38
    • 81255208437 scopus 로고    scopus 로고
    • Invariant natural killer t cells recognize lipid self antigen induced by microbial danger signals
    • Brennan, P. J. et al. Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nature Immunol. 12, 1202-1211 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 1202-1211
    • Brennan, P.J.1
  • 39
    • 84865392751 scopus 로고    scopus 로고
    • Identification of novel glycolipid ligands activating a sulfatide reactive, cd1d-restricted, type ii natural killer t lymphocyte
    • This study shows that a particular form of βGlcCer represents a self ligand for the NKT TCR that is upregulated during infection. 10 Jul(doi:10.1002/eji.201142350
    • This study shows that a particular form of βGlcCer represents a self ligand for the NKT TCR that is upregulated during infection. 39. Rhost, S. et al. Identification of novel glycolipid ligands activating a sulfatide reactive, CD1d-restricted, type II natural killer T lymphocyte. Eur. J. Immunol. 10 Jul 2012 (doi:10.1002/eji.201142350).
    • (2012) Eur. J. Immunol
    • Rhost, S.1
  • 40
    • 0030826423 scopus 로고    scopus 로고
    • Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove
    • DOI 10.1126/science.277.5324.339
    • Zeng, Z. et al. Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove. Science 277, 339-345 (1997). (Pubitemid 27450700)
    • (1997) Science , vol.277 , Issue.5324 , pp. 339-345
    • Zeng, Z.-H.1    Castano, A.R.2    Segelke, B.W.3    Stura, E.A.4    Peterson, P.A.5    Wilson, I.A.6
  • 41
    • 0035984523 scopus 로고    scopus 로고
    • Structure of human cd1b with bound ligands at 2.3 å, a maze for alkyl chains
    • Gadola, S. D. et al. Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains. Nature Immunol. 3, 721-726 (2002).
    • (2002) Nature Immunol , vol.3 , pp. 721-726
    • Gadola, S.D.1
  • 43
    • 0043198070 scopus 로고    scopus 로고
    • Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A
    • DOI 10.1038/ni948
    • Zajonc, D. M., Elsliger, M. A., Teyton, L. & Wilson, I. A. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 Å. Nature Immunol. 4, 808-815 (2003). (Pubitemid 36986766)
    • (2003) Nature Immunology , vol.4 , Issue.8 , pp. 808-815
    • Zajonc, D.M.1    Elsliger, M.A.2    Teyton, L.3    Wilson, I.A.4
  • 44
    • 78650113430 scopus 로고    scopus 로고
    • The 2.5å structure of cd1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation
    • Scharf, L. et al. The 2.5Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation. Immunity 33, 853-862 (2010).
    • (2010) Immunity , vol.33 , pp. 853-862
    • Scharf, L.1
  • 46
    • 18844376903 scopus 로고    scopus 로고
    • Anatomy of CD1-lipid antigen complexes
    • DOI 10.1038/nri1605
    • Moody, D. B., Zajonc, D. M. & Wilson, I. A. Anatomy of CD1-lipid antigen complexes. Nature Rev. Immunol. 5, 387-399 (2005). (Pubitemid 40685988)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.5 , pp. 387-399
    • Moody, D.B.1    Zajonc, D.M.2    Wilson, I.A.3
  • 48
    • 77249151524 scopus 로고    scopus 로고
    • Recent advances in processing and presentation of cd1 bound lipid antigens
    • Salio, M., Silk, J. D. & Cerundolo, V. Recent advances in processing and presentation of CD1 bound lipid antigens. Curr. Opin. Immunol. 22, 81-88 (2010).
    • (2010) Curr. Opin. Immunol , vol.22 , pp. 81-88
    • Salio, M.1    Silk, J.D.2    Cerundolo, V.3
  • 49
    • 66149179356 scopus 로고    scopus 로고
    • Antigen presentation by cd1: Lipids, t cells, and nkt cells in microbial immunity
    • Cohen, N. R., Garg, S. & Brenner, M. B. Antigen presentation by CD1: lipids, T cells, and NKT cells in microbial immunity. Adv. Immunol. 102,1-94 (2009).
    • (2009) Adv. Immunol , vol.102 , pp. 1-94
    • Cohen, N.R.1    Garg, S.2    Brenner, M.B.3
  • 50
    • 33745838249 scopus 로고    scopus 로고
    • CD1d ligands: The good, the bad, and the ugly
    • Brutkiewicz, R. R. CD1d ligands: the good, the bad, and the ugly. J. Immunol. 177, 769-775 (2006). (Pubitemid 44036575)
    • (2006) Journal of Immunology , vol.177 , Issue.2 , pp. 769-775
    • Brutkiewicz, R.R.1
  • 51
    • 84934440825 scopus 로고    scopus 로고
    • Structural insight into natural killer t cell receptor recognition of cd1d
    • Borg, N. A., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J. Structural insight into natural killer T cell receptor recognition of CD1d. Adv. Exp. Med. Biol. 598, 20-34 (2007).
    • (2007) Adv. Exp. Med. Biol , vol.598 , pp. 20-34
    • Borg, N.A.1    Kjer-Nielsen, L.2    McCluskey, J.3    Rossjohn, J.4
  • 53
    • 40449086783 scopus 로고    scopus 로고
    • The Fidelity, Occasional Promiscuity, and Versatility of T Cell Receptor Recognition
    • DOI 10.1016/j.immuni.2008.02.004, PII S1074761308000757
    • This study provides the first description of a type I NKT TCR-antigen-CD1d interaction. 53. Godfrey, D. I., Rossjohn, J. & McCluskey, J. The fidelity, occasional promiscuity, and versatility of T cell receptor recognition. Immunity 28, 304-314 (2008). (Pubitemid 351343861)
    • (2008) Immunity , vol.28 , Issue.3 , pp. 304-314
    • Godfrey, D.I.1    Rossjohn, J.2    McCluskey, J.3
  • 54
    • 77953742968 scopus 로고    scopus 로고
    • Hard wiring of t cell receptor specificity for the major histocompatibility complex is underpinned by tcr adaptability
    • Burrows, S. R. et al. Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proc. Natl Acad. Sci. USA 107, 10608-10613 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 10608-10613
    • Burrows, S.R.1
  • 55
    • 68249151165 scopus 로고    scopus 로고
    • Differential recognition of cd1d-α-galactosyl ceramide by the vβ8.2 and vβ7 semi-invariant nkt t cell receptors
    • Pellicci, D. G. et al. Differential recognition of CD1d-α- galactosyl ceramide by the Vβ8.2 and Vβ7 semi-invariant NKT T cell receptors. Immunity 31, 47-59 (2009).
    • (2009) Immunity , vol.31 , pp. 47-59
    • Pellicci, D.G.1
  • 56
    • 78149305888 scopus 로고    scopus 로고
    • The va14 invariant natural killer t cell tcr forces microbial glycolipids and cd1d into a conserved binding mode
    • Li, Y. et al. The Va14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode. J. Exp. Med. 207, 2383-2393 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 2383-2393
    • Li, Y.1
  • 57
    • 82455219437 scopus 로고    scopus 로고
    • Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for nkt cells
    • This report provided the first insights into how the type I NKT TCR can interact with microbial ligands
    • This report provided the first insights into how the type I NKT TCR can interact with microbial ligands. 57. Girardi, E. et al. Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells. PLoS Biol. 9, e1001189 (2011).
    • (2011) PLoS Biol , vol.9
    • Girardi, E.1
  • 58
    • 79952770879 scopus 로고    scopus 로고
    • A molecular basis for the exquisite cd1d-restricted antigen specificity and functional responses of natural killer t cells
    • Wun, K. S. et al. A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells. Immunity 34, 327-339 (2011).
    • (2011) Immunity , vol.34 , pp. 327-339
    • Wun, K.S.1
  • 61
    • 70450224082 scopus 로고    scopus 로고
    • Adaptability of the semi-invariant natural killer t-cell receptor towards structurally diverse cd1d-restricted ligands
    • Florence, W. C. et al. Adaptability of the semi-invariant natural killer T-cell receptor towards structurally diverse CD1d-restricted ligands. EMBO J. 28, 3579-3590 (2009).
    • (2009) EMBO J , vol.28 , pp. 3579-3590
    • Florence, W.C.1
  • 62
    • 82755187762 scopus 로고    scopus 로고
    • Vb2 natural killer t cell antigen receptor-mediated recognition of cd1d-glycolipid antigen
    • Patel, O. et al. Vb2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proc. Natl Acad. Sci. USA 108, 19007-19012 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 19007-19012
    • Patel, O.1
  • 63
    • 80051655469 scopus 로고    scopus 로고
    • Nkt cell ligand recognition logic: Molecular basis for a synaptic duet and transmission of inflammatory effectors
    • Joyce, S., Girardi, E. & Zajonc, D. M. NKT cell ligand recognition logic: molecular basis for a synaptic duet and transmission of inflammatory effectors. J. Immunol. 187, 1081-1089 (2011).
    • (2011) J. Immunol , vol.187 , pp. 1081-1089
    • Joyce, S.1    Girardi, E.2    Zajonc, D.M.3
  • 64
    • 84861732299 scopus 로고    scopus 로고
    • Strategy of lipid recognition by invariant natural killer t cells: One for all and all for one
    • Mallevaey, T. & Selvanantham, T. Strategy of lipid recognition by invariant natural killer T cells: 'one for all and all for one'. Immunology 136, 273-282 (2012).
    • (2012) Immunology , vol.136 , pp. 273-282
    • Mallevaey, T.1    Selvanantham, T.2
  • 65
    • 79952756012 scopus 로고    scopus 로고
    • The immutable recognition of cd1d
    • Adams, E. J. & Lopez-Sagaseta, J. The immutable recognition of CD1d. Immunity 34, 281-283 (2011).
    • (2011) Immunity , vol.34 , pp. 281-283
    • Adams, E.J.1    Lopez-Sagaseta, J.2
  • 66
    • 68249162543 scopus 로고    scopus 로고
    • T cell receptor cdr2β and cdr3β loops collaborate functionally to shape the inkt cell repertoire
    • Mallevaey, T. et al. T cell receptor CDR2β and CDR3β loops collaborate functionally to shape the iNKT cell repertoire. Immunity 31, 60-71 (2009).
    • (2009) Immunity , vol.31 , pp. 60-71
    • Mallevaey, T.1
  • 67
    • 80052031099 scopus 로고    scopus 로고
    • Recognition of β-linked self glycolipids mediated by natural killer t cell antigen receptors
    • Pellicci, D. G. et al. Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors. Nature Immunol. 12, 827-833 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 827-833
    • Pellicci, D.G.1
  • 68
    • 79952752495 scopus 로고    scopus 로고
    • A molecular basis for nkt cell recognition of cd1d-self-antigen
    • Mallevaey, T. et al. A molecular basis for NKT cell recognition of CD1d-self-antigen. Immunity 34, 315-326 (2011).
    • (2011) Immunity , vol.34 , pp. 315-326
    • Mallevaey, T.1
  • 69
    • 80052688692 scopus 로고    scopus 로고
    • Cutting edge: Structural basis for the recognition of β-linked glycolipid antigens by invariant nkt cells
    • This report provided the first structural insights into the basis of CD1d-mediated autoreactivity
    • This report provided the first structural insights into the basis of CD1d-mediated autoreactivity. 69. Yu, E. D., Girardi, E., Wang, J. & Zajonc, D. M. Cutting edge: structural basis for the recognition of β-linked glycolipid antigens by invariant NKT cells. J. Immunol. 187, 2079-2083 (2011).
    • (2011) J. Immunol , vol.187 , pp. 2079-2083
    • Yu, E.D.1    Girardi, E.2    Wang, J.3    Zajonc, D.M.4
  • 70
    • 84859906269 scopus 로고    scopus 로고
    • Lysophospholipid presentation by cd1d and recognition by a human natural killer t-cell receptor
    • Together With Reference 67 This Study Showed That The Type I NKT TCR Can 'bulldoze' β-linked ligands to enable CD1d engagement
    • Together with reference 67, this study showed that the type I NKT TCR can 'bulldoze' β-linked ligands to enable CD1d engagement. 70. Lopez-Sagaseta, J., Sibener, L. V., Kung, J. E., Gumperz, J. & Adams, E. J. Lysophospholipid presentation by CD1d and recognition by a human natural killer T-cell receptor. EMBO J. 31, 2047-2059 (2012).
    • (2012) EMBO J , vol.31 , pp. 2047-2059
    • Lopez-Sagaseta, J.1    Sibener, L.V.2    Kung, J.E.3    Gumperz, J.4    Adams, E.J.5
  • 71
    • 0035807302 scopus 로고    scopus 로고
    • H2 bias of natural killer T cells
    • DOI 10.1038/35097097
    • This is the first description of how an NKT TCR can recognize lysophospholipids. 71. Miyamoto, K., Miyake, S. & Yamamura, T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413, 531-534 (2001). (Pubitemid 32938752)
    • (2001) Nature , vol.413 , Issue.6855 , pp. 531-534
    • Miyamoto, K.1    Miyake, S.2    Yamamura, T.3
  • 72
    • 0345167831 scopus 로고    scopus 로고
    • Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand α -Galactosylceramide
    • DOI 10.1084/jem.20031192
    • Schmieg, J., Yang, G., Franck, R. W. & Tsuji, M. Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand α-galactosylceramide. J. Exp. Med. 198, 1631-1641 (2003). (Pubitemid 37494156)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.11 , pp. 1631-1641
    • Schmieg, J.1    Yang, G.2    Franck, R.W.3    Tsuji, M.4
  • 73
    • 79957915677 scopus 로고    scopus 로고
    • Galactose-modified inkt cell agonists stabilized by an induced fit of cd1d prevent tumour metastasis
    • Aspeslagh, S. et al. Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis. EMBO J. 30, 2294-2305 (2011).
    • (2011) EMBO J , vol.30 , pp. 2294-2305
    • Aspeslagh, S.1
  • 75
    • 80555126091 scopus 로고    scopus 로고
    • Nkt tcr recognition of cd1d-α-c-galactosylceramide
    • Patel, O. et al. NKT TCR recognition of CD1d-α-C- galactosylceramide. J. Immunol. 187, 4705-4713 (2011).
    • (2011) J. Immunol , vol.187 , pp. 4705-4713
    • Patel, O.1
  • 76
    • 84857465001 scopus 로고    scopus 로고
    • Structural and functional characterization of a novel nonglycosidic type i nkt agonist with immunomodulatory properties
    • Kerzerho, J. et al. Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. J. Immunol. 188, 2254-2265 (2012).
    • (2012) J. Immunol , vol.188 , pp. 2254-2265
    • Kerzerho, J.1
  • 77
    • 84555202450 scopus 로고    scopus 로고
    • Glycolipids that elicit ifn-γ-biased responses from natural killer t cells
    • Tyznik, A. J. et al. Glycolipids that elicit IFN-γ-biased responses from natural killer T cells. Chem. Biol. 18, 1620-1630 (2011).
    • (2011) Chem. Biol , vol.18 , pp. 1620-1630
    • Tyznik, A.J.1
  • 78
    • 0029933309 scopus 로고    scopus 로고
    • Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
    • DOI 10.1146/annurev.immunol.14.1.1
    • Sloan-Lancaster, J. & Allen, P. M. Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology. Annu. Rev. Immunol. 14, 1-27 (1996). (Pubitemid 26130175)
    • (1996) Annual Review of Immunology , vol.14 , pp. 1-27
    • Sloan-Lancaster, J.1    Allen, P.M.2
  • 79
    • 67649921971 scopus 로고    scopus 로고
    • Synthesis and evaluation of 3''-and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, krn7000
    • Raju, R. et al. Synthesis and evaluation of 3''-and 4''-deoxy and -fluoro analogs of the immunostimulatory glycolipid, KRN7000. Bioorg. Med. Chem. Lett. 19, 4122-4125 (2009).
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , pp. 4122-4125
    • Raju, R.1
  • 80
    • 84869017389 scopus 로고    scopus 로고
    • Human and mouse type i natural killer t-cell antigen receptors exhibit different fine specificities for cd1d-antigen
    • 20 Sep. (doi:10.1074/jbc.M112.412320
    • Wun, K. S. et al. Human and mouse type I natural killer T-cell antigen receptors exhibit different fine specificities for CD1d-antigen. J. Biol. Chem. 20 Sep 2012 (doi:10.1074/jbc.M112.412320).
    • (2012) J. Biol. Chem
    • Wun, K.S.1
  • 81
    • 73949148254 scopus 로고    scopus 로고
    • Mechanisms for glycolipid antigen-driven cytokine polarization by vα14i nkt cells
    • Sullivan, B. A. et al. Mechanisms for glycolipid antigen-driven cytokine polarization by Vα14i NKT cells. J. Immunol. 184, 141-153 (2010).
    • (2010) J. Immunol , vol.184 , pp. 141-153
    • Sullivan, B.A.1
  • 83
    • 66949155720 scopus 로고    scopus 로고
    • Kinetics and cellular site of glycolipid loading control the outcome of natural killer t cell activation
    • Im, J. S. et al. Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation. Immunity 30, 888-898 (2009).
    • (2009) Immunity , vol.30 , pp. 888-898
    • Im, J.S.1
  • 84
    • 67649886446 scopus 로고    scopus 로고
    • Lysosomal recycling terminates cd1d-mediated presentation of short and polyunsaturated variants of the nkt cell lipid antigen αgalcer
    • This study shows how mechanisms pertaining to antigen loading can relate to the efficacy of an antigen in activating NKT cells
    • This study shows how mechanisms pertaining to antigen loading can relate to the efficacy of an antigen in activating NKT cells. 84. Bai, L. et al. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen αGalCer. Proc. Natl Acad. Sci. USA 106, 10254-10259 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 10254-10259
    • Bai, L.1
  • 85
    • 84859375219 scopus 로고    scopus 로고
    • Distinct apcs explain the cytokine bias of α-galactosylceramide variants in vivo
    • Bai, L. et al. Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo. J. Immunol. 188, 3053-3061 (2012).
    • (2012) J. Immunol , vol.188 , pp. 3053-3061
    • Bai, L.1
  • 87
    • 20844463676 scopus 로고    scopus 로고
    • Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells
    • DOI 10.1002/eji.200526157
    • Sriram, V., Du, W., Gervay-Hague, J. & Brutkiewicz, R. R. Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur. J. Immunol. 35, 1692-1701 (2005). (Pubitemid 40862317)
    • (2005) European Journal of Immunology , vol.35 , Issue.6 , pp. 1692-1701
    • Sriram, V.1    Du, W.2    Gervay-Hague, J.3    Brutkiewicz, R.R.4
  • 88
    • 80052966551 scopus 로고    scopus 로고
    • Invariant natural killer t cells recognize glycolipids from pathogenic gram-positive bacteria
    • Kinjo, Y. et al. Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nature Immunol. 12, 966-974 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 966-974
    • Kinjo, Y.1
  • 92
    • 78650944895 scopus 로고    scopus 로고
    • Influenza infection in suckling mice expands an nkt cell subset that protects against airway hyperreactivity
    • Chang, Y.-J. et al. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. J. Clin. Invest. 121, 57-69 (2011).
    • (2011) J. Clin. Invest , vol.121 , pp. 57-69
    • Chang, Y.-J.1
  • 93
    • 33645235440 scopus 로고    scopus 로고
    • Design of natural killer t cell activators: Structure and function of a microbial glycosphingolipid bound to mouse cd1d
    • Wu, D. et al. Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. Proc. Natl Acad. Sci. USA 103, 3972-3977 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 3972-3977
    • Wu, D.1
  • 94
    • 76549103448 scopus 로고    scopus 로고
    • Lipid binding orientation within cd1d affects recognition of borrelia burgorferi antigens by nkt cells
    • Wang, J. et al. Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc. Natl Acad. Sci. USA 107, 1535-1540 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 1535-1540
    • Wang, J.1
  • 95
    • 84863707404 scopus 로고    scopus 로고
    • Hepatitis b virus-induced lipid alterations contribute to natural killer t cell-dependent protective immunity
    • Zeissig, S. et al. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nature Med. 18, 1060-1068 (2012).
    • (2012) Nature Med , vol.18 , pp. 1060-1068
    • Zeissig, S.1
  • 96
    • 79958248405 scopus 로고    scopus 로고
    • Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer t cell activation during microbial infection
    • This report describes a role for phospholipid-reactive type II NKT cells in promoting immunity to hepatitis B virus
    • This report describes a role for phospholipid-reactive type II NKT cells in promoting immunity to hepatitis B virus. 96. Brigl, M. et al. Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J. Exp. Med. 208, 1163-1177 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1163-1177
    • Brigl, M.1
  • 97
    • 0036143535 scopus 로고    scopus 로고
    • Multiple defects in antigen presentation and t cell development by mice expressing cytoplasmic tail-truncated cd1d
    • Chiu, Y. H. et al. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nature Immunol. 3, 55-60 (2002).
    • (2002) Nature Immunol , vol.3 , pp. 55-60
    • Chiu, Y.H.1
  • 102
    • 48349111099 scopus 로고    scopus 로고
    • Humans lack igb3 due to the absence of functional igb3-synthase: Implications for nkt cell development and transplantation
    • Christiansen, D. et al. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation. PLoS Biol. 6, e172 (2008).
    • (2008) PLoS Biol , vol.6
    • Christiansen, D.1
  • 103
    • 84866150230 scopus 로고    scopus 로고
    • Globosides but not isoglobosides can impact the development of invariant nkt cells and their interaction with dendritic cells
    • Porubsky, S. et al. Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells. J. Immunol. 189, 3007-3017 (2012).
    • (2012) J. Immunol , vol.189 , pp. 3007-3017
    • Porubsky, S.1
  • 104
    • 84859927634 scopus 로고    scopus 로고
    • Peroxisome-derived lipids are self antigens that stimulate invariant natural killer t cells in the thymus
    • Facciotti, F. et al. Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nature Immunol. 13, 474-480 (2012).
    • (2012) Nature Immunol , vol.13 , pp. 474-480
    • Facciotti, F.1
  • 105
    • 33749156209 scopus 로고    scopus 로고
    • Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d
    • Zajonc, D. M., Ainge, G. D., Painter, G. F., Severn, W. B. & Wilson, I. A. Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d. J. Immunol. 177, 4577-4583 (2006). (Pubitemid 44469789)
    • (2006) Journal of Immunology , vol.177 , Issue.7 , pp. 4577-4583
    • Zajonc, D.M.1    Ainge, G.D.2    Painter, G.F.3    Severn, W.B.4    Wilson, I.A.5
  • 106
    • 40449124555 scopus 로고    scopus 로고
    • Crystal structures of mouse cd1d-igb3 complex and its cognate vα14 t cell receptor suggest a model for dual recognition of foreign and self glycolipids
    • Zajonc, D. M., Savage, P. B., Bendelac, A., Wilson, I. A. & Teyton, L. Crystal structures of mouse CD1d-iGb3 complex and its cognate Vα14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J. Mol. Biol. 377, 1104-1116 (2008).
    • (2008) J. Mol. Biol , vol.377 , pp. 1104-1116
    • Zajonc, D.M.1    Savage, P.B.2    Bendelac, A.3    Wilson, I.A.4    Teyton, L.5
  • 107
    • 71749097993 scopus 로고    scopus 로고
    • T cell allorecognition via molecular mimicry
    • Macdonald, W. A. et al. T cell allorecognition via molecular mimicry. Immunity 31, 897-908 (2009).
    • (2009) Immunity , vol.31 , pp. 897-908
    • Macdonald, W.A.1
  • 108
    • 60549093248 scopus 로고    scopus 로고
    • Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition
    • Archbold, J. K. et al. Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition. J. Exp. Med. 206, 209-219 (2009).
    • (2009) J. Exp. Med , vol.206 , pp. 209-219
    • Archbold, J.K.1
  • 111
    • 77954724158 scopus 로고    scopus 로고
    • Innate-like control of human inkt cell autoreactivity via the hypervariable cdr3β loop
    • Matulis, G. et al. Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3β loop. PLoS Biol. 8, e1000402 (2010).
    • (2010) PLoS Biol , vol.8
    • Matulis, G.1
  • 112
    • 77649247780 scopus 로고    scopus 로고
    • Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by cd1d
    • Muindi, K. et al. Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d. Proc. Natl Acad. Sci. USA 107, 3052-3057 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 3052-3057
    • Muindi, K.1
  • 113
    • 69249095385 scopus 로고    scopus 로고
    • Multiple tissue-specific isoforms of sulfatide activate cd1d-restricted type ii nkt cells
    • Blomqvist, M. et al. Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells. Eur. J. Immunol. 39, 1726-1735 (2009).
    • (2009) Eur. J. Immunol , vol.39 , pp. 1726-1735
    • Blomqvist, M.1
  • 114
    • 51649127569 scopus 로고    scopus 로고
    • Inflammation associated lysophospholipids as ligands for cd1d restricted t cells in human cancer
    • Chang, D. H. et al. Inflammation associated lysophospholipids as ligands for CD1d restricted T cells in human cancer. Blood 112, 1308-1316 (2008).
    • (2008) Blood , vol.112 , pp. 1308-1316
    • Chang, D.H.1
  • 115
    • 70350503426 scopus 로고    scopus 로고
    • Recognition of lyso-phospholipids by human natural killer t lymphocytes
    • Fox, L. M. et al. Recognition of lyso-phospholipids by human natural killer T lymphocytes. PLoS Biol. 7, e1000228 (2009).
    • (2009) PLoS Biol , vol.7
    • Fox, L.M.1
  • 116
    • 79251564431 scopus 로고    scopus 로고
    • Diverse endogenous antigens for mouse nkt cells: Self-antigens that are not glycosphingolipids
    • Pei, B. et al. Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids. J. Immunol. 186, 1348-1360 (2011).
    • (2011) J. Immunol , vol.186 , pp. 1348-1360
    • Pei, B.1
  • 117
    • 44849083151 scopus 로고    scopus 로고
    • Nkt cells in tumor immunity: Opposing subsets define a new immunoregulatory axis
    • Berzofsky, J. A. & Terabe, M. NKT cells in tumor immunity: opposing subsets define a new immunoregulatory axis. J. Immunol. 180, 3627-3635 (2008).
    • (2008) J. Immunol , vol.180 , pp. 3627-3635
    • Berzofsky, J.A.1    Terabe, M.2
  • 118
    • 84865414943 scopus 로고    scopus 로고
    • Recognition of cd1d-sulfatide mediated by a type ii natural killer t cell antigen receptor
    • Patel, O. et al. Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor. Nature Immunol. 13, 857-863 (2012).
    • (2012) Nature Immunol , vol.13 , pp. 857-863
    • Patel, O.1
  • 119
    • 84865437980 scopus 로고    scopus 로고
    • Type ii natural killer t cells use features of both innate-like and conventional t cells to recognize sulfatide self antigens
    • Girardi, E. et al. Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens. Nature Immunol. 13, 851-856 (2012).
    • (2012) Nature Immunol , vol.13 , pp. 851-856
    • Girardi, E.1
  • 120
    • 77958587927 scopus 로고    scopus 로고
    • Cd1d expression in paneth cells and rat exocrine pancreas revealed by novel monoclonal antibodies which differentially affect nkt cell activation
    • Together With Reference 118 This Study Provided The First Description Of A Type II NKT TCR-antigen-CD1d interaction
    • Together with reference 118, this study provided the first description of a type II NKT TCR-antigen-CD1d interaction. 120. Monzon-Casanova, E. et al. CD1d expression in Paneth cells and rat exocrine pancreas revealed by novel monoclonal antibodies which differentially affect NKT cell activation. PLoS ONE 5, e13089 (2010).
    • (2010) PLoS ONE , vol.5
    • Monzon-Casanova, E.1
  • 121
    • 15044358353 scopus 로고    scopus 로고
    • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity
    • DOI 10.1038/nature03391
    • Krogsgaard, M. et al. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature 434, 238-243 (2005). (Pubitemid 40388057)
    • (2005) Nature , vol.434 , Issue.7030 , pp. 238-243
    • Krogsgaard, M.1    Li, Q.-J.2    Sumen, C.3    Huppa, J.B.4    Huse, M.5    Davis, M.M.6
  • 123
    • 77951666927 scopus 로고    scopus 로고
    • Natural killer t cells are important in the pathogenesis of asthma: The many pathways to asthma
    • Umetsu, D. T. & DeKruyff, R. H. Natural killer T cells are important in the pathogenesis of asthma: the many pathways to asthma. J. Allergy Clin. Immunol. 125, 975-979 (2010).
    • (2010) J. Allergy Clin. Immunol , vol.125 , pp. 975-979
    • Umetsu, D.T.1    DeKruyff, R.H.2
  • 124
    • 77954079583 scopus 로고    scopus 로고
    • Natural killer t cells and atherosclerosis: Form and function meet pathogenesis
    • Braun, N. A., Covarrubias, R. & Major, A. S. Natural killer T cells and atherosclerosis: form and function meet pathogenesis. J. Innate Immun. 2, 316-324 (2010).
    • (2010) J. Innate Immun , vol.2 , pp. 316-324
    • Braun, N.A.1    Covarrubias, R.2    Major, A.S.3
  • 125
    • 67649890782 scopus 로고    scopus 로고
    • Combination therapy of in vitro-expanded natural killer t cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma
    • Kunii, N. et al. Combination therapy of in vitro-expanded natural killer T cells and α-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma. Cancer Sci. 100, 1092-1098 (2009).
    • (2009) Cancer Sci , vol.100 , pp. 1092-1098
    • Kunii, N.1
  • 126
    • 79851515703 scopus 로고    scopus 로고
    • Induction of nkt cell-specific immune responses in cancer tissues after nkt cell-targeted adoptive immunotherapy
    • Yamasaki, K. et al. Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy. Clin. Immunol. 138, 255-265 (2011).
    • (2011) Clin. Immunol , vol.138 , pp. 255-265
    • Yamasaki, K.1
  • 127
    • 84861754240 scopus 로고    scopus 로고
    • Structural insight into mr1-mediated recognition of the mucosal associated invariant t cell receptor
    • Reantragoon, R. et al. Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor. J. Exp. Med. 209, 761-774 (2012).
    • (2012) J. Exp. Med , vol.209 , pp. 761-774
    • Reantragoon, R.1
  • 129
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the microbiota and the immune system
    • Hooper, L. V., Littman, D. R. & Macpherson, A. J. Interactions between the microbiota and the immune system. Science 336, 1268-1273 (2012).
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 130
    • 84868135044 scopus 로고    scopus 로고
    • The molecular basis for recognition of cd1d/α-galactosylceramide by a human non-vα24 t cell receptor
    • Lpez-Sagaseta, J., Kung, J. E., Savage, P. B., Gumperz, J. & Adams, E. J. The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. PLoS Biol. 10, e1001412 (2012).
    • (2012) PLoS Biol , vol.10
    • Lpez-Sagaseta, J.1    Kung, J.E.2    Savage, P.B.3    Gumperz, J.4    Adams, E.J.5
  • 131
    • 84870284140 scopus 로고    scopus 로고
    • Mr1 presents microbial vitamin b metabolites to mait cells
    • 10 Oct (doi:10.1038/nature11605
    • Kjer-Nielsen, L. et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature 10 Oct 2012 (doi:10.1038/nature11605).
    • (2012) Nature
    • Kjer-Nielsen, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.